{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T21:09:45Z","timestamp":1787173785533,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cardiacep.theclinics.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiac Electrophysiology Clinics"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.ccep.2021.04.006","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T09:57:01Z","timestamp":1625738221000},"page":"439-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Implantable Loop Recorders\u2014Syncope, Cryptogenic Stroke, Atrial Fibrillation"],"prefix":"10.1016","volume":"13","author":[{"given":"Suneet","family":"Mittal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccep.2021.04.006_bib1","first-page":"1383","article-title":"Current and future uses of insertable cardiac monitors","volume":"4","author":"Giancatrino","year":"2018","journal-title":"J\u00a0Am Coll Cardiol EP"},{"issue":"11","key":"10.1016\/j.ccep.2021.04.006_bib2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/17434440.2016.1243463","article-title":"Loop recorders for syncope evaluation: what is the evidence?","volume":"13","author":"Cheung","year":"2016","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.ccep.2021.04.006_bib3","article-title":"On behalf of the PICTURE study investigators. Use of an implantable loop recorder to increase the diagnostic yield in unexplained syncope: results from the PICTURE registry","author":"Edvardsson","year":"2010","journal-title":"Europace"},{"key":"10.1016\/j.ccep.2021.04.006_bib4","first-page":"e60","article-title":"2017 ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology\/American heart Association Task Force on clinical practice guidelines and the heart rhythm Society","volume":"136","author":"Shen","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib5","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1016\/j.jacc.2019.09.012","article-title":"ACC\/AHA\/HRS versus ESC guidelines for the diagnosis and management of syncope","volume":"74","author":"Goldberger","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccep.2021.04.006_bib6","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"2018 ESC Guidelines for the diagnosis and management of syncope","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccep.2021.04.006_bib7","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1161\/hc3601.095708","article-title":"On behalf of the International Study on Syncope of Uncertain Etiology (ISSUE) investigators. Mechanism of syncope in patients with isolated syncope and in patients with tilt-positive syncope","volume":"104","author":"Moya","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib8","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/hc4201.097837","article-title":"International Study on Syncope of Uncertain Etiology (ISSUE) Investigators. Mechanism of syncope in patients with bundle branch block and negative electrophysiological test","volume":"104","author":"Brignole","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib9","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1161\/01.CIR.0000018125.31973.87","article-title":"On behalf of the International Study on Syncope of Uncertain Etiology (ISSUE) investigators. Mechanism of syncope in patients with heart disease and negative electrophysiologic test","volume":"105","author":"Menozzi","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/eurheartj\/ehi842","article-title":"For the International Study on Syncope of Uncertain Etiology 2 (ISSUE 2) group. Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope","volume":"27","author":"Brignole","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccep.2021.04.006_bib11","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1161\/CIRCULATIONAHA.111.082313","article-title":"Pacemaker therapy in patients with neurally mediated syncope and documented asystole: third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial","volume":"125","author":"Brignole","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib12","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1056\/NEJMoa1802686","article-title":"Rivaroxaban for stroke prevention after embolic stroke of undetermined source","volume":"378","author":"Hart","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccep.2021.04.006_bib13","doi-asserted-by":"crossref","first-page":"1906_1917","DOI":"10.1056\/NEJMoa1813959","article-title":"Dabigatran for prevention of stroke after embolic stroke of undetermined source","volume":"380","author":"Diener","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccep.2021.04.006_bib14","doi-asserted-by":"crossref","unstructured":"Hindricks G, Potpara T, Dagres N, et\u00a0al, ESC Scientific Document Group, 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal, ehaa612, https:\/\/doi.org\/10.1093\/eurheartj\/ehaa612.","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"10.1016\/j.ccep.2021.04.006_bib15","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1056\/NEJMoa1311376","article-title":"For the EMRACE investigators and coordinators. Atrial fibrillation in patients with cryptogenic stroke","volume":"370","author":"Gladstone","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccep.2021.04.006_bib16","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1056\/NEJMoa1313600","article-title":"Cryptogenic stroke and underlying atrial fibrillation","volume":"370","author":"Sanna","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ccep.2021.04.006_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10840-019-00628-6","article-title":"Detection