{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:58:56Z","timestamp":1790697536887,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cerebral Circulation - Cognition and Behavior"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.cccb.2026.100560","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:01:34Z","timestamp":1787295694000},"page":"100560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Relationship between cardiac index and brain volume in the UK Biobank"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3783-5906","authenticated-orcid":false,"given":"Sarah","family":"Syed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1872-3314","authenticated-orcid":false,"given":"Chris","family":"Moran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarin","family":"Herson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taya","family":"Collyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Beare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velandai","family":"Srikanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.cccb.2026.100560_bib0001","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.jalz.2018.01.007","article-title":"Coronary heart disease, heart failure, and the risk of dementia: a systematic review and meta-analysis","volume":"14","author":"Wolters","year":"2018","journal-title":"Alzheimers Dement."},{"issue":"15","key":"10.1016\/j.cccb.2026.100560_bib0002","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1161\/CIRCULATIONAHA.114.012438","article-title":"Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham heart study","volume":"131","author":"Jefferson","year":"2015","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.cccb.2026.100560_bib0003","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrneurol.2015.195","article-title":"Brain health and shared risk factors for dementia and stroke","volume":"11","author":"Gardener","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.cccb.2026.100560_bib0004","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/WNN.0b013e3181799dc8","article-title":"Cardiac dysfunction and cognition in older adults with heart failure","volume":"21","author":"Hoth","year":"2008","journal-title":"Cogn. Behav. Neurol."},{"issue":"5","key":"10.1016\/j.cccb.2026.100560_bib0005","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrcardio.2014.223","article-title":"A major role for cardiovascular burden in age-related cognitive decline","volume":"12","author":"Qiu","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"issue":"9","key":"10.1016\/j.cccb.2026.100560_bib0006","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.amjcard.2005.11.059","article-title":"Factors associated with decreased cerebral blood flow in congestive heart failure secondary to idiopathic dilated cardiomyopathy","volume":"97","author":"Choi","year":"2006","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.cccb.2026.100560_bib0007","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/brb3.171","article-title":"The adverse effects of reduced cerebral perfusion on cognition and brain structure in older adults with cardiovascular disease","volume":"3","author":"Alosco","year":"2013","journal-title":"Brain Behav."},{"issue":"9","key":"10.1016\/j.cccb.2026.100560_bib0008","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1111\/j.1532-5415.2012.04097.x","article-title":"Prevalence of cognitive impairment in older adults with heart failure","volume":"60","author":"Gure","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"issue":"1","key":"10.1016\/j.cccb.2026.100560_bib0009","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3233\/JAD-132363","article-title":"Heart diseases and long-term risk of dementia and Alzheimer's disease: a population-based CAIDE study","volume":"42","author":"Rusanen","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"3","key":"10.1016\/j.cccb.2026.100560_bib0010","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.223008","article-title":"Cardiac MRI: state of the art","volume":"307","author":"Rajiah","year":"2023","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.cccb.2026.100560_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4564","article-title":"MRI of healthy brain aging: a review","volume":"34","author":"MacDonald","year":"2021","journal-title":"NMR Biomed."