{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:09:28Z","timestamp":1793239768094,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007904","name":"Texas A and M University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81988101"],"award-info":[{"award-number":["81988101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003213","name":"Beijing Municipal Education Commission","doi-asserted-by":"publisher","award":["BJJWZYJH01201910023027"],"award-info":[{"award-number":["BJJWZYJH01201910023027"]}],"id":[{"id":"10.13039\/501100003213","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2019-I2M-2-001"],"award-info":[{"award-number":["2019-I2M-2-001"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["81725015"],"award-info":[{"award-number":["81725015"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.ccell.2023.03.001","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T10:43:48Z","timestamp":1679568228000},"page":"903-918.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":200,"title":["Epithelial cells activate fibroblasts to promote esophageal cancer development"],"prefix":"10.1016","volume":"41","author":[{"given":"Yamei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaosen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-1011","authenticated-orcid":false,"given":"Chen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2023.03.001_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.ccell.2023.03.001_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00535-008-2298-y","article-title":"Squamous intraepithelial neoplasia of the esophagus: past, present, and future","volume":"44","author":"Shimizu","year":"2009","journal-title":"J.\u00a0Gastroenterol."},{"key":"10.1016\/j.ccell.2023.03.001_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/gut.2004.046631","article-title":"Histological precursors of oesophageal squamous cell carcinoma: results from a 13 year prospective follow up study in a high risk population","volume":"54","author":"Wang","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.ccell.2023.03.001_bib4","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1016\/j.cell.2021.11.031","article-title":"Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps","volume":"184","author":"Chen","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","author":"Hanahan","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib6","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2023.03.001_bib7","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2023.03.001_bib8","doi-asserted-by":"crossref","first-page":"6268","DOI":"10.1038\/s41467-020-20019-0","article-title":"Immune suppressive landscape in the human esophageal squamous cell carcinoma microenvironment","volume":"11","author":"Zheng","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.001_bib9","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1038\/s41467-021-27599-5","article-title":"Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment","volume":"12","author":"Dinh","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.001_bib10","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1038\/s41467-021-25539-x","article-title":"Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.001_bib11","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1053\/j.gastro.2008.02.061","article-title":"The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis","volume":"134","author":"Noma","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2023.03.001_bib12","doi-asserted-by":"crossref","first-page":"11026","DOI":"10.1073\/pnas.0914295107","article-title":"Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion","volume":"107","author":"Grugan","year":"2010","journal-title":"Proc. Natl.\u00a0Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2023.03.001_bib13","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1158\/0008-5472.CAN-20-1542","article-title":"Tumor fibroblast-derived FGF2 regulates expression of SPRY1 in esophageal tumor-infiltrating T\u00a0cells and plays a role in T-cell exhaustion","volume":"80","author":"Chen","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2023.03.001_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massagu\u00e9","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccr.2009.12.041","article-title":"Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-Dependent manner","volume":"17","author":"Erez","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2014.05.045","article-title":"The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy","volume":"158","author":"Scherz-Shouval","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib17","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ncb3228","article-title":"Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation","volume":"17","author":"Procopio","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ccell.2023.03.001_bib18","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.neo.2016.08.002","article-title":"CXCL1-Mediated interaction of cancer cells with tumor-associated macrophages and cancer-associated fibroblasts promotes tumor progression in human bladder cancer","volume":"18","author":"Miyake","year":"2016","journal-title":"Neoplasia"},{"key":"10.1016\/j.ccell.2023.03.001_bib19","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1002\/1878-0261.13053","article-title":"LAMC1 upregulation via TGFbeta induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-kappaB-CXCL1-STAT3","volume":"15","author":"Fang","year":"2021","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.ccell.2023.03.001_bib20","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/jnci\/djy234","article-title":"Impact of epithelial-stromal interactions on peritumoral fibroblasts in ductal carcinoma