{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:03:32Z","timestamp":1792821812828,"version":"4.5.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020791","name":"Hale Family Center for Pancreatic Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020791","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018805","name":"Sky Foundation Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018805","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA274276"],"award-info":[{"award-number":["U01CA274276"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI169188"],"award-info":[{"award-number":["R01AI169188"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI158488"],"award-info":[{"award-number":["R01AI158488"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA224146"],"award-info":[{"award-number":["U01CA224146"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016394","name":"Harvard Medical School Ludwig Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["GRK2099\/RTG2099"],"award-info":[{"award-number":["GRK2099\/RTG2099"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["SFB1389"],"award-info":[{"award-number":["SFB1389"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020487","name":"Commonwealth Cancer Consortium Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020487","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001784","name":"Pancreatic Cancer Action Network Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ccell.2026.04.005","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:56:15Z","timestamp":1778165775000},"page":"1381-1400.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer"],"prefix":"10.1016","volume":"44","author":[{"given":"Courtney T.S.","family":"Kureshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakeeb","family":"Kureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoire","family":"Cardot-Ruffino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Agardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lestat R.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Dougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Lenehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Jennifer","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugena","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Remland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Brais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Hornick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Huffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Mancias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Fairweather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly J.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Rubinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritchell","family":"van Dams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Wolpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruslan","family":"Novosiadly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Broz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshabad","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-363X","authenticated-orcid":false,"given":"Stephanie K.","family":"Dougan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2026.04.005_bib1","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.immuni.2018.06.006","article-title":"Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy","volume":"49","author":"Li","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.ccr.2012.04.025","article-title":"Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer","volume":"21","author":"Bayne","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/immadv\/ltab011","article-title":"Type 2 immunity is maintained during cancer-associated adipose tissue wasting","volume":"1","author":"Lenehan","year":"2021","journal-title":"Immunother. Adv."},{"key":"10.1016\/j.ccell.2026.04.005_bib5","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/jamaoncol.2019.1588","article-title":"Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Ductal Adenocarcinoma: A Phase 2 Randomized Clinical Trial","volume":"5","author":"O'Reilly","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ccell.2026.04.005_bib6","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of anti-PD-L1 antibody in patients with advanced cancer","volume":"366","author":"Brahmer","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib7","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/CJI.0b013e3181eec14c","article-title":"Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma","volume":"33","author":"Royal","year":"2010","journal-title":"J. Immunother."},{"key":"10.1016\/j.ccell.2026.04.005_bib8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.aan6733","article-title":"Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade","volume":"357","author":"Le","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib9","first-page":"55","article-title":"Cancer Immunotherapy: Beyond Checkpoint Blockade","volume":"3","author":"Dougan","year":"2019","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/j.ccell.2026.04.005_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ccell.2024.11.011","article-title":"Cytokines in cancer","volume":"43","author":"Kureshi","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature19330","article-title":"Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy","volume":"537","author":"Im","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib12","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.20130579","article-title":"Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma","volume":"210","author":"Simpson","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2016.08.069","article-title":"Loss of IFN-gamma Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy","volume":"167","author":"Gao","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJMoa1604958","article-title":"Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma","volume":"375","author":"Zaretsky","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1158\/2159-8290.CD-16-1223","article-title":"Primary Resistance to PD-1 Blockade Mediated by JAK1\/2 Mutations","volume":"7","author":"Shin","year":"2017","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.04.005_bib16","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1158\/0008-5472.CAN-10-1322","article-title":"CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes","volume":"70","author":"Bos","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib17","doi-asserted-by":"crossref","first-page":"8633","DOI":"10.1073\/pnas.96.15.8633","article-title":"CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma","volume":"96","author":"Mumberg","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2026.04.005_bib18","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1084\/jem.188.12.2357","article-title":"The central role of CD4(+) T cells in the antitumor immune response","volume":"188","author":"Hung","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib19","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1056\/NEJMoa0800251","article-title":"Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1","volume":"358","author":"Hunder","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib20","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.20091918","article-title":"Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts","volume":"207","author":"Quezada","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib21","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1126\/science.1251102","article-title":"Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer","volume":"344","author":"Tran","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41586-019-1671-8","article-title":"MHC-II neoantigens shape tumour immunity and response to immunotherapy","volume":"574","author":"Alspach","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2005.02.003","article-title":"Primary antitumor immune response mediated by CD4+ T cells","volume":"22","author":"Corthay","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib24","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1182\/blood-2006-10-051318","article-title":"CD4 cells can be more efficient at tumor rejection than CD8 cells","volume":"109","author":"Perez-Diez","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2026.04.005_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ccell.2023.12.006","article-title":"Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation","volume":"42","author":"Chandra","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccell.2020.02.008","article-title":"Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer","volume":"37","author":"Hegde","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s43018-020-0038-2","article-title":"Bystander