{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:30:41Z","timestamp":1767375041339},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","cardiacep.theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiac Electrophysiology Clinics"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.ccep.2023.12.005","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T08:33:06Z","timestamp":1705825986000},"page":"297-305","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neuromodulation for Vasovagal Syncope and Bradyarrhythmias"],"prefix":"10.1016","volume":"16","author":[{"given":"Asad","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry D.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tolga","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.ccep.2023.12.005_bib1","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1093\/eurheartj\/ehy037","article-title":"ESC guidelines for the diagnosis and management of syncope","volume":"39","author":"Brignole","year":"2018","journal-title":"Eur Heart J"},{"issue":"13","key":"10.1016\/j.ccep.2023.12.005_bib2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1136\/heartjnl-2012-303220","article-title":"Vagally mediated atrioventricular block: pathophysiology and diagnosis","volume":"99","author":"Alboni","year":"2013","journal-title":"Heart"},{"issue":"10","key":"10.1016\/j.ccep.2023.12.005_bib3","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.7326\/M20-5415","article-title":"Midodrine for the prevention of vasovagal syncope","volume":"174","author":"Sheldon","year":"2021","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.ccep.2023.12.005_bib4","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/jce.15058","article-title":"Intrinsic cardiac autonomic nervous system: what do clinical electrophysiologists need to know about the \u201cheart brain\u201d","volume":"32","author":"Aksu","year":"2021","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib5","doi-asserted-by":"crossref","DOI":"10.1007\/s10840-022-01456-x","article-title":"Permanent pacing versus cardioneuroablation for cardioinhibitory vasovagal syncope","author":"Gopinathannair","year":"2022","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/CIRCEP.121.010018","article-title":"Cardioneuroablation for treatment of atrioventricular block","volume":"14","author":"Aksu","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s10840-020-00840-9","article-title":"Catheter ablation of right atrial ganglionated plexi to treat cardioinhibitory neurocardiogenic syncope: a long-term follow-up prospective study","volume":"61","author":"Calo","year":"2021","journal-title":"J\u00a0Interv Card Electrophysiol"},{"issue":"1","key":"10.1016\/j.ccep.2023.12.005_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/pace.12756","article-title":"Simplified cardioneuroablation in the treatment of reflex syncope, functional AV block, and sinus node dysfunction","volume":"39","author":"Aksu","year":"2016","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s10840-020-00938-0","article-title":"The benefit of cardioneuroablation to reduce syncope recurrence in vasovagal syncope patients: a case-control study","volume":"63","author":"Aksu","year":"2022","journal-title":"J\u00a0Interv Card Electrophysiol"},{"issue":"9","key":"10.1016\/j.ccep.2023.12.005_bib10","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/europace\/eur163","article-title":"Catheter ablation of severe neurally meditated reflex (neurocardiogenic or vasovagal) syncope: cardioneuroablation long-term results","volume":"13","author":"Pachon","year":"2011","journal-title":"Europace"},{"key":"10.1016\/j.ccep.2023.12.005_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s10840-022-01420-9","article-title":"Improved health-related quality of life after cardioneuroablation in patients with vasovagal syncope","author":"Baysal","year":"2022","journal-title":"J\u00a0Interv Card Electrophysiol"},{"issue":"1","key":"10.1016\/j.ccep.2023.12.005_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eupc.2004.10.003","article-title":"Cardioneuroablation: new treatment for neurocardiogenic syncope, functional AV block and sinus dysfunction using catheter RF-ablation","volume":"7","author":"Pachon","year":"2005","journal-title":"Europace"},{"issue":"2","key":"10.1016\/j.ccep.2023.12.005_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/life13020383","article-title":"Intrinsic cardiac neuromodulation in the management of atrial fibrillation: a potential missing link?","volume":"13","author":"Aksu","year":"2023","journal-title":"Life"},{"issue":"2","key":"10.1016\/j.ccep.2023.12.005_bib14","first-page":"142","article-title":"Vagal denervation in atrial fibrillation ablation: a comprehensive review","volume":"18","author":"Aksu","year":"2017","journal-title":"Anatol J Cardiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10840-022-01195-z","article-title":"Management of atrial fibrillation: two decades of progress . A scientific statement from the European Cardiac Arrhythmia Society","volume":"65","author":"L\u00e9vy","year":"2022","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/(SICI)1097-0185(199702)247:2<289::AID-AR15>3.0.CO;2-L","article-title":"Gross and microscopic anatomy of the human intrinsic cardiac nervous system","volume":"247","author":"Armour","year":"1997","journal-title":"Anat Rec"},{"key":"10.1016\/j.ccep.2023.12.005_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/1097-0185(20000801)259:4<353::AID-AR10>3.0.CO;2-R","article-title":"Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart","volume":"259","author":"Pauza","year":"2000","journal-title":"Anat