{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:35:10Z","timestamp":1776706510765,"version":"3.51.2"},"reference-count":116,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Chest Medicine"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ccm.2016.07.003","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T03:01:19Z","timestamp":1478919679000},"page":"615-632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing Respiratory System Mechanical Function"],"prefix":"10.1016","volume":"37","author":[{"given":"Ruben D.","family":"Restrepo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Serrato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Adasme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib1","first-page":"64","article-title":"Lung mechanics at the bedside: make it simple","volume":"13","author":"Lucangelo","year":"2007","journal-title":"Curr Opin Crit Care"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1078-5337(03)00040-6","article-title":"Respiratory system mechanics in acute respiratory distress syndrome","volume":"9","author":"Kallet","year":"2003","journal-title":"Respir Care Clin North Am"},{"key":"10.1016\/j.ccm.2016.07.003_bib3","doi-asserted-by":"crossref","first-page":"15s","DOI":"10.1183\/09031936.03.00420303","article-title":"How respiratory system mechanics may help in minimising ventilator-induced lung injury in ARDS patients","volume":"42","author":"Terragni","year":"2003","journal-title":"Eur Respir J Suppl"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib4","first-page":"55","article-title":"Respiratory mechanics derived from signals in the ventilator circuit","volume":"50","author":"Lucangelo","year":"2005","journal-title":"Respir Care"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib5","first-page":"246","article-title":"Ventilator graphics and respiratory mechanics in the patient with obstructive lung disease","volume":"50","author":"Dhand","year":"2005","journal-title":"Respir Care"},{"issue":"18","key":"10.1016\/j.ccm.2016.07.003_bib6","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network","volume":"342","year":"2000","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/ALN.0b013e3182a05bb8","article-title":"Accuracy of plateau pressure and stress index to identify injurious ventilation in patients with acute respiratory distress syndrome","volume":"119","author":"Terragni","year":"2013","journal-title":"Anesthesiology"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/rccm.200607-915OC","article-title":"Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome","volume":"175","author":"Terragni","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib9","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/cc12500","article-title":"Expiratory time constant for determinations of plateau pressure, respiratory system compliance, and total resistance","volume":"17","author":"Al-Rawas","year":"2013","journal-title":"Crit Care"},{"issue":"6186","key":"10.1016\/j.ccm.2016.07.003_bib10","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1126\/science.344.6186.814","article-title":"Specimen collection: an essential tool","volume":"344","author":"Rocha","year":"2014","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.ccm.2016.07.003_bib11","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1164\/rccm.201102-0226PP","article-title":"Dynamic hyperinflation and auto-positive end-expiratory pressure: lessons learned over 30 years","volume":"184","author":"Marini","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib12","first-page":"110","article-title":"Measurement of air trapping, intrinsic positive end-expiratory pressure, and dynamic hyperinflation in mechanically ventilated patients","volume":"50","author":"Blanch","year":"2005","journal-title":"Respir Care"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib13","first-page":"202","article-title":"Using ventilator graphics to identify patient-ventilator asynchrony","volume":"50","author":"Nilsestuen","year":"2005","journal-title":"Respir Care"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib14","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00000542-200201000-00030","article-title":"Continuous positive airway pressure in new-generation mechanical ventilators: a lung model study","volume":"96","author":"Takeuchi","year":"2002","journal-title":"Anesthesiology"},{"issue":"26","key":"10.1016\/j.ccm.2016.07.003_bib15","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJM200106283442606","article-title":"Advances in mechanical ventilation","volume":"344","author":"Tobin","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib16","first-page":"28","article-title":"Monitoring respiratory mechanics during mechanical ventilation: where do the signals come from?","volume":"50","author":"Sanborn","year":"2005","journal-title":"Respir Care"},{"issue":"6","key":"10.1016\/j.ccm.2016.07.003_bib17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00115550-200511000-00018","article-title":"Epidural catheter entrapment caused by a double knot after combined spinal-epidural anesthesia","volume":"30","author":"Gabopoulou","year":"2005","journal-title":"Reg Anesth Pain Med"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib18","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/CIRCULATIONAHA.114.011634","article-title":"Coronary computed tomographic angiography and incidental pulmonary nodules","volume":"130","author":"Bluemke","year":"2014","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.ccm.2016.07.003_bib19","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.4187\/respcare.01812","article-title":"Volume-time curve: an alternative for endotracheal tube cuff management","volume":"57","author":"Bolzan","year":"2012","journal-title":"Respir