{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:23:10Z","timestamp":1780676590931,"version":"3.54.1"},"reference-count":133,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":211,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cerebral Circulation - Cognition and Behavior"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.cccb.2025.100392","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:51:11Z","timestamp":1754430671000},"page":"100392","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The effect of visit-to-visit blood pressure variability on cognitive function: state-of the-art"],"prefix":"10.1016","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-1369","authenticated-orcid":false,"given":"Michiaki","family":"Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel J","family":"Sible","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"Tully","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunny S.","family":"Po","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun W.","family":"Dasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cccb.2025.100392_bib0001","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(10)60309-1","article-title":"Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension","volume":"375","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cccb.2025.100392_bib0002","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(10)60309-1","article-title":"Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension","volume":"375","author":"Rothwell","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cccb.2025.100392_bib0003","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1097\/HJH.0b013e3283018333","article-title":"Ambulatory blood pressure as an independent determinant of brain atrophy and cognitive function in elderly hypertension","volume":"26","author":"Nagai","year":"2008","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0004","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/ajh.2009.212","article-title":"Hypertension and dementia","volume":"23","author":"Nagai","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0005","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/01.ATV.0000102660.99744.85","article-title":"Atherosclerosis and neurodegeneration: unexpected conspirators in Alzheimer's dementia","volume":"23","author":"Iadecola","year":"2003","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cccb.2025.100392_bib0006","first-page":"107","article-title":"The decline and resurgence of vascular dementia","volume":"142","author":"Hachinski","year":"1990","journal-title":"CMAJ"},{"key":"10.1016\/j.cccb.2025.100392_bib0007","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000346725","article-title":"Role of 24-hour blood pressure management in preventing kidney disease and stroke","volume":"179","author":"Nagai","year":"2013","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.cccb.2025.100392_bib0008","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/ajh\/hpt167","article-title":"Visit-to-visit blood pressure variability, silent cerebral injury, and risk of stroke","volume":"26","author":"Nagai","year":"2013","journal-title":"Am. J. Hypertens."},{"issue":"Suppl 1","key":"10.1016\/j.cccb.2025.100392_bib0009","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/ggi.12660","article-title":"Visit-to-visit blood pressure variability and dementia","volume":"15","author":"Nagai","year":"2015","journal-title":"Geriatr. Gerontol. Int."},{"key":"10.1016\/j.cccb.2025.100392_bib0010","volume":"6","author":"Sherlock","year":"2024"},{"key":"10.1016\/j.cccb.2025.100392_bib0011","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3233\/JAD-161172","article-title":"Visit-to-visit blood pressure variability and Alzheimer's disease: links and risks","volume":"59","author":"Nagai","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0012","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jacc.2019.12.033","article-title":"The Alzheimer's disease amyloid-beta hypothesis in cardiovascular aging and disease: JACC focus seminar","volume":"75","author":"Stakos","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0013","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7326\/M14-2803","article-title":"Visit-to-visit variability of blood pressure and coronary heart disease, stroke, heart failure, and mortality: a cohort study","volume":"163","author":"Muntner","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cccb.2025.100392_bib0014","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1097\/HJH.0000000000000739","article-title":"Blood pressure variability predicts cardiovascular events independently of traditional cardiovascular risk factors and target organ damage: a LIFE substudy","volume":"33","author":"Vishram","year":"2015","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0015","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jacc.2016.06.054","article-title":"Association of systolic blood pressure variability with mortality, coronary heart disease, stroke, and renal disease","volume":"68","author":"Gosmanova","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0016","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/eurheartj\/ehx250","article-title":"Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial","volume":"38","author":"Vidal-Petiot","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2025.100392_bib0017","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1161\/HYPERTENSIONAHA.117.09714","article-title":"Relative and combined prognostic importance of on-treatment mean and visit-to-visit blood pressure variability in ontarget and transcend