{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:01:07Z","timestamp":1791914467806,"version":"4.3.4"},"reference-count":92,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016947","name":"Swim Across America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2023YFC2506400"],"award-info":[{"award-number":["2023YFC2506400"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021177","name":"Shenzhen Bay Laboratory","doi-asserted-by":"publisher","award":["2023ZD0500400"],"award-info":[{"award-number":["2023ZD0500400"]}],"id":[{"id":"10.13039\/501100021177","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009729","name":"Ludwig Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004206","name":"Osaka University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["XJ2024003602"],"award-info":[{"award-number":["XJ2024003602"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024300408"],"award-info":[{"award-number":["2024300408"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20378"],"award-info":[{"award-number":["U24A20378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373263"],"award-info":[{"award-number":["82373263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403835"],"award-info":[{"award-number":["82403835"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471000"],"award-info":[{"award-number":["32471000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M751405"],"award-info":[{"award-number":["2024M751405"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ccell.2025.07.007","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T14:37:41Z","timestamp":1754577461000},"page":"1937-1957.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases"],"prefix":"10.1016","volume":"43","author":[{"given":"Tao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiji","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueru","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangcen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hirschhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha","family":"Merghoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-8878","authenticated-orcid":false,"given":"Jia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2025.07.007_bib1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"6","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ccell.2025.07.007_bib2","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ccell.2025.07.007_bib3","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1016\/j.ejca.2014.08.003","article-title":"Gastric cancer with initial bone metastasis: a distinct group of diseases with poor prognosis","volume":"50","author":"Kim","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41571-021-00499-9","article-title":"Novel approaches to target the microenvironment of bone metastasis","volume":"18","author":"Hofbauer","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib5","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2025.07.007_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2018.10.004","article-title":"Metastatic bone disease: Pathogenesis and therapeutic options: Up-date on bone metastasis management","volume":"15","author":"D'Oronzo","year":"2019","journal-title":"J. Bone Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1152\/physrev.00012.2019","article-title":"Bone metastasis: mechanisms, therapies, and biomarkers","volume":"101","author":"Cl\u00e9zardin","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ccell.2025.07.007_bib8","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1172\/JCI83871","article-title":"Cancer immunotherapy: harnessing the immune system to battle cancer","volume":"125","author":"Yang","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ccell.2025.07.007_bib9","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1200\/JCO.2014.59.4358","article-title":"Immune Checkpoint Blockade in Cancer Therapy","volume":"33","author":"Postow","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-pathol-042020-042741","article-title":"Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance","volume":"16","author":"Bagchi","year":"2021","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ccell.2025.07.007_bib11","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccell.2015.03.001","article-title":"Immune checkpoint blockade: a common denominator approach to cancer therapy","volume":"27","author":"Topalian","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib12","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.cell.2019.10.029","article-title":"Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy","volume":"179","author":"Jiao","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib13","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1172\/JCI133334","article-title":"PD-1 blockade inhibits osteoclast formation and murine bone cancer pain","volume":"130","author":"Wang","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ccell.2025.07.007_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1200\/JCO.2016.69.1584","article-title":"Randomized, Double-Blind, Phase III Trial of Ipilimumab Versus Placebo in Asymptomatic or Minimally Symptomatic Patients With Metastatic Chemotherapy-Naive Castration-Resistant Prostate Cancer","volume":"35","author":"Beer","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s40425-019-0793-8","article-title":"Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer","volume":"7","author":"Landi","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.critrevonc.2017.05.004","article-title":"Overcoming immunosuppression in bone metastases","volume":"117","author":"Reinstein","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.ccell.2025.07.007_bib17","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.annonc.2022.06.005","article-title":"Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicine","volume":"33","author":"Ding","year":"2022","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib18","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ccell.2021.09.005","article-title":"Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment","volume":"39","author":"Kfoury","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-021-00571-6","article-title":"Neutrophils in cancer: heterogeneous and multifaceted","volume":"22","author":"Hedrick","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","article-title":"Neutrophil diversity and plasticity in tumour progression and therapy","volume":"20","author":"Jaillon","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-022-05443-0","article-title":"Ferroptosis of tumour neutrophils causes immune suppression in cancer","volume":"612","author":"Kim","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib25","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/s41586-023-06511-9","article-title":"CD300ld on neutrophils is required for tumour-driven immune suppression","volume":"621","author":"Wang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-022-05400-x","article-title":"Liver tumour immune microenvironment subtypes and neutrophil heterogeneity","volume":"612","author":"Xue","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf6493","article-title":"Deterministic reprogramming of neutrophils within tumors","volume":"383","author":"Ng","year":"2024","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ccell.2025.07.007_bib28","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.cell.2023.03.007","article-title":"T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants","volume":"186","author":"Hirschhorn","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib29","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.cell.2023.02.032","article-title":"A neutrophil response linked to tumor control in immunotherapy","volume":"186","author":"Gungabeesoon","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ccell.2023.12.005","article-title":"Interferon-stimulated neutrophils as a predictor of immunotherapy