{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:57:46Z","timestamp":1761555466582,"version":"build-2065373602"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"am","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["U54DA016511"],"award-info":[{"award-number":["U54DA016511"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000124","name":"Office of Research on Women's Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.cct.2021.106616","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T21:15:26Z","timestamp":1635801326000},"page":"106616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial"],"prefix":"10.1016","volume":"111","author":[{"given":"Constance","family":"Guille","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viswanathan","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel","family":"Baker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Nunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimee","family":"McRae-Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Brady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6 Pt 2","key":"10.1016\/j.cct.2021.106616_bb0005","first-page":"20","article-title":"Central noradrenergic neurons: a locus for the functional interplay between alpha-2 adrenoceptors and opiate receptors","volume":"43","author":"Aghajanian","year":"1982","journal-title":"J. Clin. Psychiatry"},{"author":"Ahmad","key":"10.1016\/j.cct.2021.106616_bb0010"},{"issue":"1","key":"10.1016\/j.cct.2021.106616_bb0015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00213-004-2129-7","article-title":"Gender differences in stress reactivity among cocaine-dependent individuals","volume":"180","author":"Back","year":"2005","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.cct.2021.106616_bb0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res. Brain Res. Rev."},{"issue":"4","key":"10.1016\/j.cct.2021.106616_bb0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/archgenpsychiatry.2009.9","article-title":"Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals","volume":"66","author":"Brady","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"issue":"5","key":"10.1016\/j.cct.2021.106616_bb0030","doi-asserted-by":"crossref","first-page":"700","DOI":"10.15288\/jsa.2006.67.700","article-title":"The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response","volume":"67","author":"Brady","year":"2006","journal-title":"J. Stud. Alcohol"},{"issue":"3","key":"10.1016\/j.cct.2021.106616_bb0035","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0376-8716(98)00040-4","article-title":"Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal","volume":"50","author":"Carnwath","year":"1998","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.cct.2021.106616_bb0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.drugalcdep.2017.11.021","article-title":"Stress responding in cannabis smokers as a function of trauma exposure, sex, and relapse in the human laboratory","volume":"185","author":"Chao","year":"2018","journal-title":"Drug Alcohol Depend."},{"issue":"5","key":"10.1016\/j.cct.2021.106616_bb0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1360-0443.1986.tb00385.x","article-title":"Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal and reductions in both through extinction","volume":"81","author":"Childress","year":"1986","journal-title":"Br. J. Addict."},{"issue":"7","key":"10.1016\/j.cct.2021.106616_bb0050","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/jamapsychiatry.2014.366","article-title":"The changing face of heroin use in the United States: a retrospective analysis of the past 50 years","volume":"71","author":"Cicero","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"4","key":"10.1016\/j.cct.2021.106616_bb0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"issue":"13","key":"10.1016\/j.cct.2021.106616_bb0060","doi-asserted-by":"crossref","first-page":"RC152","DOI":"10.1523\/JNEUROSCI.21-13-j0001.2001","article-title":"Evidence for functional release of endogenous opioids in the locus ceruleus during stress termination","volume":"21","author":"Curtis","year":"2001","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"issue":"12","key":"10.1016\/j.cct.2021.106616_bb0065","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1111\/j.1360-0443.2007.02025.x","article-title":"Risk of fatal overdose during and after specialist drug treatment: the VEdeTTE study, a national multi-site prospective cohort study","volume":"102","author":"Davoli","year":"2007","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.cct.2021.106616_bb0070","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1037\/0033-2909.130.3.355","article-title":"Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research","volume":"130","author":"Dickerson","year":"2004","journal-title":"Psychol. Bull."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0075","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0893-133X(99)00158-X","article-title":"Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking","volume":"23","author":"Erb","year":"2000","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.cct.2021.106616_bb0080","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1530-0277.2011.01628.x","article-title":"Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings","volume":"36","author":"Fox","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"6","key":"10.1016\/j.cct.2021.106616_bb0090","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/npp.2014.1","article-title":"Sex differences in guanfacine effects on drug craving and stress arousal in cocaine-dependent individuals","volume":"39","author":"Fox","year":"2014","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.cct.2021.106616_bb0095","first-page":"217","article-title":"The role of guanfacine as a therapeutic agent to address stress-related pathophysiology in cocaine-dependent individuals","volume":"69","author":"Fox","year":"2014","journal-title":"Adv. Pharmacol. (San Diego, CA)"},{"key":"10.1016\/j.cct.2021.106616_bb0100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.addbeh.2018.12.022","article-title":"Gender differences in subjective stress and neuroendocrine response to a stress task among individuals with opioid dependence: a pilot study","volume":"92","author":"Gilmore","year":"2019","journal-title":"Addict. Behav."