{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:42:37Z","timestamp":1791499357232,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2007620"],"award-info":[{"award-number":["2007620"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016057","name":"Robert Connor Dawes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001543","name":"Children's Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.ccell.2023.03.007","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T12:08:52Z","timestamp":1680178132000},"page":"660-677.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities"],"prefix":"10.1016","volume":"41","author":[{"given":"Claire Xin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Daniel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Loi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Parackal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Koptyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Adjumain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Chin","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasun","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Drinkwater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahhareh","family":"Tourchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilru","family":"Habarakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanya","family":"Sooraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip B.","family":"Storm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Baubet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne C.","family":"Sayles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thy","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"P\u00f6rksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan E.","family":"Crombie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monty","family":"Panday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Zhukova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Dun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"Ludlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett W.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naama","family":"Neeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Rubens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Vinci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tyrrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie I.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Ekert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Dumevska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tsoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Farhana","family":"Syed Sulaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos Hong Pheng","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Yin Yee","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Alejandro","family":"Sweet-Cordero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Monje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Resnick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Downie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Rosenbluh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Firestein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2023.03.007_bib1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ccell.2017.08.017","article-title":"Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma","volume":"32","author":"Mackay","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.ccell.2016.11.003","article-title":"Integrated (epi)-Genomic analyses identify subgroup-specific therapeutic targets in CNS rhabdoid tumors","volume":"30","author":"Torchia","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ccell.2017.05.005","article-title":"Intertumoral heterogeneity within medulloblastoma subgroups","volume":"31","author":"Cavalli","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib4","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41591-018-0207-3","article-title":"A biobank of patient-derived pediatric brain tumor models","volume":"24","author":"Brabetz","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2023.03.007_bib5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib6","doi-asserted-by":"crossref","DOI":"10.1101\/2020.12.29.424674","article-title":"Drug screening linked to molecular profiling identifies novel dependencies in patient-derived primary cultures of paediatric high grade glioma and DIPG","author":"Carvalho","year":"2020","journal-title":"Cancer Biol."},{"key":"10.1016\/j.ccell.2023.03.007_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s43018-019-0018-6","article-title":"Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling","volume":"1","author":"Corsello","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2023.03.007_bib8","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41588-021-00819-w","article-title":"A first-generation pediatric cancer dependency map","volume":"53","author":"Dharia","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2023.03.007_bib9","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41591-020-1072-4","article-title":"Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer","volume":"26","author":"Wong","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2023.03.007_bib10","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/s41591-022-01856-6","article-title":"Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer","volume":"28","author":"Church","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2023.03.007_bib11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2023.03.007_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ccell.2016.02.001","article-title":"Atypical teratoid\/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes","volume":"29","author":"Johann","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib13","doi-asserted-by":"crossref","first-page":"627254","DOI":"10.1155\/2012\/627254","article-title":"The genetics of osteosarcoma","volume":"2012","author":"Martin","year":"2012","journal-title":"Sarcoma"},{"key":"10.1016\/j.ccell.2023.03.007_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13059-020-02015-1","article-title":"MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data","volume":"21","author":"Argelaguet","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2023.03.007_bib15","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1038\/s41467-021-24168-8","article-title":"Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma","volume":"12","author":"He","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.007_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nmeth.3853","article-title":"Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs","volume":"13","author":"Hafner","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2023.03.007_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4137\/CIN.S2846","article-title":"The bimodality index: a criterion for discovering and ranking bimodal signatures from cancer gene expression profiling data","volume":"7","author":"Wang","year":"2009","journal-title":"Cancer Inform."},{"key":"10.1016\/j.ccell.2023.03.007_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00011","article-title":"OncoKB: a precision oncology knowledge base","volume":"2017","author":"Chakravarty","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"10.1016\/j.ccell.2023.03.007_bib19","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/sj.onc.1207244","article-title":"p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition","volume":"23","author":"Wang","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ccell.2023.03.007_bib20","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1038\/onc.2011.5","article-title":"Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis","volume":"30","author":"Meng","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.ccell.2023.03.007_bib21","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/annonc\/mdg286","article-title":"Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide","volume":"14","author":"Bacci","year":"2003","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ccell.2023.03.007_bib22","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1200\/JCO.2008.14.0095","article-title":"Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival\u2014a report from the Children\u2019s oncology group","volume":"26","author":"Meyers","year":"2008","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.ccell.2023.03.007_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/2020.02.21.959627","article-title":"Gene expression has more power for predicting in\u00a0vitro cancer cell vulnerabilities than genomics","author":"Dempster","year":"2020","journal-title":"Cancer Biol."