response","volume":"42","author":"Benguigui","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib31","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.cell.2024.02.005","article-title":"Neutrophil profiling illuminates anti-tumor antigen-presenting potency","volume":"187","author":"Wu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib32","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1016\/j.cell.2023.08.043","article-title":"The local microenvironment drives activation of neutrophils in human brain tumors","volume":"186","author":"Maas","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.add5204","article-title":"Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis","volume":"8","author":"Gong","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib34","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.134.4.907","article-title":"The development of neutrophilic polymorphonuclear leukocytes in human bone marrow","volume":"134","author":"Bainton","year":"1971","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2025.07.007_bib35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.immuni.2020.07.017","article-title":"Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow","volume":"53","author":"Dinh","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2025.07.007_bib36","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/s41590-020-0736-z","article-title":"Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection","volume":"21","author":"Xie","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib37","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/s41590-022-01311-1","article-title":"Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress","volume":"23","author":"Montaldo","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.immuni.2020.06.005","article-title":"Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor","volume":"53","author":"Kwok","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2025.07.007_bib39","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2018.02.002","article-title":"Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions","volume":"48","author":"Evrard","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2025.07.007_bib40","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1038\/s41467-018-05366-3","article-title":"A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries","volume":"9","author":"Kuchimaru","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2025.07.007_bib41","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.ccell.2022.10.008","article-title":"High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer","volume":"40","author":"Salcher","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib42","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ncb3613","article-title":"Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1","volume":"19","author":"Zhuang","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ccell.2025.07.007_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101217","article-title":"Protocol for generating human immune system mice and hydrodynamic injection to analyze human hematopoiesis in vivo","volume":"3","author":"Ren","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.ccell.2025.07.007_bib44","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1111\/bph.13894","article-title":"Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology","volume":"174","author":"Kagey","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ccell.2025.07.007_bib45","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature19834","article-title":"PI3K\u03b3 is a molecular switch that controls immune suppression","volume":"539","author":"Kaneda","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-020-2227-7","article-title":"Mouse models of neutropenia reveal progenitor-stage-specific defects","volume":"582","author":"Muench","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.891220","article-title":"An update on Ym1 and its immunoregulatory role in diseases","volume":"13","author":"Kang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib48","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/STROKEAHA.119.025085","article-title":"Role of TLR4 (Toll-Like Receptor 4) in N1\/N2 Neutrophil Programming After Stroke","volume":"50","author":"Garc\u00eda-Culebras","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ccell.2025.07.007_bib49","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nature08021","article-title":"Genes that mediate breast cancer metastasis to the brain","volume":"459","author":"Bos","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib50","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1158\/0008-5472.CAN-14-3639","article-title":"CD38-Expressing Myeloid-Derived Suppressor Cells Promote Tumor Growth in a Murine Model of Esophageal Cancer","volume":"75","author":"Karakasheva","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2025.07.007_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal5081","article-title":"Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils","volume":"358","author":"Engblom","year":"2017","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.ccell.2025.07.007_bib52","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1172\/JCI77053","article-title":"Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer","volume":"124","author":"Eruslanov","year":"2014","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ccell.2025.07.007_bib53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12943-020-01165-x","article-title":"CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis","volume":"19","author":"Yang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib54","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.cell.2020.07.013","article-title":"TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy","volume":"182","author":"Molgora","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib55","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2020.01.014","article-title":"Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP","volume":"52","author":"Zhou","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2025.07.007_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103958","article-title":"Dynamic profiling of immune microenvironment during pancreatic cancer development suggests early intervention and combination strategy of immunotherapy","volume":"78","author":"Yang","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ccell.2025.07.007_bib57","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221007","article-title":"Macrophages promote anti-androgen resistance in prostate cancer bone disease","volume":"220","author":"Li","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2025.07.007_bib58","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191820","article-title":"Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth","volume":"217","author":"Ma","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2025.07.007_bib59","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1016\/j.celrep.2019.05.091","article-title":"Immature Low-Density Neutrophils Exhibit Metabolic Flexibility that Facilitates Breast Cancer Liver Metastasis","volume":"27","author":"Hsu","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2025.07.007_bib60","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.celrep.2014.12.039","article-title":"Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer","volume":"10","author":"Sagiv","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2025.07.007_bib61","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/s41467-018-07505-2","article-title":"Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression","volume":"9","author":"Rice","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2025.07.007_bib62","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1158\/2159-8290.CD-23-0762","article-title":"Combining TIGIT blockage with MDSC inhibition hinders breast cancer bone metastasis by activating anti-tumor