Rec"},{"issue":"6","key":"10.1016\/j.ccep.2023.12.005_bib18","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.eupc.2004.08.005","article-title":"A\u00a0new treatment for atrial fibrillation based on spectral analysis to guide the catheter RF-ablation","volume":"6","author":"Pachon","year":"2004","journal-title":"Europace"},{"key":"10.1016\/j.ccep.2023.12.005_bib19","doi-asserted-by":"crossref","DOI":"10.15420\/aer.2022.37","article-title":"Ganglionic plexus ablation: a step-by-step guide for electrophysiologists and review of modalities for neuromodulation for the management of atrial fibrillation","volume":"12","author":"Aksu","year":"2023","journal-title":"Arrhythm Electrophysiol Rev"},{"issue":"1","key":"10.1016\/j.ccep.2023.12.005_bib20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ar.1092390109","article-title":"Gross and microscopic anatomy of the canine intrinsic cardiac nervous system","volume":"239","author":"Yuan","year":"1994","journal-title":"Anat Rec"},{"issue":"4","key":"10.1016\/j.ccep.2023.12.005_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0002-9149(86)90908-2","article-title":"Anatomy of human extrinsic cardiac nerves and ganglia","volume":"57","author":"Janes","year":"1986","journal-title":"Am J Cardiol"},{"issue":"3","key":"10.1016\/j.ccep.2023.12.005_bib22","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00139.2007","article-title":"The ligament of Marshall as a parasympathetic conduit","volume":"293","author":"Ulphani","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ijcard.2019.12.003","article-title":"Vagal responses during cardioneuroablation on different ganglionated plexi: is there any role of ablation strategy?","volume":"304","author":"Aksu","year":"2020","journal-title":"Int J Cardiol"},{"issue":"12 Suppl","key":"10.1016\/j.ccep.2023.12.005_bib24","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.hrthm.2009.07.029","article-title":"Pathophysiologic basis of autonomic ganglionated plexus ablation in patients with atrial fibrillation","volume":"6","author":"Nakagawa","year":"2009","journal-title":"Heart Rhythm"},{"issue":"4","key":"10.1016\/j.ccep.2023.12.005_bib25","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.4022\/jafib.2440","article-title":"Comparison of fragmented electrogram based strategy and high frequency stimulation for detection of ganglionated plexi","volume":"13","author":"Aksu","year":"2020","journal-title":"J\u00a0Atr Fibrillation"},{"issue":"10","key":"10.1016\/j.ccep.2023.12.005_bib26","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1540-8167.2009.01515.x","article-title":"Localization of left atrial ganglionated plexi in patients with atrial fibrillation","volume":"20","author":"Po","year":"2009","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"issue":"5","key":"10.1016\/j.ccep.2023.12.005_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jacep.2015.06.008","article-title":"Simplified method for vagal effect evaluation in cardiac ablation and electrophysiological procedures","volume":"1","author":"Pachon","year":"2015","journal-title":"JACC Clin Electrophysiol"},{"issue":"4","key":"10.1016\/j.ccep.2023.12.005_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.hrthm.2006.01.009","article-title":"Feasibility study of endocardial mapping of ganglionated plexuses during catheter ablation of atrial fibrillation","volume":"3","author":"Lemery","year":"2006","journal-title":"Heart Rhythm"},{"issue":"14","key":"10.1016\/j.ccep.2023.12.005_bib29","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2007.03.069","article-title":"Functional characterization of atrial electrograms in sinus rhythm delineates sites of parasympathetic innervation in patients with paroxysmal atrial fibrillation","volume":"50","author":"Lellouche","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.ccep.2023.12.005_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCEP.111.966465","article-title":"Endocardial autonomic denervation of the left atrium to treat vasovagal syncope: an early experience in humans","volume":"5","author":"Yao","year":"2012","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"7","key":"10.1016\/j.ccep.2023.12.005_bib31","article-title":"Catheter ablation as a treatment for vasovagal syncope: long-term outcome of endocardial autonomic modification of the left atrium","volume":"5","author":"Sun","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.ccep.2023.12.005_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/jce.15278","article-title":"Procedural and short-term results of electroanatomic-mapping-guided ganglionated plexus ablation by first-time operators: a multicenter study","volume":"33","author":"Aksu","year":"2022","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"issue":"8","key":"10.1016\/j.ccep.2023.12.005_bib33","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.hrthm.2022.04.014","article-title":"Ultrasound-guided extracardiac vagal stimulation: new approach for visualization of the vagus nerve during cardioneuroablation","volume":"19","author":"Piotrowski","year":"2022","journal-title":"Heart Rhythm"},{"issue":"9","key":"10.1016\/j.ccep.2023.12.005_bib34","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jacep.2017.01.022","article-title":"Atrial ganglionated plexus modification: a novel approach to treat symptomatic sinus bradycardia","volume":"3","author":"Qin","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"issue":"6","key":"10.1016\/j.ccep.2023.12.005_bib35","doi-asserted-by":"crossref","first-page":"E009747","DOI":"10.1161\/CIRCEP.120.009747","article-title":"Durable physiological changes and decreased syncope burden 12 Months after unifocal right-sided ablation under computed tomographic guidance in patients with neurally mediated