{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:26:53Z","timestamp":1762543613114,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cardiacep.theclinics.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiac Electrophysiology Clinics"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ccep.2025.07.013","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:00:00Z","timestamp":1759813200000},"page":"651-661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Channelopathies in the Pediatric Patient"],"prefix":"10.1016","volume":"17","author":[{"given":"Iqbal","family":"El Assaad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Roston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios","family":"Bezzerides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ccep.2025.07.013_bib1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/CIRCRESAHA.110.226845","article-title":"Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis","volume":"108","author":"Priori","year":"2011","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.ccep.2025.07.013_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/01.CIR.103.2.196","article-title":"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia","volume":"103","author":"Priori","year":"2001","journal-title":"Circulation"},{"issue":"6 Pt 2","key":"10.1016\/j.ccep.2025.07.013_bib3","first-page":"H1796","article-title":"Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines","volume":"258","author":"Priori","year":"1990","journal-title":"Am J Physiol"},{"issue":"14","key":"10.1016\/j.ccep.2025.07.013_bib4","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1113\/JP276757","article-title":"Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia","volume":"598","author":"Wleklinski","year":"2020","journal-title":"J Physiol"},{"issue":"35","key":"10.1016\/j.ccep.2025.07.013_bib5","doi-asserted-by":"crossref","first-page":"13062","DOI":"10.1073\/pnas.0402388101","article-title":"RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)","volume":"101","author":"Jiang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ccep.2025.07.013_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/hrt.37.3.339","article-title":"Bidirectional tachycardia in a child. A study using his bundle electrography","volume":"37","author":"Reid","year":"1975","journal-title":"Br Heart J"},{"issue":"5","key":"10.1016\/j.ccep.2025.07.013_bib7","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.CIR.91.5.1512","article-title":"Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients","volume":"91","author":"Leenhardt","year":"1995","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ccep.2025.07.013_bib8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCEP.114.002217","article-title":"Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry","volume":"8","author":"Roston","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"4","key":"10.1016\/j.ccep.2025.07.013_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12512","article-title":"Catecholaminergic polymorphic ventricular tachycardia, an update","volume":"23","author":"Perez-Riera","year":"2018","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"25","key":"10.1016\/j.ccep.2025.07.013_bib10","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa1510687","article-title":"A prospective study of sudden cardiac death among children and young adults","volume":"374","author":"Bagnall","year":"2016","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.ccep.2025.07.013_bib11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.hrthm.2022.03.1225","article-title":"Expert consensus statement on the state of genetic testing for cardiac diseases","volume":"19","author":"Wilde","year":"2022","journal-title":"Heart Rhythm"},{"issue":"10","key":"10.1016\/j.ccep.2025.07.013_bib12","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1111\/jce.14043","article-title":"Chronotropic incompetence as a risk predictor in children and young adults with catecholaminergic polymorphic ventricular tachycardia","volume":"30","author":"Franciosi","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"10.1016\/j.ccep.2025.07.013_bib13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/europace\/euac177","article-title":"Repeatability of ventricular arrhythmia characteristics on the exercise-stress test in RYR2-mediated catecholaminergic polymorphic ventricular tachycardia","volume":"25","author":"Peltenburg","year":"2023","journal-title":"Europace"},{"issue":"4","key":"10.1016\/j.ccep.2025.07.013_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jacep.2021.02.013","article-title":"Burst exercise testing can unmask arrhythmias in patients with incompletely penetrant catecholaminergic polymorphic ventricular tachycardia","volume":"7","author":"Roston","year":"2021","journal-title":"JACC Clin Electrophysiol"},{"issue":"12","key":"10.1016\/j.ccep.2025.07.013_bib15","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.hrthm.2013.05.014","article-title":"HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in may 2013 and by ACCF, AHA, PACES, and AEPC in June 2013","volume":"10","author":"Priori","year":"2013","journal-title":"Heart Rhythm"},{"issue":"9","key":"10.1016\/j.ccep.2025.07.013_bib16","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/europace\/eus031","article-title":"The role of stress test for predicting genetic mutations and future cardiac events in asymptomatic relatives of catecholaminergic polymorphic ventricular tachycardia