{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:13:36Z","timestamp":1789647216206,"version":"4.0.0"},"reference-count":128,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,9,14]],"date-time":"2027-09-14T00:00:00Z","timestamp":1820880000000},"content-version":"am","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009275","name":"DeGregorio Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ccell.2026.06.018","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:42:20Z","timestamp":1784904140000},"page":"1862-1881.e18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression"],"prefix":"10.1016","volume":"44","author":[{"given":"Hiroki","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Ochiai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junya","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puran","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quin T.","family":"Waterbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"LaBella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Nagendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah B.","family":"Zamechek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuro","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger K.","family":"Eltzschig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Worthley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-3019","authenticated-orcid":false,"given":"Timothy C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccell.2026.06.018_bib1","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.cell.2023.02.002","article-title":"Cancer neuroscience: State of the field, emerging directions","volume":"186","author":"Winkler","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","article-title":"beta2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer","volume":"33","author":"Renz","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib3","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1158\/2159-8290.CD-18-0046","article-title":"Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness","volume":"8","author":"Renz","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","article-title":"Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis","volume":"640","author":"Zhi","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1158\/2159-8290.CD-23-0397","article-title":"Nerves at Play: The Peripheral Nervous System in Extracranial Malignancies","volume":"15","author":"Vermeer","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib7","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.ccell.2025.09.003","article-title":"Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses","volume":"43","author":"Ren","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib8","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41586-025-08735-3","article-title":"Characterization of single neurons reprogrammed by pancreatic cancer","volume":"640","author":"Thiel","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib9","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.cell.2026.03.018","article-title":"Cancer neuroscience: The past, the present, and the road ahead","volume":"189","author":"Winkler","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41575-019-0115-0","article-title":"Cancer-associated fibroblasts in gastrointestinal cancer","volume":"16","author":"Kobayashi","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.018_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.018_bib12","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1053\/j.gastro.2020.11.011","article-title":"The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis","volume":"160","author":"Kobayashi","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2026.06.018_bib13","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1053\/j.gastro.2021.11.037","article-title":"The Origin and Contribution of Cancer-Associated Fibroblasts in Colorectal Carcinogenesis","volume":"162","author":"Kobayashi","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2026.06.018_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1158\/2159-8290.CD-24-0287","article-title":"Neuro-Mesenchymal Interaction Mediated by a beta2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression","volume":"15","author":"Kobayashi","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib15","article-title":"Nervous system in colorectal cancer","volume":"611","author":"Xu","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ccell.2026.06.018_bib16","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41575-022-00669-9","article-title":"Nerves in gastrointestinal cancer: from mechanism to modulations","volume":"19","author":"Vaes","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.018_bib17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12967-025-06104-2","article-title":"Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth","volume":"23","author":"Wang","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ccell.2026.06.018_bib18","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.cell.2020.08.003","article-title":"The Human and Mouse Enteric Nervous System at Single-Cell Resolution","volume":"182","author":"Drokhlyansky","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib19","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.neuron.2022.04.024","article-title":"5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis","volume":"110","author":"Zhu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.ccell.2026.06.018_bib20","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.3390\/cancers13133220","article-title":"Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma","volume":"13","author":"Hering","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ccell.2026.06.018_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1471-2407-13-204","article-title":"Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis","volume":"13","author":"Peng","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ccell.2026.06.018_bib22","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1158\/0008-5472.CAN-07-6810","article-title":"Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia","volume":"68","author":"Raufman","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102678","article-title":"Netrin-1: