{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:58:17Z","timestamp":1790002697569,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Fondo de Investigaciones Sanitarias (FIS","award":["PS09\/00194"],"award-info":[{"award-number":["PS09\/00194"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["SFRH\/BPD\/76947\/2011"],"award-info":[{"award-number":["SFRH\/BPD\/76947\/2011"]}]},{"name":"Portuguese Foundation for Science and Technology","award":["PEst-OE\/SAU\/UI0617\/2011"],"award-info":[{"award-number":["PEst-OE\/SAU\/UI0617\/2011"]}]}],"content-domain":{"domain":["contemporaryclinicaltrials.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.cct.2013.05.012","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T13:48:00Z","timestamp":1370440080000},"page":"106-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Physical Activity in Pediatric Cancer patients with solid tumors (PAPEC): Trial rationale and design"],"prefix":"10.1016","volume":"36","clinical-trial-number":[{"clinical-trial-number":"nct01645436","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Luisa","family":"Soares-Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fiuza-Luces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Lassaletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Santana-Sosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio R.","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Fern\u00e1ndez-Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosal\u00eda","family":"Lorenzo-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M.","family":"L\u00f3pez-Mojares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2013.05.012_bb0005","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.cct.2013.05.012_bb0010","series-title":"Robbins and Cotran pathologic basis of disease","author":"Robbins","year":"2010"},{"key":"10.1016\/j.cct.2013.05.012_bb0015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/cancers3010298","article-title":"Cancer stem cells and pediatric solid tumors","volume":"3","author":"Friedman","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.cct.2013.05.012_bb0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/pbc.24008","article-title":"Inflammation: what role in pediatric cancer?","volume":"58","author":"Morgenstern","year":"2012","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.cct.2013.05.012_bb0025","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/pbc.22924","article-title":"The current status of follow-up services for childhood cancer survivors, are we meeting goals and expectations: a report from the Consortium for New England Childhood Cancer Survivors","volume":"57","author":"Kenney","year":"2011","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.cct.2013.05.012_bb0030","doi-asserted-by":"crossref","first-page":"461512","DOI":"10.1155\/2011\/461512","article-title":"Exercise interventions in children with cancer: a review","volume":"2011","author":"Huang","year":"2011","journal-title":"Int J Pediatr"},{"key":"10.1016\/j.cct.2013.05.012_bb0035","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1207\/S15324796ABM2304_5","article-title":"Framework PEACE: an organizational model for examining physical exercise across the cancer experience","volume":"23","author":"Courneya","year":"2001","journal-title":"Ann Behav Med"},{"key":"10.1016\/j.cct.2013.05.012_bb0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/MPH.0b013e3181978fd4","article-title":"Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program","volume":"31","author":"Moyer-Mileur","year":"2009","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.cct.2013.05.012_bb0045","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/pbc.21942","article-title":"A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia","volume":"53","author":"Hartman","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.cct.2013.05.012_bb0050","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jpainsymman.2006.09.025","article-title":"Clinical field testing of an enhanced-activity intervention in hospitalized children with cancer","volume":"33","author":"Hinds","year":"2007","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.cct.2013.05.012_bb0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/pbc.10481","article-title":"Effects of physical therapy intervention for children with acute lymphoblastic leukemia","volume":"42","author":"Marchese","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.cct.2013.05.012_bb0060","doi-asserted-by":"crossref","first-page":"663","DOI":"10.7326\/0003-4819-134-8-200104170-00012","article-title":"The revised CONSORT statement for reporting randomized trials: explanation and elaboration","volume":"134","author":"Altman","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cct.2013.05.012_bb0065","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3758\/BRM.41.4.1149","article-title":"Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses","volume":"41","author":"Faul","year":"2009","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.cct.2013.05.012_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.cct.2013.05.012_bb0075","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/pbc.20354","article-title":"Role of exercise in rehabilitation of cancer survivors","volume":"44","author":"Braith","year":"2005","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.cct.2013.05.012_bb0080","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1542\/peds.107.6.1470","article-title":"Strength training by children and adolescents","volume":"107","author":"Bernhardt","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.cct.2013.05.012_bb0085","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1519\/JSC.0b013e31819df407","article-title":"Youth resistance training: updated position statement paper from the national strength and conditioning association","volume":"23","author":"Faigenbaum","year":"2009","journal-title":"J Strength Cond Res"},{"key":"10.1016\/j.cct.2013.05.012_bb0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1249\/01.mss.0000240326.54147.fc","article-title":"Effects of an intrahospital exercise program intervention for children with leukemia","volume":"39","author":"San Juan","year":"2007","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cct.2013.05.012_bb0095","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00431-011-1617-0","article-title":"Aerobic fitness related to cardiovascular risk factors in young children","volume":"171","author":"Dencker","year":"2012","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.cct.2013.05.012_bb0100","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-2007-965571","article-title":"Benefits of intrahospital exercise training after pediatric bone marrow transplantation","volume":"29","author":"San Juan","year":"2008","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.cct.2013.05.012_bb0105","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/mpo.10266","article-title":"Strength and functional mobility in children with acute lymphoblastic leukemia","volume":"40","author":"Gocha Marchese","year":"2003","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.cct.2013.05.012_bb0110","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/00005768-200202000-00025","article-title":"Age and gender differences in objectively measured physical activity in youth","volume":"34","author":"Trost","year":"2002","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cct.2013.05.012_bb0115","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ajcn\/76.5.935","article-title":"Physical