{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:59:52Z","timestamp":1791500392634,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":508,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000589","name":"Chief Scientist Office","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000589","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA95684"],"award-info":[{"award-number":["R01 CA95684"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL77847"],"award-info":[{"award-number":["R01 HL77847"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C11074\/A11008"],"award-info":[{"award-number":["C11074\/A11008"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.ccr.2012.02.018","type":"journal-article","created":{"date-parts":[[2012,4,16]],"date-time":"2012-04-16T12:09:24Z","timestamp":1334578164000},"page":"577-592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":311,"title":["Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia"],"prefix":"10.1016","volume":"21","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u00a0Wei","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-uk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa\u00a0L.","family":"Holyoake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Huettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccr.2012.02.018_bib1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature06869","article-title":"Long-term haematopoietic reconstitution by Trp53-\/-p16Ink4a-\/-p19Arf-\/- multipotent progenitors","volume":"453","author":"Akala","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2012.02.018_bib2","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2012.02.018_bib3","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood.V85.12.3636.bloodjournal85123636","article-title":"Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages","volume":"85","author":"Bhatia","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1182\/blood-2005-05-2023","article-title":"Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines","volume":"107","author":"Bonig","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/0471142956.cy0734s45","article-title":"Cell proliferation method: click chemistry based on BrdU coupling for multiplex antibody staining","author":"Cappella","year":"2008","journal-title":"Curr. Protoc. Cytom."},{"key":"10.1016\/j.ccr.2012.02.018_bib6","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1182\/blood.V92.7.2338","article-title":"MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures","volume":"92","author":"Cashman","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib7","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1182\/blood.V99.3.792","article-title":"Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in\u00a0vitro and in NOD\/SCID mice","volume":"99","author":"Cashman","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib8","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1158\/0008-5472.CAN-09-3977","article-title":"The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms","volume":"70","author":"Cho","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.ccr.2012.02.018_bib9","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1182\/blood-2011-02-335497","article-title":"Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease","volume":"118","author":"Chomel","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib10","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI35721","article-title":"Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity","volume":"121","author":"Corbin","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ccr.2012.02.018_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1200\/JCO.2010.31.3619","article-title":"Front-line and salvage therapies with tyrosine kinase inhibitors and other treatments in chronic myeloid leukemia","volume":"29","author":"Cortes","year":"2011","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.ccr.2012.02.018_bib12","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","article-title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia","volume":"355","author":"Druker","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib13","doi-asserted-by":"crossref","first-page":"12015","DOI":"10.1073\/pnas.90.24.12015","article-title":"Unresponsiveness of primitive chronic myeloid leukemia cells to macrophage inflammatory protein 1 alpha, an inhibitor of primitive normal hematopoietic cells","volume":"90","author":"Eaves","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2012.02.018_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9343(77)90124-3","article-title":"Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte\/macrophage","volume":"63","author":"Fialkow","year":"1977","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood.V99.1.319","article-title":"Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in\u00a0vitro","volume":"99","author":"Graham","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib16","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1182\/blood.V99.10.3792","article-title":"Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation","volume":"99","author":"Holtz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib18","doi-asserted-by":"crossref","first-page":"16280","DOI":"10.1073\/pnas.1004408107","article-title":"Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein","volume":"107","author":"J\u00e4r\u00e5s","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2012.02.018_bib19","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1158\/1535-7163.MCT-07-0042","article-title":"CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells","volume":"7","author":"Jin","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.ccr.2012.02.018_bib20","first-page":"1347","article-title":"High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations","volume":"24","author":"Jordan","year":"1996","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.ccr.2012.02.018_bib21","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1056\/NEJMoa1002315","article-title":"Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia","volume":"362","author":"Kantarjian","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib22","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ccr.2012.02.018_bib23","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0092-8674(00)80453-5","article-title":"Identification of clonogenic common lymphoid progenitors in mouse bone marrow","volume":"91","author":"Kondo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ccr.2012.02.018_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1182\/blood-2003-12-4369","article-title":"Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis","volume":"105","author":"Koschmieder","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib25","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/nm1489","article-title":"Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells","volume":"12","author":"Krause","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib26","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1084\/jem.189.9.1399","article-title":"The P190, P210, and P230 forms of the BCR\/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity","volume":"189","author":"Li","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib27","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S1470-2045(10)70233-3","article-title":"Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial","volume":"11","author":"Mahon","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ccr.2012.02.018_bib28","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.immuni.2007.02.013","article-title":"Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors","volume":"26","author":"M\u00e5nsson","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.ccr.2012.02.018_bib29","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1038\/nature03669","article-title":"Dynamics of chronic myeloid leukaemia","volume":"435","author":"Michor","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2012.02.018_bib30","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1046\/j.1365-2141.2003.04217.x","article-title":"Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase","volume":"120","author":"Mihara","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ccr.2012.02.018_bib31","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1182\/blood.V92.10.3780","article-title":"Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr\/abl-transduced bone marrow","volume":"92","author":"Pear","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib32","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1126\/science.283.5403.845","article-title":"Dependence of human stem cell engraftment and repopulation of NOD\/SCID mice on CXCR4","volume":"283","author":"Peled","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ccr.2012.02.018_bib33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1634\/stemcells.20-3-259","article-title":"Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1","volume":"20","author":"Peled","year":"2002","journal-title":"Stem Cells"},{"key":"10.1016\/j.ccr.2012.02.018_bib34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/glia.20409","article-title":"HIV-1-infected and\/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta","volume":"54","author":"Peng","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.ccr.2012.02.018_bib35","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: mechanisms of blastic transformation","volume":"120","author":"Perrotti","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ccr.2012.02.018_bib36","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1182\/blood.V88.6.2162.bloodjournal8862162","article-title":"Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia","volume":"88","author":"Petzer","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ccr.2011.10.012","article-title":"IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development","volume":"20","author":"Reynaud","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccr.2012.02.018_bib38","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1056\/NEJMoa0912614","article-title":"Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia","volume":"362","author":"Saglio","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib39","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1172\/JCI41495","article-title":"Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD\/SCID\/IL2R\u03b3c-deficient mice","volume":"121","author":"Sarry","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ccr.2012.02.018_bib40","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199904293401706","article-title":"Chronic myeloid leukemia","volume":"340","author":"Sawyers","year":"1999","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ccr.2012.02.018_bib41","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1182\/blood-2009-04-215376","article-title":"BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells","volume":"115","author":"Schemionek","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2012.02.018_bib42","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1172\/JCI115985","article-title":"Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV","volume":"90","author":"Verfaillie","year":"1992","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ccr.2012.02.018_bib43","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/ar2391","article-title":"TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood","volume":"10","author":"Zhang","year":"2008","journal-title":"Arthritis Res. Ther."}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610812000803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610812000803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T23:55:50Z","timestamp":1761522950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610812000803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S1535610812000803"],"URL":"https:\/\/doi.org\/10.1016\/j.ccr.2012.02.018","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.715897861.791302962","asserted-by":"object"}]},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccr.2012.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}