{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:27:07Z","timestamp":1792524427072,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Chest Medicine"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.ccm.2016.04.016","type":"journal-article","created":{"date-parts":[[2016,6,12]],"date-time":"2016-06-12T06:33:26Z","timestamp":1465713206000},"page":"557-567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Hyper-IgE Syndromes and the Lung"],"prefix":"10.1016","volume":"37","author":[{"given":"Alexandra F.","family":"Freeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth N.","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8 Pt 2","key":"10.1016\/j.ccm.2016.04.016_bib1","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1164\/ajrccm.164.supplement_1.2103025","article-title":"Development of a monoclonal anti-immunoglobulin E antibody (omalizumab) for the treatment of allergic respiratory disorders","volume":"164","author":"Schulman","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1055\/s-0031-1295716","article-title":"Allergic bronchopulmonary aspergillosis and related allergic syndromes","volume":"32","author":"Hogan","year":"2011","journal-title":"Semin Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccm.2016.04.016_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.rdc.2015.01.004","article-title":"Pulmonary vasculitis","volume":"41","author":"Lally","year":"2015","journal-title":"Rheum Dis Clin North Am"},{"issue":"7157","key":"10.1016\/j.ccm.2016.04.016_bib4","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/nature06096","article-title":"Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome","volume":"448","author":"Minegishi","year":"2007","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.ccm.2016.04.016_bib5","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJMoa073687","article-title":"STAT3 mutations in the hyper-IgE syndrome","volume":"357","author":"Holland","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"21","key":"10.1016\/j.ccm.2016.04.016_bib6","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N\u00a0Engl J Med"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib7","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.jaci.2014.02.013","article-title":"Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment","volume":"133","author":"Zhang","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib8","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jaci.2014.02.025","article-title":"Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels","volume":"133","author":"Sassi","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ajhg.2014.05.007","article-title":"PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia","volume":"95","author":"Stray-Pedersen","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"7445","key":"10.1016\/j.ccm.2016.04.016_bib10","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(66)90119-X","article-title":"Job's syndrome. Recurrent, \u201ccold\u201d, staphylococcal abscesses","volume":"1","author":"Davis","year":"1966","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.49.1.59","article-title":"Extreme hyperimmunoglobulinemia E and undue susceptibility to infection","volume":"49","author":"Buckley","year":"1972","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.ccm.2016.04.016_bib12","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM199903043400904","article-title":"Hyper-IgE syndrome with recurrent infections: an autosomal dominant multisystem disorder","volume":"340","author":"Grimbacher","year":"1999","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jaci.2009.07.007","article-title":"Pulmonary nontuberculous mycobacterial infections in hyper-IgE syndrome","volume":"124","author":"Melia","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib14","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jaci.2006.12.666","article-title":"Causes of death in hyper-IgE syndrome","volume":"119","author":"Freeman","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.ccm.2016.04.016_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.2011.06387.x","article-title":"Hyper-IgE syndrome update","volume":"1250","author":"Sowerwine","year":"2012","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib16","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.jaci.2010.01.047","article-title":"Invasive fungal disease in autosomal-dominant hyper-IgE syndrome","volume":"125","author":"Vinh","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1067\/mpd.2002.127503","article-title":"Cutaneous manifestations of hyper-IgE syndrome in infants and children","volume":"141","author":"Chamlin","year":"2002","journal-title":"J\u00a0Pediatr"},{"issue":"9","key":"10.1016\/j.ccm.2016.04.016_bib18","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/archderm.140.9.1119","article-title":"Dermatitis and the newborn rash of hyper-IgE syndrome","volume":"140","author":"Eberting","year":"2004","journal-title":"Arch Dermatol"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1001\/archdermatol.2011.262","article-title":"Cutaneous manifestations of DOCK8 deficiency syndrome","volume":"148","author":"Chu","year":"2012","journal-title":"Arch Dermatol"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib20","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.jaci.2015.07.003","article-title":"Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome","volume":"136","author":"Odio","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"8","key":"10.1016\/j.ccm.2016.04.016_bib21","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/INF.0b013e31819b65e0","article-title":"Ileocecal histoplasmosis simulating Crohn disease in a patient with hyperimmunoglobulin E syndrome","volume":"28","author":"Steiner","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib22","first-page":"119","article-title":"Recurrent colonic histoplasmosis after standard therapy with amphotericin B in a patient with Job's syndrome","volume":"86","author":"Cappell","year":"1991","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000199290","article-title":"Ileocecal histoplasmosis mimicking Crohn's disease in a patient with Job's syndrome","volume":"33","author":"Alberti-Flor","year":"1986","journal-title":"Digestion"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib24","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0016-5085(88)90257-0","article-title":"Cryptococcosis of the colon resembling Crohn's disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job's) syndrome","volume":"94","author":"Hutto","year":"1988","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0016-5085(84)90144-6","article-title":"Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome","volume":"87","author":"Jacobs","year":"1984","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.ccm.2016.04.016_bib26","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/INF.0b013e31819866ec","article-title":"Coccidioides immitis meningitis in a patient with hyperimmunoglobulin E syndrome due to a novel mutation in signal transducer and activator of transcription","volume":"28","author":"Powers","year":"2009","journal-title":"Pediatr Infect Dis J"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib27","doi-asserted-by":"crossref","first-page":"e1271","DOI":"10.1542\/peds.2006-0311","article-title":"Pneumocystis jiroveci infection in patients with hyper-immunoglobulin E syndrome","volume":"118","author":"Freeman","year":"2006","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1601-0825.2008.01463.x","article-title":"Hyper IgE (Job's) syndrome: a primary immune deficiency with oral manifestations","volume":"15","author":"Freeman","year":"2009","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/CIRCGENETICS.111.961235","article-title":"Frequent and widespread vascular abnormalities in human signal transducer and activator of transcription 3 deficiency","volume":"5","author":"Chandesris","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib30","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s10875-011-9515-9","article-title":"Coronary artery abnormalities in hyper-IgE syndrome","volume":"31","author":"Freeman","year":"2011","journal-title":"J\u00a0Clin Immunol"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/jnnp.2009.198283","article-title":"Intracranial aneurysms associated with hyperimmunoglobulinaemia E (Job) syndrome: report of two cases","volume":"82","author":"Fathi","year":"2011","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"12","key":"10.1016\/j.ccm.2016.04.016_bib32","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1080\/10428190400004463","article-title":"Non-Hodgkin's lymphoma in Job's syndrome: a case report and literature review","volume":"45","author":"Leonard","year":"2004","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib33","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jaci.2013.08.045","article-title":"Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation","volume":"132","author":"Siegel","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib34","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.clim.2008.08.002","article-title":"Reduced memory B cells in patients with hyper IgE syndrome","volume":"129","author":"Speckmann","year":"2008","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jaci.2008.04.037","article-title":"Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome","volume":"122","author":"Renner","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib36","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2011.09.016","article-title":"A\u00a0critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory","volume":"35","author":"Siegel","year":"2011","journal-title":"Immunity"},{"issue":"7188","key":"10.1016\/j.ccm.2016.04.016_bib37","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib38","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/mi.2011.5","article-title":"New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome","volume":"4","author":"Conti","year":"2011","journal-title":"Mucosal Immunol"},{"issue":"17","key":"10.1016\/j.ccm.2016.04.016_bib39","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2011-11-392985","article-title":"Functional STAT3 deficiency compromises the generation of human T follicular helper cells","volume":"119","author":"Ma","year":"2012","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib40","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/s10875-013-9890-5","article-title":"Lung parenchyma surgery in autosomal dominant hyper-IgE syndrome","volume":"33","author":"Freeman","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"35","key":"10.1016\/j.ccm.2016.04.016_bib41","doi-asserted-by":"crossref","first-page":"E3641","DOI":"10.1073\/pnas.1409781111","article-title":"IL-6\/STAT3 promotes regeneration of airway ciliated cells from basal stem cells","volume":"111","author":"Tadokoro","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib42","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.jaci.2011.07.046","article-title":"Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome","volume":"128","author":"Sekhsaria","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib43","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/MD.0b013e31825f95b9","article-title":"Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey","volume":"91","author":"Chandesris","year":"2012","journal-title":"Medicine"},{"issue":"12","key":"10.1016\/j.ccm.2016.04.016_bib44","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1586\/14787210.2015.1102053","article-title":"Voriconazole-associated phototoxic dermatoses and skin cancer","volume":"13","author":"Goyal","year":"2015","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.ccm.2016.04.016_bib45","first-page":"A5870","article-title":"Management of persistent bronchopleural fistula in Job's syndrome","volume":"187","author":"Olivier","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib46","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s11605-012-2077-1","article-title":"Safety of major abdominal surgical procedures in patients with hyperimmunoglobulinemia E (Job's syndrome): a changing paradigm?","volume":"17","author":"Langan","year":"2013","journal-title":"J\u00a0Gastrointest Surg"},{"issue":"2","key":"10.1016\/j.ccm.2016.04.016_bib47","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/pbc.23007","article-title":"Successful bone marrow transplantation in a pediatric patient with chronic myeloid leukemia from a HLA-identical sibling selected by preimplantation HLA testing","volume":"57","author":"Goussetis","year":"2011","journal-title":"Pediatr Blood Cancer"},{"issue":"5","key":"10.1016\/j.ccm.2016.04.016_bib48","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10875-015-0167-z","article-title":"Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome","volume":"35","author":"Patel","year":"2015","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.ccm.2016.04.016_bib49","doi-asserted-by":"crossref","DOI":"10.1111\/jcpt.12308","article-title":"Drug-drug interaction between isavuconazole and tacrolimus: a case report indicating the need for tacrolimus drug-level monitoring","author":"Kim","year":"2015","journal-title":"J\u00a0Clin