{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:15:50Z","timestamp":1760573750792,"version":"build-2065373602"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","criticalcare.theclinics.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Critical Care Clinics"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ccc.2025.07.001","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:46:27Z","timestamp":1760503587000},"page":"665-681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Antipsychotic Agents for Adjunct Sedation"],"prefix":"10.1016","volume":"41","author":[{"given":"Jeremy","family":"DeGrado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Devlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ccc.2025.07.001_bib1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00134-022-06806-x","article-title":"Evolution of sedation management in the intensive care unit (ICU)","volume":"48","author":"Stollings","year":"2022","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13613-022-00985-y","article-title":"Practices in sedation, analgesia, mobilization, delirium, and sleep deprivation in adult intensive care units (SAMDS-ICU): an international survey before and during the COVID-19 pandemic","volume":"12","author":"Luz","year":"2022","journal-title":"Ann Intensive Care"},{"issue":"6 Suppl","key":"10.1016\/j.ccc.2025.07.001_bib3","doi-asserted-by":"crossref","first-page":"S231","DOI":"10.1097\/CCM.0b013e3181de125a","article-title":"Adverse drug events associated with the use of analgesics, sedatives and antipsychotics in the intensive care unit","volume":"38","author":"Devlin","year":"2010","journal-title":"Crit Care Med"},{"issue":"9","key":"10.1016\/j.ccc.2025.07.001_bib4","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1097\/CCM.0000000000005053","article-title":"Association of sedation, coma, and in-hospital mortality in mechanically ventilated patients with coronavirus disease 2019-related acute respiratory distress syndrome: a retrospective cohort study","volume":"49","author":"Wongtangman","year":"2021","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.ccc.2025.07.001_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S2213-2600(23)00141-8","article-title":"A multi-modal, patient-centric approach to remove sedation in the ICU","volume":"11","author":"Eikermann","year":"2023","journal-title":"Lancet Respir Med"},{"issue":"3","key":"10.1016\/j.ccc.2025.07.001_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2213-2600(18)30062-6","article-title":"Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study","volume":"6","author":"Girard","year":"2018","journal-title":"Lancet Respir Med"},{"issue":"9","key":"10.1016\/j.ccc.2025.07.001_bib7","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical practice guidelines for the prevention and management of pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the intensive care unit","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/CCM.0000000000003482","article-title":"Caring for critically ill patients with the ABCDEF bundle: results of the ICU Liberation Collaborative in over 15,000 adults","volume":"47","author":"Pun","year":"2019","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccc.2025.07.001_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/CCM.0000000000004116","article-title":"Effect of best practice advisories on sedation protocol compliance and drug-related hazardous condition mitigation among critical care patients","volume":"48","author":"Greene","year":"2020","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.ccc.2025.07.001_bib10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/phar.2017","article-title":"Repurposing valproate, enteral clonidine, and phenobarbital for comfort in adult ICU patients: a literature review with practical considerations","volume":"37","author":"Gagnon","year":"2017","journal-title":"Pharmacother"},{"issue":"4","key":"10.1016\/j.ccc.2025.07.001_bib11","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.clinthera.2020.02.007","article-title":"Valproic acid for the management of agitation and delirium in the intensive care setting: a retrospective analysis","volume":"42","author":"Crowley","year":"2020","journal-title":"Clin Ther"},{"issue":"2","key":"10.1016\/j.ccc.2025.07.001_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/1060028020944409","article-title":"Effectiveness of quetiapine as a sedative adjunct in mechanically ventilated adults without delirium","volume":"55","author":"Ohman","year":"2021","journal-title":"Ann Pharmacother"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/08850666231188029","article-title":"Evaluation of atypical antipsychotics for the facilitation of weaning sedation in mechanically ventilated critically ill patients","volume":"39","author":"Assadoon","year":"2024","journal-title":"J