Care"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1164\/ajrccm.150.3.8087350","article-title":"Use of flow-volume curves in detecting secretions in ventilator-dependent patients","volume":"150","author":"Jubran","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib21","first-page":"78","article-title":"Pressure-volume curves of the respiratory system","volume":"50","author":"Harris","year":"2005","journal-title":"Respir Care"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib22","first-page":"80","article-title":"Static pressure-volume curves of the respiratory system: were they just a passing fad?","volume":"14","author":"Albaiceta","year":"2008","journal-title":"Curr Opin Crit Care"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib23","first-page":"109","article-title":"Effects of volume shift on the pressure-volume curve of the respiratory system in ALI\/ARDS patients","volume":"73","author":"Chiumello","year":"2007","journal-title":"Minerva Anestesiol"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib24","first-page":"332","article-title":"Bedside evaluation of pressure-volume curves in patients with acute respiratory distress syndrome","volume":"13","author":"Blanch","year":"2007","journal-title":"Curr Opin Crit Care"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib25","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/01.CCM.0000215598.84885.01","article-title":"A\u00a0high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial","volume":"34","author":"Villar","year":"2006","journal-title":"Crit Care Med"},{"issue":"2 Pt 1","key":"10.1016\/j.ccm.2016.07.003_bib26","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1164\/ajrccm.161.2.9901061","article-title":"An objective analysis of the pressure-volume curve in the acute respiratory distress syndrome","volume":"161","author":"Harris","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ccm.2016.07.003_bib27","doi-asserted-by":"crossref","first-page":"22s","DOI":"10.1183\/09031936.03.00004204","article-title":"What has been learnt from P\/V curves in patients with acute lung injury\/acute respiratory distress syndrome","volume":"42","author":"Maggiore","year":"2003","journal-title":"Eur Respir J Suppl"},{"issue":"9","key":"10.1016\/j.ccm.2016.07.003_bib28","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.4187\/respcare.02068","article-title":"Individualized PEEP setting in subjects with ARDS: a randomized controlled pilot study","volume":"58","author":"Pintado","year":"2013","journal-title":"Respir Care"},{"issue":"21","key":"10.1016\/j.ccm.2016.07.003_bib29","first-page":"2072","article-title":"Driving pressure as a key ventilation variable","volume":"372","author":"Costa","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00423-015-1353-4","article-title":"Acute abdominal compartment syndrome: current diagnostic and therapeutic options","volume":"401","author":"Hecker","year":"2016","journal-title":"Langenbecks Arch Surg"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib31","doi-asserted-by":"crossref","first-page":"e287","DOI":"10.1097\/CCM.0000000000001036","article-title":"Impact of chest wall modifications and lung injury on the correspondence between airway and transpulmonary driving pressures","volume":"43","author":"Cortes-Puentes","year":"2015","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/resp.12563","article-title":"Optimizing respiratory function assessments to elucidate the impact of obesity on respiratory health","volume":"20","author":"Brazzale","year":"2015","journal-title":"Respirology"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1440-1843.2012.02268.x","article-title":"Static lung volumes and airway resistance reference values in healthy adults","volume":"18","author":"Koch","year":"2013","journal-title":"Respirology"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4187\/respcare.01411","article-title":"What does airway resistance tell us\u00a0about lung function?","volume":"57","author":"Kaminsky","year":"2012","journal-title":"Respir Care"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1183\/09031936.95.08010114","article-title":"Time constant\/volume relationship of passive expiration in mechanically ventilated ARDS patients","volume":"8","author":"Guttmann","year":"1995","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib36","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1164\/rccm.201312-2193CI","article-title":"The application of esophageal pressure measurement in patients with respiratory failure","volume":"189","author":"Akoumianaki","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1152\/jappl.1955.8.2.203","article-title":"A\u00a0comparison of esophageal and intrapleural pressure in man","volume":"8","author":"Cherniack","year":"1955","journal-title":"J\u00a0Appl Physiol"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/TA.0000000000000900","article-title":"How much esophageal pressure-guided end-expiratory transpulmonary pressure is sufficient to maintain lung recruitment in lavage-induced lung injury?","volume":"80","author":"Huang","year":"2016","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00134-013-3127-1","article-title":"Raising positive end-expiratory pressures in ARDS to achieve a positive transpulmonary pressure does not cause hemodynamic compromise","volume":"40","author":"Sarge","year":"2014","journal-title":"Intensive Care Med"},{"issue":"20","key":"10.1016\/j.ccm.2016.07.003_bib40","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1056\/NEJMoa0708638","article-title":"Mechanical ventilation guided by esophageal pressure in acute lung injury","volume":"359","author":"Talmor","year":"2008","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.ccm.2016.07.003_bib41","doi-asserted-by":"crossref","first-page":"e006356","DOI":"10.1136\/bmjopen-2014-006356","article-title":"The Esophageal Pressure-Guided