{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:11:45Z","timestamp":1771233105837,"version":"3.50.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Clinics"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.ccl.2022.06.010","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T18:35:06Z","timestamp":1665081306000},"page":"459-472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hemodynamic Assessment in Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1016","volume":"40","author":[{"given":"Kazunori","family":"Omote","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry A.","family":"Borlaug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccl.2022.06.010_bib1","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/CIRCRESAHA.119.313572","article-title":"Heart failure with preserved ejection fraction in Perspective","volume":"124","author":"Pfeffer","year":"2019","journal-title":"Circ Res"},{"issue":"9","key":"10.1016\/j.ccl.2022.06.010_bib2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41569-020-0363-2","article-title":"Evaluation and management of heart failure with preserved ejection fraction","volume":"17","author":"Borlaug","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib3","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-med-042220-022745","article-title":"Heart failure with preserved ejection fraction: Mechanisms and treatment Strategies","volume":"73","author":"Omote","year":"2022","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.ccl.2022.06.010_bib5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/eurjhf\/hft026","article-title":"Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction","volume":"15","author":"Abudiab","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib6","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1093\/eurheartj\/ehw241","article-title":"Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction","volume":"37","author":"Borlaug","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1161\/CIRCHEARTFAILURE.114.001825","article-title":"Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction","volume":"8","author":"Dhakal","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1253\/circj.CJ-13-1103","article-title":"Mechanisms of exercise intolerance in heart failure with preserved ejection fraction","volume":"78","author":"Borlaug","year":"2014","journal-title":"Circ J"},{"key":"10.1016\/j.ccl.2022.06.010_bib9","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1093\/eurheartj\/ehy331","article-title":"Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease","volume":"39","author":"Gorter","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib10","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1093\/eurheartj\/ehab911","article-title":"Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality","volume":"43","author":"Verbrugge","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib11","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/CIRCULATIONAHA.116.024822","article-title":"Role of diastolic stress testing in the evaluation for heart failure with preserved ejection fraction: a simultaneous invasive-echocardiographic study","volume":"135","author":"Obokata","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCHEARTFAILURE.109.930701","article-title":"Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction","volume":"3","author":"Borlaug","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib13","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1161\/CIRCULATIONAHA.118.034646","article-title":"A\u00a0Simple, evidence-based approach to help guide diagnosis of heart failure with preserved ejection fraction","volume":"138","author":"Reddy","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib14","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1161\/CIRCULATIONAHA.110.954388","article-title":"Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum","volume":"123","author":"Borlaug","year":"2011","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.ccl.2022.06.010_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1161\/CIRCULATIONAHA.121.058592","article-title":"Longitudinal Evolution of cardiac dysfunction in heart failure with normal natriuretic peptide levels","volume":"146","author":"Sorimachi","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib16","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/ejhf.1220","volume":"20","author":"Nauta","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cardfail.2021.07.012","article-title":"Hemodynamics for the heart failure clinician: a state-of-the-Art review","volume":"28","author":"Hsu","year":"2022","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib18","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/CIR.0b013e31826fb946","article-title":"EACPR\/AHA Scientific Statement. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations","volume":"126","author":"Guazzi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib19","doi-asserted-by":"crossref","first-page":"e694","DOI":"10.1161\/CIR.0000000000000406","article-title":"Focused Update: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations","volume":"133","author":"Guazzi","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib20","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jchf.2016.03.022","article-title":"Cardiopulmonary exercise testing in heart failure","volume":"4","author":"Malhotra","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib21","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/jama.2013.2024","article-title":"Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial","volume":"309","author":"Redfield","year":"2013","journal-title":"Jama"},{"key":"10.1016\/j.ccl.2022.06.010_bib22","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1001\/jama.2018.14852","article-title":"Effect of Inorganic Nitrite vs Placebo on exercise capacity among patients with heart failure with preserved ejection fraction: the INDIE-HFpEF randomized clinical trial","volume":"320","author":"Borlaug","year":"2018","journal-title":"Jama"},{"key":"10.1016\/j.ccl.2022.06.010_bib23","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.jacc.2005.07.051","article-title":"Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure","volume":"46","author":"Guazzi","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib24","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1177\/2047487313476962","article-title":"Cardiopulmonary exercise testing reflects similar pathophysiology and disease severity in heart failure patients with reduced and preserved ejection fraction","volume":"21","author":"Guazzi","year":"2014","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jacc.2011.02.055","article-title":"Determinants of exercise intolerance in elderly heart failure patients with preserved ejection fraction","volume":"58","author":"Haykowsky","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib26","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1161\/01.CIR.94.12.3176","article-title":"Hemodynamic