patients","volume":"70","author":"Mancia","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0018","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/eurheartj\/ehx760","article-title":"Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks","volume":"39","author":"Mehlum","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2025.100392_bib0019","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/jch.13346","article-title":"Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT","volume":"20","author":"Mezue","year":"2018","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"10.1016\/j.cccb.2025.100392_bib0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1161\/HYPERTENSIONAHA.110.162255","article-title":"The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994","volume":"57","author":"Muntner","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0021","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jash.2011.03.001","article-title":"Visit-to-visit blood pressure variations: new independent determinants for carotid artery measures in the elderly at high risk of cardiovascular disease","volume":"5","author":"Nagai","year":"2011","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0022","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/jch.14314","article-title":"Visit-to-visit office blood pressure variability combined with Framingham risk score to predict all-cause mortality: a post hoc analysis of the systolic blood pressure intervention trial","volume":"23","author":"Cheng","year":"2021","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"10.1016\/j.cccb.2025.100392_bib0023","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1097\/HJH.0b013e3283552735","article-title":"Visit-to-visit blood pressure variations: new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease","volume":"30","author":"Nagai","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0024","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1161\/HYPERTENSIONAHA.121.17797","article-title":"Association between blood pressure variability with dementia and cognitive impairment: a systematic review and meta-analysis","volume":"78","author":"de Heus","year":"2021","journal-title":"Hypertension"},{"issue":"5 Suppl","key":"10.1016\/j.cccb.2025.100392_bib0025","first-page":"S330","article-title":"Blood pressure variability and risk of dementia in an elderly cohort, the three-city study","volume":"10","author":"Alp\u00e9rovitch","year":"2014","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cccb.2025.100392_bib0026","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3233\/JAD-170757","article-title":"Visit-to-visit blood pressure variability and the risk of dementia in older people","volume":"62","author":"van Middelaar","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0027","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/HYPERTENSIONAHA.119.14033","article-title":"Blood pressure variability and the risk of dementia: a nationwide cohort study","volume":"75","author":"Yoo","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0028","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/ckj\/sfac020","article-title":"Association between visit-to-visit blood pressure variability and risks of dementia in CKD patients: a nationwide observational cohort study","volume":"15","author":"Park","year":"2022","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.cccb.2025.100392_bib0029","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1038\/s41598-024-52406-8","article-title":"Blood pressure variability supersedes heart rate variability as a real-world measure of dementia risk","volume":"14","author":"Ebinger","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cccb.2025.100392_bib0030","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1002\/alz.13356","article-title":"Long-term blood pressure patterns in midlife and dementia in later life: findings from the Framingham heart study","volume":"19","author":"Kim","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cccb.2025.100392_bib0031","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/01.STR.0000133128.42462.ef","article-title":"Decline in blood pressure over time and risk of dementia: a longitudinal study from the Kungsholmen project","volume":"35","author":"Qiu","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2025.100392_bib0032","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization, dysfunction, and perspective","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.cccb.2025.100392_bib0033","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000486306","article-title":"Blood pressure variability in acute ischemic stroke: influence of infarct location in the insular cortex","volume":"79","author":"Kitamura","year":"2018","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.cccb.2025.100392_bib0034","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/WAD.0000000000000340","article-title":"The insular cortex, Alzheimer disease pathology, and their effects on blood pressure variability","volume":"34","author":"Kitamura","year":"2020","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.cccb.2025.100392_bib0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/WAD.0000000000000040","article-title":"Visit-to-visit blood pressure variability in Alzheimer disease","volume":"28","author":"Lattanzi","year":"2014","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.cccb.2025.100392_bib0036","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.neurobiolaging.2014.04.023","article-title":"Blood pressure variability predicts cognitive decline in Alzheimer's disease patients","volume":"35","author":"Lattanzi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cccb.2025.100392_bib0037","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3233\/JAD-180774","article-title":"Effect of visit-to-visit blood pressure variability on cognitive and functional decline in mild to moderate Alzheimer's