Ventilation 2 (EPVent2) trial protocol: a multicentre, randomised clinical trial of mechanical ventilation guided by transpulmonary pressure","volume":"4","author":"Fish","year":"2014","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib42","first-page":"293","article-title":"Targeting transpulmonary pressure to prevent ventilator induced lung injury","volume":"75","author":"Sarge","year":"2009","journal-title":"Minerva Anestesiol"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/cc12528","article-title":"Two steps forward in bedside monitoring of lung mechanics: transpulmonary pressure and lung volume","volume":"17","author":"Cortes","year":"2013","journal-title":"Crit Care"},{"issue":"11","key":"10.1016\/j.ccm.2016.07.003_bib44","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1007\/s00134-014-3415-4","article-title":"The assessment of transpulmonary pressure in mechanically ventilated ARDS patients","volume":"40","author":"Chiumello","year":"2014","journal-title":"Intensive Care Med"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib45","first-page":"827","article-title":"Measuring (and interpreting) the esophageal pressure: a challenge for the intensivist","volume":"81","author":"Grasso","year":"2015","journal-title":"Minerva Anestesiol"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib46","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/japplphysiol.00835.2009","article-title":"Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?","volume":"108","author":"Loring","year":"2010","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib47","first-page":"959","article-title":"Esophageal pressure: benefit and limitations","volume":"78","author":"Hedenstierna","year":"2012","journal-title":"Minerva Anestesiol"},{"issue":"11","key":"10.1016\/j.ccm.2016.07.003_bib48","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.4187\/respcare.03410","article-title":"Respiratory mechanics in mechanically ventilated patients","volume":"59","author":"Hess","year":"2014","journal-title":"Respir Care"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib49","first-page":"121","article-title":"Transpulmonary pressure cannot be determined without esophageal pressure in ARDS patients","volume":"82","author":"Garnero","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.ccm.2016.07.003_bib50","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1186\/s13054-015-1153-9","article-title":"PEEP titration during prone positioning for acute respiratory distress syndrome","volume":"19","author":"Beitler","year":"2015","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib51","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/CCM.0b013e3182a6384f","article-title":"Bedside selection of positive end-expiratory pressure in mild, moderate, and severe acute respiratory distress syndrome","volume":"42","author":"Chiumello","year":"2014","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib52","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1164\/rccm.200702-193OC","article-title":"ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure","volume":"176","author":"Grasso","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib53","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/00000542-200011000-00027","article-title":"Pressure-time curve predicts minimally injurious ventilatory strategy in an isolated rat lung model","volume":"93","author":"Ranieri","year":"2000","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib54","first-page":"58","article-title":"Dynamic airway pressure-time curve profile (stress index): a systematic review","volume":"82","author":"Terragni","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"10.1016\/j.ccm.2016.07.003_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13054-014-0726-3","article-title":"Adjusting tidal volume to stress index in an open lung condition optimizes ventilation and prevents overdistension in an experimental model of lung injury and reduced chest wall compliance","volume":"19","author":"Ferrando","year":"2015","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib56","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1160\/TH04-09-0587","article-title":"Risk factors associated with symptomatic pulmonary embolism in a large cohort of deep vein thrombosis patients","volume":"93","author":"Kucher","year":"2005","journal-title":"Thromb Haemost"},{"issue":"9","key":"10.1016\/j.ccm.2016.07.003_bib57","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/aas.12590","article-title":"Stress index for positive end-expiratory pressure titration in prone position: a piglet study","volume":"59","author":"Pan","year":"2015","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib58","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/aas.12589","article-title":"Lung stress and strain calculations in mechanically ventilated patients in the intensive care unit","volume":"60","author":"Blankman","year":"2016","journal-title":"Acta Anaesthesiol Scand"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib59","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1164\/rccm.200710-1589OC","article-title":"Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome","volume":"178","author":"Chiumello","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib60","first-page":"42","article-title":"Stress and strain\u00a0within the lung","volume":"18","author":"Gattinoni","year":"2012","journal-title":"Curr Opin Crit Care"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib61","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/ALN.0000000000000946","article-title":"Impact of recruitment on static and dynamic lung strain in acute respiratory distress