Key insights in neural development and disorders","volume":"93","author":"Nabeel Mustafa","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib24","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1053\/j.gastro.2008.06.080","article-title":"NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors","volume":"135","author":"Paradisi","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ccell.2026.06.018_bib25","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1186\/s12964-025-02489-1","article-title":"Netrin-1-UNC5B\/neogenin axis enhances the stemness of colorectal cancer cells","volume":"23","author":"Xia","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ccell.2026.06.018_bib26","doi-asserted-by":"crossref","first-page":"17146","DOI":"10.1073\/pnas.0901767106","article-title":"Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression","volume":"106","author":"Paradisi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2026.06.018_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature02788","article-title":"Netrin-1 controls colorectal tumorigenesis by regulating apoptosis","volume":"431","author":"Mazelin","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib28","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1038\/s41467-025-62299-4","article-title":"Neural function of Netrin-1 in precancerous lesions of the pancreas","volume":"16","author":"Haidar","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2026.06.018_bib29","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-25-2243","article-title":"Netrin-1 Promotes Pancreatic Tumorigenesis and Innervation through NEO1","volume":"86","author":"Kobayashi","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-023-06372-2","article-title":"Pharmacological targeting of netrin-1 inhibits EMT in cancer","volume":"620","author":"Lengrand","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/s41586-023-06367-z","article-title":"Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer","volume":"620","author":"Cassier","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib32","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41586-026-10436-4","article-title":"Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer","volume":"654","author":"Roth","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib33","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1158\/0008-5472.CAN-18-2952","article-title":"Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity","volume":"79","author":"Sung","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib34","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1038\/s41467-022-29366-6","article-title":"Single-cell and spatial analysis reveal interaction of FAP(+) fibroblasts and SPP1(+) macrophages in colorectal cancer","volume":"13","author":"Qi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2026.06.018_bib35","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/s41388-025-03318-y","article-title":"Cancer-associated fibroblasts promote EGFR-TKI resistance via the CTHRC1\/glycolysis\/H3K18la positive feedback loop","volume":"44","author":"Zhang","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.ccell.2026.06.018_bib36","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.ccell.2024.08.020","article-title":"Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation","volume":"42","author":"Gao","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib37","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1158\/2159-8290.CD-21-1714","article-title":"Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors","volume":"12","author":"Grout","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib38","article-title":"THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis","volume":"44","author":"Liu","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2026.06.018_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41586-022-05272-1","article-title":"LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity","volume":"611","author":"Krishnamurty","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib40","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1158\/2159-8290.CD-19-0094","article-title":"Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts","volume":"9","author":"Elyada","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib41","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41422-020-0355-0","article-title":"A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling","volume":"30","author":"Qian","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib42","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41588-022-01100-4","article-title":"Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer","volume":"54","author":"Joanito","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccell.2026.06.018_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225677","article-title":"Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer","volume":"20","author":"Maitra","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ccell.2026.06.018_bib44","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2026.06.018_bib45","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/s41388-024-02953-1","article-title":"YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression","volume":"43","author":"Xiao","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.ccell.2026.06.018_bib46","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2012.06.037","article-title":"Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling","volume":"150","author":"Yu","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib47","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.27992","article-title":"YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors","volume":"62","author":"Marti","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ccell.2026.06.018_bib48","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1158\/0008-5472.CAN-21-2778","article-title":"Ketogenesis Attenuates KLF5-Dependent Production of CXCL12 to Overcome the Immunosuppressive Tumor Microenvironment in Colorectal Cancer","volume":"82","author":"Wei","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib50","doi-asserted-by":"crossref","first-page":"W45","DOI":"10.1093\/nar\/gkae358","article-title":"ChIP-Atlas 