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1345\/aph.1M347","article-title":"Lofexidine, an {alpha}2-receptor agonist for opioid detoxification","volume":"44","author":"Gish","year":"2010","journal-title":"Ann. Pharmacother."},{"issue":"19","key":"10.1016\/j.cct.2021.106616_bb0110","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1001\/jama.1988.03720190031026","article-title":"Heavy smokers, smoking cessation, and clonidine. Results of a double-blind, randomized trial","volume":"259","author":"Glassman","year":"1988","journal-title":"Jama"},{"issue":"8090","key":"10.1016\/j.cct.2021.106616_bb0115","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(78)92823-4","article-title":"Clonidine blocks acute opiate-withdrawal symptoms","volume":"2","author":"Gold","year":"1978","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.cct.2021.106616_bb0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.drugalcdep.2017.02.020","article-title":"A phase III, randomized, multi-center, double blind, placebo controlled study of safety and efficacy of lofexidine for relief of symptoms in individuals undergoing inpatient opioid withdrawal","volume":"176","author":"Gorodetzky","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.cct.2021.106616_bb0125","article-title":"Alpha2-adrenergic agonists for the management of opioid withdrawal","volume":"2","author":"Gowing","year":"2009","journal-title":"Cochr. Datab. Syst. Rev."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.psc.2010.01.004","article-title":"Substance abuse in women","volume":"33","author":"Greenfield","year":"2010","journal-title":"Psychiatric Clinics N. Am."},{"issue":"4","key":"10.1016\/j.cct.2021.106616_bb0135","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jsat.2006.05.009","article-title":"Heroin and cocaine craving and use during treatment: measurement validation and potential relationships","volume":"31","author":"Heinz","year":"2006","journal-title":"J. Subst. Abus. Treat."},{"issue":"3","key":"10.1016\/j.cct.2021.106616_bb0140","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0893-133X(01)00227-5","article-title":"Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats","volume":"25","author":"Highfield","year":"2001","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1037\/1064-1297.15.2.134","article-title":"Stress and drug-cue-induced craving in opioid-dependent individuals in naltrexone treatment","volume":"15","author":"Hyman","year":"2007","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.cct.2021.106616_bb0150","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.addbeh.2016.08.027","article-title":"The paradox of decreasing nonmedical opioid analgesic use and increasing abuse or dependence - an assessment of demographic and substance use trends, United States, 2003-2014","volume":"65","author":"Jones","year":"2017","journal-title":"Addict. Behav."},{"issue":"1","key":"10.1016\/j.cct.2021.106616_bb0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0376-8716(96)01316-6","article-title":"Double-blind study of lofexidine and clonidine in the detoxification of opiate addicts in hospital","volume":"44","author":"Kahn","year":"1997","journal-title":"Drug Alcohol Depend."},{"issue":"Pt B","key":"10.1016\/j.cct.2021.106616_bb0160","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neuropharm.2013.05.024","article-title":"Addiction as a stress surfeit disorder","volume":"76","author":"Koob","year":"2014","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.cct.2021.106616_bb0165","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1176\/appi.ajp.2014.14081014","article-title":"Clonidine maintenance prolongs opioid abstinence and decouples stress from craving in daily life: a randomized controlled trial with ecological momentary assessment","volume":"172","author":"Kowalczyk","year":"2015","journal-title":"Am. J. Psychiatry"},{"year":"2008","series-title":"International Affective Picture System (IAPS): Affective ratings of pictures and instruction manual [Technical Report A-8]","author":"Lang","key":"10.1016\/j.cct.2021.106616_bb0170"},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0175","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s00213-004-2036-y","article-title":"Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats","volume":"179","author":"L\u00ea","year":"2005","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0180","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0376-8716(97)00116-6","article-title":"Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal","volume":"48","author":"Lin","year":"1997","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.cct.2021.106616_bb0185","article-title":"Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence","volume":"3","author":"Mattick","year":"2009","journal-title":"Cochr. Datab. Syst. Rev."},{"key":"10.1016\/j.cct.2021.106616_bb0190","article-title":"Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence","volume":"2","author":"Mattick","year":"2014","journal-title":"Cochr. Datab. Syst. Rev."},{"issue":"6","key":"10.1016\/j.cct.2021.106616_bb0195","doi-asserted-by":"crossref","first-page":"202","DOI":"10.15585\/mmwr.mm7006a4","article-title":"Trends and geographic patterns in drug and synthetic opioid overdose deaths - United States, 2013-2019","volume":"70","author":"Mattson","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0200","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00213-019-05392-z","article-title":"The influence of gender and oxytocin on stress reactivity, cigarette craving, and smoking in a randomized, placebo-controlled laboratory relapse paradigm","volume":"237","author":"McClure","year":"2020","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.cct.2021.106616_bb0205","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/0269881114562091","article-title":"A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation","volume":"29","author":"McKee","year":"2015","journal-title":"J. Psychopharmacol. (Oxford, England)"},{"issue":"1\u20132","key":"10.1016\/j.cct.2021.106616_bb0210","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jnr.23860","article-title":"Impact of gender on corticotropin-releasing factor and noradrenergic sensitivity in cocaine use disorder","volume":"95","author":"McRae-Clark","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"21","key":"10.1016\/j.cct.2021.106616_bb0215","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1007\/s00213-014-3555-9","article-title":"Yohimbine administration and cue-reactivity in cocaine-dependent individuals","volume":"231","author":"Moran-Santa Maria","year":"2014","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0220","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.chiabu.2013.09.004","article-title":"Adverse Childhood Experiences (ACEs) questionnaire and Adult Attachment Interview (AAI): implications for parent child relationships","volume":"38","author":"Murphy","year":"2014","journal-title":"Child Abuse Negl."