{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:06:17Z","timestamp":1770221177466,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":382,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cancercell.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cancer Cell"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.ccr.2013.01.011","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T16:45:40Z","timestamp":1360601140000},"page":"200-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Growth Factor Independence 1 Antagonizes a p53-Induced DNA Damage Response Pathway in Lymphoblastic Leukemia"],"prefix":"10.1016","volume":"23","author":[{"given":"Cyrus","family":"Khandanpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James\u00a0D.","family":"Phelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lothar","family":"Vassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Sch\u00fctte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane\u00a0R.","family":"Horman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Claude","family":"Gaudreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Krongold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William\u00a0E.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"D\u00fchrsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertie","family":"G\u00f6ttgens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u00a0Leighton","family":"Grimes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"M\u00f6r\u00f6y","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ccr.2013.01.011_bib1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/318533a0","article-title":"The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice","volume":"318","author":"Adams","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2013.01.011_bib2","doi-asserted-by":"crossref","first-page":"7773","DOI":"10.1038\/sj.onc.1210881","article-title":"DNA damage signalling guards against activated oncogenes and tumour progression","volume":"26","author":"Bartek","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ccr.2013.01.011_bib3","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1038\/sj.onc.1210553","article-title":"DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours","volume":"26","author":"Bartkova","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ccr.2013.01.011_bib4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/sj.onc.1204090","article-title":"Runx2: a novel oncogenic effector revealed by in\u00a0vivo complementation and retroviral tagging","volume":"20","author":"Blyth","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.ccr.2013.01.011_bib5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.virol.2008.04.008","article-title":"Retroviral gene insertion in breast milk mediated lymphomagenesis","volume":"377","author":"Chakraborty","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.ccr.2013.01.011_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Coustan-Smith","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ccr.2013.01.011_bib7","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1182\/blood-2008-02-136762","article-title":"Targeting the Notch1 and mTOR pathways in a mouse T-ALL model","volume":"113","author":"Cullion","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib8","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1128\/JVI.00427-09","article-title":"Loss of MicroRNA targets in the 3\u2032 untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1","volume":"83","author":"Dabrowska","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ccr.2013.01.011_bib9","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication","volume":"444","author":"Di Micco","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2013.01.011_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","article-title":"Gene expression signatures define novel oncogenic pathways in T\u00a0cell acute lymphoblastic leukemia","volume":"1","author":"Ferrando","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ccr.2013.01.011_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/sj.embor.7400618","article-title":"Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development","volume":"7","author":"Fiolka","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ccr.2013.01.011_bib12","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/MCB.13.3.1759","article-title":"Progression of interleukin-2 (IL-2)-dependent rat T\u00a0cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein","volume":"13","author":"Gilks","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ccr.2013.01.011_bib13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1053\/j.seminhematol.2008.09.003","article-title":"Treatment of adult acute lymphoblastic leukemia","volume":"46","author":"G\u00f6kbuget","year":"2009","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.ccr.2013.01.011_bib14","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.1140735","article-title":"An oncogene-induced DNA damage model for cancer development","volume":"319","author":"Halazonetis","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.ccr.2013.01.011_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1152\/physiolgenomics.00019.2007","article-title":"Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues","volume":"31","author":"Hameyer","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.ccr.2013.01.011_bib16","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1182\/blood-2008-09-179747","article-title":"Gfi1 integrates progenitor versus granulocytic transcriptional programming","volume":"113","author":"Horman","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature06092","article-title":"p53 is regulated by the lysine demethylase LSD1","volume":"449","author":"Huang","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.ccr.2013.01.011_bib18","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1182\/blood-2011-02-334722","article-title":"The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice","volume":"120","author":"Khandanpour","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib19","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1182\/blood-2005-04-1447","article-title":"Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma","volume":"106","author":"Kundu","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib20","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.molcel.2007.12.025","article-title":"Methylation of p53 by Set7\/9 mediates p53 acetylation and activity in\u00a0vivo","volume":"29","author":"Kurash","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccr.2013.01.011_bib21","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1182\/blood-2009-11-255075","article-title":"Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development","volume":"116","author":"Li","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1073\/pnas.0806445106","article-title":"ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes","volume":"106","author":"Margolin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2013.01.011_bib23","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1084\/jem.20110121","article-title":"High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling","volume":"208","author":"Medyouf","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccr.2013.01.011_bib24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2144\/000113005","article-title":"Vivo-Morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues","volume":"45","author":"Morcos","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.ccr.2013.01.011_bib25","doi-asserted-by":"crossref","first-page":"14920","DOI":"10.1073\/pnas.2436557100","article-title":"Notch