{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:28:26Z","timestamp":1790440106898,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology Clinics"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.ccl.2013.09.002","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:46:56Z","timestamp":1385426816000},"page":"21-32","source":"Crossref","is-referenced-by-count":176,"title":["The Renin-Angiotensin-Aldosterone System and Heart Failure"],"prefix":"10.1016","volume":"32","author":[{"given":"Gabriel","family":"Sayer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccl.2013.09.002_bib1","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1001\/jama.1995.03520420066040","article-title":"Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure","volume":"273","author":"Garg","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ccl.2013.09.002_bib2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.ejheart.2007.09.003","article-title":"Comparison of the beneficial effect of beta-blockers on mortality in patients with ischaemic or non-ischaemic systolic heart failure: a meta-analysis of randomized controlled trials","volume":"9","author":"Fauchier","year":"2007","journal-title":"Eur J Heart Fail"},{"issue":"2","key":"10.1016\/j.ccl.2013.09.002_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/01.CIR.72.2.406","article-title":"Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril","volume":"72","author":"Pfeffer","year":"1985","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure","author":"Yancy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib5","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2013.09.002_bib6","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cardfail.2010.04.004","article-title":"HFSA 2010 Comprehensive Heart Failure Practice Guideline","volume":"16","author":"Lindenfeld","year":"2010","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.ccl.2013.09.002_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ki.1992.39","article-title":"Pressure dependent modulation of renin release in isolated perfused glomeruli","volume":"41","author":"Bock","year":"1992","journal-title":"Kidney Int"},{"key":"10.1016\/j.ccl.2013.09.002_bib8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1161\/01.RES.66.4.883","article-title":"Angiotensin II-forming pathways in normal and failing human hearts","volume":"66","author":"Urata","year":"1990","journal-title":"Circ Res"},{"key":"10.1016\/j.ccl.2013.09.002_bib9","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1172\/JCI114846","article-title":"Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat","volume":"86","author":"Seikaly","year":"1990","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.ccl.2013.09.002_bib10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/01.CIR.98.1.73","article-title":"Angiotensin production by the heart: a quantitative study in pigs with the use of radiolabeled angiotensin infusions","volume":"98","author":"van Kats","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib11","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1001\/archinte.1993.00410080011002","article-title":"Tissue renin-angiotensin system in myocardial hypertrophy and failure","volume":"153","author":"Dzau","year":"1993","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib12","first-page":"E617","article-title":"Interaction of vasopressin and angiotensin II in stimulation of prostacyclin synthesis in vascular smooth muscle cells","volume":"257","author":"Vallotton","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib13","first-page":"H610","article-title":"Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells","volume":"259","author":"Baker","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1161\/01.CIR.93.6.1148","article-title":"Plasma angiotensin II, predisposition to hypertension, and left ventricular size in healthy young adults","volume":"93","author":"Harrap","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib15","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.RES.0000047090.08299.D5","article-title":"Tumor necrosis factor-alpha-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis","volume":"91","author":"Peng","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.ccl.2013.09.002_bib16","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1161\/01.CIR.96.11.4065","article-title":"Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation","volume":"96","author":"Weber","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib17","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1161\/01.CIR.82.5.1724","article-title":"Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD)","volume":"82","author":"Francis","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1527-5299.2005.03722.x","article-title":"Mineralocorticoid receptor is overexpressed in cardiomyocytes of patients with congestive heart failure","volume":"11","author":"Yoshida","year":"2005","journal-title":"Congest Heart Fail"},{"key":"10.1016\/j.ccl.2013.09.002_bib19","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1006\/jmcc.1994.1098","article-title":"Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone","volume":"26","author":"Brilla","year":"1994","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/01.CIR.104.2.137","article-title":"Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes","volume":"104","author":"Harada","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib21","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/01.CIR.95.5.1115","article-title":"Role of bradykinin in\u00a0mediating vascular effects of angiotensin-converting enzyme inhibitors in humans","volume":"95","author":"Hornig","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/01.CIR.69.3.548","article-title":"Hemodynamic and clinical response to enalapril, a long-acting converting-enzyme inhibitor, in patients with congestive heart failure","volume":"69","author":"Levine","year":"1984","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0002-8703(88)90621-7","article-title":"Modulation of hemodynamic effects with a converting enzyme inhibitor: acute hemodynamic dose-response relationship of a new angiotensin converting enzyme inhibitor, lisinopril, with observations on long-term clinical, functional, and biochemical responses","volume":"116","author":"Uretsky","year":"1988","journal-title":"Am Heart J"},{"key":"10.1016\/j.ccl.2013.09.002_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.RES.57.1.84","article-title":"Influence of chronic captopril therapy on the infarcted left ventricle of the rat","volume":"57","author":"Pfeffer","year":"1985","journal-title":"Circ Res"},{"key":"10.1016\/j.ccl.2013.09.002_bib25","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/0140-6736(91)90202-Z","article-title":"Early prevention of left ventricular dysfunction after myocardial infarction with angiotensin-converting-enzyme inhibition","volume":"337","author":"Sharpe","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/01.CIR.89.1.68","article-title":"Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril","volume":"89","author":"St John Sutton","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/01.CIR.86.2.431","article-title":"Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure","volume":"86","author":"Konstam","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib28","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1161\/01.CIR.88.5.2277","article-title":"Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dilatation in patients with asymptomatic systolic dysfunction","volume":"88","author":"Konstam","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib29","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM198711193172112","article-title":"Enalapril for congestive heart failure","volume":"317","year":"1987","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199108013250501","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","volume":"325","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM199209033271003","article-title":"Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions","volume":"327","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib32","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1056\/NEJM199209033271001","article-title":"Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial","volume":"327","author":"Pfeffer","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib33","first-page":"821","article-title":"Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure","volume":"342","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib34","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1056\/NEJM199512213332503","article-title":"A\u00a0clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction","volume":"333","author":"Kober","year":"1995","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib35","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1056\/NEJM199108013250502","article-title":"A\u00a0comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure","volume":"325","author":"Cohn","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib36","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1161\/01.CIR.100.23.2312","article-title":"Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure","volume":"100","author":"Packer","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients","volume":"342","author":"Yusuf","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib38","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0140-6736(03)14286-9","article-title":"Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomized, double-blind, placebo-controlled, multicentre