{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:32:05Z","timestamp":1786379525728,"version":"build-2736575974"},"reference-count":101,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["2023ZT10Y094"],"award-info":[{"award-number":["2023ZT10Y094"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82530111"],"award-info":[{"award-number":["82530111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172047"],"award-info":[{"award-number":["82172047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270480"],"award-info":[{"award-number":["82270480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82225037"],"award-info":[{"award-number":["82225037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022B1515020060"],"award-info":[{"award-number":["2022B1515020060"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key Areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1111020007"],"award-info":[{"award-number":["2023B1111020007"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005153","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["82322034"],"award-info":[{"award-number":["82322034"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ccell.2026.06.010","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:09:37Z","timestamp":1784214577000},"page":"1549-1567.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["PD-1 blockade unleashes local hepatitis B virus-related B cell response inhibiting hepatocellular carcinoma"],"prefix":"10.1016","volume":"44","author":[{"given":"Shuling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanrui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youmei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunli","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnson","family":"Yiu-Nam Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-4848","authenticated-orcid":false,"given":"Ming","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2026.06.010_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","article-title":"Hepatocellular carcinoma","volume":"400","author":"Vogel","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ccell.2026.06.010_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.ccell.2026.06.010_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S2468-1253(21)00385-X","article-title":"Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial","volume":"7","author":"Marron","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.010_bib4","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s43018-021-00234-4","article-title":"Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity","volume":"2","author":"Ho","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-004656","article-title":"Efficacy and safety of camrelizumab plus apatinib during the perioperative period in resectable hepatocellular carcinoma: a single-arm, open label, phase II clinical trial","volume":"10","author":"Xia","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib6","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41591-023-02345-0","article-title":"Intratumoral dendritic cell\u2013CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma","volume":"29","author":"Magen","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1056\/NEJMcibr2106594","article-title":"Hepatocellular carcinoma\u2014origins and outcomes","volume":"385","author":"Kelley","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.cell.2020.11.041","article-title":"Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma","volume":"184","author":"Sun","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib9","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1136\/gutjnl-2022-328428","article-title":"Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences","volume":"72","author":"Chen","year":"2023","journal-title":"Gut"},{"key":"10.1016\/j.ccell.2026.06.010_bib10","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41591-021-01323-8","article-title":"A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer","volume":"27","author":"Bassez","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib11","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/s41591-018-0197-1","article-title":"Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma","volume":"24","author":"Amaria","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s43018-021-00292-8","article-title":"Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer","volume":"3","author":"Liu","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib13","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41586-019-1906-8","article-title":"B cells are associated with survival and immunotherapy response in sarcoma","volume":"577","author":"Petitprez","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ccell.2022.02.002","article-title":"Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer","volume":"40","author":"Patil","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","article-title":"B cells and tertiary lymphoid structures promote immunotherapy response","volume":"577","author":"Helmink","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41586-019-1914-8","article-title":"Tertiary lymphoid structures improve immunotherapy and survival in melanoma","volume":"577","author":"Cabrita","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s43018-021-00232-6","article-title":"Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression","volume":"2","author":"Vanhersecke","year":"2021","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41568-019-0144-6","article-title":"Tertiary lymphoid structures in the era of cancer immunotherapy","volume":"19","author":"Saut\u00e8s-Fridman","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/science.abf9419","article-title":"Tertiary lymphoid structures in cancer","volume":"375","author":"Schumacher","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.010_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41571-022-00619-z","article-title":"B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome","volume":"19","author":"Fridman","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib21","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.ccell.2024.07.006","article-title":"CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis","volume":"42","author":"Zhang","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib22","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41577-019-0257-x","article-title":"B cells, plasma cells and antibody repertoires in the tumour