{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:57:45Z","timestamp":1761555465949,"version":"build-2065373602"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.cct.2021.106334","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T18:13:20Z","timestamp":1614449600000},"page":"106334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma"],"prefix":"10.1016","volume":"104","author":[{"given":"William J.","family":"Sheehan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Mauger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James N.","family":"Moy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley J.","family":"Szefler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Cabana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronina","family":"Covar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel G.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Phipatanakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.cct.2021.106334_bb0005","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.injury.2010.03.033","article-title":"Challenging issues in randomised controlled trials","volume":"41","author":"Nichol","year":"2010","journal-title":"Injury"},{"key":"10.1016\/j.cct.2021.106334_bb0010","doi-asserted-by":"crossref","DOI":"10.1542\/peds.109.2.e20","article-title":"Asthma morbidity after the short-term use of ibuprofen in children","volume":"109","author":"Lesko","year":"2002","journal-title":"Pediatrics"},{"key":"10.1016\/j.cct.2021.106334_bb0015","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(08)61445-2","article-title":"Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6\u20137 years: analysis from Phase Three of the ISAAC programme","volume":"372","author":"Beasley","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.cct.2021.106334_bb0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1164\/rccm.201005-0757OC","article-title":"Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three","volume":"183","author":"Beasley","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cct.2021.106334_bb0025","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jaci.2005.05.045","article-title":"Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, Ethiopia","volume":"116","author":"Davey","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cct.2021.106334_bb0030","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1164\/rccm.200409-1269OC","article-title":"The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function","volume":"171","author":"McKeever","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cct.2021.106334_bb0035","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2222.2010.03610.x","article-title":"The effects of early and late paracetamol exposure on asthma and atopy: a birth cohort","volume":"41","author":"Wickens","year":"2011","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.cct.2021.106334_bb0040","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1542\/peds.2008-2869","article-title":"Medication use among children <12 years of age in the United States: results from the Slone Survey","volume":"124","author":"Vernacchio","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.cct.2021.106334_bb0045","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1542\/peds.2011-1106","article-title":"The association of acetaminophen and asthma prevalence and severity","volume":"128","author":"McBride","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.cct.2021.106334_bb0050","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jaci.2014.07.065","article-title":"Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children","volume":"135","author":"Sordillo","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cct.2021.106334_bb0055","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaci.2010.08.023","article-title":"Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood","volume":"126","author":"Schnabel","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cct.2021.106334_bb0060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1056\/NEJMoa1515990","article-title":"Acetaminophen versus ibuprofen in young children with mild persistent asthma","volume":"375","author":"Sheehan","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cct.2021.106334_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2016.09.028","article-title":"Individualized therapy for persistent asthma in young children","volume":"138","author":"Fitzpatrick","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cct.2021.106334_bb0070","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.jaci.2007.09.029","article-title":"Guidelines for the diagnosis and management of asthma - Summary Report 2007","volume":"120","author":"(EPR-3) EPR","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.cct.2021.106334_bb0075","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1542\/peds.2010-3852","article-title":"Fever and antipyretic use in children","volume":"127","author":"Sullivan","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.cct.2021.106334_bb0080","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0009922812462764","article-title":"The effect of a single dose of acetaminophen on airways response in children with asthma","volume":"52","author":"Soferman","year":"2013","journal-title":"Clin. Pediatr. (Phila)"},{"key":"10.1016\/j.cct.2021.106334_bb0085","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004324","article-title":"Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults","volume":"4","author":"Ioannides","year":"2014","journal-title":"BMJ Open"},{"key":"10.1016\/j.cct.2021.106334_bb0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/thx.2009.121459","article-title":"Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort","volume":"65","author":"Perzanowski","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.cct.2021.106334_bb0095","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2222.2005.02151.x","article-title":"Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood","volume":"35","author":"Shaheen","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.cct.2021.106334_bb0100","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/cea.12433","article-title":"Randomized controlled trial of asthma risk with paracetamol use in infancy--a feasibility study","volume":"45","author":"Riley","year":"2015","journal-title":"Clin. Exp. Allergy"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421000707?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421000707?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:51:45Z","timestamp":1761555105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714421000707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":20,"alternative-id":["S1551714421000707"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2021.106334","relation":{},"ISSN":["1551-7144"],"issn-type":[{"type":"print","value":"1551-7144"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2021.106334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106334"}}