exercise testing. A valuable tool in the selection of cardiac transplantation candidates","volume":"94","author":"Chomsky","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1161\/01.CIR.80.4.769","article-title":"Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure","volume":"80","author":"Sullivan","year":"1989","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.ccl.2022.06.010_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jchf.2018.03.003","article-title":"Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure with Preserved Ejection Fraction","volume":"6","author":"Reddy","year":"2018","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib29","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/ejhf.913","article-title":"Physiological dead space and arterial carbon dioxide contributions to exercise ventilatory inefficiency in patients with reduced or preserved ejection fraction heart failure","volume":"19","author":"Van Iterson","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib30","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1093\/eurheartj\/ehy268","article-title":"Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction","volume":"39","author":"Obokata","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1378\/chest.125.2.669","article-title":"The pulmonary manifestations of left heart failure","volume":"125","author":"Gehlbach","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.ccl.2022.06.010_bib32","article-title":"Neuromodulation of Inflammation to Treat heart failure with preserved ejection fraction: a Pilot randomized clinical trial","volume":"11","author":"Stavrakis","year":"2022","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.ccl.2022.06.010_bib33","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.chest.2020.05.552","article-title":"Performance and interpretation of invasive hemodynamic exercise testing","volume":"158","author":"Jain","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.ccl.2022.06.010_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/CIRCULATIONAHA.116.026807","article-title":"Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction","volume":"136","author":"Obokata","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib35","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.jacc.2020.07.009","article-title":"Atrial dysfunction in patients with heart failure with preserved ejection fraction and atrial fibrillation","volume":"76","author":"Reddy","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib36","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13945","article-title":"Effects of body position during cardiopulmonary exercise testing with right heart catheterization","volume":"6","author":"Mizumi","year":"2018","journal-title":"Physiol Rep"},{"key":"10.1016\/j.ccl.2022.06.010_bib37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0002-9149(78)90131-5","article-title":"Hemodynamics at rest and during supine and sitting bicycle exercise in normal subjects","volume":"41","author":"Thadani","year":"1978","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib38","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1152\/jappl.1964.19.4.713","article-title":"Distribution of blood flow in isolated lung; relation to vascular and alveolar pressures","volume":"19","author":"West","year":"1964","journal-title":"J\u00a0Appl Phys"},{"key":"10.1016\/j.ccl.2022.06.010_bib39","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0002-9149(69)90011-3","article-title":"Exercise in patients with heart disease. Effects of body position and type and intensity of exercise","volume":"23","author":"Stampfer","year":"1969","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib40","doi-asserted-by":"crossref","first-page":"e008935","DOI":"10.1161\/CIRCHEARTFAILURE.121.008935","article-title":"The Value of Passive Leg Raise During Right Heart Catheterization in Diagnosing Heart Failure With Preserved Ejection Fraction","volume":"15","author":"van de Bovenkamp","year":"2022","journal-title":"Circulation Heart failure"},{"key":"10.1016\/j.ccl.2022.06.010_bib41","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/ejhf.2254","article-title":"Obesity, venous capacitance, and venous compliance in heart failure with preserved ejection fraction","volume":"23","author":"Sorimachi","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib42","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/eurheartj\/ehaa823","article-title":"Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction","volume":"42","author":"Sorimachi","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib43","article-title":"Left atrial myopathy in heart failure with preserved ejection fraction","author":"Omote","year":"2021","journal-title":"Circ J"},{"key":"10.1016\/j.ccl.2022.06.010_bib44","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01897-2018","article-title":"Pulmonary hypertension due to left heart disease","volume":"53","author":"Vachiery","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ccl.2022.06.010_bib45","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/01.CIR.35.6.1049","article-title":"Characterization of the circulatory response to maximal upright exercise in normal subjects and patients with heart disease","volume":"35","author":"Epstein","year":"1967","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib46","doi-asserted-by":"crossref","unstructured":"Ho JE, Zern EK, Lau ES, et al. Exercise pulmonary hypertension Predicts clinical Outcomes in patients with dyspnea on effort. J Am Coll Cardiol 2020;75:17\u201326.","DOI":"10.1016\/j.jacc.2019.10.048"},{"key":"10.1016\/j.ccl.2022.06.010_bib47","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004750","article-title":"Pulmonary capillary wedge pressure patterns during exercise predict exercise capacity and incident heart failure","volume":"11","author":"Eisman","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib48","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCHEARTFAILURE.114.001575","article-title":"The hemodynamic basis of exercise intolerance in tricuspid regurgitation","volume":"7","author":"Andersen","year":"2014","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.80.1.178","article-title":"Effects of volume loading during experimental acute pulmonary embolism","volume":"80","author":"Belenkie","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib50","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/01.CIR.73.3.428","article-title":"The relationship between pericardial pressure and right atrial pressure: an intraoperative study","volume":"73","author":"Tyberg","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib51","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jchf.2019.03.021","article-title":"The role of the pericardium in heart failure: implications for pathophysiology and treatment","volume":"7","author":"Borlaug","year":"2019","journal-title":"JACC Heart