{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:36:59Z","timestamp":1791319019153,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":375,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Roche Pharmaceuticals"}],"content-domain":{"domain":["cancercell.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.ccell.2016.02.018","type":"journal-article","created":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T12:03:27Z","timestamp":1458821007000},"page":"548-562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":201,"title":["mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells"],"prefix":"10.1016","volume":"29","author":[{"given":"Raju V.","family":"Pusapati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneleen","family":"Daemen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Sandoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Haley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas R.","family":"Baudy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Hatzivassiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Settleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2016.02.018_bib1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1228792","article-title":"Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1","volume":"339","author":"Ben-Sahra","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ccell.2016.02.018_bib2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2016.02.018_bib3","doi-asserted-by":"crossref","first-page":"196ra198","DOI":"10.1126\/scitranslmed.3005753","article-title":"TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma","volume":"5","author":"Corcoran","year":"2013","journal-title":"Sci. Transl Med."},{"key":"10.1016\/j.ccell.2016.02.018_bib4","doi-asserted-by":"crossref","first-page":"19345","DOI":"10.1073\/pnas.0709747104","article-title":"Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis","volume":"104","author":"DeBerardinis","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2016.02.018_bib5","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.1063518","article-title":"Mammalian TOR: a homeostatic ATP sensor","volume":"294","author":"Dennis","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ccell.2016.02.018_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1358\/dot.2003.39.3.799451","article-title":"Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors","volume":"39","author":"Di Cosimo","year":"2003","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.ccell.2016.02.018_bib7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncb2763","article-title":"Signal integration by mTORC1 coordinates nutrient input with biosynthetic output","volume":"15","author":"Dibble","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ccell.2016.02.018_bib8","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1016\/j.bmcl.2013.04.001","article-title":"Identification of\u00a0substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase","volume":"23","author":"Dragovich","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ccell.2016.02.018_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.molcel.2012.05.043","article-title":"Glutaminolysis activates Rag-mTORC1 signaling","volume":"47","author":"Dur\u00e1n","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccell.2016.02.018_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molcel.2010.06.022","article-title":"Activation of a metabolic gene regulatory network downstream of mTOR complex 1","volume":"39","author":"D\u00fcvel","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccell.2016.02.018_bib11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature13236","article-title":"Quantitative flux analysis reveals folate-dependent NADPH production","volume":"510","author":"Fan","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2016.02.018_bib12","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1038\/bjc.1996.667","article-title":"Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer","volume":"74","author":"Hirono","year":"1996","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ccell.2016.02.018_bib13","first-page":"485","article-title":"Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose","volume":"21","author":"Landau","year":"1958","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.ccell.2016.02.018_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2016.02.018_bib15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cmet.2011.12.009","article-title":"Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells","volume":"15","author":"Le","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.ccell.2016.02.018_bib16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ng.890","article-title":"Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis","volume":"43","author":"Locasale","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2016.02.018_bib17","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2016.02.018_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/0008-5472.CAN-03-3294","article-title":"2-Deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in\u00a0vivo","volume":"64","author":"Maschek","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2016.02.018_bib19","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1158\/0008-5472.CAN-13-1222","article-title":"PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition","volume":"73","author":"Metcalfe","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2016.02.018_bib20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s11064-013-1014-3","article-title":"Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain","volume":"39","author":"Morken","year":"2014","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ccell.2016.02.018_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature10642","article-title":"Reductive carboxylation supports growth in tumour cells with defective mitochondria","volume":"481","author":"Mullen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2016.02.018_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2008.07.007","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth","volume":"8","author":"Porstmann","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.ccell.2016.02.018_bib23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10350","article-title":"Functional genomics reveal that the serine synthesis pathway is essential in breast cancer","volume":"476","author":"Possemato","year":"2011","journal-title":"Nature"},{"issue":"Suppl 1","key":"10.1016\/j.ccell.2016.02.018_bib24","first-page":"S44","article-title":"Differential responses of tumors and normal brain to the combined treatment of 2DG and radiation in glioablastoma","volume":"5","author":"Prasanna","year":"2009","journal-title":"J.\u00a0Cancer Res. Ther."},{"key":"10.1016\/j.ccell.2016.02.018_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40170-015-0134-4","article-title":"Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells","volume":"3","author":"Rajagopalan","year":"2015","journal-title":"Cancer Metab."},{"key":"10.1016\/j.ccell.2016.02.018_bib26","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.1228771","article-title":"Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis","volume":"339","author":"Robitaille","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ccell.2016.02.018_bib27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2016.02.018_bib28","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.cell.2015.07.017","article-title":"Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells","volume":"162","author":"Sullivan","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2016.02.018_bib29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrd3504","article-title":"Targeting cancer metabolism: a therapeutic window opens","volume":"10","author":"Vander Heiden","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ccell.2016.02.018_bib30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.ccell.2016.02.018_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrm3305","article-title":"A two-way street: reciprocal regulation of metabolism and signalling","volume":"13","author":"Wellen","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ccell.2016.02.018_bib32","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1101\/gad.1985910","article-title":"The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism","volume":"24","author":"Wellen","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccell.2016.02.018_bib33","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","article-title":"Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport","volume":"56","author":"Yang","year":"2014","journal-title":"Mol. Cell"}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610816300526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610816300526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T19:36:06Z","timestamp":1567712166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610816300526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1535610816300526"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2016.02.018","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2016.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2016.03.016","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}