disease","volume":"68","author":"O'Caoimh","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0038","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/HYPERTENSIONAHA.119.13664","article-title":"Blood pressure variability and progression of clinical Alzheimer Disease","volume":"74","author":"de Heus","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0039","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer\u2019s disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.cccb.2025.100392_bib0040","doi-asserted-by":"crossref","first-page":"f4600","DOI":"10.1136\/bmj.f4600","article-title":"Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study","volume":"347","author":"Sabayan","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.cccb.2025.100392_bib0041","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/HYPERTENSIONAHA.114.03978","article-title":"Long-term blood pressure variability throughout young adulthood and cognitive function in midlife: the coronary artery risk development in young adults (CARDIA) study","volume":"64","author":"Yano","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0042","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/ageing\/afx102","article-title":"Increased diastolic blood pressure is associated with MRI biomarkers of dementia-related brain pathology in normative ageing","volume":"47","author":"McNeil","year":"2018","journal-title":"Age Ageing"},{"key":"10.1016\/j.cccb.2025.100392_bib0043","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.3233\/JAD-200221","article-title":"Alzheimer\u2019s disease neuroimaging initiative. Long-term blood pressure variability across the clinical and biomarker spectrum of Alzheimer's disease","volume":"77","author":"Sible","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/JAD-210435","article-title":"Nation DA. Antemortem visit-to-visit blood pressure variability predicts cerebrovascular lesion burden in autopsy-confirmed Alzheimer's disease","volume":"83","author":"Sible","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0045","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neurobiolaging.2021.04.009","article-title":"Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults","volume":"105","author":"Sible","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cccb.2025.100392_bib0046","doi-asserted-by":"crossref","first-page":"e2812","DOI":"10.1212\/WNL.0000000000012065","article-title":"Visit-to-visit blood pressure variability, neuropathology, and cognitive decline","volume":"96","author":"Ma","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.cccb.2025.100392_bib0047","doi-asserted-by":"crossref","first-page":"e2446","DOI":"10.1212\/WNL.0000000000200302","article-title":"Alzheimer's disease neuroimaging initiative. Visit-to-visit blood pressure variability and CSF Alzheimer disease biomarkers in cognitively unimpaired and mildly impaired older adults","volume":"98","author":"Sible","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.cccb.2025.100392_bib0048","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/HYPERTENSIONAHA.121.18479","article-title":"Visit-to-visit blood pressure variability and longitudinal Tau accumulation in older adults","volume":"79","author":"Sible","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0049","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s11682-021-00553-1","article-title":"Alzheimer\u2019s disease neuroimaging initiative. Blood pressure variability and medial temporal atrophy in apolipoprotein \u03f54 carriers","volume":"16","author":"Sible","year":"2022","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.cccb.2025.100392_bib0050","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3233\/JAD-221103","article-title":"Alzheimer\u2019s disease neuroimaging initiative. Visit-to-visit blood pressure variability and cognitive decline in apolipoprotein \u025b4 carriers versus apolipoprotein \u025b3 homozygotes","volume":"93","author":"Sible","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0051","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3233\/JAD-230930","article-title":"Blood pressure variability and plasma Alzheimer's disease biomarkers in the SPRINT trial","volume":"97","author":"Sible","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0052","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13195-024-01483-y","article-title":"Distinct effects of blood pressure parameters on Alzheimer's and vascular markers in 1952 Asian individuals without dementia","volume":"16","author":"Lee","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.cccb.2025.100392_bib0053","article-title":"Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of cognitive impairment and dementia","volume":"5","author":"Cunningham","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.cccb.2025.100392_bib0054","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1093\/eurheartj\/ehac584","article-title":"Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis","volume":"43","author":"Peters","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2025.100392_bib0055","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.33353","article-title":"Use of antihypertensives, blood pressure, and estimated risk of dementia in late life: an individual participant data meta-analysis","volume":"6","author":"Lennon","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.cccb.2025.100392_bib0056","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1161\/HYPERTENSIONAHA.121.18255","article-title":"Effect of antihypertensive treatment on cerebral blood flow in older adults: a systematic review and meta-analysis","volume":"79","author":"van Rijssel","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0057","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/eurheartj\/ehad814","article-title":"ASCOT-10 investigators. Legacy benefits of blood pressure treatment on cardiovascular events are primarily mediated by improved