microenvironment","volume":"20","author":"Sharonov","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ccell.2026.06.010_bib23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41586-025-09188-4","article-title":"Humoral determinants of checkpoint immunotherapy","volume":"644","author":"Dai","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib24","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/S0140-6736(25)01720-9","article-title":"Perioperative camrelizumab plus rivoceranib versus surgery alone in patients with resectable hepatocellular carcinoma at intermediate or high risk of recurrence (CARES-009): a randomised phase 2\/3 trial","volume":"406","author":"Wang","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.ccell.2026.06.010_bib25","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0140-6736(23)01796-8","article-title":"Atezolizumab plus bevacizumab versus active surveillance in patients with resected or ablated high-risk hepatocellular carcinoma (IMbrave050): a randomised, open-label, multicentre, phase 3 trial","volume":"402","author":"Qin","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ccell.2026.06.010_bib26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41568-022-00466-1","article-title":"Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities","volume":"22","author":"Laumont","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib27","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.cell.2022.02.012","article-title":"Tumor-reactive antibodies evolve from non-binding and autoreactive precursors","volume":"185","author":"Mazor","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib28","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.immuni.2022.02.001","article-title":"Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer","volume":"55","author":"Meylan","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.06.010_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.06.010_bib30","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.immuni.2021.06.013","article-title":"Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma","volume":"54","author":"Cheng","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.ccell.2026.06.010_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf8486","article-title":"Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics","volume":"382","author":"Engblom","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.010_bib32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.virol.2015.02.031","article-title":"Molecular biology of hepatitis B virus infection","volume":"479\u2013480","author":"Seeger","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.ccell.2026.06.010_bib33","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1462-5822.2010.01557.x","article-title":"Alix regulates egress of hepatitis B virus naked capsid particles in an ESCRT-independent manner","volume":"13","author":"Bardens","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ccell.2026.06.010_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005123","article-title":"The Dual Role of an ESCRT-0 Component HGS in HBV Transcription and Naked Capsid Secretion","volume":"11","author":"Chou","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ccell.2026.06.010_bib35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/cmi.12398","article-title":"Rab33B and its autophagic Atg5\/12\/16L1 effector assist in hepatitis B virus naked capsid formation and release","volume":"17","author":"D\u00f6ring","year":"2015","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ccell.2026.06.010_bib36","doi-asserted-by":"crossref","first-page":"14648","DOI":"10.1073\/pnas.94.26.14648","article-title":"Role of B cells in antigen presentation of the hepatitis B core","volume":"94","author":"Milich","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2026.06.010_bib37","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1126\/science.3491425","article-title":"The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen","volume":"234","author":"Milich","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.010_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-immunol-042617-053245","article-title":"Complement and the Regulation of T Cell Responses","volume":"36","author":"West","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ccell.2026.06.010_bib39","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1365-2249.2000.01305.x","article-title":"Cytokine-mediated up-regulation of CD55 and CD59 protects human hepatoma cells from complement attack","volume":"121","author":"Spiller","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ccell.2026.06.010_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.aax0182","article-title":"Neoadjuvant checkpoint blockade for cancer immunotherapy","volume":"367","author":"Topalian","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.010_bib41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41591-019-0357-y","article-title":"A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma","volume":"25","author":"Huang","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib42","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41591-020-0805-8","article-title":"Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers","volume":"26","author":"Chalabi","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-immunol-041015-055605","article-title":"Follicular Helper T Cells","volume":"34","author":"Vinuesa","year":"2016","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ccell.2026.06.010_bib44","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/imr.12860","article-title":"T follicular helper cells in germinal center B cell selection and lymphomagenesis","volume":"296","author":"Mintz","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ccell.2026.06.010_bib45","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.ccell.2025.03.011","article-title":"Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures","volume":"43","author":"Tang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cell.2019.11.032","article-title":"Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting","volume":"180","author":"Mesin","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib47","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41568-019-0210-0","article-title":"Context-dependent roles of complement in cancer","volume":"19","author":"Roumenina","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nri.2017.97","article-title":"Complement in cancer: untangling an intricate relationship","volume":"18","author":"Reis","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ccell.2026.06.010_bib49","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41568-024-00690-x","article-title":"Cancer