{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:12:01Z","timestamp":1769127121294,"version":"3.49.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.fr","clinicalkey.com.au","criticalcare.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Care Clinics"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.ccc.2018.03.003","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T14:38:10Z","timestamp":1529332690000},"page":"465-477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Complications of Durable Left Ventricular Assist Device Therapy"],"prefix":"10.1016","volume":"34","author":[{"given":"Sitaramesh","family":"Emani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"20","key":"10.1016\/j.ccc.2018.03.003_bib1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"17","key":"10.1016\/j.ccc.2018.03.003_bib2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.jacc.2014.01.053","article-title":"Results of the destination therapy post-food and drug administration approval study with a continuous flow left ventricular assist device: a prospective study using the INTERMACS registry (interagency registry for mechanically assisted circulatory support)","volume":"63","author":"Jorde","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.ccc.2018.03.003_bib3","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.healun.2017.07.005","article-title":"Eighth annual INTERMACS report: special focus on framing the impact of adverse events","volume":"36","author":"Kirklin","year":"2017","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"17","key":"10.1016\/j.ccc.2018.03.003_bib4","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.jacc.2009.12.052","article-title":"Continuous flow left ventricular assist device improves functional capacity and quality of life of advanced heart failure patients","volume":"55","author":"Rogers","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"12","key":"10.1016\/j.ccc.2018.03.003_bib5","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jacc.2012.08.1029","article-title":"Patient selection for ventricular assist devices: a moving target","volume":"61","author":"Miller","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib6","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/CIRCULATIONAHA.112.128132","article-title":"Prospective, multicenter study of ventricular assist device infections","volume":"127","author":"Gordon","year":"2013","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ccc.2018.03.003_bib7","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1586\/erc.09.86","article-title":"The future is here: ventricular assist devices for the failing heart","volume":"7","author":"Alba","year":"2009","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.healun.2010.12.001","article-title":"Third INTERMACS annual report: the evolution of destination therapy in the United States","volume":"30","author":"Kirklin","year":"2011","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jtcvs.2008.07.032","article-title":"Gastrointestinal bleeding rates in recipients of nonpulsatile and pulsatile left ventricular assist devices","volume":"137","author":"Crow","year":"2009","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"issue":"3","key":"10.1016\/j.ccc.2018.03.003_bib10","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s11239-013-0899-7","article-title":"Assessing bleeding risk in patients taking anticoagulants","volume":"35","author":"Shoeb","year":"2013","journal-title":"J\u00a0Thromb Thrombolysis"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib11","first-page":"573","article-title":"Comparison of continuous-flow and pulsatile-flow left ventricular assist devices: is there an advantage to pulsatility?","volume":"3","author":"Cheng","year":"2014","journal-title":"Ann Cardiothorac Surg"},{"issue":"3 Suppl","key":"10.1016\/j.ccc.2018.03.003_bib12","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/S0003-4975(00)02639-4","article-title":"HeartMate II left ventricular assist system: from concept to first clinical use","volume":"71","author":"Griffith","year":"2001","journal-title":"Ann Thorac Surg"},{"issue":"9","key":"10.1016\/j.ccc.2018.03.003_bib13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMoa067758","article-title":"Use of a continuous-flow device in patients awaiting heart transplantation","volume":"357","author":"Miller","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.ccc.2018.03.003_bib14","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.healun.2010.05.016","article-title":"Initial clinical experience with a novel left ventricular assist device with a magnetically levitated rotor in a multi-institutional trial","volume":"29","author":"Wieselthaler","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"20","key":"10.1016\/j.ccc.2018.03.003_bib15","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1056\/NEJMcibr1205363","article-title":"From clinical observation to mechanism: Heyde's syndrome","volume":"367","author":"Loscalzo","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib16","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597","article-title":"Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device","volume":"3","author":"Meyer","year":"2010","journal-title":"Circ Heart Fail"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jchf.2013.10.008","article-title":"Acquired von Willebrand syndrome in patients with a centrifugal or axial continuous flow left ventricular assist device","volume":"2","author":"Meyer","year":"2014","journal-title":"JACC Heart Fail"},{"issue":"8","key":"10.1016\/j.ccc.2018.03.003_bib18","first-page":"849","article-title":"Arteriovenous malformation and gastrointestinal bleeding in patients with the HeartMate II left ventricular assist device","volume":"30","author":"Demirozu","year":"2011","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"3","key":"10.1016\/j.ccc.2018.03.003_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/CIRCHEARTFAILURE.112.000206","article-title":"Pulsatility