in\u00a0situ","volume":"111","author":"Strell","year":"2019","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.ccell.2023.03.001_bib21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.ccell.2023.03.001_bib22","first-page":"6293","article-title":"Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma","volume":"60","author":"Paweletz","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2023.03.001_bib23","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.biochi.2007.02.015","article-title":"The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview","volume":"89","author":"Rabiet","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.ccell.2023.03.001_bib24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.it.2018.08.005","article-title":"Formyl-peptide receptors in infection, inflammation, and cancer","volume":"39","author":"Wei\u00df","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ccell.2023.03.001_bib25","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1182\/blood.2020009166","article-title":"Targeting the AnxA1\/Fpr2\/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease","volume":"137","author":"Ansari","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2023.03.001_bib26","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1084\/jem.20140692","article-title":"Fibroblast heterogeneity in the cancer wound","volume":"211","author":"\u00d6hlund","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccell.2023.03.001_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/j.gastro.2017.03.046","article-title":"Activation of transforming growth factor beta 1 signaling in gastric cancer-associated fibroblasts increases their motility, via expression of rhomboid 5 homolog 2, and ability to induce invasiveness of gastric cancer cells","volume":"153","author":"Ishimoto","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2023.03.001_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1158\/2159-8290.CD-18-0710","article-title":"IL1-Induced JAK\/STAT signaling is antagonized by TGF\u03b2 to shape CAF heterogeneity in pancreatic ductal adenocarcinoma","volume":"9","author":"Biffi","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2023.03.001_bib29","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1038\/s41467-020-17492-y","article-title":"Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer","volume":"11","author":"Yao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.001_bib30","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nrrheum.2013.126","article-title":"Annexin A1: potential for glucocorticoid sparing in RA","volume":"9","author":"Yang","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ccell.2023.03.001_bib31","doi-asserted-by":"crossref","first-page":"15290","DOI":"10.1038\/ncomms15290","article-title":"Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations","volume":"8","author":"Chang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.001_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature20805","article-title":"Integrated genomic characterization of oesophageal carcinoma","volume":"541","author":"Cancer Genome Atlas Research Network","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2023.03.001_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-019-1906-x","article-title":"scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation","volume":"21","author":"Madissoon","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2023.03.001_bib34","doi-asserted-by":"crossref","first-page":"108819","DOI":"10.1016\/j.celrep.2021.108819","article-title":"Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution","volume":"34","author":"Busslinger","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2023.03.001_bib35","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1158\/0008-5472.CAN-22-0668","article-title":"Computational identification of preneoplastic cells displaying high stemness and risk of cancer progression","volume":"82","author":"Liu","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2023.03.001_bib36","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2217\/fon.13.114","article-title":"Potential role of Anxa1 in cancer","volume":"9","author":"Guo","year":"2013","journal-title":"Future Oncol."},{"key":"10.1016\/j.ccell.2023.03.001_bib37","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/1471-2407-14-520","article-title":"Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers","volume":"14","author":"Gao","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ccell.2023.03.001_bib38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/CS20150415","article-title":"Annexin A1 localization and its relevance to cancer","volume":"130","author":"Boudhraa","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ccell.2023.03.001_bib39","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/abbs\/gmab067","article-title":"ANXA1-GSK3beta interaction and its involvement in NSCLC metastasis","volume":"53","author":"Deng","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.ccell.2023.03.001_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.molmed.2019.02.004","article-title":"Annexin-A1 - a blessing or a curse in cancer?","volume":"25","author":"Foo","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ccell.2023.03.001_bib41","doi-asserted-by":"crossref","first-page":"e1647760","DOI":"10.1080\/2162402X.2019.1647760","article-title":"Contribution of annexin A1 to anticancer immunosurveillance","volume":"8","author":"Baracco","year":"2019","journal-title":"OncoImmunology"},{"key":"10.1016\/j.ccell.2023.03.001_bib42","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2006-05-022798","article-title":"Annexin-1 modulates T-cell activation and differentiation","volume":"109","author":"D'Acquisto","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2023.03.001_bib43","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejca.2018.07.123","article-title":"Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers","volume":"102","author":"Raulf","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ccell.2023.03.001_bib44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.canlet.2021.03.021","article-title":"Cancer-associated