{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:10:36Z","timestamp":1793963436473,"version":"4.8.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013030","name":"William and Ella Owens Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009238","name":"Virginia Commonwealth University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA203108"],"award-info":[{"award-number":["R01 CA203108"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA247234"],"award-info":[{"award-number":["R01 CA247234"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA225520"],"award-info":[{"award-number":["P30 CA225520"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA186338"],"award-info":[{"award-number":["R01 CA186338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.ccell.2024.03.009","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T10:33:01Z","timestamp":1712831581000},"page":"885-903.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":167,"title":["The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia"],"prefix":"10.1016","volume":"42","author":[{"given":"Mingyang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhui","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex X.","family":"Arreola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kar-Ming","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan D.","family":"Nipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Bronze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney W.","family":"Houchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2024.03.009_bib1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.ccell.2024.03.009_bib2","doi-asserted-by":"crossref","first-page":"e214708","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated Projection of US Cancer Incidence and Death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ccell.2024.03.009_bib3","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.ccell.2024.03.009_bib4","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ccell.2024.03.009_bib5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ccell.2023.02.007","article-title":"Cancer cachexia: involvement of an expanding macroenvironment","volume":"41","author":"Pryce","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib6","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ccell.2024.03.009_bib7","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1200\/JCO.20.00611","article-title":"Management of Cancer Cachexia: ASCO Guideline","volume":"38","author":"Roeland","year":"2020","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.ccell.2024.03.009_bib8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41575-020-0300-1","article-title":"Pancreatic cancer stroma: an update on therapeutic targeting strategies","volume":"17","author":"Hosein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2024.03.009_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ccell.2022.04.011","article-title":"Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T\u00a0cells in pancreatic cancer","volume":"40","author":"Huang","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib10","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1158\/1078-0432.CCR-18-3567","article-title":"A C-X-C Chemokine Receptor Type 2-Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis","volume":"25","author":"Zhou","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2024.03.009_bib11","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1038\/s41467-021-27607-8","article-title":"Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis","volume":"12","author":"Lee","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.03.009_bib12","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.ccell.2021.09.009","article-title":"Redirecting tumor macrophage activity to fight cancer: Make room for the next era of anti-cancer drugs","volume":"39","author":"Pucci","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41556-018-0151-y","article-title":"Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis","volume":"20","author":"Madaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ccell.2024.03.009_bib14","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1158\/2159-8290.CD-20-0490","article-title":"It Takes a Village to Overcome KRAS Dependence in Pancreatic Cancer","volume":"10","author":"Carr","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2024.03.009_bib15","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1158\/2159-8290.CD-19-0597","article-title":"Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer","volume":"10","author":"Hou","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2024.03.009_bib16","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jcsm.12251","article-title":"Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naive pancreatic cancer patients","volume":"9","author":"Talbert","year":"2018","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ccell.2024.03.009_bib17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1101\/gad.276733.115","article-title":"Mechanisms of metabolic dysfunction in cancer-associated cachexia","volume":"30","author":"Petruzzelli","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccell.2024.03.009_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41574-018-0123-0","article-title":"Inter-tissue communication in cancer cachexia","volume":"15","author":"Argil\u00e9s","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ccell.2024.03.009_bib19","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.3390\/nu12061543","article-title":"Pancreatic Cancer and Cachexia-Metabolic Mechanisms and Novel Insights","volume":"12","author":"Poulia","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.ccell.2024.03.009_bib20","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3390\/jcm7120502","article-title":"Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes","volume":"7","author":"Hou","year":"2018","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.ccell.2024.03.009_bib21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fphys.2014.00088","article-title":"Pancreatic cancer cachexia: a review of mechanisms and therapeutics","volume":"5","author":"Tan","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ccell.2024.03.009_bib22","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1053\/j.gastro.2022.02.017","article-title":"Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer","volume":"162","author":"Shi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2024.03.009_bib23","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1053\/j.gastro.2018.10.026","article-title":"ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells","volume":"156","author":"Yang","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2024.03.009_bib24","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1053\/j.gastro.2022.06.058","article-title":"Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer","volume":"163","author":"Zhou","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2024.03.009_bib25","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/bjc.2016.3","article-title":"Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia","volume":"114","author":"Penafuerte","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ccell.2024.03.009_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib27","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/jcsm.12565","article-title":"The expression landscape of cachexia-inducing factors in human