{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:28:53Z","timestamp":1786494533055,"version":"build-2736575974"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cardiacep.theclinics.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiac Electrophysiology Clinics"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ccep.2026.06.008","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:50:55Z","timestamp":1786492255000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baroreflex Activation Therapy in Patients with Heart Failure with a Reduced Ejection Fraction"],"prefix":"10.1016","volume":"18","author":[{"given":"Jean M.","family":"Ruddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kroman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin F.","family":"Baicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ccep.2026.06.008_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jacc.2009.03.061","article-title":"Sympathetic nervous system activation in human heart failure: clinical implications of an updated model","volume":"54","author":"Floras","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.ccep.2026.06.008_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0735-1097(94)90427-8","article-title":"Arterial baroreflex regulation of blood pressure in patients with congestive heart failure","volume":"23","author":"Creager","year":"1994","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"10.1016\/j.ccep.2026.06.008_bib3","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1161\/01.CIR.96.10.3450","article-title":"Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications","volume":"96","author":"Mortara","year":"1997","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ccep.2026.06.008_bib4","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jchf.2022.02.006","article-title":"Chemoreflex and Baroreflex Sensitivity Hold a Strong Prognostic Value in Chronic Heart Failure","volume":"10","author":"Giannoni","year":"2022","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ccep.2026.06.008_bib5","first-page":"e240","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ccep.2026.06.008_bib6","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","volume":"136","author":"Yancy","year":"2017","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.ccep.2026.06.008_bib7","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.ccep.2026.06.008_bib8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/ejhf.138","article-title":"Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof-of-concept study","volume":"16","author":"Gronda","year":"2014","journal-title":"Eur J Heart Fail"},{"issue":"3","key":"10.1016\/j.ccep.2026.06.008_bib9","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1161\/HYPERTENSIONAHA.109.134023","article-title":"Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension","volume":"54","author":"Wustmann","year":"2009","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ccep.2026.06.008_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2020.05.015","article-title":"Baroreflex Activation Therapy in Patients With Heart Failure With Reduced Ejection Fraction","volume":"76","author":"Zile","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.ccep.2026.06.008_bib11","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1161\/HYPERTENSIONAHA.107.095216","article-title":"Chronic Baroreceptor Activation Enhances Survival in Dogs With Pacing-Induced Heart Failure","volume":"50","author":"Zucker","year":"2007","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.ccep.2026.06.008_bib12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCHEARTFAILURE.110.955013","article-title":"Chronic Electrical Stimulation of the Carotid Sinus Baroreflex Improves Left Ventricular Function and Promotes Reversal of Ventricular Remodeling in Dogs With Advanced Heart Failure","volume":"4","author":"Sabbah","year":"2011","journal-title":"Circ Heart Fail"},{"issue":"1","key":"10.1016\/j.ccep.2026.06.008_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/HYPERTENSIONAHA.114.04492","article-title":"Bilateral or Unilateral Stimulation for Baroreflex Activation Therapy","volume":"65","author":"de Leeuw","year":"2015","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.ccep.2026.06.008_bib14","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jacc.2011.06.008","article-title":"Baroreflex Activation Therapy Lowers Blood Pressure in Patients With Resistant Hypertension","volume":"58","author":"Bisognano","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.ccep.2026.06.008_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jchf.2015.02.006","article-title":"Baroreflex Activation Therapy for the Treatment of Heart Failure With a Reduced Ejection Fraction","volume":"3","author":"Abraham","year":"2015","journal-title":"JACC Heart Fail"},{"issue":"10","key":"10.1016\/j.ccep.2026.06.008_bib16","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/ejhf.299","article-title":"Baroreflex activation therapy for the treatment of heart failure with a reduced ejection fraction: safety and efficacy in patients with and without cardiac resynchronization therapy","volume":"17","author":"Zile","year":"2015","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ccep.2026.06.008_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ahj.2018.07.011","article-title":"First granted example of novel FDA trial design under Expedited Access Pathway for premarket approval: BeAT-HF","volume":"204","author":"Zile","year":"2018","journal-title":"Am Heart J"},{"issue":"6","key":"10.1016\/j.ccep.2026.06.008_bib18","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jchf.2021.01.012","article-title":"Response by Sex in Patient-Centered Outcomes With Baroreflex Activation Therapy in Systolic Heart Failure","volume":"9","author":"Lindenfeld","year":"2021","journal-title":"JACC Heart Fail"},{"issue":"2","key":"10.1016\/j.ccep.2026.06.008_bib19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1053\/j.semtcvs.2016.04.017","article-title":"Surgical Experience and Long-term Results of Baroreflex Activation Therapy for Heart Failure With Reduced Ejection Fraction","volume":"28","author":"Weaver","year":"2016","journal-title":"Semin Thorac Cardiovasc Surg"}],"container-title":["Cardiac Electrophysiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877918226000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1877918226000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:51:14Z","timestamp":1786492274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1877918226000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1877918226000328"],"URL":"https:\/\/doi.org\/10.1016\/j.ccep.2026.06.008","relation":{},"ISSN":["1877-9182"],"issn-type":[{"value":"1877-9182","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baroreflex Activation Therapy in Patients with Heart Failure with a Reduced Ejection Fraction","name":"articletitle","label":"Article Title"},{"value":"Cardiac Electrophysiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccep.2026.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}