{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:30:29Z","timestamp":1791487829297,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7254540"],"award-info":[{"award-number":["7254540"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402499"],"award-info":[{"award-number":["82402499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024ZD0539800"],"award-info":[{"award-number":["2024ZD0539800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cerebral Circulation - Cognition and Behavior"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.cccb.2026.100532","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:36:01Z","timestamp":1770482161000},"page":"100532","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Evaluation of cerebrovascular reactivity impairment using resting-state BOLD MRI in symptomatic patients with unilateral intracranial artery occlusion"],"prefix":"10.1016","volume":"10","author":[{"given":"Yi","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-yan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-xiao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-zhen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-3921","authenticated-orcid":false,"given":"Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cccb.2026.100532_bib0001","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/STROKEAHA.113.003508","article-title":"Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese Intracranial Atherosclerosis (CICAS) Study","volume":"45","author":"Wang","year":"2014","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.cccb.2026.100532_bib0002","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/jama.2023.13390","article-title":"Extracranial-intracranial bypass and risk of stroke and death in patients with symptomatic artery occlusion","volume":"330","author":"Ma","year":"2023","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.cccb.2026.100532_bib0003","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1161\/01.STR.0000135024.54608.3f","article-title":"Population-based study of symptomatic internal carotid artery occlusion","volume":"35","author":"Flaherty","year":"2004","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.cccb.2026.100532_bib0004","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1474-4422(20)30079-X","article-title":"Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study","volume":"19","author":"Hurford","year":"2020","journal-title":"Lancet Neurol."},{"issue":"8","key":"10.1016\/j.cccb.2026.100532_bib0005","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1212\/01.wnl.0000208404.94585.b2","article-title":"Prospective study of symptomatic atherothrombotic intracranial stenoses: the GESICA study","volume":"66","author":"Mazighi","year":"2006","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.cccb.2026.100532_bib0006","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1161\/STROKEAHA.111.627745","article-title":"Failure of cerebral hemodynamic selection in general or of specific positron emission tomography methodology?","volume":"42","author":"Carlson","year":"2011","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.cccb.2026.100532_bib0007","doi-asserted-by":"crossref","first-page":"e599","DOI":"10.1161\/STROKEAHA.120.033991","article-title":"Patients receiving extracranial to intracranial bypass for atherosclerotic vessel occlusion today differ significantly from the COSS population","volume":"52","author":"Wessels","year":"2021","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.cccb.2026.100532_bib0008","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1186\/s13063-016-1600-1","article-title":"The carotid and middle cerebral artery occlusion surgery study (CMOSS): a study protocol for a randomised controlled trial","volume":"17","author":"Ma","year":"2016","journal-title":"Trials"},{"issue":"9","key":"10.1016\/j.cccb.2026.100532_bib0009","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1161\/STROKEAHA.115.009656","article-title":"Do patient characteristics explain the differences in outcome between medically treated patients in SAMMPRIS and WASID?","volume":"46","author":"Chaturvedi","year":"2015","journal-title":"Stroke"},{"issue":"18","key":"10.1016\/j.cccb.2026.100532_bib0010","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1001\/jama.2011.1610","article-title":"Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the carotid occlusion surgery study randomized trial","volume":"306","author":"Powers","year":"2011","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.cccb.2026.100532_bib0011","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/01.WCB.0000125887.48838.37","article-title":"Identification of hemodynamic compromise by cerebrovascular reserve and oxygen extraction fraction in occlusive vascular disease","volume":"24","author":"Nemoto","year":"2004","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"11","key":"10.1016\/j.cccb.2026.100532_bib0012","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1161\/STROKEAHA.112.663716","article-title":"Cerebrovascular reserve and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis","volume":"43","author":"Gupta","year":"2012","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.cccb.2026.100532_bib0013","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3171\/2014.11.JNS141553","article-title":"Improvement in cerebral hemodynamic parameters and outcomes after superficial temporal artery-middle cerebral artery bypass in patients with severe stenoocclusive disease of the intracranial internal carotid or middle cerebral arteries","volume":"123","author":"Low","year":"2015","journal-title":"J. Neurosurg."},{"issue":"4","key":"10.1016\/j.cccb.2026.100532_bib0014","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00701-019-03841-4","article-title":"Factors related to improvement of cerebrovascular reserve after superficial temporal artery to middle cerebral artery anastomosis for patients with atherosclerotic steno-occlusive disease","volume":"161","author":"Otsuka","year":"2019","journal-title":"Acta Neurochir. (Wien)"},{"issue":"3","key":"10.1016\/j.cccb.2026.100532_bib0015","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1161\/STROKEAHA.111.635995","article-title":"Novel MRI approaches for assessing cerebral hemodynamics in ischemic cerebrovascular disease","volume":"43","author":"Donahue","year":"2012","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.cccb.2026.100532_bib0016","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neurad.2014.10.005","article-title":"Imaging of acute stroke: CT and\/or MRI","volume":"42","author":"L\u00f6vblad","year":"2015","journal-title":"J. Neuroradiol."