{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:35:57Z","timestamp":1760056557404,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Clinics"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.ccl.2019.01.011","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T10:23:50Z","timestamp":1551263030000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mechanisms of Improved Mortality Following Ablation"],"prefix":"10.1016","volume":"37","author":[{"given":"T. Jared","family":"Bunch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi T.","family":"May","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kia","family":"Afshar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Alharethi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Day","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccl.2019.01.011_bib1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2019.01.011_bib2","doi-asserted-by":"crossref","first-page":"e147","DOI":"10.1016\/j.jacc.2013.05.019","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"62","author":"Yancy","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(98)11181-9","article-title":"The cardiac insufficiency bisoprolol study II (CIBIS-II): a randomised trial","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2019.01.011_bib4","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1056\/NEJM199605233342101","article-title":"The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group","volume":"334","author":"Packer","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2019.01.011_bib5","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(99)04440-2","article-title":"Effect of metoprolol CR\/XL in chronic heart failure: metoprolol CR\/XL randomised intervention trial in congestive heart failure (MERIT-HF)","volume":"353","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2019.01.011_bib6","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1056\/NEJM198409273111303","article-title":"Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure","volume":"311","author":"Cohn","year":"1984","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2019.01.011_bib7","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/jama.1995.03530180056031","article-title":"Rationale for treatment of patients with chronic heart failure with adrenergic blockade","volume":"274","author":"Sackner-Bernstein","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.ccl.2019.01.011_bib8","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/j.jacc.2017.04.001","article-title":"Heart rate and rhythm and the benefit of beta-blockers in patients with heart failure","volume":"69","author":"Kotecha","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib9","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0735-1097(00)01006-8","article-title":"Antiremodeling effects on the left ventricle during beta-blockade with metoprolol in the treatment of chronic heart failure","volume":"36","author":"Groenning","year":"2000","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib10","doi-asserted-by":"crossref","first-page":"f55","DOI":"10.1136\/bmj.f55","article-title":"Benefits of beta blockers in patients with heart failure and reduced ejection fraction: network meta-analysis","volume":"346","author":"Chatterjee","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.ccl.2019.01.011_bib11","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1161\/01.CIR.94.11.2817","article-title":"Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart","volume":"94","author":"Gilbert","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2019.01.011_bib12","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/jce.13307","article-title":"Predicting appropriate shocks in patients with heart failure: patient level meta-analysis from SCD-HeFT and MADIT II","volume":"28","author":"Zeitler","year":"2017","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib13","doi-asserted-by":"crossref","first-page":"2N","DOI":"10.1016\/S0002-9149(98)00583-9","article-title":"Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates","volume":"82","author":"Kannel","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.hrthm.2008.09.025","article-title":"Newly detected atrial fibrillation in patients with an implantable cardioverter-defibrillator is a strong risk marker of increased mortality","volume":"6","author":"Bunch","year":"2009","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ccl.2019.01.011_bib15","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/eurheartj\/ehl484","article-title":"Prevention of atrial fibrillation onset by beta-blocker treatment in heart failure: a meta-analysis","volume":"28","author":"Nasr","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2019.01.011_bib16","doi-asserted-by":"crossref","first-page":"35669","DOI":"10.1074\/jbc.M112.357871","article-title":"Induction of cardiac fibrosis by beta-blocker in G protein-independent and G protein-coupled receptor kinase 5\/beta-arrestin2-dependent Signaling pathways","volume":"287","author":"Nakaya","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.ccl.2019.01.011_bib17","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.amjhyper.2004.07.007","article-title":"Beta-blocker improves survival, left ventricular function, and myocardial remodeling in hypertensive rats with diastolic heart failure","volume":"17","author":"Kobayashi","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.ccl.2019.01.011_bib18","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/01.CIR.101.5.558","article-title":"beta-adrenergic receptor blockade in chronic heart failure","volume":"101","author":"Bristow","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2019.01.011_bib19","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/S0140-6736(14)61373-8","article-title":"Efficacy