of atrial fibrillation using an implantable loop recorder following cryptogenic stroke: implications for post-stroke electrocardiographic monitoring","volume":"57","author":"Milstein","year":"2020","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ccep.2021.04.006_bib18","doi-asserted-by":"crossref","first-page":"e003333","DOI":"10.1161\/CIRCEP.115.003333","article-title":"Uncovering atrial fibrillation beyond short- term monitoring in cryptogenic stroke patients: three-year results from the cryptogenic stroke and underlying atrial fibrillation trial","volume":"9","author":"Brachmann","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ccep.2021.04.006_bib19","article-title":"Cost\u2013effectiveness of an insertable cardiac monitor to detect atrial fibrillation in patients with cryptogenic stroke","author":"Sawyer","year":"2020","journal-title":"J\u00a0Comp Eff Res"},{"key":"10.1016\/j.ccep.2021.04.006_bib20","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.hrthm.2016.05.010","article-title":"Real-world performance of an enhanced atrial fibrillation detection algorithm in an insertable cardiac monitor","volume":"13","author":"Mittal","year":"2016","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ccep.2021.04.006_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.hrthm.2017.09.009","article-title":"Utility and limitations of long-term monitoring of atrial fibrillation using an implantable loop recorder","volume":"15","author":"Lee","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ccep.2021.04.006_bib22","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1161\/CIRCULATIONAHA.119.042622","article-title":"Khairy, for the CIRCA-DOSE study investigators. Cryoballoon or radiofrequency ablation for atrial fibrillation assessed by continuous monitoring: a randomized clinical trial","volume":"140","author":"Andrade","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jelectrocard.2020.03.008","article-title":"For the CIRCA-DOSE study investigators. Clinical assessment of AF pattern is poorly correlated with AF burden and post ablation outcomes: a CIRCA-DOSE sub-study","volume":"60","author":"Andrade","year":"2020","journal-title":"J\u00a0Electrocardiol"},{"issue":"7","key":"10.1016\/j.ccep.2021.04.006_bib24","doi-asserted-by":"crossref","first-page":"e208748","DOI":"10.1001\/jamanetworkopen.2020.8748","article-title":"Association of atrial fibrillation episode duration with arrhythmia recurrence following ablation: a secondary analysis\u00a0of a randomized clinical trial","volume":"3","author":"Andrade","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.ccep.2021.04.006_bib25","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cvdhj.2020.10.003","article-title":"Incidence, duration, pattern, and burden of de novo atrial arrhythmias detected by continuous ECG monitoring using an implantable loop recorder following ablation of the cavotricuspid isthmus","volume":"1","author":"Musat","year":"2020","journal-title":"Cardiovasc Digital Health J"},{"key":"10.1016\/j.ccep.2021.04.006_bib26","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1161\/CIRCULATIONAHA.119.041303","article-title":"Stroke risk as a function of atrial fibrillation duration and CHA2DS2-VASc score","volume":"140","author":"Kaplan","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2021.04.006_bib27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/jce.12864","article-title":"Targeted anticoagulation for atrial fibrillation guided by continuous rhythm assessment with an insertable cardiac monitor: the Rhythm Evaluation for Anticoagulation with Continuous Monitoring (REACT.COM) pilot study","volume":"27","author":"Passman","year":"2016","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.ccep.2021.04.006_bib28","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/pace.12625","article-title":"Anticoagulation after catheter ablation of atrial fibrillation guided by implantable cardiac monitors","volume":"38","author":"Zuern","year":"2015","journal-title":"PACE"},{"key":"10.1016\/j.ccep.2021.04.006_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ahj.2017.12.007","article-title":"The optimal anti-coagulation for enhanced-risk patients post-catheter ablation for atrial fibrillation (OCEAN) trial","volume":"197","author":"Verma","year":"2018","journal-title":"Am Heart J"},{"key":"10.1016\/j.ccep.2021.04.006_bib30","doi-asserted-by":"crossref","first-page":"e008646","DOI":"10.1161\/CIRCEP.120.008646","article-title":"Incidence and predictors of very late recurrence of atrial fibrillation following cryoballoon pulmonary vein isolation","volume":"13","author":"Musat","year":"2020","journal-title":"Circ Arrhythmi Electrophysiol"}],"container-title":["Cardiac Electrophysiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187791822100037X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187791822100037X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:40:40Z","timestamp":1761802840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187791822100037X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S187791822100037X"],"URL":"https:\/\/doi.org\/10.1016\/j.ccep.2021.04.006","relation":{},"ISSN":["1877-9182"],"issn-type":[{"value":"1877-9182","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implantable Loop Recorders\u2014Syncope, Cryptogenic Stroke, Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"Cardiac Electrophysiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccep.2021.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}