immunity","volume":"14","author":"Monteran","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2025.07.007_bib63","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41590-024-01808-x","article-title":"An IL-1\u03b2-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma","volume":"25","author":"de Jong","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib64","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ccell.2024.08.008","article-title":"Glioblastoma induces the recruitment and differentiation of dendritic-like \"hybrid\" neutrophils from skull bone marrow","volume":"42","author":"Lad","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2020.1870811","article-title":"Tumors exploit CXCR4(hi)CD62L(lo) aged neutrophils to facilitate metastatic spread","volume":"10","author":"Peng","year":"2021","journal-title":"OncoImmunology"},{"key":"10.1016\/j.ccell.2025.07.007_bib66","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ccell.2024.01.013","article-title":"Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment","volume":"42","author":"He","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib67","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.3389\/fimmu.2019.01912","article-title":"Neutrophil Maturity in Cancer","volume":"10","author":"Mackey","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib68","doi-asserted-by":"crossref","first-page":"9850","DOI":"10.1038\/s41598-017-10464-1","article-title":"A Dynamic Metabolic Flux Analysis of Myeloid-Derived Suppressor Cells Confirms Immunosuppression-Related Metabolic Plasticity","volume":"7","author":"Goffaux","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ccell.2025.07.007_bib69","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-981-33-6785-2_7","article-title":"Lipid Metabolism in Tumor-Associated Myeloid-Derived Suppressor Cells","volume":"1316","author":"Liu","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ccell.2025.07.007_bib70","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.canlet.2017.12.035","article-title":"SIRT1 and HIF1\u03b1 signaling in metabolism and immune responses","volume":"418","author":"Yu","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ccell.2025.07.007_bib71","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1172\/JCI97973","article-title":"Spleen mediates a distinct hematopoietic progenitor response supporting tumor-promoting myelopoiesis","volume":"128","author":"Wu","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ccell.2025.07.007_bib72","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2025.07.007_bib73","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.bbrc.2013.12.076","article-title":"Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation","volume":"443","author":"Chu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ccell.2025.07.007_bib74","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s10585-018-9937-3","article-title":"Dickkopf-1 (Dkk1) protein expression in breast cancer with special reference to bone metastases","volume":"35","author":"Kasoha","year":"2018","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.ccell.2025.07.007_bib75","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/pros.21277","article-title":"Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases","volume":"71","author":"Thudi","year":"2011","journal-title":"Prostate"},{"key":"10.1016\/j.ccell.2025.07.007_bib76","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1158\/2326-6066.CIR-22-0218","article-title":"DKK1 Promotes Tumor Immune Evasion and Impedes Anti-PD-1 Treatment by Inducing Immunosuppressive Macrophages in Gastric Cancer","volume":"10","author":"Shi","year":"2022","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2025.07.007_bib77","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.20150950","article-title":"Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer","volume":"213","author":"D'Amico","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2025.07.007_bib78","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/s12885-018-4420-8","article-title":"Prognostic value of Dickkopf-1 and ss-catenin expression in advanced gastric cancer","volume":"18","author":"Hong","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib79","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1186\/s12885-019-6399-1","article-title":"Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study","volume":"19","author":"Sui","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib80","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1470-2045(12)70233-4","article-title":"Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study","volume":"13","author":"Shen","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib81","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2016.02.025","article-title":"Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT","volume":"165","author":"Malladi","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib82","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001498","article-title":"Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer","volume":"9","author":"Sui","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ccell.2025.07.007_bib83","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ccell.2025.07.007_bib84","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ccell.2023.01.002","article-title":"Neutrophil-activating therapy for the treatment of cancer","volume":"41","author":"Linde","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib85","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2025.07.007_bib86","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2021.04.004","article-title":"MDSC: Markers, development, states, and unaddressed complexity","volume":"54","author":"Hegde","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2025.07.007_bib87","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1016\/j.cell.2022.10.006","article-title":"Systemic vaccination induces CD8(+) T cells and remodels the tumor microenvironment","volume":"185","author":"Baharom","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2025.07.007_bib88","doi-asserted-by":"crossref","first-page":"e003","DOI":"10.48130\/git-0024-0004","article-title":"Is the \u2018PD-L1 macrophage score\u2019 possible as an immunotherapy target in colon adenocarcinoma?","volume":"11","author":"Ba\u015f","year":"2024","journal-title":"Gastrointest. Tumors"},{"key":"10.1016\/j.ccell.2025.07.007_bib89","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1200\/JCO.2023.41.16_suppl.4027","article-title":"A phase 2 study (DisTinGuish) of DKN-01 in combination with tislelizumab + chemotherapy as first-line (1L) therapy in patients with advanced gastric or GEJ adenocarcinoma (GEA)","volume":"41","author":"Klempner","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ccell.2025.07.007_bib92","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1158\/1541-7786.MCR-20-0799","article-title":"mDKN-01, a Novel Anti-DKK1 Monoclonal Antibody, Enhances Innate Immune Responses in the Tumor Microenvironment","volume":"19","author":"Haas","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.ccell.2025.07.007_bib93","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/s41596-018-0016-7","article-title":"Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry","volume":"13","author":"Han","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ccell.2025.07.007_bib94","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610825003137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610825003137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:20:48Z","timestamp":1778271648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610825003137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":92,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1535610825003137"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2025.07.007","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CHI3L3+ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2025.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}