{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T23:04:13Z","timestamp":1776035053270,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100011912","name":"Washington University School of Medicine in Saint Louis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ccell.2025.02.020","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T10:39:33Z","timestamp":1741603173000},"page":"328-329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Targeting brain macrophages: NF-\u03baB as a therapeutic gateway in melanoma brain metastasis"],"prefix":"10.1016","volume":"43","author":[{"given":"Martina","family":"Molgora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2025.02.020_bib1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1158\/2159-8290.CD-18-1489","article-title":"Molecular profiling reveals unique immune and metabolic features of melanoma brain metastases","volume":"9","author":"Fischer","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2025.02.020_bib2","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-018-1389-9","article-title":"Long-term characterization of activated microglia\/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging","volume":"16","author":"Qiao","year":"2019","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ccell.2025.02.020_bib3","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s43018-021-00254-0","article-title":"Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis","volume":"2","author":"Klemm","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2025.02.020_bib4","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.cell.2020.09.064","article-title":"CNS-native myeloid cells drive immune suppression in the brain metastatic niche through Cxcl10","volume":"183","author":"Guldner","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.02.020_bib5","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ccell.2025.01.008","article-title":"Microglial reprogramming enhances antitumor immunity and immunotherapy response in melanoma brain metastases","volume":"43","author":"Rodriguez-Baena","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.02.020_bib6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.immuni.2024.04.006","article-title":"Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma","volume":"57","author":"De Leo","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2025.02.020_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-021-01156-z","article-title":"Macrophages and microglia: the cerberus of glioblastoma","volume":"9","author":"Buonfiglioli","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ccell.2025.02.020_bib8","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1158\/1078-0432.CCR-21-1694","article-title":"Single-cell characterization of the immune microenvironment of melanoma brain and leptomeningeal metastases","volume":"27","author":"Smalley","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2025.02.020_bib9","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1158\/2326-6066.CIR-17-0036","article-title":"Protumor steering of cancer inflammation by p50 NF-\u03baB enhances colorectal cancer\u00a0progression","volume":"6","author":"Porta","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2025.02.020_bib10","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1435250","article-title":"NF-\u03baB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T\u00a0cells for tumor promotion","volume":"7","author":"Li","year":"2018","journal-title":"OncoImmunology"}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610825000728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610825000728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:40:19Z","timestamp":1773157219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610825000728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1535610825000728"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2025.02.020","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting brain macrophages: NF-\u03baB as a therapeutic gateway in melanoma brain metastasis","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2025.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2025.01.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}