cancers","volume":"11","author":"Freire","year":"2020","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.ccell.2024.03.009_bib28","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ccell.2019.02.009","article-title":"Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets","volume":"35","author":"Cassetta","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib29","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/s41467-022-32135-0","article-title":"Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer","volume":"13","author":"Queiroz","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.03.009_bib30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ccell.2021.05.002","article-title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma","volume":"39","author":"Hara","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib31","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ccell.2024.03.009_bib32","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.cell.2015.08.031","article-title":"Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival","volume":"162","author":"Johnston","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib33","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.3390\/cells11172756","article-title":"Patient-Derived Pancreatic Cancer Cells Induce C2C12 Myotube Atrophy by Releasing Hsp70 and Hsp90","volume":"11","author":"Wu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ccell.2024.03.009_bib34","doi-asserted-by":"crossref","first-page":"e43653","DOI":"10.7554\/eLife.43653","article-title":"CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors","volume":"8","author":"Walens","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.ccell.2024.03.009_bib35","doi-asserted-by":"crossref","first-page":"4821","DOI":"10.1172\/JCI68523","article-title":"NF-kappaB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia","volume":"123","author":"He","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ccell.2024.03.009_bib36","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/hep.30931","article-title":"A hMTR4-PDIA3P1-miR-125\/124-TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance","volume":"71","author":"Xie","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.ccell.2024.03.009_bib37","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/cr.2013.21","article-title":"UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination","volume":"23","author":"Zhang","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.ccell.2024.03.009_bib38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbi.2015.11.004","article-title":"Upregulation of CCL2 via ATF3\/c-Jun interaction mediated the Bortezomib-induced peripheral neuropathy","volume":"53","author":"Liu","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ccell.2024.03.009_bib39","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000265568","article-title":"Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the upregulation of early growth response-1 transcription in human coronary artery endothelial cells","volume":"47","author":"Maekawa","year":"2010","journal-title":"J.\u00a0Vasc. Res."},{"key":"10.1016\/j.ccell.2024.03.009_bib40","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.molimm.2013.07.001","article-title":"The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression","volume":"56","author":"Ramsey","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ccell.2024.03.009_bib41","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1158\/0008-5472.CAN-15-2973","article-title":"FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling","volume":"76","author":"Yang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2024.03.009_bib42","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1053\/j.gastro.2022.03.056","article-title":"Pancreatic Cancer: Pathogenesis, Screening, Diagnosis, and Treatment","volume":"163","author":"Wood","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2024.03.009_bib43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.critrevonc.2013.07.015","article-title":"Clinical evaluation and optimal management of cancer cachexia","volume":"88","author":"Tuca","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ccell.2024.03.009_bib44","doi-asserted-by":"crossref","first-page":"18636","DOI":"10.1073\/pnas.0709307104","article-title":"Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression","volume":"104","author":"Li","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2024.03.009_bib45","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/j.gastro.2019.10.038","article-title":"ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin alpha3beta1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2024.03.009_bib46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.immuni.2017.07.014","article-title":"Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression","volume":"47","author":"Zhu","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2024.03.009_bib47","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.ccell.2023.04.018","article-title":"Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity","volume":"41","author":"Liu","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2020.04.017","article-title":"Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia","volume":"484","author":"Shukla","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ccell.2024.03.009_bib49","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1038\/s41467-020-18244-8","article-title":"IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models","volume":"11","author":"Lu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.03.009_bib50","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1002\/cpph.80","article-title":"Preclinical Models for Studying the Impact of Macrophages on Cancer Cachexia","volume":"91","author":"Markov","year":"2020","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.ccell.2024.03.009_bib51","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.ccell.2023.09.014","article-title":"In\u00a0vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases","volume":"41","author":"Kerzel","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib52","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ncb3169","article-title":"Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver","volume":"17","author":"Costa-Silva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ccell.2024.03.009_bib53","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06114-4","article-title":"Tumour extracellular vesicles and particles induce liver metabolic dysfunction","volume":"618","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.03.009_bib54","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ccell.2019.05.004","article-title":"Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors","volume":"35","author":"Dangaj","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/annonc\/mdx685","article-title":"A novel pretherapeutic gene expression-based risk score for treatment guidance in gastric cancer","volume":"29","author":"Bauer","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ccell.2024.03.009_bib56","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/j.gastro.2017.09.039","article-title":"Interleukin 35 Expression Correlates With Microvessel Density in Pancreatic Ductal Adenocarcinoma, Recruits Monocytes, and Promotes Growth and Angiogenesis of Xenograft Tumors in Mice","volume":"154","author":"Huang","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2024.03.009_bib57","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1038\/s41418-019-0460-0","article-title":"Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65\/STAT3-CSN5-PD-L1 