3.0: a data-mining suite to explore chromosome architecture together with large-scale regulome data","volume":"52","author":"Zou","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib51","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.3390\/cells10123288","article-title":"An Insight into GPCR and G-Proteins as Cancer Drivers","volume":"10","author":"Chaudhary","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ccell.2026.06.018_bib52","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41589-021-00755-0","article-title":"YAP-dependent proliferation by a small molecule targeting annexin A2","volume":"17","author":"Shalhout","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ccell.2026.06.018_bib53","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuron.2016.01.040","article-title":"DREADDs for Neuroscientists","volume":"89","author":"Roth","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.ccell.2026.06.018_bib54","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nature15382","article-title":"Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer","volume":"526","author":"Gregorieff","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.stem.2017.11.001","article-title":"YAP\/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration","volume":"22","author":"Yui","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib56","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.celrep.2018.10.001","article-title":"Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.ccell.2026.06.018_bib57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12079-018-0485-z","article-title":"A network map of netrin receptor UNC5B-mediated signaling","volume":"13","author":"Bhat","year":"2019","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/j.ccell.2026.06.018_bib58","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)81253-2","article-title":"Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice","volume":"85","author":"Gautam","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib59","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2008.10.006","article-title":"LRP4 serves as a coreceptor of agrin","volume":"60","author":"Zhang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ccell.2026.06.018_bib60","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/90476","article-title":"CRMP-2 induces axons in cultured hippocampal neurons","volume":"4","author":"Inagaki","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ccell.2026.06.018_bib61","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.cell.2004.11.012","article-title":"GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity","volume":"120","author":"Yoshimura","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2014.02.019","article-title":"Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice","volume":"82","author":"Sun","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ccell.2026.06.018_bib63","doi-asserted-by":"crossref","first-page":"ra67","DOI":"10.1126\/scisignal.2000522","article-title":"STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death","volume":"2","author":"Berna-Erro","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ccell.2026.06.018_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5050051","article-title":"Tumor Budding: The Name is EMT. Partial EMT","volume":"5","author":"Grigore","year":"2016","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ccell.2026.06.018_bib65","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.cell.2018.02.052","article-title":"An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics","volume":"173","author":"Liu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib66","article-title":"Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors","volume":"5","author":"Gy\u0151rffy","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.ccell.2026.06.018_bib67","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/nm.3967","article-title":"The consensus molecular subtypes of colorectal cancer","volume":"21","author":"Guinney","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccell.2026.06.018_bib68","doi-asserted-by":"crossref","first-page":"D679","DOI":"10.1093\/nar\/gkad960","article-title":"WikiPathways 2024: next generation pathway database","volume":"52","author":"Agrawal","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib69","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.ccell.2026.06.018_bib70","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.15252\/emmm.201404208","article-title":"Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients","volume":"6","author":"Tan","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ccell.2026.06.018_bib71","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1038\/s43018-025-01033-x","article-title":"Colorectal cancer cells hijack a brain-gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth","volume":"6","author":"Li","year":"2025","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.06.018_bib72","doi-asserted-by":"crossref","DOI":"10.1172\/JCI160152","article-title":"Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse","volume":"132","author":"Nie","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ccell.2026.06.018_bib73","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.ccell.2025.07.024","article-title":"Long-range cholinergic input promotes glioblastoma progression","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib74","doi-asserted-by":"crossref","first-page":"4640","DOI":"10.1016\/j.cell.2025.05.031","article-title":"Cholinergic neuronal activity promotes diffuse midline glioma growth through muscarinic signaling","volume":"188","author":"Drexler","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib75","article-title":"Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccell.2026.06.018_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.557","article-title":"Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling","volume":"6","author":"Secq","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ccell.2026.06.018_bib77","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1158\/2159-8290.CD-20-0775","article-title":"Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression","volume":"11","author":"Francescone","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib78","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41422-025-01098-4","article-title":"Nociceptor