blood pressure variability: the ASCOT trial","volume":"45","author":"Gupta","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2025.100392_bib0058","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(10)60235-8","article-title":"Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis","volume":"375","author":"Webb","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cccb.2025.100392_bib0059","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(98)03086-4","article-title":"Prevention of dementia in randomised double-blind placebo-controlled systolic hypertension in Europe (Syst-Eur) trial","volume":"352","author":"Forette","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.cccb.2025.100392_bib0060","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1001\/archinte.162.18.2046","article-title":"The prevention of dementia with antihypertensive treatment: new evidence from the systolic hypertension in Europe (Syst-Eur) study","volume":"162","author":"Forette","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.cccb.2025.100392_bib0061","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1002\/alz.12935","article-title":"Blood pressure variability, dementia, and role of antihypertensive medications in older adults","volume":"19","author":"Mahinrad","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.cccb.2025.100392_bib0062","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1212\/WNL.0000000000002946","article-title":"Dementia risk with antihypertensive use and blood pressure variability: a cohort study","volume":"87","author":"Tully","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.cccb.2025.100392_bib0063","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002660","article-title":"Nilvadipine in mild to moderate Alzheimer disease: a randomised controlled trial","volume":"15","author":"Lawlor","year":"2018","journal-title":"PLoS Med."},{"key":"10.1016\/j.cccb.2025.100392_bib0064","doi-asserted-by":"crossref","first-page":"715","DOI":"10.14283\/jpad.2022.77","article-title":"Antihypertensive agents and incident Alzheimer's disease: a systematic review and meta-analysis of observational studies","volume":"9","author":"Adesuyan","year":"2022","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0065","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/brain\/awac076","article-title":"Blood-brain barrier permeable \u03b2-blockers linked to lower risk of Alzheimer's disease in hypertension","volume":"146","author":"Beaman","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.cccb.2025.100392_bib0066","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1474-4422(19)30393-X","article-title":"Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies","volume":"19","author":"Ding","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cccb.2025.100392_bib0067","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1212\/WNL.0000000000008732","article-title":"Investigation of antihypertensive class, dementia, and cognitive decline: a meta-analysis","volume":"94","author":"Peters","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.cccb.2025.100392_bib0068","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/HJH.0000000000003033","article-title":"Effect of dihydropyridine calcium channel blockers on blood pressure variability in the SPRINT trial: a treatment effects approach","volume":"40","author":"de Havenon","year":"2022","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0069","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/jch.12037","article-title":"Association between antihypertensive medication adherence and visit-to-visit variability of blood pressure","volume":"15","author":"Muntner","year":"2013","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"10.1016\/j.cccb.2025.100392_bib0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/jhh.2015.26","article-title":"Medication adherence and visit-to-visit variability of systolic blood pressure in African Americans with chronic kidney disease in the AASK trial","volume":"30","author":"Hong","year":"2016","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0071","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/HYPERTENSIONAHA.115.06960","article-title":"The association between antihypertensive medication nonadherence and visit-to-visit variability of blood pressure: findings from the antihypertensive and lipid-lowering treatment to prevent heart attack trial","volume":"68","author":"Kronish","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0072","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1524-6175.2007.06602.x","article-title":"The pathophysiologic role of the brain renin-angiotensin system in stroke protection: clinical implications","volume":"9","author":"Chrysant","year":"2007","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"10.1016\/j.cccb.2025.100392_bib0073","article-title":"Amyloid-beta metabolism in age-related neurocardiovascular diseases","author":"Aivalioti","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2025.100392_bib0074","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/jhh.2016.77","article-title":"Visit-to-visit blood pressure variability, average BP level and carotid arterial stiffness in the elderly: a prospective study","volume":"31","author":"Nagai","year":"2017","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0075","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/jch.14313","article-title":"Visit-to-visit office blood pressure variability revisited in SPRINT","volume":"23","author":"Nagai","year":"2021","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"10.1016\/j.cccb.2025.100392_bib0076","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1161\/01.STR.0000181771.82518.1c","article-title":"Relationship between arterial stiffness and cognitive function in elderly subjects with complaints of memory