syndrome","volume":"124","author":"Garcia-Prieto","year":"2016","journal-title":"Anesthesiology"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib62","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1152\/jappl.1970.28.5.596","article-title":"Stress distribution in lungs: a model of pulmonary elasticity","volume":"28","author":"Mead","year":"1970","journal-title":"J\u00a0Appl Physiol"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib63","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.jamcollsurg.2014.09.011","article-title":"Airway pressure release ventilation reduces conducting airway micro-strain in lung injury","volume":"219","author":"Kollisch-Singule","year":"2014","journal-title":"J\u00a0Am Coll Surg"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib64","first-page":"33","article-title":"Which is the most important strain in the pathogenesis of ventilator-induced lung injury: dynamic or static?","volume":"20","author":"Protti","year":"2014","journal-title":"Curr Opin Crit Care"},{"issue":"7","key":"10.1016\/j.ccm.2016.07.003_bib65","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1097\/CCM.0000000000000346","article-title":"Effect of local tidal lung strain on inflammation in normal and lipopolysaccharide-exposed sheep\u2217","volume":"42","author":"Wellman","year":"2014","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib66","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/000313481508100134","article-title":"Airway pressures as surrogate estimates of intra-abdominal pressure","volume":"81","author":"Bunnell","year":"2015","journal-title":"Am Surg"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib67","first-page":"254","article-title":"Utility of monitoring intra-abdominal pressure in critically ill children","volume":"77","author":"Gonzalez","year":"2012","journal-title":"An Pediatr (Barc)"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib68","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4187\/respcare.02287","article-title":"The correlation between esophageal and abdominal pressures in mechanically ventilated patients undergoing laparoscopic surgery","volume":"59","author":"Sindi","year":"2014","journal-title":"Respir Care"},{"issue":"9","key":"10.1016\/j.ccm.2016.07.003_bib69","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1183\/09031936.95.08091532","article-title":"The effect of lung volume on transdiaphragmatic pressure","volume":"8","author":"Hamnegard","year":"1995","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.ccm.2016.07.003_bib70","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1164\/rccm.200203-241OC","article-title":"Transdiaphragmatic pressure control of airway pressure support in healthy subjects","volume":"168","author":"Sharshar","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib71","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1378\/chest.100.1.112","article-title":"Determination of the optimal pressure support level evaluated by measuring transdiaphragmatic pressure","volume":"100","author":"Kimura","year":"1991","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib72","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1186\/cc3516","article-title":"Clinical review: respiratory mechanics in spontaneous and assisted ventilation","volume":"9","author":"Grinnan","year":"2005","journal-title":"Crit Care"},{"issue":"3 Pt 1","key":"10.1016\/j.ccm.2016.07.003_bib73","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1164\/ajrccm\/144.3_Pt_1.531","article-title":"Evaluation of a new weaning index based on ventilatory endurance and the efficiency of gas exchange","volume":"144","author":"Jabour","year":"1991","journal-title":"Am Rev Respir Dis"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib74","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00000542-200703000-00012","article-title":"Measurement of pressure-time product during spontaneous assisted breathing by rapid interrupter technique","volume":"106","author":"Bellani","year":"2007","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib75","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0272-5231(05)70327-0","article-title":"Monitoring during mechanical ventilation","volume":"17","author":"Jubran","year":"1996","journal-title":"Clin Chest Med"},{"issue":"7","key":"10.1016\/j.ccm.2016.07.003_bib76","first-page":"878","article-title":"Effects of inspiratory rise time on triggering work load during pressure-support ventilation: a lung model study","volume":"55","author":"Murata","year":"2010","journal-title":"Respir Care"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib77","first-page":"1","article-title":"Current incidence and outcome of the acute respiratory distress syndrome","volume":"22","author":"Villar","year":"2016","journal-title":"Curr Opin Crit Care"},{"issue":"9","key":"10.1016\/j.ccm.2016.07.003_bib78","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/jama.2010.218","article-title":"Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis","volume":"303","author":"Briel","year":"2010","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.ccm.2016.07.003_bib79","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1164\/rccm.200407-940OC","article-title":"Effects of high versus low positive end-expiratory pressures in acute respiratory distress syndrome","volume":"171","author":"Grasso","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib80","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00003246-199403000-00024","article-title":"Components of the work of breathing and implications for monitoring ventilator-dependent patients","volume":"22","author":"Banner","year":"1994","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib81","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/01.CCM.0000206288.90613.1C","article-title":"Power of breathing determined noninvasively with use of an artificial neural network in patients with respiratory