activity but not energy expenditure is reduced in obese adolescents: a case-control study","volume":"76","author":"Ekelund","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cct.2013.05.012_bb0120","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1249\/01.MSS.0000079078.62035.EC","article-title":"Reexamination of validity and reliability of the CSA monitor in walking and running","volume":"35","author":"Brage","year":"2003","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cct.2013.05.012_bb0125","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-2000-8487","article-title":"Field evaluation of the Computer Science and Application's Inc. Activity monitor during running and skating training in adolescent athletes","volume":"21","author":"Ekelund","year":"2000","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.cct.2013.05.012_bb0130","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00005768-199804000-00023","article-title":"Validity of the computer science and applications (CSA) activity monitor in children","volume":"30","author":"Trost","year":"1998","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cct.2013.05.012_bb0135","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1093\/ajcn\/80.3.584","article-title":"Associations between objectively assessed physical activity and indicators of body fatness in 9- to 10-y-old European children: a population-based study from 4 distinct regions in Europe (the European Youth Heart Study)","volume":"80","author":"Ekelund","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.cct.2013.05.012_bb0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1249\/01.MSS.0000106174.43932.92","article-title":"Physical activity levels and patterns of 9- and 15-yr-old European children","volume":"36","author":"Riddoch","year":"2004","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cct.2013.05.012_bb0145","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1023\/A:1023220912211","article-title":"The Spanish version of the Child Health and Illness Profile-Adolescent Edition (CHIP-AE)","volume":"12","author":"Rajmil","year":"2003","journal-title":"Qual Life Res"},{"key":"10.1016\/j.cct.2013.05.012_bb0150","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.mlr.0000114910.46921.73","article-title":"The Child Report Form of the CHIP-Child Edition: reliability and validity","volume":"42","author":"Riley","year":"2004","journal-title":"Med Care"},{"key":"10.1016\/j.cct.2013.05.012_bb0155","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/01.mlr.0000114909.33878.ca","article-title":"The Parent Report Form of the CHIP-Child Edition: reliability and validity","volume":"42","author":"Riley","year":"2004","journal-title":"Med Care"},{"key":"10.1016\/j.cct.2013.05.012_bb0160","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/bmj.319.7211.670","article-title":"What is meant by intention to treat analysis? Survey of published randomised controlled trials","volume":"319","author":"Hollis","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.cct.2013.05.012_bb0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1139\/h06-014","article-title":"Physical activity during treatment in children with leukemia: a pilot study","volume":"31","author":"Aznar","year":"2006","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.cct.2013.05.012_bb0170","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jpeds.2005.01.055","article-title":"Evidence based physical activity for school-age youth","volume":"146","author":"Strong","year":"2005","journal-title":"J Pediatr"},{"key":"10.1016\/j.cct.2013.05.012_bb0175","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1126\/science.1203486","article-title":"Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion","volume":"331","author":"Schreiber","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.cct.2013.05.012_bb0180","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJMsa060185","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cct.2013.05.012_bb0185","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/leu.2010.54","article-title":"Exercise in adult and pediatric hematological cancer survivors: an intervention review","volume":"24","author":"Wolin","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.cct.2013.05.012_bb0190","first-page":"8","article-title":"Human natural killer cell subsets and acute exercise: a brief review","volume":"14","author":"Timmons","year":"2008","journal-title":"Exerc Immunol Rev"},{"key":"10.1016\/j.cct.2013.05.012_bb0195","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/physrev.2000.80.3.1055","article-title":"Exercise and the immune system: regulation, integration, and adaptation","volume":"80","author":"Pedersen","year":"2000","journal-title":"Physiol Rev"},{"key":"10.1016\/j.cct.2013.05.012_bb0200","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1152\/japplphysiol.00566.2004","article-title":"Randomized controlled trial of exercise and blood immune function in postmenopausal breast cancer survivors","volume":"98","author":"Fairey","year":"2005","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.cct.2013.05.012_bb0205","first-page":"307","article-title":"Effect of a periodized exercise training and active recovery program on antitumor activity and development of dendritic cells","volume":"46","author":"Liao","year":"2006","journal-title":"J Sports Med Phys Fitness"},{"key":"10.1016\/j.cct.2013.05.012_bb0210","doi-asserted-by":"crossref","first-page":"520258","DOI":"10.1155\/2010\/520258","article-title":"The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases","volume":"2010","author":"Brandt","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.cct.2013.05.012_bb0215","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1158\/1078-0432.CCR-05-1824","article-title":"Pediatric cancers are infiltrated predominantly by macrophages and contain a paucity of dendritic cells: a major nosologic difference with adult tumors","volume":"12","author":"Vakkila","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.cct.2013.05.012_bb0220","series-title":"Cancer epidemiology, biomarkers & prevention","first-page":"1588","article-title":"Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis","volume":"14","author":"Schmitz","year":"2005"},{"key":"10.1016\/j.cct.2013.05.012_bb0225","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1249\/MSS.0b013e3181c4dac1","article-title":"Exercise during hematopoietic stem cell transplant hospitalization in children","volume":"42","author":"Chamorro-Vina","year":"2010","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.cct.2013.05.012_bb0230","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1249\/MSS.0b013e318228c302","article-title":"Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial","volume":"44","author":"Santana Sosa","year":"2012","journal-title":"Med Sci Sports Exerc"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714413000797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714413000797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T02:40:44Z","timestamp":1645670444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714413000797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1551714413000797"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2013.05.012","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical Activity in Pediatric Cancer patients with solid tumors (PAPEC): Trial rationale and design","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2013.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}