loss","volume":"36","author":"Hanon","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2025.100392_bib0077","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1161\/STROKEAHA.116.013508","article-title":"Aortic Stiffness and the risk of incident mild cognitive impairment and dementia","volume":"47","author":"Pase","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2025.100392_bib0078","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1212\/01.wnl.0000435301.64776.37","article-title":"Pulse wave velocity is associated with \u03b2-amyloid deposition in the brains of very elderly adults","volume":"81","author":"Hughes","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.cccb.2025.100392_bib0079","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1097\/HJH.0000000000000954","article-title":"Arterial stiffness and medial temporal lobe atrophy in elders with memory disorders","volume":"34","author":"Lilamand","year":"2016","journal-title":"J. Hypertens."},{"key":"10.1016\/j.cccb.2025.100392_bib0080","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/STROKEAHA.116.012949","article-title":"Effects of arterial stiffness on brain integrity in young adults from the Framingham heart study","volume":"47","author":"Maillard","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2025.100392_bib0081","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13195-021-00851-2","article-title":"Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia","volume":"13","author":"Bangen","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.cccb.2025.100392_bib0082","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3233\/JAD-191073","article-title":"Carotid stiffness is associated with brain amyloid-\u03b2 burden in amnestic mild cognitive impairment","volume":"74","author":"Pasha","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0083","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1177\/0271678X20910302","article-title":"Assessment of vascular stiffness in the internal carotid artery proximal to the carotid canal in Alzheimer's disease using pulse wave velocity from low rank reconstructed 4D flow MRI","volume":"41","author":"Rivera-Rivera","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.cccb.2025.100392_bib0084","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/physrev.00022.2020","article-title":"Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation","volume":"101","author":"Claassen","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cccb.2025.100392_bib0085","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2147\/VHRM.S34874","article-title":"Cerebral blood flow in Alzheimer's disease","volume":"8","author":"Roher","year":"2012","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.cccb.2025.100392_bib0086","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1161\/ATVBAHA.120.311909","article-title":"Impact of cardiovascular hemodynamics on cognitive aging","volume":"41","author":"Moore","year":"2021","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"10.1016\/j.cccb.2025.100392_bib0087","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1007\/s11682-020-00398-0","article-title":"Lower cardiac output is associated with neurodegeneration among older adults with normal cognition but not mild cognitive impairment","volume":"15","author":"Moore","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.cccb.2025.100392_bib0088","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1161\/CIRCULATIONAHA.118.032410","article-title":"Higher aortic stiffness is related to lower cerebral blood flow and preserved cerebrovascular reactivity in older adults","volume":"138","author":"Jefferson","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.cccb.2025.100392_bib0089","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106206","article-title":"Visit-to-visit blood pressure variations and hemodynamic deterioration in atherosclerotic major cerebral artery disease","volume":"31","author":"Yamauchi","year":"2022","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063829","article-title":"Increases in the risk of cognitive impairment and alterations of cerebral \u03b2-amyloid metabolism in mouse model of heart failure","volume":"8","author":"Hong","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cccb.2025.100392_bib0091","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41467-023-44520-4","article-title":"Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity","volume":"15","author":"Hall","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cccb.2025.100392_bib0092","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/eurheartj\/ehad205","article-title":"Big tau aggregation disrupts microtubule tyrosination and causes myocardial diastolic dysfunction: from discovery to therapy","volume":"44","author":"Luciani","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2025.100392_bib0093","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.cccb.2025.100392_bib0094","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2967\/jnumed.111.102053","article-title":"In vivo visualization of amyloid deposits in the heart with 11C-PIB and PET","volume":"54","author":"Antoni","year":"2013","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.cccb.2025.100392_bib0095","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.jacc.2016.08.073","article-title":"A\u03b2 amyloid pathology affects the hearts of patients with Alzheimer's disease: mind the heart","volume":"68","author":"Troncone","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0096","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jchf.2018.10.022","article-title":"Cardiac abnormalities in Alzheimer disease: clinical relevance beyond pathophysiological rationale and instrumental