{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:14:06Z","timestamp":1791630846076,"version":"4.3.4"},"reference-count":84,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32CA009207"],"award-info":[{"award-number":["T32CA009207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"publisher","award":["17-40-11-DUNB"],"award-info":[{"award-number":["17-40-11-DUNB"]}],"id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01 CA108671"],"award-info":[{"award-number":["P01 CA108671"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005991"],"award-info":[{"award-number":["I01BX005991"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020086","name":"William Raveis Charitable Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017556","name":"Marie-Jos\u00e9e and Henry R. Kravis Center for Molecular Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005968","name":"Leukemia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","award":["U01AG077925"],"award-info":[{"award-number":["U01AG077925"]}],"id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","award":["R56DK138826"],"award-info":[{"award-number":["R56DK138826"]}],"id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","award":["NIDDK R56"],"award-info":[{"award-number":["NIDDK R56"]}],"id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001021","name":"Damon Runyon Cancer Research Foundation","doi-asserted-by":"publisher","award":["PST-24-19"],"award-info":[{"award-number":["PST-24-19"]}],"id":[{"id":"10.13039\/100001021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.ccell.2024.10.009","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T10:36:40Z","timestamp":1731321400000},"page":"1955-1969.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["In\u00a0vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8294-8748","authenticated-orcid":false,"given":"Robert L.","family":"Bowman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Dunbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmay","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Waarts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s Fern\u00e1ndez","family":"Maestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira E.","family":"Eisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoron","family":"Mowla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisargbhai","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Youn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suean","family":"Fontenard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreeya","family":"Gounder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushka","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavi","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Zaroogian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"S\u00e1nchez-Vela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony R.","family":"Martinez Benitez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Werewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle S.","family":"Csete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayla","family":"Boorady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad R.","family":"Potts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng F.","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linde A.","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"P. Brent","family":"Ferrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Trowbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2024.10.009_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cell.2017.01.018","article-title":"Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future","volume":"168","author":"McGranahan","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.09.042","article-title":"Universal Patterns of Selection in Cancer and Somatic Tissues","volume":"171","author":"Martincorena","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41586-019-1775-1","article-title":"Longitudinal molecular trajectories of diffuse glioma in adults","volume":"576","author":"Barthel","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib4","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41591-019-0595-z","article-title":"A clonal expression biomarker associates with lung cancer mortality","volume":"25","author":"Biswas","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib5","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJMoa0903840","article-title":"Recurring mutations found by sequencing an acute myeloid leukemia genome","volume":"361","author":"Mardis","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41586-020-2864-x","article-title":"Single-cell mutation analysis of clonal evolution in myeloid malignancies","volume":"587","author":"Miles","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib7","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.1038\/s41467-020-19119-8","article-title":"Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics","volume":"11","author":"Morita","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.10.009_bib8","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib9","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib10","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib11","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ng.2413","article-title":"Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis","volume":"44","author":"Busque","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2024.10.009_bib12","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMoa1005143","article-title":"DNMT3A mutations in acute myeloid leukemia","volume":"363","author":"Ley","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib13","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","article-title":"Mutation in TET2 in myeloid cancers","volume":"360","author":"Delhommeau","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib14","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.391","article-title":"Acquired mutations in TET2 are common in myelodysplastic syndromes","volume":"41","author":"Langemeijer","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2024.10.009_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004315","article-title":"Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia","volume":"4","author":"Jan","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib16","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Cancer Genome Atlas Research","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib17","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature13038","article-title":"Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia","volume":"506","author":"Shlush","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib18","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic Classification and Prognosis in Acute Myeloid Leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ccr.2006.08.020","article-title":"Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia","volume":"10","author":"Somervaille","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib20","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nature04980","article-title":"Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9","volume":"442","author":"Krivtsov","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib21","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1101\/gad.226613.113","article-title":"Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition","volume":"27","author":"Chen","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccell.2024.10.009_bib22","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ccell.2015.03.009","article-title":"Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia","volume":"27","author":"Shih","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib23","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1101\/gad.1940710","article-title":"p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccell.2024.10.009_bib24","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood-2017-01-760595","article-title":"Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia","volume":"130","author":"Dovey","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2024.10.009_bib25","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature13906","article-title":"Rapid