{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:40:07Z","timestamp":1762983607477,"version":"3.45.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":140,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00c3\u00b6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003006","name":"Eidgen\u00c3\u00b6ssische Technische Hochschule Z\u00c3\u00bcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007214","name":"Velux Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00c3\u00b6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2EZP3_148738","33CM30_124111","320030_125378\/1"],"award-info":[{"award-number":["P2EZP3_148738","33CM30_124111","320030_125378\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cerebral Circulation - Cognition and Behavior"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.cccb.2020.100001","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T12:20:32Z","timestamp":1591359632000},"page":"100001","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life"],"prefix":"10.1016","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0942-9797","authenticated-orcid":false,"given":"Irene B.","family":"Meier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick J.","family":"Lao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Gietl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9780-0343","authenticated-orcid":false,"given":"Robert S.","family":"Vorburger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.G.","family":"Guttmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik S.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Buck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger M.","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Hock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G.","family":"Unschuld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.cccb.2020.100001_bib0001","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"34","key":"10.1016\/j.cccb.2020.100001_bib0002","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1523\/JNEUROSCI.2177-05.2005","article-title":"Molecular, structural, and functional characterization of Alzheimer\u2019s disease: evidence for a relationship between default activity, amyloid, and memory","volume":"25","author":"Buckner","year":"2005","journal-title":"J. Neurosci."},{"issue":"47","key":"10.1016\/j.cccb.2020.100001_bib0003","doi-asserted-by":"crossref","first-page":"14770","DOI":"10.1523\/JNEUROSCI.3669-09.2009","article-title":"Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve","volume":"29","author":"Cohen","year":"2009","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.cccb.2020.100001_bib0004","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/jcbfm.2015.66","article-title":"Quantification of blood flow-dependent component in estimates of beta-amyloid load obtained using quasi-steady-state standardized uptake value ratio","volume":"35","author":"Cselenyi","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.cccb.2020.100001_bib0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/2051-5960-1-75","article-title":"Mild chronic cerebral hypoperfusion induces neurovascular dysfunction, triggering peripheral beta-amyloid brain entry and aggregation","volume":"1","author":"ElAli","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"issue":"5","key":"10.1016\/j.cccb.2020.100001_bib0006","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1179\/016164101101198758","article-title":"Physiological levels of beta-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production","volume":"23","author":"Price","year":"2001","journal-title":"Neurol. Res."},{"issue":"2","key":"10.1016\/j.cccb.2020.100001_bib0007","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.cccb.2020.100001_bib0008","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.nbd.2010.06.002","article-title":"Vascular response to acetazolamide decreases as a function of age in the arcA beta mouse model of cerebral amyloidosis","volume":"40","author":"Princz-Kranz","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.cccb.2020.100001_bib0009","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.tics.2011.09.004","article-title":"Lifespan brain activity, beta-amyloid, and Alzheimer\u2019s disease","volume":"15","author":"Jagust","year":"2011","journal-title":"Trends Cognit. Sci."},{"issue":"6","key":"10.1016\/j.cccb.2020.100001_bib0010","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.cccb.2020.100001_bib0011","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1073\/pnas.90.11.5191","article-title":"Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices","volume":"90","author":"Nitsch","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.cccb.2020.100001_bib0012","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ana.410380304","article-title":"Aging, energy, and oxidative stress in neurodegenerative diseases","volume":"38","author":"Beal","year":"1995","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.cccb.2020.100001_bib0013","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.neurobiolaging.2014.12.036","article-title":"Regional cerebral blood flow estimated by early PiB uptake is reduced in mild cognitive impairment and associated with age in an amyloid-dependent manner","volume":"36","author":"Gietl","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cccb.2020.100001_bib0014","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A rating scale for depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.cccb.2020.100001_bib0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnagi.2014.00052","article-title":"Cortical amyloid beta in cognitively normal elderly adults is associated with decreased network efficiency within the cerebro-cerebellar system","volume":"6","author":"Steininger","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.cccb.2020.100001_bib0016","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/1053-8119(92)90006-9","article-title":"Anatomical mapping of functional activation in stereotactic coordinate space","volume":"1","author":"Evans","year":"1992","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.cccb.2020.100001_bib0017","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/hbm.10123","article-title":"Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe","volume":"19","author":"Hammers","year":"2003","journal-title":"Hum. Brain Mapp."