IFN-gamma activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment","volume":"1","author":"Thibaut","year":"2020","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.04.005_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112219","article-title":"IFNgamma is a central node of cancer immune equilibrium","volume":"42","author":"Walsh","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2026.04.005_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature22311","article-title":"Tumour ischaemia by interferon-gamma resembles physiological blood vessel regression","volume":"545","author":"Kammertoens","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.1083317","article-title":"Defective CD8 T cell memory following acute infection without CD4 T cell help","volume":"300","author":"Sun","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2017.10.009","article-title":"CD4(+) T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness","volume":"47","author":"Ahrends","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1082305","article-title":"Requirement for CD4 T cell help in generating functional CD8 T cell memory","volume":"300","author":"Shedlock","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib33","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1126\/science.1072615","article-title":"A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory","volume":"297","author":"Bourgeois","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib34","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature01441","article-title":"CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes","volume":"421","author":"Janssen","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib35","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.immuni.2019.10.009","article-title":"CD4(+) T Cell Help Is Required for the Formation of a Cytolytic CD8(+) T Cell Subset that Protects against Chronic Infection and Cancer","volume":"51","author":"Zander","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib36","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/s41586-023-06199-x","article-title":"CD4(+) T cell-induced inflammatory cell death controls immune-evasive tumours","volume":"618","author":"Kruse","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib37","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41586-024-08507-5","article-title":"A neoantigen vaccine generates antitumour immunity in renal cell carcinoma","volume":"639","author":"Braun","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature22991","article-title":"An immunogenic personal neoantigen vaccine for patients with melanoma","volume":"547","author":"Ott","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib39","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41586-020-2611-3","article-title":"cDC1 prime and are licensed by CD4(+) T cells to induce anti-tumour immunity","volume":"584","author":"Ferris","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s43018-022-00338-5","article-title":"The interaction of CD4(+) helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response","volume":"3","author":"Cohen","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.04.005_bib41","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.ccell.2014.11.010","article-title":"Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity","volume":"26","author":"Broz","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib42","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.immuni.2021.10.020","article-title":"Type I interferon activates MHC class I-dressed CD11b(+) conventional dendritic cells to promote protective anti-tumor CD8(+) T cell immunity","volume":"55","author":"Duong","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.immuni.2022.12.002","article-title":"CD8(+) T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor","volume":"56","author":"Prokhnevska","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib44","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4(+) T Cell Immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib45","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1158\/2326-6066.CIR-21-0946","article-title":"Systemic Alterations in Type-2 Conventional Dendritic Cells Lead to Impaired Tumor Immunity in Pancreatic Cancer","volume":"11","author":"James","year":"2023","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib46","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190673","article-title":"Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis","volume":"217","author":"Lin","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib47","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151593","article-title":"Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer","volume":"7","author":"Burrack","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.ccell.2026.04.005_bib48","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib49","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib50","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41586-024-08257-4","article-title":"Cancer cells impair monocyte-mediated T cell stimulation to evade immunity","volume":"637","author":"Elewaut","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s40425-019-0573-5","article-title":"STING agonist inflames the pancreatic cancer immune microenvironment and reduces tumor burden in mouse models","volume":"7","author":"Jing","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ccell.2026.04.005_bib52","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.immuni.2018.09.016","article-title":"Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response","volume":"49","author":"Marcus","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaz2738","article-title":"NK cells mediate clearance of CD8(+) T cell-resistant tumors in response to STING agonists","volume":"5","author":"Nicolai","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.ccell.2026.04.005_bib54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jcmgh.2021.01.018","article-title":"STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer","volume":"12","author":"Vonderhaar","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.04.005_bib55","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/s41586-023-05880-5","article-title":"STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma","volume":"616","author":"Hu","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf5058","article-title":"cIAP1\/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes","volume":"13","author":"Roehle","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib57","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210245","article-title":"Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer","volume":"11","author":"Stump","year":"2021","journal-title":"Open Biol."},{"key":"10.1016\/j.ccell.2026.04.005_bib58","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1053\/j.gastro.2023.05.038","article-title":"Transforming Growth Factor-beta Blockade in Pancreatic Cancer Enhances Sensitivity to Combination Chemotherapy","volume":"165","author":"Qiang","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2026.04.005_bib59","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/s41586-022-05254-3","article-title":"STING-induced regulatory B cells compromise NK function in cancer immunity","volume":"610","author":"Li","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib60","article-title":"Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity","volume":"3","author":"Mirlekar","year":"2022","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib61","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1126\/science.272.5262.719","article-title":"Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1\/CIP1 mediated by STAT1","volume":"272","author":"Chin","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib62","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nature11824","article-title":"T-helper-1-cell cytokines drive cancer into senescence","volume":"494","author":"Braum\u00fcller","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib63","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1182\/blood-2005-04-1393","article-title":"T-bet is required for optimal proinflammatory CD4+ T-cell trafficking","volume":"106","author":"Lord","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ccell.2026.04.005_bib64","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41586-022-05593-1","article-title":"gammadelta T cells are effectors of