{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:35:13Z","timestamp":1771367713589,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1016\/j.cct.2011.11.006","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T19:25:05Z","timestamp":1321039505000},"page":"260-267","source":"Crossref","is-referenced-by-count":29,"title":["Methylene blue MMX\u00ae tablets for chromoendoscopy. Safety tolerability and bioavailability in healthy volunteers"],"prefix":"10.1016","volume":"33","author":[{"given":"A.","family":"Repici","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.F.D.","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Radicioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Jas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Danese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cct.2011.11.006_bb0005","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2036.2003.01445.x","article-title":"Gastrointestinal transit and 5-ASA release from a new mesalazine extended-release formulation","volume":"17","author":"Brunner","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.cct.2011.11.006_bb0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2125.2005.02517.x","article-title":"Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation","volume":"61","author":"Brunner","year":"2006","journal-title":"Br J Clin Pharmacol"},{"issue":"5","key":"10.1016\/j.cct.2011.11.006_bb0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-2001-14427","article-title":"Methylene blue staining of dysplastic and nondysplastic Barrett's esophagus: an in vivo and ex vivo study","volume":"33","author":"Canto","year":"2001","journal-title":"Endoscopy"},{"issue":"Suppl. IV","key":"10.1016\/j.cct.2011.11.006_bb0020","first-page":"iv7","article-title":"Magnification endoscopy, high resolution endoscopy, and chromoscopy; towards a better optical diagnosis","volume":"52","author":"Bruno","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.cct.2011.11.006_bb0025","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1136\/gut.2004.061283","article-title":"In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy","volume":"54","author":"Becker","year":"2005","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.cct.2011.11.006_bb0030","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/ibd.20118","article-title":"Role of chromoendoscopy in colon cancer surveillance in inflammatory bowel disease","volume":"13","author":"Thorlacius","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.cct.2011.11.006_bb0035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0046-8177(91)90163-J","article-title":"Identification and quantification of aberrant crypt foci and microadenomas in the human colon","volume":"22","author":"Roncucci","year":"1991","journal-title":"Hum Pathol"},{"key":"10.1016\/j.cct.2011.11.006_bb0040","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s002280000124","article-title":"Pharmacokinetics and organ distribution of intravenous and oral methylene blue","volume":"56","author":"Peter","year":"2000","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.cct.2011.11.006_bb0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00228-008-0563-x","article-title":"High absolute bioavailability of methylene blue given as an aqueous oral formulation","volume":"65","author":"Walter-Sack","year":"2009","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.cct.2011.11.006_bb0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1054\/bjoc.1999.0917","article-title":"Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature","volume":"82","author":"Pelgrims","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.cct.2011.11.006_bb0055","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/00045391-200307000-00009","article-title":"Methylene blue","volume":"10","author":"Clifton","year":"2003","journal-title":"Am J Ther"},{"key":"10.1016\/j.cct.2011.11.006_bb0065","unstructured":"U.S. Department of Health and Human Services and U.S. Department of Agriculture, Nutrition and your health: dietary guidelines for Americans, 2005."},{"key":"10.1016\/j.cct.2011.11.006_bb0070","unstructured":"Guidance for Industry. Bioanalytical Methods Validation. U.S. Department of Health and Human Services. Food and Drug Administration, Center for Drug Evaluation and Research. CDER, June 2001."},{"issue":"10","key":"10.1016\/j.cct.2011.11.006_bb0075","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s11095-007-9291-7","article-title":"Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays","volume":"24","author":"Viswanathan","year":"2007","journal-title":"Pharm Res"},{"key":"10.1016\/j.cct.2011.11.006_bb0080","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2036.2006.03212.x","article-title":"Systematic review: oral bowel preparation for colonoscopy","volume":"25","author":"Belsey","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"10.1016\/j.cct.2011.11.006_bb0085","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3949\/ccjm.77a.09122","article-title":"Making the most of currently available bowel preparations for colonoscopy","volume":"77","author":"Atreja","year":"2010","journal-title":"Cleve Clin J Med"},{"issue":"6","key":"10.1016\/j.cct.2011.11.006_bb0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1055\/s-1999-8041","article-title":"Staining in gastrointestinal endoscopy: the basics","volume":"31","author":"Canto","year":"1999","journal-title":"Endoscopy"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714411002722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714411002722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T12:20:14Z","timestamp":1543407614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714411002722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S1551714411002722"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2011.11.006","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}