therapy with antibodies","volume":"24","author":"Paul","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib50","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cgh.2021.06.019","article-title":"Risk of hepatitis B virus reactivation in patients treated with immunotherapy for anti-cancer treatment","volume":"20","author":"Yoo","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.010_bib51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s40249-023-01128-6","article-title":"Hepatitis B reactivation in cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis","volume":"12","author":"Xia","year":"2023","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.ccell.2026.06.010_bib52","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2020.4564","article-title":"Efficacy and safety of nivolumab plus ipilimumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib: the CheckMate 040 randomized clinical trial","volume":"6","author":"Yau","year":"2020","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib53","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s00432-022-04133-8","article-title":"Hepatitis B virus reactivation in patients undergoing immune checkpoint inhibition: systematic review with meta-analysis","volume":"149","author":"Ding","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib54","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-021-03362-0","article-title":"NASH limits anti-tumour surveillance in immunotherapy-treated HCC","volume":"592","author":"Pfister","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib55","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41586-021-03862-z","article-title":"Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer","volume":"597","author":"Eberhardt","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib56","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41586-020-2931-3","article-title":"Defining HPV-specific B cell responses in patients with head and neck cancer","volume":"597","author":"Wieland","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ccell.2025.01.001","article-title":"Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer","volume":"43","author":"Guo","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib58","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/bjc.2016.239","article-title":"Impact of non-neoplastic vs intratumoural hepatitis B viral DNA and replication on hepatocellular carcinoma recurrence","volume":"115","author":"Wang","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib59","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/hep.29463","article-title":"Hepatitis B Virus Pregenomic RNA in Hepatocellular Carcinoma: A Nosological and Prognostic Determinant","volume":"67","author":"Halgand","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ccell.2026.06.010_bib60","first-page":"112","article-title":"[Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)]","volume":"28","year":"2020","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"10.1016\/j.ccell.2026.06.010_bib61","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib62","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1038\/s41591-021-01510-7","article-title":"Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB\u2013IVM1a melanoma: a randomized, open-label, phase 2 trial","volume":"27","author":"Dummer","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib63","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejca.2021.05.018","article-title":"Trastuzumab-lapatinib as neoadjuvant therapy for HER2-positive early breast cancer: Survival analyses of the CHER-Lob trial","volume":"153","author":"Guarneri","year":"2021","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib64","first-page":"1035","article-title":"[Chinese expert consensus on neoadjuvant therapy for hepatocellular carcinoma (2023 edition)]","volume":"61","year":"2023","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"10.1016\/j.ccell.2026.06.010_bib65","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jhep.2012.03.027","article-title":"An in situ molecular signature to predict early recurrence in hepatitis B virus-related hepatocellular carcinoma","volume":"57","author":"Xu","year":"2012","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.010_bib66","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11605-018-3927-2","article-title":"Characteristics of Early Recurrence After Curative Liver Resection for Solitary Hepatocellular Carcinoma","volume":"23","author":"Jung","year":"2019","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.ccell.2026.06.010_bib67","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jtho.2020.01.005","article-title":"IASLC Multidisciplinary Recommendations for Pathologic Assessment of Lung Cancer Resection Specimens After Neoadjuvant Therapy","volume":"15","author":"Travis","year":"2020","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib68","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/annonc\/mdv161","article-title":"Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration","volume":"26","author":"Bossuyt","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib69","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1093\/annonc\/mdy226","article-title":"Pathological assessment of resection specimens after neoadjuvant therapy for metastatic melanoma","volume":"29","author":"Tetzlaff","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib70","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/annonc\/mdy218","article-title":"Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)","volume":"29","author":"Cottrell","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.ccell.2026.06.010_bib71","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ad.2019.05.009","article-title":"Using the Common Terminology Criteria for Adverse Events (CTCAE - Version 5.0) to Evaluate the Severity of Adverse Events of Anticancer Therapies","volume":"112","author":"Freites-Martinez","year":"2021","journal-title":"Actas Dermosifiliogr."