neurons promote PDAC progression and cancer pain by interaction with cancer-associated fibroblasts and suppression of natural killer cells","volume":"35","author":"Wang","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib79","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.jcmgh.2024.01.012","article-title":"Optogenetic Activation of Cholinergic Enteric Neurons Reduces Inflammation in Experimental Colitis","volume":"17","author":"Rahman","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.018_bib80","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib81","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41568-025-00831-w","article-title":"Neuro-immune cross-talk in cancer","volume":"25","author":"Amit","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ccell.2026.06.018_bib82","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1158\/2326-6066.CIR-22-0658","article-title":"Netrin-1 Promotes the Immunosuppressive Activity of MDSCs in Colorectal Cancer","volume":"11","author":"Xia","year":"2023","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib83","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1038\/s41418-023-01209-x","article-title":"Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor","volume":"30","author":"Ducarouge","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ccell.2026.06.018_bib84","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s43018-023-00624-w","article-title":"Tumor-specific cholinergic CD4(+) T lymphocytes guide immunosurveillance of hepatocellular carcinoma","volume":"4","author":"Zheng","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.ccell.2026.06.018_bib85","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ccell.2026.06.018_bib86","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13046-015-0159-0","article-title":"Extrinsic intestinal denervation modulates tumor development in the small intestine of Apc(Min\/+) mice","volume":"34","author":"Liu","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib87","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.stem.2025.02.016","article-title":"Vagal pathway activation links chronic stress to decline in intestinal stem cell function","volume":"32","author":"Zhang","year":"2025","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib88","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.cell.2026.01.001","article-title":"Sensory neurons drive immune exclusion by stimulating a dense extracellular matrix in the breast cancer tumor microenvironment","volume":"189","author":"Zhang","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib89","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1158\/2159-8290.CD-25-1337","article-title":"Myofibroblasts induce neuroplasticity to promote pancreatic inflammation and cancer progression","volume":"16","author":"Nigri","year":"2026","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ccell.2026.06.018_bib90","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.ccell.2025.10.001","article-title":"Functional pseudo-synapses: A new nexus in extracranial cancer","volume":"43","author":"Zhi","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110846","article-title":"Ca(2+) signaling and the Hippo pathway: Intersections in cellular regulation","volume":"110","author":"Sayedyahossein","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ccell.2026.06.018_bib92","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature25492","article-title":"TGFbeta drives immune evasion in genetically reconstituted colon cancer metastasis","volume":"554","author":"Tauriello","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ccell.2026.06.018_bib93","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41575-024-00934-z","article-title":"Mechanisms of metastatic colorectal cancer","volume":"21","author":"Ca\u00f1ellas-Socias","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ccell.2026.06.018_bib94","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ccell.2016.01.001","article-title":"Structural Decoding of the Netrin-1\/UNC5 Interaction and its Therapeutical Implications in Cancers","volume":"29","author":"Grandin","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib95","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210008","article-title":"PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling","volume":"218","author":"Li","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ccell.2026.06.018_bib96","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cmet.2006.04.009","article-title":"A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo","volume":"3","author":"Gautam","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.ccell.2026.06.018_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ccell.2026.06.018_bib98","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ccell.2026.06.018_bib99","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.06.018_bib100","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2026.06.018_bib101","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ccell.2026.06.018_bib102","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.ccell.2026.06.018_bib103","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ccell.2026.06.018_bib104","doi-asserted-by":"crossref","first-page":"D174","DOI":"10.1093\/nar\/gkad1059","article-title":"JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles","volume":"52","author":"Rauluseviciute","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib105","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s42003-020-01625-6","article-title":"Mapping the immune environment in clear cell renal carcinoma by single-cell genomics","volume":"4","author":"Borcherding","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ccell.2026.06.018_bib106","series-title":"survminer: Drawing Survival Curves using \u2018ggplot2\u2019","author":"Kassambara","year":"2016"},{"key":"10.1016\/j.ccell.2026.06.018_bib107","doi-asserted-by":"crossref","unstructured":"Therneau, T., and Grambsch, P. (2000). Modeling Survival Data: Extending The Cox Model https:\/\/doi.org\/10.1007\/978-1-4757-3294-8","DOI":"10.1007\/978-1-4757-3294-8"},{"key":"10.1016\/j.ccell.2026.06.018_bib108","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.2","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2016","journal-title":"F1000Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib109","doi-asserted-by":"crossref","first-page":"570","DOI":"10.32614\/RJ-2021-053","article-title":"Reproducible Summary Tables with the gtsummary Package","volume":"13","author":"Sjoberg","year":"2021","journal-title":"R J."