{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:39:06Z","timestamp":1792600746383,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3029,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.ccr.2005.03.023","type":"journal-article","created":{"date-parts":[[2005,4,19]],"date-time":"2005-04-19T09:53:39Z","timestamp":1113904419000},"page":"387-397","source":"Crossref","is-referenced-by-count":2540,"title":["Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis"],"prefix":"10.1016","volume":"7","author":[{"given":"Ross L.","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Wadleigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Cools","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"Ebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde","family":"Wernig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.P.","family":"Huntly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus J.","family":"Boggon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Wlodarska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Adelsperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Mercher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"D\u2019Andrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Fr\u00f6hling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstanze","family":"D\u00f6hner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Marynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben A.","family":"Mesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Eck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Sellers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Meyerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd R.","family":"Golub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Gary","family":"Gilliland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccr.2005.03.023_bib1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1056\/NEJM197610212951702","article-title":"Polycythemia vera: Stem-cell and probable clonal origin of the disease","volume":"295","author":"Adamson","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1056\/NEJMoa020150","article-title":"Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta","volume":"347","author":"Apperley","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib3","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1182\/blood.V89.12.4628","article-title":"Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene","volume":"89","author":"Arcasoy","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/306277a0","article-title":"Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia","volume":"306","author":"Bartram","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2005.03.023_bib5","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib6","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1182\/blood-2003-07-2479","article-title":"The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia","volume":"103","author":"Cools","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib7","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/MCB.11.4.1980","article-title":"The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains","volume":"11","author":"D\u2019Andrea","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ccr.2005.03.023_bib8","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJMoa020461","article-title":"Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors","volume":"347","author":"Demetri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM200104053441401","article-title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia","volume":"344","author":"Druker","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0263-7855(93)87009-T","article-title":"SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules","volume":"11","author":"Evans","year":"1993","journal-title":"J. Mol. Graph."},{"key":"10.1016\/j.ccr.2005.03.023_bib11","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1182\/blood-2002-05-1440","article-title":"Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm","volume":"100","author":"Frohling","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib12","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1172\/JCI116761","article-title":"Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product","volume":"92","author":"Furitsu","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ccr.2005.03.023_bib13","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1073\/pnas.88.15.6848","article-title":"Clonality in myeloproliferative disorders: Analysis by means of the polymerase chain reaction","volume":"88","author":"Gilliland","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2005.03.023_bib14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1067\/msy.2002.128559","article-title":"RET proto-oncogene mutations affecting codon 790\/791: A mild form of multiple endocrine neoplasia type 2A syndrome?","volume":"132","author":"Gimm","year":"2002","journal-title":"Surgery"},{"key":"10.1016\/j.ccr.2005.03.023_bib15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0092-8674(94)90322-0","article-title":"Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation","volume":"77","author":"Golub","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ccr.2005.03.023_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00005650-199601000-00006","article-title":"Can comorbidity be measured by questionnaire rather than medical record review?","volume":"34","author":"Katz","year":"1996","journal-title":"Med. Care"},{"key":"10.1016\/j.ccr.2005.03.023_bib17","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1182\/blood.V90.5.2057","article-title":"Two new EPO receptor mutations: Truncated EPO receptors are most frequently associated with primary familial and congenital polycythemias","volume":"90","author":"Kralovics","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0301-472X(01)00789-5","article-title":"Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera","volume":"30","author":"Kralovics","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.ccr.2005.03.023_bib19","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1182\/blood-2003-03-0885","article-title":"Clonal hematopoiesis in familial polycythemia vera suggests the involvement of multiple mutational events in the early pathogenesis of the disease","volume":"102","author":"Kralovics","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib20","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.278.5341.1309","article-title":"A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia","volume":"278","author":"Lacronique","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ccr.2005.03.023_bib21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1006\/jmbi.1998.2369","article-title":"Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine","volume":"285","author":"Lamers","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ccr.2005.03.023_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/protein\/14.1.27","article-title":"Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation","volume":"14","author":"Lindauer","year":"2001","journal-title":"Protein Eng."