immunotherapy in cancers with HLA class I defects","volume":"613","author":"de Vries","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124507","article-title":"Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy","volume":"3","author":"Fransen","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.ccell.2026.04.005_bib66","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2016.06.003","article-title":"Critical Role for CD103(+)\/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma","volume":"30","author":"Roberts","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib67","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.immuni.2016.03.012","article-title":"Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition","volume":"44","author":"Salmon","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.04.005_bib68","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-022-04866-z","article-title":"Ablation of cDC2 development by triple mutations within the Zeb2 enhancer","volume":"607","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1158\/2326-6066.CIR-13-0047","article-title":"Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity","volume":"1","author":"Dougan","year":"2013","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib70","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1158\/2326-6066.CIR-18-0348","article-title":"Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8(+) T Cell-Effector Responses","volume":"6","author":"Clancy-Thompson","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib71","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41586-025-08758-w","article-title":"STING agonist-based ER-targeting molecules boost antigen cross-presentation","volume":"641","author":"Wang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib72","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1200\/JCO.2018.78.9636","article-title":"Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update","volume":"36","author":"Sohal","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ccell.2026.04.005_bib73","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/cts.13563","article-title":"Analysis of a large cohort of pancreatic cancer transcriptomic profiles to reveal the strongest prognostic factors","volume":"16","author":"Posta","year":"2023","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.ccell.2026.04.005_bib74","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1158\/1078-0432.CCR-24-2183","article-title":"Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor Cells","volume":"31","author":"Loveless","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib75","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41588-022-01134-8","article-title":"Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment","volume":"54","author":"Hwang","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2026.04.005_bib76","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib77","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006589","article-title":"G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans","volume":"11","author":"Cardot-Ruffino","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ccell.2026.04.005_bib78","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1158\/1078-0432.CCR-22-1125","article-title":"Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer","volume":"28","author":"Dias Costa","year":"2022","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib79","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1158\/2326-6066.CIR-23-1073","article-title":"Blockade of IL1beta and PD1 with Combination Chemotherapy Reduces Systemic Myeloid Suppression in Metastatic Pancreatic Cancer with Heterogeneous Effects in the Tumor","volume":"12","author":"Oberstein","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib80","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1126\/science.1198443","article-title":"CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans","volume":"331","author":"Beatty","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.04.005_bib81","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1158\/2159-8290.CD-15-1032","article-title":"IFNgamma and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma","volume":"6","author":"Long","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.04.005_bib82","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S1470-2045(24)00263-8","article-title":"Combining CD40 agonist mitazalimab with mFOLFIRINOX in previously untreated metastatic pancreatic ductal adenocarcinoma (OPTIMIZE-1): a single-arm, multicentre phase 1b\/2 study","volume":"25","author":"Van Laethem","year":"2024","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ccell.2026.04.005_bib83","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1073\/pnas.1918971117","article-title":"Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity","volume":"117","author":"Morrison","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2026.04.005_bib84","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1158\/1078-0432.CCR-23-1444","article-title":"PD-1 Blockade Induces Reactivation of Nonproductive T-Cell Responses Characterized by NF-kappaB Signaling in Patients with Pancreatic Cancer","volume":"30","author":"Ali","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2026.04.005_bib85","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature24462","article-title":"Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer","volume":"551","author":"Balachandran","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib86","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88328","article-title":"Lack of immunoediting in murine pancreatic cancer reversed with neoantigen","volume":"1","author":"Evans","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.ccell.2026.04.005_bib87","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41591-023-02760-3","article-title":"Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial","volume":"30","author":"Pant","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.04.005_bib88","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41586-023-06063-y","article-title":"Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer","volume":"618","author":"Rojas","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.04.005_bib89","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.04.005_bib90","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.04.005_bib91","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.04.005_bib92","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2026.04.005_bib93","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1038\/s41467-018-05083-x","article-title":"Detection and removal of barcode swapping in single-cell RNA-seq data","volume":"9","author":"Griffiths","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2026.04.005_bib94","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2026.04.005_bib95","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nbt.3190","article-title":"Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining","volume":"33","author":"Maruyama","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.04.005_bib96","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1021\/acs.jmedchem.1c01986","article-title":"Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization","volume":"65","author":"Cherney","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ccell.2026.04.005_bib97","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fimmu.2011.00035","article-title":"Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells","volume":"2","author":"Fletcher","year":"2011","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ccell.2026.04.005_bib98","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk1853","article-title":"DGKalpha\/zeta inhibition lowers the TCR affinity threshold and potentiates antitumor immunity","volume":"9","author":"Kureshi","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ccell.2026.04.005_bib99","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.04.005_bib100","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610826002163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610826002163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:03:32Z","timestamp":1786017812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610826002163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":100,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1535610826002163"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2026.04.005","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2026.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}