},{"key":"10.1016\/j.ccell.2026.06.010_bib72","doi-asserted-by":"crossref","DOI":"10.1126\/science.abp9444","article-title":"Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration","volume":"377","author":"Wei","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.010_bib73","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/s41587-019-0217-9","article-title":"Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome","volume":"37","author":"Wenger","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.06.010_bib74","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1016\/j.molcel.2021.07.003","article-title":"N(7)-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression","volume":"81","author":"Dai","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib75","article-title":"IMGT\/V-QUEST: IMGT standardized analysis of the immunoglobulin (IG) and T cell receptor (TR) nucleotide sequences","volume":"2011","author":"Giudicelli","year":"2011","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.ccell.2026.06.010_bib76","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giaa151","article-title":"SoupX removes ambient RNA contamination from droplet-based single-cell RNA sequencing data","volume":"9","author":"Young","year":"2020","journal-title":"GigaScience"},{"key":"10.1016\/j.ccell.2026.06.010_bib77","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41586-018-0694-x","article-title":"Lineage tracking reveals dynamic relationships of T cells in colorectal cancer","volume":"564","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib78","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.06.010_bib79","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.ccell.2026.06.010_bib80","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ccell.2026.06.010_bib81","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","article-title":"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells","volume":"184","author":"Cheng","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib82","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41568-019-0235-4","article-title":"CD8(+) T cell states in human cancer: insights from single-cell analysis","volume":"20","author":"van der Leun","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.010_bib83","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nmeth.4150","article-title":"Single-cell mRNA quantification and differential analysis with Census","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2026.06.010_bib84","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.06.010_bib85","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.010_bib86","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13059-019-1663-x","article-title":"PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells","volume":"20","author":"Wolf","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2026.06.010_bib87","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/s41591-023-02369-6","article-title":"The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment","volume":"29","author":"Lv","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.010_bib88","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/eji.201041370","article-title":"Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: towards designing better vaccines","volume":"41","author":"Liu","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ccell.2026.06.010_bib89","article-title":"A Systematic Review of T Cell Epitopes Defined from the Proteome of Hepatitis B Virus","volume":"10","author":"Wu","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.ccell.2026.06.010_bib90","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad284","article-title":"epiTCR: a highly sensitive predictor for TCR-peptide binding","volume":"39","author":"Pham","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ccell.2026.06.010_bib91","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/bioinformatics\/btv359","article-title":"Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data","volume":"31","author":"Gupta","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ccell.2026.06.010_bib92","doi-asserted-by":"crossref","first-page":"W34","DOI":"10.1093\/nar\/gkt382","article-title":"IgBLAST: an immunoglobulin variable domain sequence analysis tool","volume":"41","author":"Ye","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2026.06.010_bib93","doi-asserted-by":"crossref","first-page":"47","DOI":"10.12688\/f1000research.22139.1","article-title":"scRepertoire: An R-based toolkit for single-cell immune receptor analysis","volume":"9","author":"Borcherding","year":"2020","journal-title":"F1000Res."},{"key":"10.1016\/j.ccell.2026.06.010_bib94","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ccell.2026.06.010_bib95","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib96","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/14786440109462720","article-title":"LIII. On lines and planes of closest fit to systems of points in space","volume":"2","author":"Pearson","year":"1901","journal-title":"London, Edinburgh Dublin Phil. Mag. J. Sci."},{"key":"10.1016\/j.ccell.2026.06.010_bib97","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab043","article-title":"SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes","volume":"49","author":"Elosua-Bayes","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2026.06.010_bib98","doi-asserted-by":"crossref","first-page":"7351","DOI":"10.1016\/j.cell.2024.10.011","article-title":"Spatiotemporal modeling of molecular holograms","volume":"187","author":"Qiu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.010_bib99","doi-asserted-by":"crossref","first-page":"D20","DOI":"10.1093\/nar\/gkab1112","article-title":"Database resources of the national center for biotechnology information","volume":"50","author":"Sayers","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2026.06.010_bib100","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.aad3439","article-title":"Visualizing antibody affinity maturation in germinal centers","volume":"351","author":"Tas","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.010_bib101","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1101\/gr.257246.119","article-title":"Accurate and efficient detection of gene fusions from RNA sequencing data","volume":"31","author":"Uhrig","year":"2021","journal-title":"Genome Res."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610826002977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610826002977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:20:06Z","timestamp":1786378806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610826002977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":101,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1535610826002977"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2026.06.010","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PD-1 blockade unleashes local hepatitis B virus-related B cell response inhibiting hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2026.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}