},{"issue":"6","key":"10.1016\/j.cccb.2026.100532_bib0017","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3174\/ajnr.A3070","article-title":"Imaging brain oxygenation with MRI using blood oxygenation approaches: methods, validation, and clinical applications","volume":"34","author":"Christen","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.cccb.2026.100532_bib0018","article-title":"Cerebrovascular reactivity mapping without gas challenges: a methodological guide","volume":"11","author":"Pinto","year":"2020","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.cccb.2026.100532_bib0019","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1161\/STROKEAHA.118.021012","article-title":"Magnetic resonance imaging-based cerebrovascular reactivity and hemodynamic reserve","volume":"49","author":"Fisher","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.cccb.2026.100532_bib0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neubiorev.2017.05.003","article-title":"Cerebrovascular reactivity measured by functional magnetic resonance imaging during breath-hold challenge: a systematic review","volume":"79","author":"Urback","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.cccb.2026.100532_bib0021","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2016.11.054","article-title":"Cerebrovascular reactivity mapping without gas challenges","volume":"146","author":"Liu","year":"2017","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.cccb.2026.100532_bib0022","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1148\/radiol.2021203568","article-title":"Cerebrovascular reactivity mapping using resting-state BOLD functional MRI in healthy adults and patients with moyamoya disease","volume":"299","author":"Liu","year":"2021","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.cccb.2026.100532_bib0023","doi-asserted-by":"crossref","DOI":"10.1038\/s41746-023-00859-y","article-title":"Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI","volume":"6","author":"Hou","year":"2023","journal-title":"npj Digit. Med."},{"issue":"6","key":"10.1016\/j.cccb.2026.100532_bib0024","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/jmri.28194","article-title":"Cerebrovascular reactivity mapping using resting-state functional MRI in patients with gliomas","volume":"56","author":"Yeh","year":"2022","journal-title":"J. Magn. Resonance Imaging"},{"issue":"1","key":"10.1016\/j.cccb.2026.100532_bib0025","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41597-022-01923-0","article-title":"Digital 3D brain MRI arterial territories atlas","volume":"10","author":"Liu","year":"2023","journal-title":"Sci. Data"},{"issue":"3\u20134","key":"10.1016\/j.cccb.2026.100532_bib0026","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000446081","article-title":"Arterial spin labeling and blood oxygen level-dependent MRI cerebrovascular reactivity in cerebrovascular disease: a systematic review and meta-analysis","volume":"42","author":"Smeeing","year":"2016","journal-title":"Cerebrovasc. Dis."},{"issue":"2","key":"10.1016\/j.cccb.2026.100532_bib0027","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000362084","article-title":"Reduced contralateral cerebrovascular reserve in patients with unilateral steno-occlusive disease","volume":"38","author":"Sam","year":"2014","journal-title":"Cerebrovasc. Dis."},{"issue":"1","key":"10.1016\/j.cccb.2026.100532_bib0028","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/0271678X18803951","article-title":"Non-invasive monitoring of longitudinal changes in cerebral hemodynamics in acute ischemic stroke using BOLD signal delay","volume":"40","author":"Khalil","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"3","key":"10.1016\/j.cccb.2026.100532_bib0029","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/0271678X19830532","article-title":"Characterizing ipsilateral thalamic diaschisis in symptomatic cerebrovascular steno-occlusive patients","volume":"40","author":"Hendrik Bas van Niftrik","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"14","key":"10.1016\/j.cccb.2026.100532_bib0030","doi-asserted-by":"crossref","first-page":"e1328","DOI":"10.1212\/WNL.0000000000006287","article-title":"BOLD cerebrovascular reactivity as a novel marker for crossed cerebellar diaschisis","volume":"91","author":"Sebok","year":"2018","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.cccb.2026.100532_bib0031","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3174\/ajnr.A2365","article-title":"Quantitative measurement of cerebrovascular reactivity by blood oxygen level-dependent MR imaging in patients with intracranial stenosis: preoperative cerebrovascular reactivity predicts the effect of extracranial-intracranial bypass surgery","volume":"32","author":"Mandell","year":"2011","journal-title":"AJNR Am. J. Neuroradiol."}],"container-title":["Cerebral Circulation - Cognition and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266624502600005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266624502600005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T08:19:13Z","timestamp":1781338753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266624502600005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":31,"alternative-id":["S266624502600005X"],"URL":"https:\/\/doi.org\/10.1016\/j.cccb.2026.100532","relation":{},"ISSN":["2666-2450"],"issn-type":[{"value":"2666-2450","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of cerebrovascular reactivity impairment using resting-state BOLD MRI in symptomatic patients with unilateral intracranial artery occlusion","name":"articletitle","label":"Article Title"},{"value":"Cerebral Circulation - Cognition and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cccb.2026.100532","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100532"}}