modelling of cooperating genetic events in cancer through somatic genome editing","volume":"516","author":"Sanchez-Rivera","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib26","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1158\/2159-8290.CD-19-1242","article-title":"Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis","volume":"10","author":"Leibold","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2024.10.009_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.abi8175","article-title":"Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment","volume":"376","author":"Hodis","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ccell.2024.10.009_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.stem.2017.07.015","article-title":"Multiplex CRISPR\/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia","volume":"21","author":"Tothova","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ccr.2007.08.031","article-title":"FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia","volume":"12","author":"Lee","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib30","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1182\/blood-2007-08-109942","article-title":"Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model","volume":"111","author":"Li","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2024.10.009_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.18882","article-title":"Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations","volume":"5","author":"Porter","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ccell.2024.10.009_bib32","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1084\/jem.20161418","article-title":"Niche-mediated depletion of the normal hematopoietic stem cell reservoir by Flt3-ITD-induced myeloproliferation","volume":"214","author":"Mead","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib33","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.stem.2012.05.027","article-title":"FLT3-ITD knockin impairs hematopoietic stem cell quiescence\/homeostasis, leading to myeloproliferative neoplasm","volume":"11","author":"Chu","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib34","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41375-018-0368-6","article-title":"Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis","volume":"33","author":"Loberg","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.ccell.2024.10.009_bib35","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/nm.4210","article-title":"DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling","volume":"22","author":"Guryanova","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib36","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1182\/blood-2005-02-0560","article-title":"Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance","volume":"106","author":"Alcalay","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2024.10.009_bib37","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1182\/blood-2005-05-2168","article-title":"Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance","volume":"106","author":"Verhaak","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2024.10.009_bib38","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1242\/dmm.003087","article-title":"Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli, mammalian cells and mice","volume":"2","author":"Anastassiadis","year":"2009","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ccell.2024.10.009_bib39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1534\/g3.115.025841","article-title":"Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies","volume":"6","author":"Chuang","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.ccell.2024.10.009_bib40","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0378-1119(85)90056-3","article-title":"Formation of small circular DNA molecules via an in\u00a0vitro site-specific recombination system","volume":"40","author":"Hoess","year":"1985","journal-title":"Gene"},{"key":"10.1016\/j.ccell.2024.10.009_bib41","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41586-018-0623-z","article-title":"Functional genomic landscape of acute myeloid leukaemia","volume":"562","author":"Tyner","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib42","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/s41591-022-01819-x","article-title":"A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia","volume":"28","author":"Zeng","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib43","doi-asserted-by":"crossref","first-page":"6522","DOI":"10.1038\/s41467-021-26771-1","article-title":"Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses","volume":"12","author":"Contreras-Trujillo","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.10.009_bib44","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1073\/pnas.1801480116","article-title":"Clonal-level lineage commitment pathways of hematopoietic stem cells in\u00a0vivo","volume":"116","author":"Lu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2024.10.009_bib45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41592-018-0041-z","article-title":"StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins","volume":"15","author":"Jacobs","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2024.10.009_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/msb.2009.25","article-title":"Efficient protein depletion by genetically controlled deprotection of a dormant N-degron","volume":"5","author":"Taxis","year":"2009","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.ccell.2024.10.009_bib47","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/1752-0509-4-176","article-title":"Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron","volume":"4","author":"Jungbluth","year":"2010","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ccell.2024.10.009_bib48","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.stemcr.2017.04.012","article-title":"SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells","volume":"8","author":"Morcos","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ccell.2024.10.009_bib49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1084\/jem.20131043","article-title":"Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons","volume":"211","author":"Pietras","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib50","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1182\/bloodadvances.2018029850","article-title":"Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemia","volume":"3","author":"Sung","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.ccell.2024.10.009_bib51","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1056\/NEJMoa1616288","article-title":"Tracking the Evolution of Non-Small-Cell Lung Cancer","volume":"376","author":"Jamal-Hanjani","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib52","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nature10738","article-title":"Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib53","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41587-020-00795-2","article-title":"Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes","volume":"39","author":"Gao","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2024.10.009_bib54","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.stem.2021.01.007","article-title":"A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting","volume":"28","author":"Han","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib55","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/nm.4437","article-title":"Enhancing the precision of genetic lineage tracing using dual recombinases","volume":"23","author":"He","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib56","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1093\/nar\/gkt1361","article-title":"Binary