},{"key":"10.1016\/j.ccell.2026.06.018_bib110","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ccell.2026.06.018_bib111","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/mi12040412","article-title":"Analyzing Developing Brain-On-Chip Cultures with the CALIMA Calcium Imaging Tool","volume":"12","author":"Raaijmakers","year":"2021","journal-title":"Micromachines"},{"key":"10.1016\/j.ccell.2026.06.018_bib112","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41592-021-01105-7","article-title":"SNT: a unifying toolbox for quantification of neuronal anatomy","volume":"18","author":"Arshadi","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ccell.2026.06.018_bib113","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1089\/crispr.2020.0022","article-title":"Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data","volume":"4","author":"Bloh","year":"2021","journal-title":"CRISPR J."},{"key":"10.1016\/j.ccell.2026.06.018_bib114","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41467-023-36296-4","article-title":"Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment","volume":"14","author":"Werba","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ccell.2026.06.018_bib115","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.3390\/molecules26082258","article-title":"Cholinergic Signaling, Neural Excitability, and Epilepsy","volume":"26","author":"Wang","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ccell.2026.06.018_bib116","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5688\/aj710478","article-title":"Physiology of the autonomic nervous system","volume":"71","author":"McCorry","year":"2007","journal-title":"Am. J. Pharm. Educ."},{"key":"10.1016\/j.ccell.2026.06.018_bib117","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11154-021-09687-5","article-title":"Leptin as a key regulator of the adipose organ","volume":"23","author":"Pic\u00f3","year":"2022","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.ccell.2026.06.018_bib118","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.tcb.2018.08.001","article-title":"The Intestinal Stem Cell Niche: Homeostasis and Adaptations","volume":"28","author":"Santos","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ccell.2026.06.018_bib119","doi-asserted-by":"crossref","first-page":"G193","DOI":"10.1152\/ajpgi.00239.2020","article-title":"Neuronal innervation of the intestinal crypt","volume":"320","author":"Ten Hove","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ccell.2026.06.018_bib120","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/modpathol.2017.156","article-title":"Implications of the tumor immune microenvironment for staging and therapeutics","volume":"31","author":"Taube","year":"2018","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.ccell.2026.06.018_bib121","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/s41589-025-02026-8","article-title":"Enhancing RNA base editing on mammalian transcripts with small nuclear RNAs","volume":"22","author":"Smargon","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ccell.2026.06.018_bib122","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-62703-640-5_6","article-title":"Mouse enteric neuronal cell culture","volume":"1078","author":"Zhang","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ccell.2026.06.018_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/cells13100815","article-title":"Isolation of Myenteric and Submucosal Plexus from Mouse Gastrointestinal Tract and Subsequent Co-Culture with Small Intestinal Organoids","volume":"13","author":"Llorente","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ccell.2026.06.018_bib124","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2144\/000113250","article-title":"A simplified, 96-well-adapted, ATP luminescence-based motility assay","volume":"47","author":"Restouin","year":"2009","journal-title":"Biotechniques"},{"key":"10.1016\/j.ccell.2026.06.018_bib125","first-page":"238","article-title":"Neuronal guidance genes in health and diseases","volume":"14","author":"Yuasa-Kawada","year":"2023","journal-title":"Protein Cell"},{"key":"10.1016\/j.ccell.2026.06.018_bib126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1200\/PO.17.00073","article-title":"Landscape of Microsatellite Instability Across 39 Cancer Types","volume":"2017","author":"Bonneville","year":"2017","journal-title":"JCO Precis. Oncol."},{"key":"10.1016\/j.ccell.2026.06.018_bib127","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","article-title":"Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal","volume":"83","author":"de Bruijn","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccell.2026.06.018_bib128","doi-asserted-by":"crossref","DOI":"10.2196\/27633","article-title":"Web-Based Survival Analysis Tool Tailored for Medical Research (KMplot): Development and Implementation","volume":"23","author":"L\u00e1nczky","year":"2021","journal-title":"J. Med. Internet Res."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610826003053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610826003053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:30:23Z","timestamp":1789399823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610826003053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":128,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1535610826003053"],"URL":"https:\/\/doi.org\/10.1016\/j.ccell.2026.06.018","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A self-amplifying nerve-fibroblast circuit drives colorectal cancer progression","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccell.2026.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}