findings?","volume":"7","author":"Sanna","year":"2019","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.cccb.2025.100392_bib0097","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3233\/JAD-190813","article-title":"Lower left ventricular ejection fraction relates to cerebrospinal fluid biomarker evidence of neurodegeneration in older adults","volume":"74","author":"Kresge","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0098","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3233\/JAD-201222","article-title":"Left ventricular ejection fraction and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively normal older adults: the CABLE study","volume":"81","author":"Zheng","year":"2021","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cccb.2025.100392_bib0099","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jacc.2018.06.027","article-title":"Amyloid-beta (1-40) peptide and subclinical cardiovascular disease","volume":"72","author":"Stamatelopoulos","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jchf.2022.09.006","article-title":"Plasma amyloid-\u03b2 in relation to cardiac function and risk of heart failure in general population","volume":"11","author":"Zhu","year":"2023","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.cccb.2025.100392_bib0101","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jchf.2024.03.005","article-title":"Serum markers of neurodegeneration are strongly linked to heart failure severity and outcome","volume":"12","author":"Wurm","year":"2024","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.cccb.2025.100392_bib0102","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.cardfail.2021.12.011","article-title":"Apolipoprotein E polymorphism, cardiac remodeling, and heart failure in the ARIC study","volume":"28","author":"Selvaraj","year":"2022","journal-title":"J. Card. Fail."},{"issue":"67","key":"10.1016\/j.cccb.2025.100392_bib0103","first-page":"564","article-title":"Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort","volume":"2010","author":"Brickman","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.cccb.2025.100392_bib0104","article-title":"Blood pressure variability and white matter hyperintensities after ischemic stroke","volume":"6","author":"Hilkens","year":"2024","journal-title":"Cereb. Circ. Cogn. Behav."},{"key":"10.1016\/j.cccb.2025.100392_bib0105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/hs0102.101890","article-title":"Variability in midlife systolic blood pressure is related to late-life brain white matter lesions: the Honolulu-Asia aging study","volume":"33","author":"Havlik","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2025.100392_bib0106","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1161\/STROKEAHA.112.658369","article-title":"Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions","volume":"43","author":"Liu","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2025.100392_bib0107","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1007\/s00330-009-1655-4","article-title":"Aortic stiffness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: assessment by magnetic resonance imaging","volume":"20","author":"van Elderen","year":"2010","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0108","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF02281905","article-title":"Blood pressure and heart rate variability in autonomic disorders: a critical review","volume":"6","author":"Omboni","year":"1996","journal-title":"Clin. Aut. Res."},{"key":"10.1016\/j.cccb.2025.100392_bib0109","first-page":"H411","article-title":"Dart AM. Arterial compliance may influence baroreflex function in athletes and hypertensives","volume":"268","author":"Kingwell","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0110","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neurobiolaging.2012.10.010","article-title":"Baroreflex function is reduced in Alzheimer's disease: a candidate biomarker?","volume":"34","author":"Meel-van den Abeelen","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cccb.2025.100392_bib0111","doi-asserted-by":"crossref","first-page":"H1159","DOI":"10.1152\/ajpheart.00109.2014","article-title":"Slow and deep respiration suppresses steady-state sympathetic nerve activity in patients with chronic heart failure: from modeling to clinical application","volume":"307","author":"Harada","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.cccb.2025.100392_bib0112","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s13195-024-01486-9","article-title":"Central autonomic network dysfunction and plasma Alzheimer's disease biomarkers in older adults","volume":"16","author":"Lohman","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.cccb.2025.100392_bib0113","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fnagi.2015.00115","article-title":"Impaired A\u03b2 clearance: a potential link between atherosclerosis and Alzheimer's disease","volume":"7","author":"Gupta","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.cccb.2025.100392_bib0114","article-title":"Is hypertension associated with an accelerated aging of the brain?","volume":"6","author":"Tzourio","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/nlme.1996.0039","article-title":"Cotman CW. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine","volume":"66","author":"Cummings","year":"1996","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.cccb.2025.100392_bib0116","first-page":"463","article-title":"Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model","volume":"10","author":"Ujiie","year":"2003","journal-title":"Microcirculation"},{"key":"10.1016\/j.cccb.2025.100392_bib0117","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nm0798-832","article-title":"Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer\u2019s patients by fluorescence correlation spectroscopy","volume":"4","author":"Pitschke","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.cccb.2025.100392_bib0118","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1161\/HYPERTENSIONAHA.120.16757","article-title":"Visit-to-visit blood pressure variability and clinical outcomes in patients with heart failure with preserved ejection fraction","volume":"77","author":"Wei","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.cccb.2025.100392_bib0119","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1002\/ehf2.13542","article-title":"Blood pressure visit-to-visit variability and outcomes in patients with heart failure with preserved ejection fraction","volume":"8","author":"Zhang","year":"2021","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.cccb.2025.100392_bib0120","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2022.866434","article-title":"Vagus nerve stimulation as a potential therapy in early Alzheimer's disease: a review","volume":"16","author":"Vargas-Caballero","year":"2022","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.cccb.2025.100392_bib0121","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.neurobiolaging.2015.02.023","article-title":"Transcutaneous vagus nerve stimulation boosts associative memory in older individuals","volume":"36","author":"Jacobs","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cccb.2025.100392_bib0122","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s13311-022-01318-4","article-title":"The effects of transcutaneous vagus nerve stimulation on functional connectivity within semantic and hippocampal networks in mild cognitive impairment","volume":"20","author":"Murphy","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.cccb.2025.100392_bib0123","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.brs.2018.01.034","article-title":"Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke","volume":"11","author":"Yang","year":"2018","journal-title":"Brain Stimul."},{"key":"10.1016\/j.cccb.2025.100392_bib0124","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12265-018-9853-6","article-title":"Autonomic neuromodulation acutely ameliorates left ventricular strain in humans","volume":"12","author":"Tran","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.cccb.2025.100392_bib0125","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2023.1149449","article-title":"Afterload reduction after non-invasive vagus nerve stimulation in acute heart failure","volume":"17","author":"Nagai","year":"2023","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.cccb.2025.100392_bib0126","doi-asserted-by":"crossref","DOI":"10.1088\/1741-2560\/11\/3\/036011","article-title":"Blood pressure control with selective vagal nerve stimulation and minimal side effects","volume":"11","author":"Plachta","year":"2014","journal-title":"J. Neural Eng."},{"key":"10.1016\/j.cccb.2025.100392_bib0127","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.brs.2017.05.006","article-title":"Non-invasive vagus nerve stimulation acutely improves spontaneous cardiac baroreflex sensitivity in healthy young men: a randomized placebo-controlled trial","volume":"10","author":"Antonino","year":"2017","journal-title":"Brain Stimul."},{"key":"10.1016\/j.cccb.2025.100392_bib0128","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.999831","article-title":"Case report: SGLT2i, transcutaneous vagus nerve stimulation, and their effects on intrarenal venous flow pattern in HFpEF","volume":"16","author":"Nagai","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cccb.2025.100392_bib0129","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.1097\/MJT.0000000000001750","article-title":"Effects of non-invasive neuromodulation on ventricular mechanics in Takotsubo syndrome","volume":"31","author":"Nagai","year":"2024","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.cccb.2025.100392_bib0130","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10286-023-00997-z","article-title":"Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure","volume":"33","author":"Dasari","year":"2023","journal-title":"Clin. Aut. Res."},{"key":"10.1016\/j.cccb.2025.100392_bib0131","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cardfail.2020.12.017","article-title":"Effects of low-level tragus stimulation on endothelial function in heart failure with reduced ejection fraction","volume":"27","author":"Dasari","year":"2021","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.cccb.2025.100392_bib0132","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s12265-024-10544-4","article-title":"Blood pressure variability after non-invasive low-level tragus stimulation in acute heart failure","volume":"17","author":"Nagai","year":"2024","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"Suppl 1","key":"10.1016\/j.cccb.2025.100392_bib0133","first-page":"S3","article-title":"Sympathetic activity, blood pressure variability and end organ damage in hypertension","volume":"11","author":"Mancia","year":"1997","journal-title":"J. Hum. Hypertens."}],"container-title":["Cerebral Circulation - Cognition and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666245025000169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666245025000169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T14:06:47Z","timestamp":1765894007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666245025000169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":133,"alternative-id":["S2666245025000169"],"URL":"https:\/\/doi.org\/10.1016\/j.cccb.2025.100392","relation":{},"ISSN":["2666-2450"],"issn-type":[{"value":"2666-2450","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of visit-to-visit blood pressure variability on cognitive function: state-of the-art","name":"articletitle","label":"Article Title"},{"value":"Cerebral Circulation - Cognition and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cccb.2025.100392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100392"}}