syncope or functional sinus node dysfunction","volume":"14","author":"Debruyne","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"10","key":"10.1016\/j.ccep.2023.12.005_bib36","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.hrthm.2019.07.018","article-title":"Right anterior ganglionated plexus: the primary target of cardioneuroablation?","volume":"16","author":"Hu","year":"2019","journal-title":"Heart Rhythm"},{"issue":"11","key":"10.1016\/j.ccep.2023.12.005_bib37","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.hrthm.2022.06.017","article-title":"Cardioneuroablation for vasovagal syncope: A systematic review and meta-analysis","volume":"19","author":"Vandenberk","year":"2022","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.ccep.2023.12.005_bib38","first-page":"e60","article-title":"2017 ACC\/AHA\/HRS guideline for the evaluation and management of patients with syncope: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society","volume":"136","author":"Shen","year":"2017","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ccep.2023.12.005_bib39","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.jacc.2018.10.044","volume":"74","author":"Kusumoto","year":"2019","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.ccep.2023.12.005_bib40","first-page":"e382","volume":"140","author":"Kusumoto","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2023.12.005_bib41","doi-asserted-by":"crossref","DOI":"10.1177\/2050312119836308","article-title":"Potential usage of cardioneuroablation in vagally mediated functional atrioventricular block","volume":"7","author":"Aksu","year":"2019","journal-title":"SAGE Open Med"},{"issue":"1","key":"10.1016\/j.ccep.2023.12.005_bib42","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1161\/01.CIR.104.1.46","article-title":"Randomized assessment of syncope trial: conventional diagnostic testing versus a prolonged monitoring strategy","volume":"104","author":"Krahn","year":"2001","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ccep.2023.12.005_bib43","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/europace\/euaa230","article-title":"Usefulness of post-procedural heart rate response to predict syncope recurrence or positive head up tilt table testing after cardioneuroablation","volume":"22","author":"Aksu","year":"2020","journal-title":"Europace"},{"key":"10.1016\/j.ccep.2023.12.005_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10840-022-01212-1","article-title":"Pulmonary vein isolation with adjunctive left atrial ganglionic plexus ablation for treatment of atrial fibrillation: a meta-analysis of randomized controlled trials","volume":"66","author":"Rackley","year":"2023","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib45","doi-asserted-by":"crossref","first-page":"958316","DOI":"10.3389\/fcvm.2022.958316","article-title":"Cryoballoon ablation for atrial fibrillation: effects on neuromodulation","volume":"9","author":"Del Monte","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.ccep.2023.12.005_bib46","doi-asserted-by":"crossref","DOI":"10.1007\/s10840-022-01270-5","article-title":"The impact of the clinical diagnosis on the vagal response and heart rate after ganglionated plexus ablation","author":"Aksu","year":"2022","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib47","doi-asserted-by":"crossref","DOI":"10.1007\/s10840-023-01516-w","article-title":"Stellate ganglia stimulation counteracts vagal stimulation by significantly increasing heart rate and blood pressure","author":"Killu","year":"2023","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ccep.2023.12.005_bib48","doi-asserted-by":"crossref","DOI":"10.1007\/s10840-022-01198-w","article-title":"Cardioneuroablation for the treatment of vasovagal syncope and sinus bradycardia with atrial escape","author":"Aksu","year":"2022","journal-title":"J\u00a0Interv Card Electrophysiol"},{"issue":"7","key":"10.1016\/j.ccep.2023.12.005_bib49","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/europace\/euab331","article-title":"Cardioneuroablation of the right anterior ganglionated plexus in symptomatic sinus bradycardia after extensive weight loss","volume":"24","author":"Reek","year":"2022","journal-title":"Europace"},{"key":"10.1016\/j.ccep.2023.12.005_bib50","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10840-020-00831-w","article-title":"Potential therapeutic effects of electrogram-guided cardioneuroablation in long QT syndrome: case series","volume":"61","author":"Aksu","year":"2021","journal-title":"J\u00a0Interv Card Electrophysiol"},{"issue":"15","key":"10.1016\/j.ccep.2023.12.005_bib51","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1161\/01.CIR.0000125523.14403.1E","article-title":"Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome","volume":"109","author":"Schwartz","year":"2004","journal-title":"Circulation"}],"container-title":["Cardiac Electrophysiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877918223001466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877918223001466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:13:57Z","timestamp":1722330837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877918223001466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S1877918223001466"],"URL":"https:\/\/doi.org\/10.1016\/j.ccep.2023.12.005","relation":{},"ISSN":["1877-9182"],"issn-type":[{"type":"print","value":"1877-9182"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuromodulation for Vasovagal Syncope and Bradyarrhythmias","name":"articletitle","label":"Article Title"},{"value":"Cardiac Electrophysiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccep.2023.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}