Intensive Care Med"},{"issue":"5","key":"10.1016\/j.ccc.2025.07.001_bib14","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/00185787241242769","article-title":"Evaluation of the impact of the addition of atypical antipsychotics to continuous infusion propofol therapy","volume":"59","author":"Crocker","year":"2024","journal-title":"Hosp Pharm"},{"issue":"10","key":"10.1016\/j.ccc.2025.07.001_bib15","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1177\/10600280211069617","article-title":"Impact of ketamine on analgosedative consumption in critically ill patients: a systematic review and meta-analysis","volume":"56","author":"Chan","year":"2022","journal-title":"Ann Pharmacother"},{"issue":"2","key":"10.1016\/j.ccc.2025.07.001_bib16","doi-asserted-by":"crossref","first-page":"e257","DOI":"10.1097\/CCM.0000000000006534","article-title":"Propranolol as an anxiolytic to reduce the use of sedatives for critically ill adults receiving mechanical ventilation (PROACTIVE): an open-label randomized controlled trial","volume":"53","author":"Downer","year":"2025","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ccc.2025.07.001_bib17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/08850666221138234","article-title":"Agitated patients in the intensive care unit: guidelines for causal rather than symptomatic treatment are warranted","volume":"38","author":"Azimaraghi","year":"2023","journal-title":"J Intensive Care Med"},{"issue":"15","key":"10.1016\/j.ccc.2025.07.001_bib18","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1056\/NEJMoa2024922","article-title":"Dexmedetomidine vs. propofol for sedation in mechanically ventilated adults with sepsis","volume":"384","author":"Hughes","year":"2021","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ccc.2025.07.001_bib19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.anclin.2011.09.001","article-title":"Pharmacology of commonly used analgesics and sedatives in the ICU: benzodiazepines, propofol and opioids","volume":"29","author":"Devlin","year":"2011","journal-title":"Anesth Clin"},{"issue":"11","key":"10.1016\/j.ccc.2025.07.001_bib20","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/phar.2768","article-title":"A pharmacogenetic precision medicine approach to analgesia and sedation optimization in critically ill adults","volume":"43","author":"Dzierba","year":"2023","journal-title":"Pharmacotherapy"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13054-016-1405-3","article-title":"Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption","volume":"20","author":"Mehta","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.ccc.2025.07.001_bib22","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/CCM.0000000000003071","article-title":"Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: a multinational prospective longitudinal cohort study","volume":"46","author":"Shehabi","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ccc.2025.07.001_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13054-022-04042-9","article-title":"A dual-center cohort study on the association between early deep sedation and clinical outcomes in mechanically ventilated patients during the COVID-19 pandemic: the COVID-SED study","volume":"26","author":"Stephens","year":"2022","journal-title":"Crit Care"},{"issue":"12","key":"10.1016\/j.ccc.2025.07.001_bib24","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1007\/s00134-015-4063-z","article-title":"Benzodiazepine-associated delirium in critically ill adults","volume":"41","author":"Zaal","year":"2015","journal-title":"Intensive Care Med"},{"issue":"5","key":"10.1016\/j.ccc.2025.07.001_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1164\/rccm.202010-3794OC","article-title":"Opioid use increases the risk of delirium independently of pain in critically ill adults","volume":"204","author":"Duprey","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.ccc.2025.07.001_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s40801-019-00161-y","article-title":"Serious cardiovascular adverse events reported with intravenous sedatives: a retrospective analysis of the MedWatch adverse event reporting. System","volume":"6","author":"Duprey","year":"2019","journal-title":"Drugs Real World Outcomes"},{"issue":"12","key":"10.1016\/j.ccc.2025.07.001_bib27","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00134-023-07254-x","article-title":"Scheduled IV opioids","volume":"49","author":"McKenze","year":"2023","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13054-019-2531-5","article-title":"Asynchronies in the Intensive Care Unit (ASYNICU) Group. Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients","volume":"23","author":"de Haro","year":"2019","journal-title":"Crit Care"},{"issue":"12","key":"10.1016\/j.ccc.2025.07.001_bib29","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1007\/s00134-020-06307-9","article-title":"Analgesia and sedation in patients with ARDS","volume":"46","author":"Chanques","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ccc.2025.07.001_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102417","article-title":"The influence of drugs used for sedation during mechanical ventilation on respiratory pattern during unassisted breathing and assisted mechanical ventilation: a physiological systematic review and meta-analysis","volume":"68","author":"Quickfall","year":"2024","journal-title":"eClinicalMedicine"},{"issue":"3","key":"10.1016\/j.ccc.2025.07.001_bib31","article-title":"Multimodal strategy to counteract vasodilation in septic shock","volume":"42","author":"Leone","year":"2023","journal-title":"Anaesth Crit Care Pain Med"},{"issue":"7","key":"10.1016\/j.ccc.2025.07.001_bib32","article-title":"Adjuvant analgesic use in the critically ill: a systematic review and meta-analysis","volume":"2","author":"Wheeler","year":"2020","journal-title":"Crit Care Explor"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1055\/s-0040-1716736","article-title":"Optimal sedation and pain management: a patient- and symptom-oriented paradigm","volume":"42","author":"Shehabi","year":"2021","journal-title":"Semin Respir Crit"},{"issue":"11","key":"10.1016\/j.ccc.2025.07.001_bib34","doi-asserted-by":"crossref","first-page":"e1111","DOI":"10.1097\/CCM.0000000000002640","article-title":"Worldwide survey of the \u201cassessing pain, both spontaneous awakening and breathing trials, choice of drugs, delirium monitoring\/management, early exercise\/mobility, and family empowerment\u201d (ABCDEF) bundle","volume":"45","author":"Morandi","year":"2017","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.ccc.2025.07.001_bib35","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1213\/ANE.0000000000005365","article-title":"Pharmacologic management of intensive care unit delirium: clinical prescribing practices and outcomes in more than 8500 patient encounters","volume":"133","author":"Boncyk","year":"2021","journal-title":"Anesth Analg"},{"issue":"9","key":"10.1016\/j.ccc.2025.07.001_bib36","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/1060028020988734","article-title":"Safety of intravenous olanzapine administration at a tertiary academic medical center","volume":"55","author":"Hunt","year":"2021","journal-title":"Ann Pharmacother"},{"issue":"6","key":"10.1016\/j.ccc.2025.07.001_bib37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1177\/10600280241290254","article-title":"Olanzapine Versus Quetiapine: Corrected QT Changes in Critically Ill Patients. et al","volume":"59","author":"Shen","year":"2025","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.ccc.2025.07.001_bib38","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.euroneuro.2023.04.015","article-title":"Comparing the pharmacology and pharmacokinetics of antipsychotics: choosing an antipsychotic and dosing a long-acting injectable","volume":"73","author":"Stahl","year":"2023","journal-title":"Eur Neuropsyhcopharm"},{"key":"10.1016\/j.ccc.2025.07.001_bib39","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1176\/appi.ajp.20240738","article-title":"Antipsychotic drugs: a concise review of history, classification, indications, mechanism, efficacy, side effects, dosing, and clinical application","volume":"181","author":"Leucht","year":"2024","journal-title":"Am J Psych"},{"issue":"4","key":"10.1016\/j.ccc.2025.07.001_bib40","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jsmc.2010.08.010","article-title":"Antidepressant and antipsychotic drugs","volume":"5","author":"Krystal","year":"2010","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.ccc.2025.07.001_bib41","first-page":"1163","article-title":"Clinical pharmacology of atypical antipsychotics: an update","volume":"13","author":"Mauri","year":"2014","journal-title":"EXCLI J"},{"issue":"suppl 10","key":"10.1016\/j.ccc.2025.07.001_bib42","first-page":"55","article-title":"The relationship of pharmacology to side effects","volume":"58","author":"Casey","year":"1997","journal-title":"J Clin Psych"},{"issue":"6","key":"10.1016\/j.ccc.2025.07.001_bib43","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1055\/s-0044-1791246","article-title":"Pharmacologic treatment strategies for delirium in hospitalized adults: past, present and future","volume":"44","author":"Devlin","year":"2024","journal-title":"Semin Neurol"},{"issue":"7","key":"10.1016\/j.ccc.2025.07.001_bib44","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00134-018-5204-y","article-title":"Prevalence and risk factor related to haloperidol use for delirium in adult intensive care unit patients: the multinational AID-ICU inception cohort study","volume":"44","author":"Collet","year":"2018","journal-title":"Intensive Care