},{"key":"10.1016\/j.cccb.2026.100560_bib0012","article-title":"Beattie, health and deprivation: inequality and the north","volume":"8","author":"Townsend","year":"2023","journal-title":"Taylor & Francis"},{"key":"10.1016\/j.cccb.2026.100560_bib0013","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroimage.2016.07.018","article-title":"BIANCA (Brain Intensity AbNormality Classification Algorithm): a new tool for automated segmentation of white matter hyperintensities","volume":"141","author":"Griffanti","year":"2016","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.cccb.2026.100560_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273704","article-title":"Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: the COVID-CNS travelling heads study","volume":"17","author":"Duff","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.cccb.2026.100560_bib0015","series-title":"A Review and Comparison of Methods for Detecting Outliers in Univariate Data Sets","author":"Seo","year":"2006"},{"issue":"2","key":"10.1016\/j.cccb.2026.100560_bib0016","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1210\/clinem\/dgaa847","article-title":"Interactions between age, sex, menopause, and brain structure at midlife: a UK biobank study","volume":"106","author":"Than","year":"2021","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.cccb.2026.100560_bib0017","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1111\/dom.15727","article-title":"Interactions between age, sex and visceral adipose tissue on brain ageing","volume":"26","author":"Moran","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.cccb.2026.100560_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/frdem.2024.1456716","article-title":"Interactions between muscle volume and body mass index on brain structure in the UK Biobank","volume":"3","author":"Lu","year":"2024","journal-title":"Front. Dement."},{"issue":"1","key":"10.1016\/j.cccb.2026.100560_bib0019","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-04010-7","article-title":"Associations between physical activity and brain structure in a large community cohort","volume":"15","author":"La Hood","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cccb.2026.100560_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132037","article-title":"Associations of cardiac function and arterial stiffness with cerebrovascular disease","volume":"407","author":"Tan","year":"2024","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.cccb.2026.100560_bib0021","first-page":"1","article-title":"Cardiovascular disease risk scores and incident dementia and cognitive decline in older men and women","author":"Vishwanath","year":"2023","journal-title":"Gerontology (Basel)"},{"issue":"5","key":"10.1016\/j.cccb.2026.100560_bib0022","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11897-022-00564-z","article-title":"Cognitive dysfunction in heart failure: pathophysiology and implications for patient management","volume":"19","author":"Ye","year":"2022","journal-title":"Curr. Heart Fail. Rep."},{"issue":"1","key":"10.1016\/j.cccb.2026.100560_bib0023","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/JCN.0000000000000711","article-title":"Factors associated with cognitive impairment in heart failure with preserved ejection fraction","volume":"37","author":"Faulkner","year":"2022","journal-title":"J. Cardiovasc. Nurs."},{"issue":"2","key":"10.1016\/j.cccb.2026.100560_bib0024","article-title":"Associations between cardiac function and brain health in diverse middle-aged adults: the Dallas heart study-2","volume":"3","author":"Giacona","year":"2024","journal-title":"JACC: Adv."},{"issue":"7","key":"10.1016\/j.cccb.2026.100560_bib0025","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/CIRCULATIONAHA.109.905091","article-title":"Cardiac index is associated with brain aging: the Framingham heart study","volume":"122","author":"Jefferson","year":"2010","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.cccb.2026.100560_bib0026","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2176","article-title":"Cerebral blood flow impairment and cognitive decline in heart failure","volume":"11","author":"Ovsenik","year":"2021","journal-title":"Brain Behav."},{"issue":"7","key":"10.1016\/j.cccb.2026.100560_bib0027","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-045896","article-title":"Associations of subclinical heart failure and atrial fibrillation with mild cognitive impairment: a cross-sectional study in a subclinical heart failure screening programme","volume":"11","author":"Potter","year":"2021","journal-title":"BMJ Open"},{"issue":"7","key":"10.1016\/j.cccb.2026.100560_bib0028","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cardfail.2016.03.006","article-title":"Relationships among cognitive function and cerebral blood flow, oxidative stress, and inflammation in older heart failure patients","volume":"22","author":"Kure","year":"2016","journal-title":"J. Card. Fail."},{"issue":"s3","key":"10.1016\/j.cccb.2026.100560_bib0029","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3233\/JAD-2011-0010","article-title":"Effects of hypoperfusion in Alzheimer's disease","volume":"26","author":"Austin","year":"2011","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.cccb.2026.100560_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/595821","article-title":"Cognitive impairment in heart failure","volume":"2012","author":"Dardiotis","year":"2012","journal-title":"Cardiol. Res. Pract."