failure","volume":"34","author":"Banner","year":"2006","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.ccm.2016.07.003_bib82","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/EJA.0b013e328361d323","article-title":"Difficult diagnosis of malignant hyperthermia during laparoscopic surgery","volume":"30","author":"Freiermuth","year":"2013","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib83","first-page":"423","article-title":"Abnormally increased power of breathing as a complication of closed endotracheal suction catheter systems","volume":"51","author":"Ozcan","year":"2006","journal-title":"Respir Care"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib84","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00134-011-2402-2","article-title":"Noninvasive work of breathing improves prediction of post-extubation outcome","volume":"38","author":"Banner","year":"2012","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib85","first-page":"352","article-title":"Assessing effort and work of breathing","volume":"20","author":"Bellani","year":"2014","journal-title":"Curr Opin Crit Care"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib86","first-page":"261","article-title":"Evolving approaches to assessing and monitoring patient-ventilator interactions","volume":"16","author":"Unroe","year":"2010","journal-title":"Curr Opin Crit Care"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib87","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1097\/CCM.0b013e3182451c40","article-title":"Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model: high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury","volume":"40","author":"Yoshida","year":"2012","journal-title":"Crit Care Med"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib88","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1152\/jappl.1982.53.5.1190","article-title":"Effect of pressure and timing of contraction on human diaphragm fatigue","volume":"53","author":"Bellemare","year":"1982","journal-title":"J\u00a0Appl Physiol Respir Environ Exerc Physiol"},{"issue":"2","key":"10.1016\/j.ccm.2016.07.003_bib89","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1152\/jappl.1995.78.2.646","article-title":"Validation of a noninvasive tension-time index of inspiratory muscles","volume":"78","author":"Ramonatxo","year":"1995","journal-title":"J\u00a0Appl Physiol (1985)"},{"issue":"10","key":"10.1016\/j.ccm.2016.07.003_bib90","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1164\/rccm.200811-1725OC","article-title":"Tension-time index as a predictor of extubation outcome in ventilated children","volume":"180","author":"Harikumar","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib91","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1056\/NEJMsa1410639","article-title":"Driving pressure and survival in the acute respiratory distress syndrome","volume":"372","author":"Amato","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib92","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1164\/ajrccm.158.1.9708031","article-title":"Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?","volume":"158","author":"Gattinoni","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib93","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00134-015-3776-3","article-title":"Understanding the setting of PEEP from esophageal pressure in patients with ARDS","volume":"41","author":"Chiumello","year":"2015","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib94","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/CCM.0000000000001383","article-title":"Open lung approach for the acute respiratory distress syndrome: a pilot, randomized controlled trial","volume":"44","author":"Kacmarek","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ccm.2016.07.003_bib95","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s13054-015-1063-x","article-title":"Altering the mechanical scenario to decrease the driving pressure","volume":"19","author":"Borges","year":"2015","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib96","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/CCM.0b013e31827417a6","article-title":"Lung stress and strain during mechanical ventilation: any difference between statics and dynamics?","volume":"41","author":"Protti","year":"2013","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.ccm.2016.07.003_bib97","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1586\/17476348.2015.1103650","article-title":"Electrical impedance tomography: functional lung imaging on its way to clinical practice?","volume":"9","author":"Gong","year":"2015","journal-title":"Expert Rev Respir Med"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib98","first-page":"323","article-title":"Electrical impedance tomography imaging of the cardiopulmonary system","volume":"20","author":"Frerichs","year":"2014","journal-title":"Curr Opin Crit Care"},{"issue":"6","key":"10.1016\/j.ccm.2016.07.003_bib99","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1186\/s13054-014-0679-6","article-title":"Assessment of respiratory system compliance with electrical impedance tomography using a positive end-expiratory pressure wave maneuver during pressure support ventilation: a pilot clinical study","volume":"18","author":"Becher","year":"2014","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib100","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1097\/CCM.0B013E3181652EDD","article-title":"Electrical impedance tomography compared with thoracic computed tomography during a slow inflation maneuver in experimental models of lung injury","volume":"36","author":"Wrigge","year":"2008","journal-title":"Crit Care Med"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib101","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.medin.2011.05.005","article-title":"Electrical