},{"year":"1987","series-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","key":"10.1016\/j.cct.2021.106616_bb0225"},{"issue":"1","key":"10.1016\/j.cct.2021.106616_bb0230","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1460-9568.2000.00899.x","article-title":"Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons","volume":"12","author":"Shaham","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"Suppl. 20","key":"10.1016\/j.cct.2021.106616_bb0235","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"year":"2012","series-title":"Imagery Script Development Procedures Manual","author":"Sinha","key":"10.1016\/j.cct.2021.106616_bb0240"},{"issue":"5","key":"10.1016\/j.cct.2021.106616_bb0245","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11920-007-0050-6","article-title":"The role of stress in addiction relapse","volume":"9","author":"Sinha","year":"2007","journal-title":"Curr. Psychiatry Rep."},{"issue":"4","key":"10.1016\/j.cct.2021.106616_bb0250","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00213-006-0640-8","article-title":"Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings","volume":"190","author":"Sinha","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.cct.2021.106616_bb0255","series-title":"Measuring Alcohol Consumption: Psychosocial and Biochemical Methods","first-page":"41","article-title":"Timeline follow-back: A technique for assessing self-reported alcohol consumption","author":"Sobell","year":"1992"},{"issue":"5","key":"10.1016\/j.cct.2021.106616_bb0260","first-page":"412","article-title":"Gender differences in individuals with comorbid alcohol dependence and post-traumatic stress disorder","volume":"12","author":"Sonne","year":"2003","journal-title":"Am. J. Addict."},{"key":"10.1016\/j.cct.2021.106616_bb0265","article-title":"State-Trait Anxiety Inventory for Adults (STAI-AD) [database record]","author":"Spielberger","year":"1983","journal-title":"APA PsycTests"},{"key":"10.1016\/j.cct.2021.106616_bb0270","first-page":"405","article-title":"Neuropeptide regulation of the locus coeruleus and opiate-induced plasticity of stress responses","volume":"68","author":"Van Bockstaele","year":"2013","journal-title":"Adv. Pharmacol. (San Diego, CA)"},{"issue":"3","key":"10.1016\/j.cct.2021.106616_bb0275","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1177\/0049124117747303","article-title":"How many imputations do you need? A two-stage calculation using a quadratic rule","volume":"49","author":"von Hippel","year":"2020","journal-title":"Sociol. Methods Res."},{"issue":"2","key":"10.1016\/j.cct.2021.106616_bb0280","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1037\/a0015617","article-title":"Evaluation of cue reactivity in the natural environment of smokers using ecological momentary assessment","volume":"17","author":"Warthen","year":"2009","journal-title":"Exp. Clin. Psychopharmacol."},{"author":"Wolfe","key":"10.1016\/j.cct.2021.106616_bb0285"},{"issue":"4","key":"10.1016\/j.cct.2021.106616_bb0290","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1037\/a0023687","article-title":"Cue-reactivity in the natural environment of cigarette smokers: the impact of photographic and in vivo smoking stimuli","volume":"25","author":"Wray","year":"2011","journal-title":"Psychol. Addict. Behav. J. Soc. Psychol. Addict. Behav."},{"issue":"38","key":"10.1016\/j.cct.2021.106616_bb0295","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1523\/JNEUROSCI.1657-04.2004","article-title":"Chronic morphine sensitizes the brain norepinephrine system to corticotropin-releasing factor and stress","volume":"24","author":"Xu","year":"2004","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.cct.2021.106616_bb0300","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuropharm.2010.09.013","article-title":"Stimulation of \u03b12-adrenergic receptors in the central nucleus of the amygdala attenuates stress-induced reinstatement of nicotine seeking in rats","volume":"60","author":"Yamada","year":"2011","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.cct.2021.106616_bb9060","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/00273171.2015.1022644","article-title":"A Comparison of Imputation Strategies for Ordinal Missing Data on Likert Scale Variables","volume":"50","author":"Wu","year":"2015","journal-title":"Multivariate Behavioral Research"},{"key":"10.1016\/j.cct.2021.106616_bb9061","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00213-011-2187-6","article-title":"Enhancement of cue-induced reinstatement of cocaine-seeking in rats by yohimbine: sex differences and the role of the estrous cycle","volume":"216","author":"Feltenstein","year":"2011","journal-title":"Psychopharmacology"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421003529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714421003529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:53:43Z","timestamp":1761555223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714421003529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":62,"alternative-id":["S1551714421003529"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2021.106616","relation":{},"ISSN":["1551-7144"],"issn-type":[{"type":"print","value":"1551-7144"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2021.106616","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106616"}}