pathway","volume":"27","author":"Liu","year":"2020","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ccell.2024.03.009_bib58","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41419-020-2435-y","article-title":"CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating beta-catenin\/STAT3 signaling","volume":"11","author":"Huang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ccell.2024.03.009_bib59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.biopha.2015.12.004","article-title":"CCL5 secreted by tumor associated macrophages may be a new target in treatment of gastric cancer","volume":"77","author":"Ding","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ccell.2024.03.009_bib60","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/neuonc\/noz189","article-title":"CCL5 of glioma-associated microglia\/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2","volume":"22","author":"Yu-Ju Wu","year":"2020","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.ccell.2024.03.009_bib61","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cytogfr.2013.12.004","article-title":"The TWEAK-Fn14 pathway: a potent regulator of skeletal muscle biology in health and disease","volume":"25","author":"Tajrishi","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ccell.2024.03.009_bib62","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fimmu.2014.00018","article-title":"TWEAK\/Fn14 Signaling Axis Mediates Skeletal Muscle Atrophy and Metabolic Dysfunction","volume":"5","author":"Sato","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ccell.2024.03.009_bib63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13395-022-00301-z","article-title":"Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice","volume":"12","author":"Meijboom","year":"2022","journal-title":"Skelet. Muscle"},{"key":"10.1016\/j.ccell.2024.03.009_bib64","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1093\/hmg\/ddv094","article-title":"Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis","volume":"24","author":"Bowerman","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ccell.2024.03.009_bib65","first-page":"233","article-title":"TWEAK and TRAF6 regulate skeletal muscle atrophy","volume":"15","author":"Kumar","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.ccell.2024.03.009_bib66","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1096\/fj.06-7537com","article-title":"TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine","volume":"21","author":"Dogra","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.ccell.2024.03.009_bib67","doi-asserted-by":"crossref","first-page":"e2305","DOI":"10.1038\/cddis.2016.220","article-title":"TWEAK favors phosphate-induced calcification of vascular smooth muscle cells through canonical and non-canonical activation of NFkappaB","volume":"7","author":"H\u00e9naut","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ccell.2024.03.009_bib68","doi-asserted-by":"crossref","first-page":"e001138","DOI":"10.1136\/jitc-2020-001138","article-title":"Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B","volume":"8","author":"Alvarez de Cienfuegos","year":"2020","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.ccell.2024.03.009_bib69","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1158\/1535-7163.MCT-17-0330","article-title":"Phase I Study of Enavatuzumab, a First-in-Class Humanized Monoclonal Antibody Targeting the TWEAK Receptor, in Patients with Advanced Solid Tumors","volume":"17","author":"Lam","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ccell.2024.03.009_bib70","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s10637-019-00830-3","article-title":"Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel\/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma","volume":"38","author":"Noel","year":"2020","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.ccell.2024.03.009_bib71","doi-asserted-by":"crossref","first-page":"111797","DOI":"10.1016\/j.celrep.2022.111797","article-title":"Recruited monocytes\/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis","volume":"41","author":"\u00d6z","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2024.03.009_bib72","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.immuni.2020.06.003","article-title":"Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis","volume":"53","author":"Tran","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2024.03.009_bib73","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.cell.2023.11.036","article-title":"Human inherited CCR2 deficiency underlies progressive polycystic lung disease","volume":"187","author":"Neehus","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2024.03.009_bib74","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1136\/gutjnl-2017-313738","article-title":"Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma","volume":"67","author":"Nywening","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.ccell.2024.03.009_bib75","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/0008-5472.CAN-12-2731","article-title":"Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses","volume":"73","author":"Mitchem","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2024.03.009_bib76","doi-asserted-by":"crossref","first-page":"108917","DOI":"10.1016\/j.celrep.2021.108917","article-title":"Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality","volume":"34","author":"Dang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2024.03.009_bib77","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/s41467-023-37361-8","article-title":"Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma","volume":"14","author":"Chen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.03.009_bib78","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.1182\/blood-2008-01-136895","article-title":"Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice","volume":"111","author":"Sawanobori","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2024.03.009_bib79","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.ajpath.2016.02.009","article-title":"Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture","volume":"186","author":"Pham","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ccell.2024.03.009_bib80","doi-asserted-by":"crossref","first-page":"ra77","DOI":"10.1126\/scisignal.aaa5823","article-title":"Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer","volume":"8","author":"Foley","year":"2015","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ccell.2024.03.009_bib81","doi-asserted-by":"crossref","first-page":"103271","DOI":"10.1016\/j.ebiom.2021.103271","article-title":"An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer","volume":"65","author":"Zhou","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ccell.2024.03.009_bib82","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1053\/j.gastro.2020.12.077","article-title":"Zinc-dependent regulation of ZEB1 and YAP1 Coactivation promotes Epithelial-Mesenchymal transition Plasticity and metastasis in pancreatic cancer","volume":"160","author":"Liu","year":"2021","journal-title":"Gastroenterology"}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610824000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610824000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:32:20Z","timestamp":1773235940000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610824000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":82,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1535610824000941"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2024.03.009","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2024.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}