and the risk of nonsurgical bleeding in patients supported with the continuous-flow left ventricular assist device HeartMate II","volume":"6","author":"Wever-Pinzon","year":"2013","journal-title":"Circ Heart Fail"},{"issue":"Suppl 2","key":"10.1016\/j.ccc.2018.03.003_bib20","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1055\/s-0029-1240709","article-title":"Effect of pulsatile and non-pulsatile left ventricular assist devices on the renin-angiotensin system in patients with end-stage heart failure","volume":"58","author":"Welp","year":"2010","journal-title":"Thorac Cardiovasc Surg"},{"issue":"10","key":"10.1016\/j.ccc.2018.03.003_bib21","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1182\/blood-2009-01-199166","article-title":"Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells","volume":"114","author":"Shao","year":"2009","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib22","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/jcp.21706","article-title":"Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis","volume":"219","author":"Ferrari","year":"2009","journal-title":"J\u00a0Cell Physiol"},{"issue":"Suppl 6","key":"10.1016\/j.ccc.2018.03.003_bib23","doi-asserted-by":"crossref","first-page":"585S","DOI":"10.1378\/chest.128.6_suppl.585S","article-title":"Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders","volume":"128","author":"Bertolino","year":"2005","journal-title":"Chest"},{"issue":"26","key":"10.1016\/j.ccc.2018.03.003_bib24","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","article-title":"Angiotensin II blockade and aortic-root dilation in Marfan's syndrome","volume":"358","author":"Brooke","year":"2008","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.ccc.2018.03.003_bib25","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.2337\/dc06-0911","article-title":"Transforming growth factor-beta in human diabetic nephropathy: effects of ACE inhibition","volume":"29","author":"Langham","year":"2006","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.ccc.2018.03.003_bib26","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000072820","article-title":"Effect of angiotensin II receptor blocker on plasma levels of TGF-beta 1 and interstitial fibrosis in hypertensive kidney transplant patients","volume":"23","author":"el-Agroudy","year":"2003","journal-title":"Am J Nephrol"},{"issue":"4","key":"10.1016\/j.ccc.2018.03.003_bib27","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.healun.2016.12.016","article-title":"Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices","volume":"36","author":"Houston","year":"2017","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"7","key":"10.1016\/j.ccc.2018.03.003_bib28","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.RES.0000093984.48643.D7","article-title":"Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors","volume":"93","author":"Yamakawa","year":"2003","journal-title":"Circ Res"},{"issue":"11","key":"10.1016\/j.ccc.2018.03.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/CIRCHEARTFAILURE.117.004500","article-title":"Multicenter evaluation of octreotide as secondary prophylaxis in patients with left ventricular assist devices and gastrointestinal bleeding","volume":"10","author":"Shah","year":"2017","journal-title":"Circ Heart Fail"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib30","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765","article-title":"The development of aortic insufficiency in left ventricular assist device-supported patients","volume":"3","author":"Cowger","year":"2010","journal-title":"Circ Heart Fail"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.healun.2013.10.005","article-title":"Device thrombosis in HeartMate II continuous-flow left ventricular assist devices: a multifactorial phenomenon","volume":"33","author":"Uriel","year":"2014","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"15","key":"10.1016\/j.ccc.2018.03.003_bib32","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1056\/NEJMc1402278","article-title":"A\u00a0different perspective on thrombosis and the HeartMate II","volume":"370","author":"Stulak","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib33","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.healun.2010.02.003","article-title":"Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy","volume":"29","author":"Slaughter","year":"2010","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ejcts\/ezr312","article-title":"Low stroke rate and few thrombo-embolic events after HeartMate II implantation under mild anticoagulation","volume":"42","author":"Menon","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"issue":"9","key":"10.1016\/j.ccc.2018.03.003_bib35","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.healun.2009.05.018","article-title":"Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation","volume":"28","author":"Boyle","year":"2009","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib36","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/MAT.0000000000000592","article-title":"Anticoagulation control in patients with ventricular assist devices","volume":"63","author":"Boehme","year":"2017","journal-title":"ASAIO J"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa1313385","article-title":"Unexpected abrupt increase in left ventricular assist device thrombosis","volume":"370","author":"Starling","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.ccc.2018.03.003_bib38","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.athoracsur.2013.05.081","article-title":"Surgical technique influences HeartMate II left ventricular assist device thrombosis","volume":"96","author":"Taghavi","year":"2013","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2016.10.001","article-title":"PREVENtion of HeartMate II pump thrombosis through clinical