signaling controls multiple steps of pancreatic differentiation","volume":"100","author":"Murtaugh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2013.01.011_bib26","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.20070876","article-title":"FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors","volume":"204","author":"O\u2019Neil","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccr.2013.01.011_bib27","doi-asserted-by":"crossref","first-page":"18261","DOI":"10.1073\/pnas.0606108103","article-title":"NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth","volume":"103","author":"Palomero","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2013.01.011_bib28","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/eji.200737130","article-title":"Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function","volume":"37","author":"Pargmann","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ccr.2013.01.011_bib29","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ng1170","article-title":"Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2","volume":"34","author":"Person","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ccr.2013.01.011_bib30","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.4049\/jimmunol.177.4.2153","article-title":"Structurally distinct ligand-binding or ligand-independent Notch1 mutants are leukemogenic but affect thymocyte development, apoptosis, and metastasis differently","volume":"177","author":"Priceputu","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ccr.2013.01.011_bib31","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.molcel.2007.06.039","article-title":"Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1","volume":"27","author":"Saleque","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ccr.2013.01.011_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1128\/JVI.71.1.9-16.1997","article-title":"Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice","volume":"71","author":"Scheijen","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ccr.2013.01.011_bib33","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1093\/nar\/24.13.2528","article-title":"MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc\/pim bitransgenic mice correlate with activation of the gfi-1 gene","volume":"24","author":"Schmidt","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ccr.2013.01.011_bib34","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1038\/sj.onc.1202191","article-title":"Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis","volume":"17","author":"Schmidt","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.ccr.2013.01.011_bib35","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1128\/MCB.01091-06","article-title":"Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc","volume":"26","author":"Sharma","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ccr.2013.01.011_bib36","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.immuni.2009.07.011","article-title":"A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates","volume":"31","author":"Spooner","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.ccr.2013.01.011_bib37","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2013.01.011_bib38","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1084\/jem.20070872","article-title":"The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T\u00a0cell leukemia","volume":"204","author":"Thompson","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccr.2013.01.011_bib39","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2008.03.021","article-title":"Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks","volume":"133","author":"Uren","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ccr.2013.01.011_bib40","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1182\/blood-2007-09-111872","article-title":"The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia","volume":"111","author":"Van Vlierberghe","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib41","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1182\/blood-2008-11-190215","article-title":"Gfi1 regulates miR-21 and miR-196b to control myelopoiesis","volume":"113","author":"Velu","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.ccr.2013.01.011_bib42","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T\u00a0cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ccr.2013.01.011_bib43","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1101\/gad.1450406","article-title":"c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia\/lymphoma","volume":"20","author":"Weng","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ccr.2013.01.011_bib44","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2217\/epi.11.21","article-title":"Regulation of p53 function by lysine methylation","volume":"3","author":"West","year":"2011","journal-title":"Epigenomics"},{"key":"10.1016\/j.ccr.2013.01.011_bib45","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.1073\/pnas.171321298","article-title":"AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations","volume":"98","author":"Yuan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2013.01.011_bib46","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1084\/jem.20021417","article-title":"The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T\u00a0cell progenitors and CD4\/CD8 lineage decision in the thymus","volume":"197","author":"Y\u00fccel","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.ccr.2013.01.011_bib47","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.immuni.2007.12.020","article-title":"Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1","volume":"28","author":"Zarebski","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.ccr.2013.01.011_bib48","doi-asserted-by":"crossref","first-page":"18214","DOI":"10.1073\/pnas.0608981103","article-title":"Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion","volume":"103","author":"Zhu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ccr.2013.01.011_bib49","first-page":"1789","article-title":"Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2","volume":"12","author":"Z\u00f6rnig","year":"1996","journal-title":"Oncogene"}],"container-title":["Cancer Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610813000366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535610813000366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T05:22:35Z","timestamp":1595395355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535610813000366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1535610813000366"],"URL":"https:\/\/doi.org\/10.1016\/j.ccr.2013.01.011","relation":{},"ISSN":["1535-6108"],"issn-type":[{"value":"1535-6108","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth Factor Independence 1 Antagonizes a p53-Induced DNA Damage Response Pathway in Lymphoblastic Leukemia","name":"articletitle","label":"Article Title"},{"value":"Cancer Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ccr.2013.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}