{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:15:30Z","timestamp":1790262930200,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG047146-01"],"award-info":[{"award-number":["R01AG047146-01"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["contemporaryclinicaltrials.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.cct.2018.05.019","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T04:38:29Z","timestamp":1527827909000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Lithium Treatment for Agitation in Alzheimer's disease (Lit-AD): Clinical rationale and study design"],"prefix":"10.1016","volume":"71","author":[{"given":"D.P.","family":"Devanand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse G.","family":"Strickler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Huey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Crocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent P.","family":"Forester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa M.","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipsit V.","family":"Vahia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Pelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2018.05.019_bb0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archpsyc.1997.01830150083012","article-title":"The course of psychopathologic symptoms in mild to moderate Alzheimer's disease","volume":"54","author":"Devanand","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0010","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1176\/appi.ajp.157.5.708","article-title":"Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging","volume":"157","author":"Lyketsos","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0015","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1001\/archneur.62.10.1601","article-title":"Delusions and hallucinations are associated with worse outcome in Alzheimer disease","volume":"62","author":"Scarmeas","year":"2005","journal-title":"Arch. Neurol."},{"issue":"9","key":"10.1016\/j.cct.2018.05.019_bb0020","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1176\/appi.ajp.2012.11101529","article-title":"Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia","volume":"169","author":"Brodaty","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrneurol.2009.39","article-title":"Management of agitation and aggression associated with Alzheimer disease","volume":"5","author":"Ballard","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cct.2018.05.019_bb0030","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4088\/JCP.08m04606","article-title":"Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo controlled, multicenter 10-week study","volume":"70","author":"Hampel","year":"2009","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0035","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1192\/bjp.bp.110.080044","article-title":"Disease modifying properties of long term lithium treatment for amnestic mild cognitive impairment: randomized controlled trial","volume":"198","author":"Forlenza","year":"2011","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0040","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/gps.1964","article-title":"A feasibility and tolerability study of lithium in Alzheimer's disease","volume":"23","author":"Macdonald","year":"2008","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0045","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00004714-198202000-00013","article-title":"Successful treatment of dementia with lithium","volume":"2","author":"Havens","year":"1982","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.cct.2018.05.019_bb0050","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1017\/S0007125000120197","article-title":"The use of lithium in severely demented patiens with behavioural disturbance","volume":"146","author":"Holton","year":"1985","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.cct.2018.05.019_bb0055","first-page":"117","article-title":"Possible lithium-induced extrapyramidal effects in Alzheimer's disease","volume":"6","author":"Randels","year":"1984","journal-title":"Hillside J. Clin. Psychiatry"},{"key":"10.1016\/j.cct.2018.05.019_bb0060","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1755-5949.2011.00260.x","article-title":"Lithium: still a major option in the management of bipolar disorder","volume":"18","author":"Licht","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.cct.2018.05.019_bb0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-0327(01)00380-9","article-title":"Lithium treatment at 52","volume":"67","author":"Schou","year":"2001","journal-title":"J. Affect. Disord."},{"issue":"4","key":"10.1016\/j.cct.2018.05.019_bb0070","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.kjms.2011.10.025","article-title":"Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: an update review","volume":"28","author":"Yeh","year":"2012","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.cct.2018.05.019_bb0075","author":"ClinicalTrials.gov [Internet]. Bethesda (MD)"},{"key":"10.1016\/j.cct.2018.05.019_bb0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/WAD.0000000000000161","article-title":"Low-dose Lithium treatment for agitation and psychosis in Alzheimer's disease and Frontotemporal dementia: a case series","volume":"31","author":"Devanand","year":"2017","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"7","key":"10.1016\/j.cct.2018.05.019_bb0085","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.cct.2018.05.019_bb0090","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement."},{"issue":"5","key":"10.1016\/j.cct.2018.05.019_bb0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/1060028014524375","article-title":"Lithium dosing equations: are they accurate?","volume":"48","author":"Nichols","year":"2014","journal-title":"Ann. Pharmacother."},{"issue":"10","key":"10.1016\/j.cct.2018.05.019_bb0100","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1001\/jama.285.10.1299","article-title":"Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial","volume":"285","author":"Sackeim","year":"2001","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.cct.2018.05.019_bb0105","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2217\/pgs.11.102","article-title":"Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder","volume":"12","author":"Squassina","year":"2011","journal-title":"Pharmacogenomics"},{"issue":"5","key":"10.1016\/j.cct.2018.05.019_bb0110","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/sj.mp.4000888","article-title":"Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium","volume":"6","author":"Turecki","year":"2001","journal-title":"Mol. Psychiatry"},{"issue":"3","key":"10.1016\/j.cct.2018.05.019_bb0115","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3233\/JAD-2009-1004","article-title":"Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease","volume":"16","author":"Leyhe","year":"2009","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.cct.2018.05.019_bb0120","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1056\/NEJMoa1114058","article-title":"Relapse risk after discontinuation of risperidone in Alzheimer's disease","volume":"367","author":"Devanand","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.cct.2018.05.019_bb0125","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2190\/UURL-2RYU-WRYD-EY3K","article-title":"A measure of primary sociobiological functions","volume":"6","author":"Katz","year":"1976","journal-title":"Int. J. Health Serv."},{"issue":"3","key":"10.1016\/j.cct.2018.05.019_bb0130","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2340\/165019778416125132","article-title":"Katz index of independence in ADL: reliability and validity in short-term care","volume":"16","author":"Brorsson","year":"1984","journal-title":"Scand. J. Rehabil. Med."},{"issue":"9817","key":"10.1016\/j.cct.2018.05.019_bb0135","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(11)61516-X","article-title":"Lithium toxicity profile: a systematic review and meta-analysis","volume":"379","author":"McKnight","year":"2012","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.cct.2018.05.019_bb0140","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jad.2010.04.018","article-title":"Effects of chronic lithium treatment on renal function","volume":"126","author":"Tredget","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.cct.2018.05.019_bb0145","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/JCP.0b013e31823607db","article-title":"Lithium-induced renal insufficiency: a longitudinal study of creatinine increases in intellectually disabled adults","volume":"31","author":"Janowsky","year":"2011","journal-title":"J. Clin. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.cct.2018.05.019_bb0150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1053\/j.ackd.2010.03.010","article-title":"ESRD in the elderly: current prevalence, future projections, and clinical significance","volume":"17","author":"Stevens","year":"2010","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.cct.2018.05.019_bb0155","series-title":"Applied Mixed Models in Medicine","author":"Brown","year":"1999"},{"key":"10.1016\/j.cct.2018.05.019_bb0160","series-title":"Analysis of Longitudinal Data","author":"Diggle","year":"2002"},{"issue":"3","key":"10.1016\/j.cct.2018.05.019_bb0165","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1541-0420.2007.00769.x","article-title":"Sample size determination for hierarchical longitudinal designs with differential attrition rates","volume":"63","author":"Roy","year":"2007","journal-title":"Biometrics"},{"issue":"7","key":"10.1016\/j.cct.2018.05.019_bb0170","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/jama.2014.93","article-title":"Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial","volume":"311","author":"Porsteinsson","year":"2014","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.cct.2018.05.019_bb0175","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1001\/archgenpsychiatry.2011.72","article-title":"Alzheimer's disease cooperative study group: chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease","volume":"68","author":"Tariot","year":"2011","journal-title":"Arch. Gen. Psychiatry"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714418301435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714418301435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T22:59:26Z","timestamp":1693695566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714418301435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":35,"alternative-id":["S1551714418301435"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2018.05.019","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lithium Treatment for Agitation in Alzheimer's disease (Lit-AD): Clinical rationale and study design","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2018.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}