},{"key":"10.1016\/j.ccell.2023.03.007_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/jnc.13092","article-title":"Major involvement of Na + -dependent multivitamin transporter (SLC5A6\/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells","volume":"134","author":"Uchida","year":"2015","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ccell.2023.03.007_bib25","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1200\/JCO.2010.29.9024","article-title":"Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the pivotal PROPEL study","volume":"29","author":"O\u2019Connor","year":"2011","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.ccell.2023.03.007_bib26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1182\/blood-2017-09-806737","article-title":"A phase 1 study of romidepsin and pralatrexate reveals marked activity in relapsed and refractory T-cell lymphoma","volume":"131","author":"Amengual","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2023.03.007_bib27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2023.03.007_bib28","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nmeth.2689","article-title":"DGIdb: mining the druggable genome","volume":"10","author":"Griffith","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2023.03.007_bib29","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/s41598-019-41277-z","article-title":"A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma","volume":"9","author":"Stringer","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ccell.2023.03.007_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrclinonc.2018.28","article-title":"Targeting the PI3K pathway in cancer: are we making headway?","volume":"15","author":"Janku","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ccell.2023.03.007_bib31","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1158\/1541-7786.MCR-06-0172","article-title":"PIK3CA gene mutations in pediatric and adult glioblastoma multiforme","volume":"4","author":"Gallia","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ccell.2023.03.007_bib32","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1056\/NEJMoa1813904","article-title":"Alpelisib for PIK3CA -mutated, hormone receptor\u2013positive advanced breast cancer","volume":"380","author":"Andr\u00e9","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2023.03.007_bib33","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ccr.2010.09.006","article-title":"Epigenetic antagonism between polycomb and SWI\/SNF complexes during oncogenic transformation","volume":"18","author":"Wilson","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib34","doi-asserted-by":"crossref","first-page":"7922","DOI":"10.1073\/pnas.1303800110","article-title":"Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2","volume":"110","author":"Knutson","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2023.03.007_bib35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ccell.2018.11.014","article-title":"Comprehensive analysis of chromatin states in atypical teratoid\/rhabdoid tumor identifies diverging roles for SWI\/SNF and polycomb in gene regulation","volume":"35","author":"Erkek","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib36","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1200\/JCO.2019.37.15_suppl.3014","article-title":"Phase I trial of IACS-010759 (IACS), a potent, selective inhibitor of complex I of the mitochondrial electron transport chain, in patients (pts) with advanced solid tumors","volume":"37","author":"Yap","year":"2019","journal-title":"J.\u00a0Clin. Orthod."},{"key":"10.1016\/j.ccell.2023.03.007_bib37","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41591-022-01720-7","article-title":"Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia","volume":"28","author":"Khabirova","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2023.03.007_bib38","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1158\/2159-8290.CD-NB2020-120","article-title":"AML prognoses better with menin\u2013MLL inhibitor?","volume":"11","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2023.03.007_bib39","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ccell.2023.03.007_bib40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00401-015-1478-0","article-title":"Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes","volume":"130","author":"Castel","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ccell.2023.03.007_bib41","doi-asserted-by":"crossref","first-page":"e9405","DOI":"10.15252\/msb.20199405","article-title":"Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens","volume":"16","author":"Gon\u00e7alves","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.ccell.2023.03.007_bib42","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3389\/fgene.2019.00996","article-title":"A novel compound heterozygous CYP17A1 variant causes 17\u03b1-hydroxylase\/17, 20-lyase deficiency","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.ccell.2023.03.007_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng.2529","article-title":"The genetic landscape of high-risk neuroblastoma","volume":"45","author":"Pugh","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2023.03.007_bib44","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ccell.2023.03.007_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.molcel.2018.06.012","article-title":"A systematic p53 mutation library links differential functional impact to cancer mutation pattern and evolutionary conservation","volume":"71","author":"Kotler","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/hmg\/ddh011","article-title":"Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity","volume":"13","author":"Ibrahimi","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ccell.2023.03.007_bib47","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/s41467-021-21898-7","article-title":"Integrated cross-study datasets of genetic dependencies in cancer","volume":"12","author":"Pacini","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2023.03.007_bib48","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cell.2015.11.015","article-title":"High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities","volume":"163","author":"Hart","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib49","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.celrep.2015.02.002","article-title":"An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in\u00a0vivo","volume":"10","author":"Aubrey","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2023.03.007_bib50","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nbt.3026","article-title":"Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation","volume":"32","author":"Doench","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2023.03.007_bib51","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.cell.2017.11.008","article-title":"YY1 is a structural regulator of enhancer-promoter loops","volume":"171","author":"Weintraub","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib52","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccell.2018.01.021","article-title":"Systematic functional annotation of somatic mutations in cancer","volume":"33","author":"Ng","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2023.03.007_bib53","article-title":"dbscan: fast density-based clustering with R","volume":"91","author":"Hahsler","year":"2019","journal-title":"J.\u00a0Stat. Soft."},{"key":"10.1016\/j.ccell.2023.03.007_bib54","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ccell.2023.03.007_bib55","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","article-title":"Next-generation characterization of the cancer cell line Encyclopedia","volume":"569","author":"Ghandi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2023.03.007_bib56","doi-asserted-by":"crossref","first-page":"583","DOI":"10.21105\/joss.00583","article-title":"RNAsik: a Pipeline for complete and reproducible RNA-seq analysis that runs anywhere with speed and ease","volume":"3","author":"Tsyganov","year":"2018","journal-title":"J.\u00a0Open Source Softw."},{"key":"10.1016\/j.ccell.2023.03.007_bib57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13059-019-1842-9","article-title":"Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods","volume":"20","author":"Haas","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2023.03.007_bib58","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/bioinformatics\/btt684","article-title":"ChAMP: 450k chip analysis methylation pipeline","volume":"30","author":"Morris","year":"2014","journal-title":"Bioinformatics"}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610823000806?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610823000806?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:23:10Z","timestamp":1778617390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610823000806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S1535610823000806"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2023.03.007","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2023.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}