{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:03:44Z","timestamp":1788260624896,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.cct.2021.106462","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T12:09:50Z","timestamp":1622462990000},"page":"106462","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Individualized prescribing portraits to reduce inappropriate initiation of opioid analgesics to opioid na\u00efve patients in primary care: Protocol for a randomized controlled trial"],"prefix":"10.1016","volume":"107","author":[{"given":"J.","family":"Klimas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Carney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.R.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Croteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dormuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maclure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Soc\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"McCracken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cct.2021.106462_bb0005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s13181-012-0269-4","article-title":"Dependence and addiction during chronic opioid therapy","volume":"8","author":"Juurlink","year":"2012","journal-title":"J. Med. Toxicol."},{"issue":"18","key":"10.1016\/j.cct.2021.106462_bb0010","doi-asserted-by":"crossref","first-page":"E659","DOI":"10.1503\/cmaj.170363","article-title":"Guideline for opioid therapy and chronic noncancer pain","volume":"189","author":"Busse","year":"2017","journal-title":"CMAJ"},{"issue":"5","key":"10.1016\/j.cct.2021.106462_bb0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/M17-0865","article-title":"Prescription opioid use, misuse, and use disorders in U.S. adults: 2015 national survey on drug use and health","volume":"167","author":"Han","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cct.2021.106462_bb0020","series-title":"Canadian Drug Summary: Prescription Opioids","author":"Canadian Centre on Substance Abuse","year":"2015"},{"key":"10.1016\/j.cct.2021.106462_bb0025","series-title":"Behind the Prescriptions: A Snapshot of Opioid Use Across All Ontarians","author":"Gomes","year":"2017"},{"issue":"6","key":"10.1016\/j.cct.2021.106462_bb0030","first-page":"465","article-title":"Opioid prescribing is a surrogate for inadequate pain management resources","volume":"62","author":"Finestone","year":"2016","journal-title":"Can. Fam. Physician"},{"issue":"23","key":"10.1016\/j.cct.2021.106462_bb0035","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1001\/jama.2018.18472","article-title":"Opioids for chronic noncancer pain: a systematic review and meta-analysis","volume":"320","author":"Busse","year":"2018","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.cct.2021.106462_bb0040","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/jama.2018.0899","article-title":"Effect of opioid vs nonopioid medications on pain- related function in patients with chronic back pain or hip or knee osteoarthritis pain: the SPACE randomized clinical trial","volume":"319","author":"Krebs","year":"2018","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.cct.2021.106462_bb0045","doi-asserted-by":"crossref","first-page":"276","DOI":"10.7326\/M14-2559","article-title":"The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop","volume":"162","author":"Chou","year":"2015","journal-title":"Ann. Intern. Med."},{"issue":"19","key":"10.1016\/j.cct.2021.106462_bb0050","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1001\/jama.2019.15802","article-title":"Pain management with opioids in 2019-2020","volume":"322","author":"Wood","year":"2019","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.cct.2021.106462_bb0055","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jamapsychiatry.2018.1867","article-title":"Effect of peer comparison letters for high-volume primary care prescribers of quetiapine in older and disabled adults: a randomized clinical trial","volume":"75","author":"Sacarny","year":"2018","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1016\/j.cct.2021.106462_bb0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/chp.21140","article-title":"A randomized trial assessing the impact of a personal printed feedback portrait on statin prescribing in primary care","volume":"32","author":"Dormuth","year":"2012","journal-title":"J. Contin. Educ. Heal. Prof."},{"issue":"6","key":"10.1016\/j.cct.2021.106462_bb0065","article-title":"Audit and feedback: effects on professional practice and healthcare outcomes","author":"Ivers","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"issue":"5","key":"10.1016\/j.cct.2021.106462_bb0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/fampra\/cmh515","article-title":"Better Prescribing Project: a randomized controlled trial of the impact of case-based educational modules and personal prescribing feedback on prescribing for hypertension in primary care","volume":"21","author":"Herbert","year":"2004","journal-title":"Fam. Pract."},{"issue":"9132","key":"10.1016\/j.cct.2021.106462_bb0075","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0140-6736(97)11390-3","article-title":"Influences of educational interventions and adverse news about calcium-channel blockers on first-line prescribing of antihypertensive drugs to elderly people in British Columbia","volume":"352","author":"Maclure","year":"1998","journal-title":"Lancet (London, England)"},{"issue":"5","key":"10.1016\/j.cct.2021.106462_bb0080","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.3365","article-title":"Strategies to identify patient risks of prescription opioid addiction when initiating opioids for pain: a systematic review","volume":"2","author":"Klimas","year":"2019","journal-title":"JAMA Netw. Open"},{"issue":"7","key":"10.1016\/j.cct.2021.106462_bb0085","first-page":"234","article-title":"Think twice: evidence-based opioid sparing approaches to pain management","volume":"62","author":"Klimas","year":"2020","journal-title":"BC Med. J."},{"issue":"7441","key":"10.1016\/j.cct.2021.106462_bb0090","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.328.7441.702","article-title":"CONSORT statement: extension to cluster randomised trials","volume":"328","author":"Campbell","year":"2004","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.cct.2021.106462_bb0095","doi-asserted-by":"crossref","DOI":"10.2196\/12474","article-title":"Development and evaluation of the online addiction medicine certificate: free novel program in a Canadian setting","volume":"5","author":"Gorfinkel","year":"2019","journal-title":"JMIR Med. Educ."