probands","volume":"14","author":"Hayashi","year":"2012","journal-title":"Europace"},{"issue":"18","key":"10.1016\/j.ccep.2025.07.013_bib17","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1161\/CIRCULATIONAHA.108.829267","article-title":"Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia","volume":"119","author":"Hayashi","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.ccep.2025.07.013_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/europace\/eur277","article-title":"Therapeutic approach for patients with catecholaminergic polymorphic ventricular tachycardia: state of the art and future developments","volume":"14","author":"van der Werf","year":"2012","journal-title":"Europace"},{"issue":"5","key":"10.1016\/j.ccep.2025.07.013_bib19","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCULATIONAHA.121.056018","article-title":"An international multicenter cohort study on beta-Blockers for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia","volume":"145","author":"Peltenburg","year":"2022","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ccep.2025.07.013_bib20","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1001\/jamacardio.2022.0219","article-title":"Outcomes of patients with catecholaminergic polymorphic ventricular tachycardia treated with beta-blockers","volume":"7","author":"Mazzanti","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"4","key":"10.1016\/j.ccep.2025.07.013_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nm.1942","article-title":"Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans","volume":"15","author":"Watanabe","year":"2009","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.ccep.2025.07.013_bib22","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1001\/jamacardio.2017.1320","article-title":"Efficacy of flecainide in the treatment of Catecholaminergic polymorphic ventricular tachycardia: a randomized clinical trial","volume":"2","author":"Kannankeril","year":"2017","journal-title":"JAMA Cardiol"},{"issue":"11","key":"10.1016\/j.ccep.2025.07.013_bib23","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.hrthm.2021.07.061","article-title":"Evaluation of age at symptom onset, proband status, and sex as predictors of disease severity in pediatric catecholaminergic polymorphic ventricular tachycardia","volume":"18","author":"Kallas","year":"2021","journal-title":"Heart Rhythm"},{"issue":"1","key":"10.1016\/j.ccep.2025.07.013_bib24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.hrthm.2013.10.027","article-title":"Outcomes of defibrillator therapy in catecholaminergic polymorphic ventricular tachycardia","volume":"11","author":"Roses-Noguer","year":"2014","journal-title":"Heart Rhythm"},{"issue":"3","key":"10.1016\/j.ccep.2025.07.013_bib25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1161\/CIRCEP.113.000170","article-title":"Efficacy of implantable cardioverter defibrillators in young patients with catecholaminergic polymorphic ventricular tachycardia: success depends on substrate","volume":"6","author":"Miyake","year":"2013","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"10","key":"10.1016\/j.ccep.2025.07.013_bib26","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.hrthm.2024.04.006","article-title":"An international multicenter cohort study on implantable cardioverter-defibrillators for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia","volume":"21","author":"Lamba","year":"2024","journal-title":"Heart Rhythm"},{"issue":"35","key":"10.1016\/j.ccep.2025.07.013_bib27","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1093\/eurheartj\/ehz309","article-title":"Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest","volume":"40","author":"van der Werf","year":"2019","journal-title":"Eur Heart J"},{"issue":"579","key":"10.1016\/j.ccep.2025.07.013_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aba7287","article-title":"Cardiac ryanodine receptor calcium release deficiency syndrome","volume":"13","author":"Sun","year":"2021","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.ccep.2025.07.013_bib29","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.121.010013","article-title":"Human RyR2 (Ryanodine receptor 2) loss-of-function mutations: clinical phenotypes and in vitro characterization","volume":"14","author":"Li","year":"2021","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"1","key":"10.1016\/j.ccep.2025.07.013_bib30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1001\/jamacardio.2021.4458","article-title":"Clinical and functional characterization of ryanodine receptor 2 variants implicated in calcium-release deficiency syndrome","volume":"7","author":"Roston","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"1","key":"10.1016\/j.ccep.2025.07.013_bib31","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.121.003589","article-title":"Provocation testing and therapeutic response in a newly described channelopathy: ryR2 calcium release deficiency syndrome","volume":"15","author":"Ormerod","year":"2022","journal-title":"Circ Genom Precis Med"},{"issue":"3","key":"10.1016\/j.ccep.2025.07.013_bib32","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1001\/jama.2024.8599","article-title":"A clinical diagnostic test for calcium release deficiency syndrome","volume":"332","author":"Ni","year":"2024","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.ccep.2025.07.013_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jelectrocard.2016.09.006","article-title":"A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia","volume":"50","author":"Roston","year":"2017","journal-title":"J Electrocardiol"},{"issue":"2","key":"10.1016\/j.ccep.2025.07.013_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1161\/CIRCRESAHA.123.322504","article-title":"Increased