{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:08:12Z","timestamp":1775257692291,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005747","name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065799"],"award-info":[{"award-number":["NNF20OC0065799"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["0134\u201300363B"],"award-info":[{"award-number":["0134\u201300363B"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004785","name":"NordForsk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cardiacep.theclinics.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiac Electrophysiology Clinics"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.ccep.2023.04.008","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T16:00:39Z","timestamp":1687276839000},"page":"343-348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Novel Familial ST-Depression Syndrome \u2013 Current Knowledge and Perspectives"],"prefix":"10.1016","volume":"15","author":[{"given":"Alex H\u00f8rby","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccep.2023.04.008_bib1","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1056\/NEJMc1807668","article-title":"A\u00a0novel familial cardiac arrhythmia syndrome with Widespread ST-segment depression","volume":"379","author":"Bundgaard","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccep.2023.04.008_bib2","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1016\/j.jacc.2021.03.313","article-title":"Natural history and clinical characteristics of the first 10 Danish families with familial ST-depression syndrome","volume":"77","author":"Christensen","year":"2021","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib3","doi-asserted-by":"crossref","first-page":"e010688","DOI":"10.1161\/CIRCEP.121.010688","article-title":"Electrocardiographic findings, arrhythmias, and left ventricular Involvement in familial ST-depression syndrome","volume":"15","author":"Christensen","year":"2022","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0002-8703(57)90079-0","article-title":"Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death","volume":"54","author":"Jervell","year":"1957","journal-title":"Am Heart J"},{"key":"10.1016\/j.ccep.2023.04.008_bib5","first-page":"656","article-title":"Rare cardiac arrhythmias of the Pediatric age. II. Syncopal Attacks due to paroxysmal ventricular fibrillation. (Presentation of 1st case in Italian Pediatric Literature)","volume":"45","author":"Romano","year":"1963","journal-title":"Clin Pediatr (Bologna)"},{"issue":"supplement","key":"10.1016\/j.ccep.2023.04.008_bib6","first-page":"28","article-title":"Catecholaminergic-induced severe ventricular arrhythmias with Adams-Stokes syndrome in children: report of four cases","volume":"40","author":"Coumel","year":"1978","journal-title":"Br Heart J"},{"key":"10.1016\/j.ccep.2023.04.008_bib7","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report","volume":"20","author":"Brugada","year":"1992","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/12618","article-title":"Cardiac conduction defects associate with mutations in SCN5A","volume":"23","author":"Schott","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.ccep.2023.04.008_bib9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1161\/01.CIR.0000085071.28695.C4","article-title":"Short QT Syndrome: a familial cause of sudden death","volume":"108","author":"Gaita","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2023.04.008_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000047299","article-title":"Idiopathic short QT interval: a new clinical syndrome?","volume":"94","author":"Gussak","year":"2000","journal-title":"Cardiology"},{"key":"10.1016\/j.ccep.2023.04.008_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1540-8167.2000.tb00743.x","article-title":"Ventricular fibrillation in a patient with prominent J (Osborn) waves and ST segment elevation in the inferior electrocardiographic leads: a Brugada syndrome variant?","volume":"11","author":"Kalla","year":"2000","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib12","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/eurheartj\/ehac262","article-title":"ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death","volume":"43","author":"Zeppenfeld","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccep.2023.04.008_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijcard.2016.02.039","article-title":"Healthy aging and myocardium: a complicated process with various effects in cardiac structure and physiology","volume":"209","author":"Nakou","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib14","first-page":"1065","article-title":"Sex Differences in the Biology and Pathology of the aging heart","volume":"32","author":"Keller","year":"2016","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib15","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.ehj.2004.06.016","article-title":"Low incidence of cardiac events with beta-blocking therapy in children with long QT syndrome","volume":"25","author":"Villain","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccep.2023.04.008_bib16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jacc.2014.05.068","article-title":"Efficacy of different beta-blockers in the treatment of long QT syndrome","volume":"64","author":"Abu-Zeitone","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.15420\/aer.2018.21.2","article-title":"Pharmacological therapy in Brugada syndrome","volume":"7","author":"Brodie","year":"2018","journal-title":"Arrhythmia Electrophysiol Rev"},{"key":"10.1016\/j.ccep.2023.04.008_bib18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41588-021-01007-6","article-title":"Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility","volume":"54","author":"Barc","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.ccep.2023.04.008_bib19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jacep.2020.08.032","article-title":"Brugada syndrome risk Investigators. A primary prevention clinical risk Score Model for patients with Brugada syndrome (BRUGADA-RISK)","volume":"7","author":"Honarbakhsh","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.ccep.2023.04.008_bib20","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1161\/CIRCULATIONAHA.105.520999","article-title":"Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome","volume":"112","author":"Frustaci","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2023.04.008_bib21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jcmg.2014.12.023","article-title":"Cardiac Mechanical Alterations and Genotype specific Differences in Subjects with long QT syndrome","volume":"8","author":"Leren","year":"2015","journal-title":"JACC Cardiovasc Imaging"}],"container-title":["Cardiac Electrophysiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187791822300045X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187791822300045X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:42:30Z","timestamp":1761802950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187791822300045X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S187791822300045X"],"URL":"https:\/\/doi.org\/10.1016\/j.ccep.2023.04.008","relation":{},"ISSN":["1877-9182"],"issn-type":[{"value":"1877-9182","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Novel Familial ST-Depression Syndrome \u2013 Current Knowledge and Perspectives","name":"articletitle","label":"Article Title"},{"value":"Cardiac Electrophysiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccep.2023.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}