management: the PREVENT multi-center study","volume":"36","author":"Maltais","year":"2017","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.healun.2013.12.001","article-title":"An analysis of pump thrombus events in patients in the HeartWare ADVANCE bridge to transplant and continued access protocol trial","volume":"33","author":"Najjar","year":"2014","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"5","key":"10.1016\/j.ccc.2018.03.003_bib41","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1056\/NEJMoa1610426","article-title":"A\u00a0fully magnetically levitated circulatory pump for advanced heart failure","volume":"376","author":"Mehra","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.ccc.2018.03.003_bib42","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/MAT.0000000000000074","article-title":"Stroke while on long-term left ventricular assist device support: incidence, outcome, and predictors","volume":"60","author":"Morgan","year":"2014","journal-title":"ASAIO J"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2012.10.001","article-title":"Axial and centrifugal continuous-flow rotary pumps: a translation from pump mechanics to clinical practice","volume":"32","author":"Moazami","year":"2013","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.athoracsur.2013.07.069","article-title":"Blood pressure control in continuous flow left ventricular assist devices: efficacy and impact on adverse events","volume":"97","author":"Lampert","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"10.1016\/j.ccc.2018.03.003_bib45","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCHEARTFAILURE.114.001955","article-title":"Changes in aortic wall structure, composition, and stiffness with continuous-flow left ventricular assist devices: a pilot study","volume":"8","author":"Ambardekar","year":"2015","journal-title":"Circ Heart Fail"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jacc.2012.09.041","article-title":"Readmissions after implantation of axial flow left ventricular assist device","volume":"61","author":"Hasin","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.ccc.2018.03.003_bib47","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ahj.2007.03.012","article-title":"Temporal trends in clinical characteristics, treatments, and outcomes for heart failure hospitalizations, 2002 to 2004: findings from Acute Decompensated Heart Failure National Registry (ADHERE)","volume":"153","author":"Fonarow","year":"2007","journal-title":"Am Heart J"},{"issue":"3","key":"10.1016\/j.ccc.2018.03.003_bib48","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jchf.2015.10.001","article-title":"Hemodynamic ramp tests in patients with left ventricular assist devices","volume":"4","author":"Uriel","year":"2016","journal-title":"JACC Heart Fail"},{"issue":"4","key":"10.1016\/j.ccc.2018.03.003_bib49","first-page":"352","article-title":"Clinical implications of hemodynamic assessment during left ventricular assist device therapy","volume":"71","author":"Imamura","year":"2018","journal-title":"J\u00a0Cardiol"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.healun.2012.09.013","article-title":"The 2013 international society for heart and lung transplantation guidelines for mechanical circulatory support: executive summary","volume":"32","author":"Feldman","year":"2013","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.ccc.2018.03.003_bib51","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.cardfail.2009.10.018","article-title":"Left ventricular remodeling and myocardial recovery on mechanical circulatory support","volume":"16","author":"Simon","year":"2010","journal-title":"J\u00a0Card Fail"},{"issue":"3","key":"10.1016\/j.ccc.2018.03.003_bib52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jacbts.2016.12.003","article-title":"Advancing the science of myocardial recovery with mechanical circulatory support: a working group of the National, Heart, Lung, and Blood Institute","volume":"2","author":"Drakos","year":"2017","journal-title":"JACC Basic Transl Sci"},{"issue":"9","key":"10.1016\/j.ccc.2018.03.003_bib53","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.healun.2015.06.015","article-title":"Right ventricular failure after left ventricular assist devices","volume":"34","author":"Lampert","year":"2015","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"8","key":"10.1016\/j.ccc.2018.03.003_bib54","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.healun.2015.03.011","article-title":"Incidence and clinical significance of late right heart failure during continuous-flow left ventricular assist device support","volume":"34","author":"Takeda","year":"2015","journal-title":"J\u00a0Heart Lung Transplant"},{"issue":"1","key":"10.1016\/j.ccc.2018.03.003_bib55","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.healun.2017.10.019","article-title":"Quality of life and functional capacity outcomes in the MOMENTUM 3 trial at 6\u00a0months: a call for new metrics for left ventricular assist device patients","volume":"37","author":"Cowger","year":"2018","journal-title":"J\u00a0Heart Lung Transplant"}],"container-title":["Critical Care Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749070418306808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749070418306808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T09:45:51Z","timestamp":1532079951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0749070418306808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0749070418306808"],"URL":"https:\/\/doi.org\/10.1016\/j.ccc.2018.03.003","relation":{},"ISSN":["0749-0704"],"issn-type":[{"value":"0749-0704","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complications of Durable Left Ventricular Assist Device Therapy","name":"articletitle","label":"Article Title"},{"value":"Critical Care Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccc.2018.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}