Pharm Ther"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3201\/eid2101.140855","article-title":"WU polyomavirus in respiratory epithelial cells from lung transplant patient with Job syndrome","volume":"21","author":"Siebrasse","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"3\u20134","key":"10.1016\/j.ccm.2016.04.016_bib51","first-page":"131","article-title":"Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome","volume":"29","author":"Zhang","year":"2010","journal-title":"Dis Markers"},{"issue":"2","key":"10.1016\/j.ccm.2016.04.016_bib52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10875-014-0126-0","article-title":"DOCK8 deficiency: clinical and immunological phenotype and treatment options: a review of 136 patients","volume":"35","author":"Aydin","year":"2015","journal-title":"J\u00a0Clin Immunol"},{"issue":"2","key":"10.1016\/j.ccm.2016.04.016_bib53","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jaci.2014.12.1945","article-title":"The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency","volume":"136","author":"Engelhardt","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib54","doi-asserted-by":"crossref","first-page":"E52","DOI":"10.1002\/ppul.22814","article-title":"Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient","volume":"49","author":"Tsuge","year":"2014","journal-title":"Pediatr Pulmonol"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib55","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3109\/14397595.2013.874735","article-title":"Grave aortic aneurysmal dilatation in DOCK8 deficiency","volume":"24","author":"Al Mutairi","year":"2014","journal-title":"Mod Rheumatol"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib56","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jaci.2013.11.031","article-title":"Vaccine strain varicella-zoster virus-induced central nervous system vasculopathy as the presenting feature of DOCK8 deficiency","volume":"133","author":"Sabry","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib57","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10875-012-9769-x","article-title":"Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients","volume":"33","author":"Alsum","year":"2013","journal-title":"J\u00a0Clin Immunol"},{"issue":"3\u20134","key":"10.1016\/j.ccm.2016.04.016_bib58","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1155\/2010\/397291","article-title":"DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction","volume":"29","author":"McGhee","year":"2010","journal-title":"Dis Markers"},{"issue":"3","key":"10.1016\/j.ccm.2016.04.016_bib59","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.jaci.2012.12.1568","article-title":"Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency","volume":"131","author":"Mizesko","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.ccm.2016.04.016_bib60","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ni.1820","article-title":"Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production","volume":"10","author":"Randall","year":"2009","journal-title":"Nat Immunol"},{"issue":"13","key":"10.1016\/j.ccm.2016.04.016_bib61","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1084\/jem.20141307","article-title":"DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity","volume":"211","author":"Zhang","year":"2014","journal-title":"J\u00a0Exp Med"},{"issue":"2","key":"10.1016\/j.ccm.2016.04.016_bib62","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jaci.2011.03.025","article-title":"Successful allogeneic hematopoietic stem cell transplantation for DOCK8 deficiency","volume":"128","author":"Barlogis","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib63","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-0030-1265135","article-title":"Successful long-term correction of autosomal recessive hyper-IgE syndrome due to DOCK8 deficiency by hematopoietic stem cell transplantation","volume":"222","author":"Bittner","year":"2010","journal-title":"Klin Padiatr"},{"issue":"7","key":"10.1016\/j.ccm.2016.04.016_bib64","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/08880018.2012.714844","article-title":"Clinical and immunological correction of DOCK8 deficiency by allogeneic hematopoietic stem cell transplantation following a reduced toxicity conditioning regimen","volume":"29","author":"Boztug","year":"2012","journal-title":"Pediatr Hematol Oncol"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib65","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.bbmt.2015.01.022","article-title":"Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK8 deficiency","volume":"21","author":"Cuellar-Rodriguez","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"10.1016\/j.ccm.2016.04.016_bib66","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1399-3046.2011.01641.x","article-title":"Successful bone marrow transplantation for DOCK8 deficient hyper IgE syndrome","volume":"16","author":"Metin","year":"2012","journal-title":"Pediatr Transplant"},{"issue":"1","key":"10.1016\/j.ccm.2016.04.016_bib67","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clim.2014.04.005","article-title":"Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency","volume":"153","author":"Al-Zahrani","year":"2014","journal-title":"Clin Immunol"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib68","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.jaci.2014.03.032","article-title":"Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-alpha 2b therapy","volume":"133","author":"Keles","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"6","key":"10.1016\/j.ccm.2016.04.016_bib69","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa1206605","article-title":"Multiple phenotypes in phosphoglucomutase 1 deficiency","volume":"370","author":"Tegtmeyer","year":"2014","journal-title":"N\u00a0Engl J Med"}],"container-title":["Clinics in Chest Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272523116300533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272523116300533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:52:44Z","timestamp":1759452764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272523116300533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0272523116300533"],"URL":"https:\/\/doi.org\/10.1016\/j.ccm.2016.04.016","relation":{},"ISSN":["0272-5231"],"issn-type":[{"value":"0272-5231","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyper-IgE Syndromes and the Lung","name":"articletitle","label":"Article Title"},{"value":"Clinics in Chest Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccm.2016.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}