impedance tomography in acute lung injury","volume":"35","author":"Riera","year":"2011","journal-title":"Med Intensiva"},{"key":"10.1016\/j.ccm.2016.07.003_bib102","first-page":"4073","article-title":"The ACE1 thoracic Electrical Impedance Tomography system for ventilation and perfusion","volume":"2015","author":"Mellenthin","year":"2015","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"issue":"Suppl A","key":"10.1016\/j.ccm.2016.07.003_bib103","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1088\/0143-0815\/11\/4A\/306","article-title":"Quantification in impedance imaging","volume":"11","author":"Barber","year":"1990","journal-title":"Clin Phys Physiol Meas"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib104","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1007\/s00134-009-1512-6","article-title":"Lung volume calculated from electrical impedance tomography in ICU patients at different PEEP levels","volume":"35","author":"Bikker","year":"2009","journal-title":"Intensive Care Med"},{"issue":"12","key":"10.1016\/j.ccm.2016.07.003_bib105","first-page":"1024","article-title":"Regional intratidal gas distribution in acute lung injury and acute respiratory distress syndrome\u2013assessed by electric impedance tomography","volume":"76","author":"Lowhagen","year":"2010","journal-title":"Minerva Anestesiol"},{"issue":"5","key":"10.1016\/j.ccm.2016.07.003_bib106","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/ALN.0000000000000862","article-title":"Physiological effects of the open lung approach in patients with early, mild, diffuse acute respiratory distress syndrome: an electrical impedance tomography study","volume":"123","author":"Cinnella","year":"2015","journal-title":"Anesthesiology"},{"issue":"6","key":"10.1016\/j.ccm.2016.07.003_bib107","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1088\/0967-3334\/36\/6\/1137","article-title":"Influence of tidal volume on ventilation inhomogeneity assessed by electrical impedance tomography during controlled mechanical ventilation","volume":"36","author":"Becher","year":"2015","journal-title":"Physiol Meas"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib108","first-page":"161","article-title":"Electrical impedance tomography-guided prone positioning in a patient with acute cor pulmonale associated with severe acute respiratory distress syndrome","volume":"30","author":"Kotani","year":"2015","journal-title":"J\u00a0Anesth"},{"issue":"4","key":"10.1016\/j.ccm.2016.07.003_bib109","doi-asserted-by":"crossref","first-page":"406","DOI":"10.5935\/0103-507X.20150068","article-title":"Use of thoracic electrical impedance tomography as an auxiliary tool for alveolar recruitment maneuvers in acute respiratory distress syndrome: case report and brief literature review","volume":"27","author":"Rosa","year":"2015","journal-title":"Rev Bras Ter Intensiva"},{"issue":"8","key":"10.1016\/j.ccm.2016.07.003_bib110","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1097\/01.CCM.0000275390.71601.83","article-title":"Regional lung volume changes in children with acute respiratory distress syndrome during a derecruitment maneuver","volume":"35","author":"Wolf","year":"2007","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib111","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13054-015-1173-5","article-title":"Electrical impedance tomography (EIT) for quantification of pulmonary edema in acute lung injury","volume":"20","author":"Trepte","year":"2016","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13054-015-1161-9","article-title":"Influence of different electrode belt positions on electrical impedance tomography imaging of regional ventilation: a prospective observational study","volume":"20","author":"Karsten","year":"2016","journal-title":"Crit Care"},{"issue":"11","key":"10.1016\/j.ccm.2016.07.003_bib113","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1164\/rccm.201507-1413OC","article-title":"Lung recruitment assessed by respiratory mechanics and by CT Scan: what is the relationship?","volume":"193","author":"Chiumello","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.ccm.2016.07.003_bib114","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00408-015-9823-6","article-title":"End-expiratory volume and oxygenation: targeting PEEP in ARDS patients","volume":"194","author":"Casserly","year":"2016","journal-title":"Lung"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00265800","article-title":"The role of total static lung compliance in the management of severe ARDS unresponsive to conventional treatment","volume":"10","author":"Gattinoni","year":"1984","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.ccm.2016.07.003_bib116","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/jappl.1988.65.3.1093","article-title":"Direct measurement of static chest wall compliance in animal and human neonates","volume":"65","author":"Davis","year":"1988","journal-title":"J\u00a0Appl Physiol (1985)"}],"container-title":["Clinics in Chest Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272523116300788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0272523116300788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:53:07Z","timestamp":1759452787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0272523116300788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":116,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0272523116300788"],"URL":"https:\/\/doi.org\/10.1016\/j.ccm.2016.07.003","relation":{},"ISSN":["0272-5231"],"issn-type":[{"value":"0272-5231","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing Respiratory System Mechanical Function","name":"articletitle","label":"Article Title"},{"value":"Clinics in Chest Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccm.2016.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}