fibroblasts activated by miR-196a promote the migration and invasion of lung cancer cells","volume":"508","author":"Lee","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ccell.2023.03.001_bib45","doi-asserted-by":"crossref","first-page":"5520832","DOI":"10.1155\/2021\/5520832","article-title":"Role of annexin A1 in squamous cell lung cancer progression","volume":"2021","author":"Elakad","year":"2021","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ccell.2023.03.001_bib46","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S1097-2765(00)80323-8","article-title":"A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR","volume":"5","author":"Walther","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib47","doi-asserted-by":"crossref","first-page":"24690","DOI":"10.1074\/jbc.M112.377101","article-title":"Annexin A1 interaction with the FPR2\/ALX receptor: identification of distinct domains and downstream associated signaling","volume":"287","author":"Bena","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ccell.2023.03.001_bib48","doi-asserted-by":"crossref","first-page":"e111317","DOI":"10.1371\/journal.pone.0111317","article-title":"Inflammation and cancer: role of annexin A1 and FPR2\/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma","volume":"9","author":"Gastardelo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ccell.2023.03.001_bib49","doi-asserted-by":"crossref","first-page":"13993","DOI":"10.1096\/fj.202000726RRR","article-title":"ANXA1 directs Schwann cells proliferation and migration to accelerate nerve regeneration through the FPR2\/AMPK pathway","volume":"34","author":"Xia","year":"2020","journal-title":"Faseb j"},{"key":"10.1016\/j.ccell.2023.03.001_bib50","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1158\/0008-5472.CAN-12-2290","article-title":"Cell surface receptor FPR2 promotes antitumor host defense by limiting M2 polarization of macrophages","volume":"73","author":"Liu","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2023.03.001_bib51","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41568-019-0196-7","article-title":"Targeting transcription factors in cancer - from undruggable to reality","volume":"19","author":"Bushweller","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2023.03.001_bib52","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1111\/cas.14910","article-title":"The roles and regulation of the KLF5 transcription factor in cancers","volume":"112","author":"Luo","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ccell.2023.03.001_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.gene.2017.02.025","article-title":"Kr\u00fcppel-like factor 4 (KLF4): what we currently know","volume":"611","author":"Ghaleb","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.ccell.2023.03.001_bib54","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/j.gastro.2005.02.022","article-title":"Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach","volume":"128","author":"Katz","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2023.03.001_bib55","doi-asserted-by":"crossref","first-page":"13567","DOI":"10.1074\/jbc.M114.629717","article-title":"Kruppel-like factor 4 promotes esophageal squamous cell carcinoma differentiation by up-regulating keratin 13 expression","volume":"290","author":"He","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ccell.2023.03.001_bib56","first-page":"6679","article-title":"Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients","volume":"7","author":"Ma","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ccell.2023.03.001_bib57","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/j.gastro.2010.03.048","article-title":"Esophageal squamous cell dysplasia and delayed differentiation with deletion of kruppel-like factor 4 in murine esophagus","volume":"139","author":"Tetreault","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2023.03.001_bib58","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1074\/jbc.M211027200","article-title":"Kruppel-like factor 4 mediates p53-dependent G1\/S cell cycle arrest in response to DNA damage","volume":"278","author":"Yoon","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ccell.2023.03.001_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc1780","article-title":"KLF4, p21 and context-dependent opposing forces in cancer","volume":"6","author":"Rowland","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2023.03.001_bib60","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.001_bib61","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nmeth.4150","article-title":"Single-cell mRNA quantification and differential analysis with Census","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2023.03.001_bib62","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2023.03.001_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ccell.2023.03.001_bib64","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41392-021-00735-9","article-title":"VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance","volume":"6","author":"Liu","year":"2021","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610823000491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610823000491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:11:30Z","timestamp":1761523890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610823000491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S1535610823000491"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2023.03.001","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial cells activate fibroblasts to promote esophageal cancer development","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2023.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}