trial (the EUROPA study)","volume":"362","author":"Fox","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib39","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1056\/NEJMoa042739","article-title":"Angiotensin-converting-enzyme inhibition in stable coronary artery disease","volume":"351","author":"Braunwald","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib40","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(06)69201-5","article-title":"Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials","volume":"368","author":"Dagenais","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib41","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0735-1097(98)00695-0","article-title":"Dose-related beneficial long-term hemodynamic and clinical efficacy of irbesartan in heart failure","volume":"33","author":"Havranek","year":"1999","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib42","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0735-1097(97)00253-2","article-title":"Comparative effects of losartan and enalapril on exercise capacity and clinical status in patients with heart failure","volume":"30","author":"Lang","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib43","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(00)02213-3","article-title":"Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial\u2013the Losartan Heart Failure Survival Study ELITE II","volume":"355","author":"Pitt","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib44","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(02)09895-1","article-title":"Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial","volume":"360","author":"Dickstein","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib45","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1056\/NEJMoa032292","article-title":"Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both","volume":"349","author":"Pfeffer","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib46","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0140-6736(03)14284-5","article-title":"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial","volume":"362","author":"Granger","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib47","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0140-6736(09)61913-9","article-title":"Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial","volume":"374","author":"Konstam","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib48","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1056\/NEJMoa010713","article-title":"A\u00a0randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure","volume":"345","author":"Cohn","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib49","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(03)14283-3","article-title":"Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial","volume":"362","author":"McMurray","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib50","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0140-6736(03)14285-7","article-title":"Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial","volume":"362","author":"Yusuf","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2013.09.002_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/01.CIR.103.1.148","article-title":"Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure","volume":"103","author":"Kim","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib52","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1161\/01.CIR.99.20.2658","article-title":"Augmented short- and long-term hemodynamic and hormonal effects of an angiotensin receptor blocker added to angiotensin converting enzyme inhibitor therapy in patients with heart failure","volume":"99","author":"Baruch","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib53","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1161\/01.CIR.99.8.990","article-title":"Addition of angiotensin II receptor blockade to maximal angiotensin-converting enzyme inhibition improves exercise capacity in patients with severe congestive heart failure","volume":"99","author":"Hamroff","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib54","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cardfail.2007.11.008","volume":"14","author":"Lakhdar","year":"2008","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.ccl.2013.09.002_bib55","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jacc.2003.05.003","article-title":"Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction","volume":"42","author":"Fraccarollo","year":"2003","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2013.09.002_bib56","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1161\/01.CIR.0000039104.56479.42","article-title":"Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure","volume":"106","author":"Suzuki","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib57","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1161\/01.CIR.0000068340.96506.0F","volume":"107","author":"Hayashi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib58","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1161\/01.CIR.102.22.2700","article-title":"Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES)","volume":"102","author":"Zannad","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2013.09.002_bib59","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure","volume":"341","author":"Pitt","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib60","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"Pitt","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"Zannad","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib62","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1056\/NEJMoa040135","article-title":"Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study","volume":"351","author":"Juurlink","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/CIRCHEARTFAILURE.107.740704","article-title":"Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure","volume":"1","author":"McMurray","year":"2008","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2013.09.002_bib64","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1056\/NEJMoa1208799","article-title":"Cardiorenal end points in a trial of aliskiren for type 2 diabetes","volume":"367","author":"Parving","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib65","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/eurheartj\/ehq522","article-title":"Effect of the direct renin inhibitor aliskiren on left ventricular remodeling following myocardial infarction with systolic dysfunction","volume":"32","author":"Solomon","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2013.09.002_bib66","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1001\/jama.2013.1954","article-title":"Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial","volume":"309","author":"Gheorghiade","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.ccl.2013.09.002_bib67","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/eurheartj\/ehl250","article-title":"The perindopril in elderly people with chronic heart failure (PEP-CHF) study","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2013.09.002_bib68","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1056\/NEJMoa0805450","article-title":"Irbesartan in patients with heart failure and preserved ejection fraction","volume":"359","author":"Massie","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2013.09.002_bib69","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1001\/jama.2013.905","article-title":"Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial","volume":"309","author":"Edelmann","year":"2013","journal-title":"JAMA"}],"container-title":["Cardiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733865113000854?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733865113000854?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T14:54:57Z","timestamp":1539010497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733865113000854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0733865113000854"],"URL":"https:\/\/doi.org\/10.1016\/j.ccl.2013.09.002","relation":{},"ISSN":["0733-8651"],"issn-type":[{"value":"0733-8651","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}