},{"issue":"4","key":"10.1016\/j.cccb.2020.100001_bib0018","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1161\/STROKEAHA.107.497438","article-title":"Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging","volume":"39","author":"Holland","year":"2008","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.cccb.2020.100001_bib0019","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn.2801","article-title":"Neuronal activity regulates the regional vulnerability to amyloid-beta deposition","volume":"14","author":"Bero","year":"2011","journal-title":"Nat. Neurosci."},{"issue":"12","key":"10.1016\/j.cccb.2020.100001_bib0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11910-013-0415-7","article-title":"Contemplating Alzheimer\u2019s disease and the contribution of white matter hyperintensities","volume":"13","author":"Brickman","year":"2013","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"2","key":"10.1016\/j.cccb.2020.100001_bib0021","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","article-title":"Impact of multiple pathologies on the threshold for clinically overt dementia","volume":"134","author":"Kapasi","year":"2017","journal-title":"Acta Neuropathol."},{"issue":"7","key":"10.1016\/j.cccb.2020.100001_bib0022","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/brain\/awx112","article-title":"Disease Neuroimaging, Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia","volume":"140","author":"Yew","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.cccb.2020.100001_bib0023","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fnagi.2017.00181","article-title":"Cerebral blood flow and amyloid-beta interact to affect memory performance in cognitively normal older adults","volume":"9","author":"Bangen","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.cccb.2020.100001_bib0024","article-title":"Increased cerebral blood flow with increased amyloid burden in the preclinical phase of alzheimer\u2019s disease","author":"Fazlollahi","year":"2019","journal-title":"J. Magn. Reson. Imaging"},{"issue":"12","key":"10.1016\/j.cccb.2020.100001_bib0025","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1038\/nm.3734","article-title":"Longitudinal PET-MRI reveals beta-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion","volume":"20","author":"Maier","year":"2014","journal-title":"Nat. Med."},{"issue":"Pt 5","key":"10.1016\/j.cccb.2020.100001_bib0026","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/brain\/awu043","article-title":"Association of brain amyloid-beta with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment","volume":"137","author":"Mattsson","year":"2014","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.cccb.2020.100001_bib0027","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"issue":"28","key":"10.1016\/j.cccb.2020.100001_bib0028","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1523\/JNEUROSCI.0639-16.2016","article-title":"In vivo tau, amyloid, and gray matter profiles in the aging brain","volume":"36","author":"Sepulcre","year":"2016","journal-title":"J. Neurosci."},{"issue":"Suppl 4","key":"10.1016\/j.cccb.2020.100001_bib0029","doi-asserted-by":"crossref","first-page":"S421","DOI":"10.3233\/JAD-141461","article-title":"Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies","volume":"42","author":"Thal","year":"2014","journal-title":"J Alzheimers Dis"},{"issue":"41","key":"10.1016\/j.cccb.2020.100001_bib0030","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1073\/pnas.1010461107","article-title":"Spatial correlation between brain aerobic glycolysis and amyloid-beta (Abeta ) deposition","volume":"107","author":"Vlassenko","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.cccb.2020.100001_bib0031","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/jcbfm.2009.188","article-title":"Cerebral blood flow response to functional activation","volume":"30","author":"Paulson","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"10.1016\/j.cccb.2020.100001_bib0032","doi-asserted-by":"crossref","DOI":"10.1038\/nrn2579","article-title":"Brain metabolism: astrocytes bridge the gap","volume":"10","author":"Welberg","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"9","key":"10.1016\/j.cccb.2020.100001_bib0033","first-page":"2755","article-title":"Molecular properties underlying regional vulnerability to Alzheimer's disease pathology","volume":"141","author":"Grothe","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.cccb.2020.100001_bib34","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2796.2004.01380.x","article-title":"Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.","author":"Winblad","year":"2004","journal-title":"J. Intern. Med."}],"container-title":["Cerebral Circulation - Cognition and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666245020300015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666245020300015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:24:55Z","timestamp":1762979095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666245020300015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":34,"alternative-id":["S2666245020300015"],"URL":"https:\/\/doi.org\/10.1016\/j.cccb.2020.100001","relation":{},"ISSN":["2666-2450"],"issn-type":[{"type":"print","value":"2666-2450"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life","name":"articletitle","label":"Article Title"},{"value":"Cerebral Circulation - Cognition and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cccb.2020.100001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100001"}}