},{"key":"10.1016\/j.ccr.2005.03.023_bib23","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1056\/NEJMoa040938","article-title":"Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib","volume":"350","author":"Lynch","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib24","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ccr.2005.03.023_bib25","doi-asserted-by":"crossref","first-page":"41435","DOI":"10.1074\/jbc.M104828200","article-title":"Crystal structure of Bruton\u2019s tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia","volume":"276","author":"Mao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ccr.2005.03.023_bib26","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/ijc.10169","article-title":"Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci","volume":"98","author":"Martin-Subero","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ccr.2005.03.023_bib27","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1056\/NEJM199802263380903","article-title":"Impaired expression of the thrombopoietin receptor by platelets from patients with polycythemia vera","volume":"338","author":"Moliterno","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib28","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/363458a0","article-title":"Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A","volume":"363","author":"Mulligan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2005.03.023_bib29","first-page":"1911","article-title":"Internal tandem duplication of the flt3 gene found in acute myeloid leukemia","volume":"10","author":"Nakao","year":"1996","journal-title":"Leukemia"},{"key":"10.1016\/j.ccr.2005.03.023_bib30","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1099314","article-title":"EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy","volume":"304","author":"Paez","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ccr.2005.03.023_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)81167-8","article-title":"Jak2 is essential for signaling through a variety of cytokine receptors","volume":"93","author":"Parganas","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ccr.2005.03.023_bib32","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1182\/blood-2002-06-1843","article-title":"Mutations in the VHL gene in sporadic apparently congenital polycythemia","volume":"101","author":"Pastore","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib33","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1182\/blood.V90.7.2535","article-title":"Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia","volume":"90","author":"Peeters","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib34","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJM197406132902419","article-title":"Letter: Bone-marrow responses in polycythemia vera","volume":"290","author":"Prchal","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib35","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/MCB.20.10.3387-3395.2000","article-title":"Regulation of the Jak2 tyrosine kinase by its pseudokinase domain","volume":"20","author":"Saharinen","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ccr.2005.03.023_bib36","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1093\/emboj\/17.18.5321","article-title":"Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL\/JAK2 fusion genes","volume":"17","author":"Schwaller","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.ccr.2005.03.023_bib37","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJM199802263380910","article-title":"Polycythemia vera\u2013chance, death, and mutability","volume":"338","author":"Schwartz","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib38","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL: An automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccr.2005.03.023_bib39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJM199802263380902","article-title":"Expression of Bcl-x in erythroid precursors from patients with polycythemia vera","volume":"338","author":"Silva","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ccr.2005.03.023_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1097-2765(03)00274-0","article-title":"Autoinhibition of Bcr-Abl through its SH3 domain","volume":"12","author":"Smith","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccr.2005.03.023_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood.V86.1.15.bloodjournal86115","article-title":"Primary familial polycythemia: A frameshift mutation in the erythropoietin receptor gene and increased sensitivity of erythroid progenitors to erythropoietin","volume":"86","author":"Sokol","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng772","article-title":"Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome","volume":"29","author":"Tartaglia","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccr.2005.03.023_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng1156","article-title":"Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia","volume":"34","author":"Tartaglia","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccr.2005.03.023_bib44","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The International HapMap Project","volume":"426","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2005.03.023_bib45","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0960-894X(02)00106-3","article-title":"Photochemical preparation of a pyridone containing tetracycle: A Jak protein kinase inhibitor","volume":"12","author":"Thompson","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.ccr.2005.03.023_bib46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00005650-199603000-00003","article-title":"A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity","volume":"34","author":"Ware","year":"1996","journal-title":"Med. Care"},{"key":"10.1016\/j.ccr.2005.03.023_bib47","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1182\/blood.V94.7.2530.419k35_2530_2532","article-title":"Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state","volume":"94","author":"Watowich","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2005.03.023_bib48","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/1098-1004(200011)16:5<431::AID-HUMU8>3.0.CO;2-Z","article-title":"Diagnosis of haploidy and triploidy based on measurement of gene copy number by real-time PCR","volume":"16","author":"Wilke","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ccr.2005.03.023_bib49","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/ng0198-84","article-title":"FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia\/lymphoma syndrome","volume":"18","author":"Xiao","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccr.2005.03.023_bib50","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1172\/JCI108706","article-title":"Erythroid colony formation by polycythemia vera bone marrow in vitro. Dependence on erythropoietin","volume":"59","author":"Zanjani","year":"1977","journal-title":"J. Clin. Invest."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610805000942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610805000942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T20:19:21Z","timestamp":1586204361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610805000942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S1535610805000942"],"URL":"https:\/\/doi.org\/10.1016\/j.ccr.2005.03.023","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.720540175.793516205","asserted-by":"object"}]},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}