recombinase systems for high-resolution conditional mutagenesis","volume":"42","author":"Hermann","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2024.10.009_bib57","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.yjmcc.2020.07.002","article-title":"Simultaneous quantitative assessment of two distinct cell lineages with a nuclear-localized dual genetic reporter","volume":"146","author":"Tang","year":"2020","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.ccell.2024.10.009_bib58","first-page":"1","article-title":"Heterogeneity in clone dynamics within and adjacent to intestinal tumours identified by Dre-mediated lineage tracing","volume":"14","author":"Thorsen","year":"2021","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ccell.2024.10.009_bib59","doi-asserted-by":"crossref","first-page":"8971","DOI":"10.1073\/pnas.93.17.8971","article-title":"Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination","volume":"93","author":"Westerman","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2024.10.009_bib60","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1158\/0008-5472.CAN-10-4563","article-title":"Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis","volume":"71","author":"Young","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2024.10.009_bib61","first-page":"397","article-title":"Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice","volume":"5","author":"Lee","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ccell.2024.10.009_bib62","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/nm.3646","article-title":"A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer","volume":"20","author":"Schonhuber","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2024.10.009_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00231-8","article-title":"Dual recombinase action in the normal and neoplastic mammary gland epithelium","volume":"11","author":"Radler","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ccell.2024.10.009_bib64","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.stem.2022.06.012","article-title":"Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging","volume":"29","author":"Bogeska","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib65","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41375-023-01832-0","article-title":"Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia","volume":"37","author":"Straube","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.ccell.2024.10.009_bib66","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1158\/2159-8290.CD-20-0738","article-title":"Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia","volume":"11","author":"Bjelosevic","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2024.10.009_bib67","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gad.307504.117","article-title":"JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias","volume":"32","author":"Kim","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccell.2024.10.009_bib68","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ng2045","article-title":"Tissue-specific and reversible RNA interference in transgenic mice","volume":"39","author":"Dickins","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2024.10.009_bib69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1097-2765(00)80367-6","article-title":"Reversible tumorigenesis by MYC in hematopoietic lineages","volume":"4","author":"Felsher","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib70","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1101\/gad.1417406","article-title":"Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors","volume":"20","author":"Politi","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccell.2024.10.009_bib71","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1038\/ncomms9783","article-title":"Recombinase-based conditional and reversible gene regulation via XTR alleles","volume":"6","author":"Robles-Oteiza","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2024.10.009_bib72","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-019-1172-9","article-title":"RB constrains lineage fidelity and multiple stages of tumour progression and metastasis","volume":"569","author":"Walter","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib73","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500221","article-title":"Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia","volume":"1","author":"Green","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ccell.2024.10.009_bib74","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1158\/1078-0432.CCR-20-3114","article-title":"Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia","volume":"27","author":"Dumas","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2024.10.009_bib75","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cell.2018.03.043","article-title":"Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal","volume":"173","author":"Turajlic","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib76","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.cell.2022.04.015","article-title":"Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2024.10.009_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aaw3381","article-title":"Lineage tracing on transcriptional landscapes links state to fate during differentiation","volume":"367","author":"Weinreb","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ccell.2024.10.009_bib78","doi-asserted-by":"crossref","first-page":"7358","DOI":"10.4049\/jimmunol.180.11.7358","article-title":"Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte\/macrophage progenitor stages to maintain cell survival","volume":"180","author":"Kikushige","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ccell.2024.10.009_bib79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41586-021-04206-7","article-title":"Non-genetic determinants of malignant clonal fitness at single-cell resolution","volume":"601","author":"Fennell","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib80","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/s41586-019-1672-7","article-title":"The landscape of somatic mutation in normal colorectal epithelial cells","volume":"574","author":"Lee-Six","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2024.10.009_bib81","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.stemcr.2015.08.018","article-title":"Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis","volume":"5","author":"Poulos","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.ccell.2024.10.009_bib82","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/ng.796","article-title":"Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice","volume":"43","author":"Vassiliou","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2024.10.009_bib83","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1158\/2159-8290.CD-16-1049","article-title":"Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia","volume":"7","author":"Shih","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2024.10.009_bib84","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gr.232272.117","article-title":"High-throughput single-cell DNA sequencing of acute myeloid leukemia tumors with droplet microfluidics","volume":"28","author":"Pellegrino","year":"2018","journal-title":"Genome Res."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610824003970?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610824003970?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:57:55Z","timestamp":1762959475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610824003970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":84,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1535610824003970"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2024.10.009","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2024.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}