of beta blockers in patients with heart failure plus atrial fibrillation: an individual-patient data meta-analysis","volume":"384","author":"Kotecha","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ccl.2019.01.011_bib20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchf.2012.09.002","article-title":"Beta-blockers and outcome in heart failure and atrial fibrillation: a meta-analysis","volume":"1","author":"Rienstra","year":"2013","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ccl.2019.01.011_bib21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jchf.2016.10.015","article-title":"Decreased mortality with beta-blockers in patients with heart failure and coexisting atrial fibrillation: an AF-CHF substudy","volume":"5","author":"Cadrin-Tourigny","year":"2017","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ccl.2019.01.011_bib22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/CIRCHEARTFAILURE.115.002285","article-title":"Prognostic significance of resting heart rate and use of beta-blockers in atrial fibrillation and sinus rhythm in patients with heart failure and reduced ejection fraction: findings from the Swedish Heart Failure registry","volume":"8","author":"Li","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2019.01.011_bib23","doi-asserted-by":"crossref","first-page":"e002597","DOI":"10.1161\/CIRCHEARTFAILURE.115.002597","article-title":"beta-blockers in atrial fibrillation patients with or without heart failure: association with mortality in a nationwide cohort study","volume":"9","author":"Nielsen","year":"2016","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2019.01.011_bib24","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1056\/NEJMoa0708789","article-title":"Rhythm control versus rate control for atrial fibrillation and heart failure","volume":"358","author":"Roy","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2019.01.011_bib25","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.jacc.2010.01.023","article-title":"Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillation","volume":"55","author":"Talajic","year":"2010","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib26","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1056\/NEJM199909163411201","article-title":"Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group","volume":"341","author":"Torp-Pedersen","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2019.01.011_bib27","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1161\/CIRCEP.114.001938","article-title":"Catheter ablation of atrial fibrillation in patients with left ventricular systolic dysfunction: a systematic review and meta-analysis","volume":"7","author":"Anselmino","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1161\/CIRCEP.113.000806","article-title":"A\u00a0randomized controlled trial of catheter ablation versus medical treatment of atrial fibrillation in heart failure (the CAMTAF trial)","volume":"7","author":"Hunter","year":"2014","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib29","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1161\/CIRCULATIONAHA.115.019406","article-title":"Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device: results from the AATAC multicenter randomized trial","volume":"133","author":"Di Biase","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2019.01.011_bib30","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.jacc.2017.08.041","article-title":"Catheter ablation versus medical rate control in atrial fibrillation and systolic dysfunction: the CAMERA-MRI Study","volume":"70","author":"Prabhu","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMoa1707855","article-title":"Catheter ablation for atrial fibrillation with heart failure","volume":"378","author":"Marrouche","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ccl.2019.01.011_bib32","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.jacc.2013.01.069","article-title":"A\u00a0randomized trial to assess catheter ablation versus rate control in the management of persistent atrial fibrillation in heart failure","volume":"61","author":"Jones","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2019.01.011_bib33","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/hrt.2010.207340","article-title":"Radiofrequency ablation for persistent atrial fibrillation in patients with advanced heart failure and severe left ventricular systolic dysfunction: a randomised controlled trial","volume":"97","author":"MacDonald","year":"2011","journal-title":"Heart"},{"key":"10.1016\/j.ccl.2019.01.011_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/europace\/euu376","article-title":"Radiofrequency ablation vs. antiarrhythmic drug therapy as first line treatment of symptomatic atrial fibrillation: systematic review and meta-analysis","volume":"17","author":"Hakalahti","year":"2015","journal-title":"Europace"}],"container-title":["Cardiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733865119300116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733865119300116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:50:07Z","timestamp":1760007007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733865119300116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0733865119300116"],"URL":"https:\/\/doi.org\/10.1016\/j.ccl.2019.01.011","relation":{},"ISSN":["0733-8651"],"issn-type":[{"type":"print","value":"0733-8651"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of Improved Mortality Following Ablation","name":"articletitle","label":"Article Title"},{"value":"Cardiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccl.2019.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}