Med"},{"issue":"22","key":"10.1016\/j.ccc.2025.07.001_bib45","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa052827","article-title":"Risk of death in elderly users of conventional vs. atypical antipsychotic medications","volume":"353","author":"Wang","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ccc.2025.07.001_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10673229.2011.565247","article-title":"Antipsychotics for the prevention and treatment of delirium in the ICU: what is their role?","volume":"19","author":"Devlin","year":"2011","journal-title":"Harv Rev Psychiatr"},{"issue":"2","key":"10.1016\/j.ccc.2025.07.001_bib47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/CCM.0b013e3181b9e302","article-title":"Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study","volume":"38","author":"Devlin","year":"2010","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.ccc.2025.07.001_bib48","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S2213-2600(13)70166-8","article-title":"Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial","volume":"1","author":"Page","year":"2013","journal-title":"Lancet Respir Med"},{"issue":"26","key":"10.1016\/j.ccc.2025.07.001_bib49","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1056\/NEJMoa1808217","article-title":"Haloperidol and ziprasidone for treatment of delirium in critical illness","volume":"379","author":"Girard","year":"2018","journal-title":"N Engl J Med"},{"issue":"26","key":"10.1016\/j.ccc.2025.07.001_bib50","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1056\/NEJMoa2211868","article-title":"Haloperidol for the treatment of delirium in ICU patients","volume":"387","author":"Andersen-Ranberg","year":"2022","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib51","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1186\/s13054-023-04692-3","article-title":"Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial","volume":"27","author":"Smit","year":"2023","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.ccc.2025.07.001_bib52","doi-asserted-by":"crossref","DOI":"10.1186\/cc10450","article-title":"Impact of quetiapine on the resolution of individual delirium symptoms in critically ill patients with delirium: a double-blind, randomized, placebo-controlled pilot study","volume":"15","author":"Devlin","year":"2021","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.ccc.2025.07.001_bib53","article-title":"Characterization of nocturnal neuroactive medication use and related sleep documentation in critically ill adults","volume":"3","author":"Hamidi","year":"2021","journal-title":"Crit Care Explor"},{"issue":"6","key":"10.1016\/j.ccc.2025.07.001_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287929","article-title":"Impacts of antipsychotic medication prescribing practices in critically ill adult patients on health resource utilization and new psychoactive medication prescriptions","volume":"18","author":"Jaworska","year":"2023","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.ccc.2025.07.001_bib55","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1378\/chest.13-1448","article-title":"Efficacy and safety of dexmedetomidine during non-invasive ventilation for patients with acute respiratory failure: a randomized, double-blind, placebo-controlled, pilot study","volume":"145","author":"Devlin","year":"2014","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.ccc.2025.07.001_bib56","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1097\/CCM.0000000000002103","article-title":"Intended and unintended consequences of constraining clinician prescribing: the case of antipsychotics","volume":"44","author":"Devlin","year":"2016","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccc.2025.07.001_bib57","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1097\/CCM.0000000000006514","article-title":"Advancing delirium treatment trials: recommendation for future research from the NIDUS Delirium Network","volume":"53","author":"Devlin","year":"2025","journal-title":"Crit Care Med"}],"container-title":["Critical Care Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749070425000478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0749070425000478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:48:27Z","timestamp":1760503707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0749070425000478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0749070425000478"],"URL":"https:\/\/doi.org\/10.1016\/j.ccc.2025.07.001","relation":{},"ISSN":["0749-0704"],"issn-type":[{"value":"0749-0704","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Antipsychotic Agents for Adjunct Sedation","name":"articletitle","label":"Article Title"},{"value":"Critical Care Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccc.2025.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}