{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:42:09Z","timestamp":1776490929896,"version":"3.51.2"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006093","name":"PCORI","doi-asserted-by":"publisher","award":["COVID-19-2020-001"],"award-info":[{"award-number":["COVID-19-2020-001"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.cct.2021.106525","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T03:35:47Z","timestamp":1628393747000},"page":"106525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform"],"prefix":"10.1016","volume":"109","author":[{"given":"Anne","family":"Friedland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian F.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin J.","family":"Anstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei Lin","family":"Chen-Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren W.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith S.","family":"Currier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Forrest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Fraulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoop","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Handberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Jackman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Koellhoffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee","family":"Leverty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patty","family":"McAdams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"McCourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Mickley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Hasan","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clyde","family":"Prater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell L.","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Shenkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Shostak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kisha Batey","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Webb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Naggie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2021.106525_bb0005","series-title":"Coronavirus Disease 2019 (COVID-19): Epidemiology, Virology, and Prevention - UpToDate","author":"McIntosh","year":"2021"},{"key":"10.1016\/j.cct.2021.106525_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/S2468-2667(20)30164-X","article-title":"Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study","author":"Nguyen","year":"2020","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.cct.2021.106525_bb0015","doi-asserted-by":"crossref","DOI":"10.5582\/bst.2020.01043","article-title":"Challenges to the system of reserve medical supplies for public health emergencies: reflections on the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in China","author":"Wang","year":"2020","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.cct.2021.106525_bb0020","doi-asserted-by":"crossref","DOI":"10.1007\/s11606-020-06529-z","article-title":"Impact of the early phase of the COVID-19 pandemic on US healthcare workers: results from the HERO registry","author":"Forrest","year":"2021","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.cct.2021.106525_bb0025","doi-asserted-by":"crossref","DOI":"10.1080\/1062936X.2017.1411642","article-title":"Repurposing drugs for use against Zika virus infection$","author":"Devillers","year":"2018","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.cct.2021.106525_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.curtheres.2017.01.007","article-title":"Repurposed therapeutic agents targeting the Ebola virus: a systematic review","author":"Sweiti","year":"2017","journal-title":"Curr. Ther. Res. - Clin. Exp."},{"key":"10.1016\/j.cct.2021.106525_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.26193","article-title":"Hydroxychloroquine treatment in COVID-19: a descriptive observational analysis of 30 cases from a single center in Wuhan, China","author":"Xue","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.cct.2021.106525_bb0040","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa237","article-title":"In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","author":"Yao","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.cct.2021.106525_bb0045","article-title":"Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro","author":"Liu","year":"2020","journal-title":"Cell Disc."},{"key":"10.1016\/j.cct.2021.106525_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinepi.2020.09.036","article-title":"PCORnet\u00ae 2020: current state, accomplishments, and future directions","author":"Forrest","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.cct.2021.106525_bb0055","doi-asserted-by":"crossref","DOI":"10.1136\/amiajnl-2014-002747","article-title":"Launching PCORnet, a national patient-centered clinical research network","author":"Fleurence","year":"2014","journal-title":"J. Am. Med. Inform. Assoc."},{"key":"10.1016\/j.cct.2021.106525_bb0060","doi-asserted-by":"crossref","DOI":"10.2165\/00003088-199325050-00005","article-title":"Clinical pharmacokinetics of slow-acting Antirheumatic drugs","author":"Tett","year":"1993","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.cct.2021.106525_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/job.4030020205","article-title":"The measurement of experienced burnout","author":"Maslach","year":"1981","journal-title":"J. Organ. Behav."},{"key":"10.1016\/j.cct.2021.106525_bb0070","doi-asserted-by":"crossref","DOI":"10.1590\/S0034-89102005000100001","article-title":"Factorial validity of the Maslach burnout inventory (MBI-HSS) among Spanish professionals","author":"Gil-Monte","year":"2005","journal-title":"Rev. Saude Publica"},{"key":"10.1016\/j.cct.2021.106525_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/j.1442-2018.2006.00283.x","article-title":"Factor structure of the Maslach burnout inventory among Finnish nursing staff","author":"Kanste","year":"2006","journal-title":"Nurs. Health Sci."},{"key":"10.1016\/j.cct.2021.106525_bb0080","doi-asserted-by":"crossref","DOI":"10.1007\/s11606-009-1129-z","article-title":"Single item measures of emotional exhaustion and depersonalization are useful for assessing burnout in medical professionals","author":"West","year":"2009","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.cct.2021.106525_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/smi.1002","article-title":"Validation of a single-item measure of burnout against the Maslach Burnout Inventory among physicians","author":"Rohland","year":"2004","journal-title":"Stress. Health"},{"key":"10.1016\/j.cct.2021.106525_bb0090","doi-asserted-by":"crossref","DOI":"10.1001\/archgenpsychiatry.2010.41","article-title":"A prospective cohort study investigating factors associated with depression during medical internship","author":"Sen","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.cct.2021.106525_bb0095","doi-asserted-by":"crossref","DOI":"10.1177\/1073191111411667","article-title":"Item banks for measuring emotional distress from the patient-reported outcomes measurement information system (PROMIS\u00ae): depression, anxiety, and anger","author":"Pilkonis","year":"2011","journal-title":"Assessment"},{"key":"10.1016\/j.cct.2021.106525_bb0100","doi-asserted-by":"crossref","DOI":"10.1177\/1073191116685809","article-title":"Psychometric properties of 7- and 30-day versions of the PROMIS emotional distress item banks in an Australian adult sample","author":"Batterham","year":"2019","journal-title":"Assessment"},{"key":"10.1016\/j.cct.2021.106525_bb0105","article-title":"Clinical validity of PROMIS depression, anxiety, and anger across diverse clinical samples","author":"Schalet","year":"2016","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.cct.2021.106525_bb0110","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2010-0852","article-title":"Evaluation of the PHQ-2 as a brief screen for detecting major depression among adolescents","author":"Richardson","year":"2010","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.cct.2021.106525_bb0120","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"Patient health questionnaire (PHQ-9)","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"10.1016\/j.cct.2021.106525_bb0125","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2016638","article-title":"A randomized trial of Hydroxychloroquine as Postexposure prophylaxis for Covid-19","author":"Boulware","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cct.2021.106525_bb0130","article-title":"Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: a randomized trial","author":"Rajasingham","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.cct.2021.106525_bb0145","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12016-010-8243-x","article-title":"Hydroxychloroquine: from malaria to autoimmunity","volume":"42","author":"Ben-Zvi","year":"2012","journal-title":"Clin. Rev. Allerg. Immunol."},{"issue":"4","key":"10.1016\/j.cct.2021.106525_bb0150","doi-asserted-by":"crossref","DOI":"10.2196\/medinform.8092","article-title":"Patient portal use and experience among older adults: systematic review","volume":"5","author":"Sakaguchi-Tang","year":"2017","journal-title":"JMIR Med. Inform."}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421002615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421002615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:53:40Z","timestamp":1761555220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714421002615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":27,"alternative-id":["S1551714421002615"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2021.106525","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2021.106525","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106525"}}