Ca(2+) transient underlies RyR2-Related left ventricular noncompaction","volume":"133","author":"Ni","year":"2023","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.ccep.2025.07.013_bib35","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.str.2011.03.016","article-title":"The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching","volume":"19","author":"Lobo","year":"2011","journal-title":"Structure"},{"issue":"7","key":"10.1016\/j.ccep.2025.07.013_bib36","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCRESAHA.111.256560","article-title":"Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies","volume":"110","author":"Tang","year":"2012","journal-title":"Circ Res"},{"issue":"14","key":"10.1016\/j.ccep.2025.07.013_bib37","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/CIRCULATIONAHA.107.711606","article-title":"Expanding spectrum of human RYR2-related disease: new electrocardiographic, structural, and genetic features","volume":"116","author":"Bhuiyan","year":"2007","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.ccep.2025.07.013_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/anec.12623","article-title":"Identification of a novel exon3 deletion of RYR2 in a family with catecholaminergic polymorphic ventricular tachycardia","volume":"24","author":"Dharmawan","year":"2019","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"11","key":"10.1016\/j.ccep.2025.07.013_bib39","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1093\/europace\/eut382","article-title":"Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction","volume":"16","author":"Ohno","year":"2014","journal-title":"Europace"},{"issue":"9","key":"10.1016\/j.ccep.2025.07.013_bib40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.hrthm.2022.06.025","article-title":"Posttraumatic stress disorder in pediatric patients with implantable cardioverter-defibrillators and their parents","volume":"19","author":"Schneider","year":"2022","journal-title":"Heart Rhythm"},{"issue":"5","key":"10.1016\/j.ccep.2025.07.013_bib41","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1017\/S1047951120000803","article-title":"The impact of physical activity modification on the well-being of a cohort of children with an inherited arrhythmia or cardiomyopathy","volume":"30","author":"Christian","year":"2020","journal-title":"Cardiol Young"},{"issue":"2","key":"10.1016\/j.ccep.2025.07.013_bib42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.hrthm.2018.08.025","article-title":"Linking the heart and the brain: neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia","volume":"16","author":"Lieve","year":"2019","journal-title":"Heart Rhythm"},{"issue":"3","key":"10.1016\/j.ccep.2025.07.013_bib43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jacep.2016.01.020","article-title":"Competitive sports participation in patients with catecholaminergic polymorphic ventricular tachycardia: a single center's early experience","volume":"2","author":"Ostby","year":"2016","journal-title":"JACC Clin Electrophysiol"},{"issue":"9","key":"10.1016\/j.ccep.2025.07.013_bib44","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1093\/cvr\/cvaa107","article-title":"Gene therapy for inherited arrhythmias","volume":"116","author":"Bezzerides","year":"2020","journal-title":"Cardiovasc Res"},{"issue":"25","key":"10.1016\/j.ccep.2025.07.013_bib45","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1161\/CIRCULATIONAHA.113.006901","article-title":"Single delivery of an adeno-associated viral construct to transfer the CASQ2 gene to knock-in mice affected by catecholaminergic polymorphic ventricular tachycardia is able to cure the disease from birth to advanced age","volume":"129","author":"Denegri","year":"2014","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ccep.2025.07.013_bib46","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.hrthm.2017.03.025","article-title":"Viral delivered gene therapy to treat catecholaminergic polymorphic ventricular tachycardia (CPVT2) in mouse models","volume":"14","author":"Kurtzwald-Josefson","year":"2017","journal-title":"Heart Rhythm"},{"issue":"8","key":"10.1016\/j.ccep.2025.07.013_bib47","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1161\/CIRCRESAHA.118.313369","article-title":"In vivo Ryr2 editing corrects catecholaminergic polymorphic ventricular tachycardia","volume":"123","author":"Pan","year":"2018","journal-title":"Circ Res"},{"issue":"5","key":"10.1016\/j.ccep.2025.07.013_bib48","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/CIRCULATIONAHA.118.038514","article-title":"Gene therapy for catecholaminergic polymorphic ventricular tachycardia by inhibition of Ca(2+)\/Calmodulin-Dependent kinase II","volume":"140","author":"Bezzerides","year":"2019","journal-title":"Circulation"}],"container-title":["Cardiac Electrophysiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877918225000565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877918225000565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:21:36Z","timestamp":1762543296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877918225000565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1877918225000565"],"URL":"https:\/\/doi.org\/10.1016\/j.ccep.2025.07.013","relation":{},"ISSN":["1877-9182"],"issn-type":[{"type":"print","value":"1877-9182"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac Channelopathies in the Pediatric Patient","name":"articletitle","label":"Article Title"},{"value":"Cardiac Electrophysiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccep.2025.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}