},{"key":"10.1016\/j.cct.2021.106462_bb0100","first-page":"35","article-title":"A62 \u201cOptimizing strategies to reduce initiation of prescription opioid analgesics to opioid na\u00efve patients in primary care: study design and protocol\u201d (IS12)","volume":"15","author":"Klimas","year":"2020"},{"issue":"5","key":"10.1016\/j.cct.2021.106462_bb0105","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-025567","article-title":"Outcomes associated with hospital admissions for accidental opioid overdose in British Columbia: a retrospective cohort study","volume":"9","author":"Morrow","year":"2019","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.cct.2021.106462_bb0110","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1741-3737.2011.00861.x","article-title":"Toward best practices in analyzing datasets with missing data: comparisons and recommendations","volume":"73","author":"Johnson","year":"2011","journal-title":"J. Marriage Fam."},{"issue":"16","key":"10.1016\/j.cct.2021.106462_bb0115","doi-asserted-by":"crossref","first-page":"E852","DOI":"10.1503\/cmaj.120465","article-title":"Effect of a centralized prescription network on inappropriate prescriptions for opioid analgesics and benzodiazepines","volume":"184","author":"Dormuth","year":"2012","journal-title":"Can. Med. Assoc. J."},{"key":"10.1016\/j.cct.2021.106462_bb0120","series-title":"The Design and Analysis of Sequential Clinical Trials","author":"Whitehead","year":"1997"},{"key":"10.1016\/j.cct.2021.106462_bb0125","series-title":"Paper Presented at the Therapeutics Initiative Conference on Oct 5th in Vancouver, BC","article-title":"Prescriber know thyself: The utility of personalized prescribing feedback","author":"McCracken","year":"2019"},{"issue":"8","key":"10.1016\/j.cct.2021.106462_bb0130","first-page":"II46","article-title":"Successes and failures in the implementation of evidence-based guidelines for clinical practice","volume":"39","author":"Grol","year":"2001","journal-title":"Med. Care"},{"key":"10.1016\/j.cct.2021.106462_bb0135","doi-asserted-by":"crossref","DOI":"10.1177\/1525822X05279903","article-title":"How many interviews are enough?: An experiment with data saturation and variability","volume":"18","author":"Guest","year":"2006","journal-title":"Field Methods"},{"issue":"1","key":"10.1016\/j.cct.2021.106462_bb0140","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12909-017-0862-y","article-title":"Two birds with one stone: experiences of combining clinical and research training in addiction medicine","volume":"17","author":"Klimas","year":"2017","journal-title":"BMC Med. Educ."},{"key":"10.1016\/j.cct.2021.106462_bb0145","doi-asserted-by":"crossref","DOI":"10.1080\/02791072.2014.991859","article-title":"Alcohol screening among opioid agonist patients in a primary care clinic and an opioid treatment program","volume":"47","author":"Klimas","year":"2015","journal-title":"J. Psychoactive Drugs"},{"issue":"2","key":"10.1016\/j.cct.2021.106462_bb0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1191\/1478088706qp063oa","article-title":"Using thematic analysis in psychology","volume":"3","author":"Braun","year":"2006","journal-title":"Qual. Res. Psychol."},{"key":"10.1016\/j.cct.2021.106462_bb0155","first-page":"1","article-title":"Addiction social work fellowship program in Canada","author":"Callon","year":"2018","journal-title":"J. Soc. Work. Pract. Addict."},{"issue":"3","key":"10.1016\/j.cct.2021.106462_bb0160","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/JAN.0000000000000179","article-title":"Nursing fellowship in addiction medicine: a novel program in a Canadian setting","volume":"28","author":"Voon","year":"2017","journal-title":"J. Addict. Nurs."},{"issue":"2","key":"10.1016\/j.cct.2021.106462_bb0165","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1037\/0022-0167.52.2.250","article-title":"Quality and trustworthiness in qualitative research in counseling psychology","volume":"52","author":"Morrow","year":"2005","journal-title":"J. Couns. Psychol."},{"issue":"4\u20135","key":"10.1016\/j.cct.2021.106462_bb0170","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/10503300802702113","article-title":"Achieving trustworthiness in qualitative research: a pan-paradigmatic perspective","volume":"19","author":"Williams","year":"2009","journal-title":"Psychother. Res."},{"issue":"8","key":"10.1016\/j.cct.2021.106462_bb0175","doi-asserted-by":"crossref","first-page":"437","DOI":"10.7547\/87507315-91-8-437","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"91","author":"Moher","year":"2001","journal-title":"J. Am. Podiatr. Med. Assoc."},{"issue":"3","key":"10.1016\/j.cct.2021.106462_bb0180","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","article-title":"SPIRIT 2013 statement: defining standard protocol items for clinical trials","volume":"158","author":"Chan","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.cct.2021.106462_bb0185","author":"Current Controlled Trials [Internet]"},{"issue":"5","key":"10.1016\/j.cct.2021.106462_bb0190","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jech-2018-210599","article-title":"Public health responses to the opioid crisis in North America","volume":"73","author":"Kerr","year":"2019","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.cct.2021.106462_bb0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jsat.2019.05.001","article-title":"Opioid medication discontinuation and risk of adverse opioid-related health care events","volume":"103","author":"Mark","year":"2019","journal-title":"J. Subst. Abus. Treat."}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421001981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421001981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:53:17Z","timestamp":1761555197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714421001981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":39,"alternative-id":["S1551714421001981"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2021.106462","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individualized prescribing portraits to reduce inappropriate initiation of opioid analgesics to opioid na\u00efve patients in primary care: Protocol for a randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2021.106462","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106462"}}