Fail"},{"issue":"2","key":"10.1016\/j.ccl.2022.06.010_bib52","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/ehf2.13853","article-title":"Right atrial pressure represents cumulative cardiac burden in heart failure with preserved ejection fraction","volume":"9","author":"Nagata","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib53","first-page":"ehac184","article-title":"Pulmonary Vascular Disease in Pulmonary Hypertension Due to Left Heart Disease: Pathophysiologic Implications","volume":"7","author":"Omote","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib54","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cardfail.2019.07.010","article-title":"Long-term prognostic significance of Admission tricuspid regurgitation pressure Gradient in Hospitalized patients with heart failure with preserved ejection fraction: a report from the Japanese Real-World Multicenter Registry","volume":"25","author":"Omote","year":"2019","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib55","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.115.003754","article-title":"Prognostic utility and clinical significance of cardiac Mechanics in heart failure with preserved ejection fraction: importance of left atrial strain","volume":"9","author":"Freed","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.ccl.2022.06.010_bib56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1161\/CIRCHEARTFAILURE.114.001667","article-title":"Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction","volume":"8","author":"Melenovsky","year":"2015","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib57","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jcmg.2016.12.024","article-title":"RV contractile function and its coupling to pulmonary circulation in heart failure with preserved ejection fraction: Stratification of clinical phenotypes and Outcomes","volume":"10","author":"Guazzi","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ccl.2022.06.010_bib58","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1093\/eurheartj\/ehu193","article-title":"Right heart dysfunction in heart failure with preserved ejection fraction","volume":"35","author":"Melenovsky","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib59","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/eurheartj\/ehy809","article-title":"Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction","volume":"40","author":"Obokata","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib60","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jcmg.2016.09.021","article-title":"Left atrial function Dynamics during exercise in heart failure: pathophysiological implications on the right heart and exercise ventilation inefficiency","volume":"10","author":"Sugimoto","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.ccl.2022.06.010_bib61","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/01.CIR.86.2.513","article-title":"Effective arterial elastance as index of arterial vascular load in humans","volume":"86","author":"Kelly","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib62","first-page":"H500","article-title":"Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans","volume":"274","author":"Chemla","year":"1998","journal-title":"Am J Phys"},{"key":"10.1016\/j.ccl.2022.06.010_bib63","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/eurheartj\/ehq426","article-title":"Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment","volume":"32","author":"Borlaug","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ccl.2022.06.010_bib64","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jacc.2017.05.029","article-title":"Arterial stiffening with exercise in patients with heart failure and preserved ejection fraction","volume":"70","author":"Reddy","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib65","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cardfail.2021.10.019","article-title":"Arterial stiffness and vascular load in HFpEF: differences among women and men","volume":"28","author":"Lau","year":"2022","journal-title":"J\u00a0Card Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib66","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/CIRCULATIONAHA.117.029058","article-title":"Exercise intolerance in heart failure with preserved ejection fraction: diagnosing and Ranking its causes using Personalized O(2) Pathway analysis","volume":"137","author":"Houstis","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ccl.2022.06.010_bib67","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1007\/s00421-019-04222-6","article-title":"Unexplained exertional intolerance associated with impaired systemic oxygen extraction","volume":"119","author":"Melamed","year":"2019","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.ccl.2022.06.010_bib68","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.1464","article-title":"Left atrial strain and compliance in the diagnostic evaluation of heart failure with preserved ejection fraction","volume":"21","author":"Reddy","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib69","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jchf.2020.04.016","article-title":"Hemodynamic and functional impact of Epicardial adipose tissue in heart failure with preserved ejection fraction","volume":"8","author":"Koepp","year":"2020","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ccl.2022.06.010_bib70","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.hfc.2021.02.009","article-title":"Clinical phenogroups in heart failure with preserved ejection fraction","volume":"17","author":"Sorimachi","year":"2021","journal-title":"Heart Fail Clin"},{"issue":"10330","key":"10.1016\/j.ccl.2022.06.010_bib71","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0140-6736(22)00016-2","article-title":"Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial","volume":"399","author":"Shah","year":"2022","journal-title":"Lancet"},{"issue":"21","key":"10.1016\/j.ccl.2022.06.010_bib72","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1161\/CIRCULATIONAHA.122.059486","article-title":"Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure","volume":"145","author":"Borlaug","year":"2022","journal-title":"Circulation"}],"container-title":["Cardiology Clinics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733865122000443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0733865122000443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:54:42Z","timestamp":1760007282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0733865122000443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0733865122000443"],"URL":"https:\/\/doi.org\/10.1016\/j.ccl.2022.06.010","relation":{},"ISSN":["0733-8651"],"issn-type":[{"value":"0733-8651","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemodynamic Assessment in Heart Failure with Preserved Ejection Fraction","name":"articletitle","label":"Article Title"},{"value":"Cardiology Clinics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccl.2022.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}