},{"issue":"3","key":"10.1016\/j.cccb.2026.100560_bib0031","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.neurobiolaging.2006.01.001","article-title":"Systemic hypoperfusion is associated with executive dysfunction in geriatric cardiac patients","volume":"28","author":"Jefferson","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.cccb.2026.100560_bib0032","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijcard.2014.10.087","article-title":"Heart failure and cognitive dysfunction","volume":"178","author":"Ampadu","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.cccb.2026.100560_bib0033","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/ANA.0000000000000768","article-title":"Cardiac output and cerebral blood flow: a systematic review of cardio-cerebral coupling","volume":"34","author":"Castle-Kirszbaum","year":"2022","journal-title":"J. Neurosurg. Anesthesiol."},{"issue":"11","key":"10.1016\/j.cccb.2026.100560_bib0034","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/hs1101.098360","article-title":"Cerebral blood flow in patients with chronic heart failure before and after heart transplantation","volume":"32","author":"Gruhn","year":"2001","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.cccb.2026.100560_bib0035","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cardfail.2017.04.007","article-title":"Cognitive impairment and heart failure: systematic review and meta-analysis","volume":"23","author":"Cannon","year":"2017","journal-title":"J. Card. Fail."},{"issue":"8","key":"10.1016\/j.cccb.2026.100560_bib0036","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/STROKEAHA.123.040499","article-title":"Cognitive impairment in patients with cardiac disease: implications for clinical practice","volume":"54","author":"van Nieuwkerk","year":"2023","journal-title":"Stroke"},{"issue":"14","key":"10.1016\/j.cccb.2026.100560_bib0037","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/eurheartj\/ehr467","article-title":"Cognitive and brain changes associated with ischaemic heart disease and heart failure","volume":"33","author":"Almeida","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.cccb.2026.100560_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2020.569355","article-title":"Lower cardiac output relates to longitudinal cognitive decline in aging adults","volume":"11","author":"Bown","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.cccb.2026.100560_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.844396","article-title":"Education level may modify the association between cardiac index and cognitive function among elders with normal ejection function","volume":"9","author":"Cheng","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"8","key":"10.1016\/j.cccb.2026.100560_bib0040","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1212\/WNL.0000000000001289","article-title":"Subclinical cardiac dysfunction increases the risk of stroke and dementia: the Rotterdam Study","volume":"84","author":"de Bruijn","year":"2015","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.cccb.2026.100560_bib0041","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2174\/1573403X15666190313112841","article-title":"Heart failure and cognitive impairment: clinical relevance and therapeutic considerations","volume":"15","author":"Mene-Afejuku","year":"2019","journal-title":"Curr. Cardiol. Rev."},{"issue":"2","key":"10.1016\/j.cccb.2026.100560_bib0042","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3233\/JAD-201222","article-title":"Left ventricular ejection fraction and cerebrospinal fluid biomarkers of Alzheimer's Disease pathology in cognitively normal older adults: the CABLE study","volume":"81","author":"Zheng","year":"2021","journal-title":"J. Alzheimer's Dis."},{"issue":"3","key":"10.1016\/j.cccb.2026.100560_bib0043","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3233\/JAD-190813","article-title":"Lower left ventricular ejection fraction relates to cerebrospinal fluid biomarker evidence of neurodegeneration in older adults","volume":"74","author":"Kresge","year":"2020","journal-title":"J. Alzheimer's Dis."},{"issue":"6","key":"10.1016\/j.cccb.2026.100560_bib0044","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1161\/CIRCRESAHA.119.315813","article-title":"Brain damage with heart failure: cardiac biomarker alterations and gray matter decline","volume":"126","author":"Mueller","year":"2020","journal-title":"Circ. Res."}],"container-title":["Cerebral Circulation - Cognition and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666245026000334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666245026000334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:54:55Z","timestamp":1790693695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666245026000334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":44,"alternative-id":["S2666245026000334"],"URL":"https:\/\/doi.org\/10.1016\/j.cccb.2026.100560","relation":{},"ISSN":["2666-2450"],"issn-type":[{"value":"2666-2450","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relationship between cardiac index and brain volume in the UK Biobank","name":"articletitle","label":"Article Title"},{"value":"Cerebral Circulation - Cognition and Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cccb.2026.100560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100560"}}