{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:28:31Z","timestamp":1771302511168,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"am","delay-in-days":317,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA097186"],"award-info":[{"award-number":["CA097186"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 CA015704"],"award-info":[{"award-number":["P30 CA015704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["W81XWH-17-2-0043"],"award-info":[{"award-number":["W81XWH-17-2-0043"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","award":["19CHAL05"],"award-info":[{"award-number":["19CHAL05"]}],"id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.cct.2022.106821","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T21:13:59Z","timestamp":1655154839000},"page":"106821","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing"],"prefix":"10.1016","volume":"119","author":[{"given":"Stacy","family":"Loeb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather H.","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Leader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana Sanchez","family":"Nolasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Hollifield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren H.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Slater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Pieczonka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard G.","family":"Gomella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William K.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard J.","family":"Trabulsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Handley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costas D.","family":"Lallas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thenappan","family":"Chandrasekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Mille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Ryan","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jade","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Somers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veda N.","family":"Giri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2022.106821_bb0005","series-title":"Cancer Facts and Figures 2022","year":"2022"},{"issue":"24","key":"10.1016\/j.cct.2022.106821_bb0010","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.1200\/JCO.20.00046","article-title":"Implementation of germline testing for prostate cancer: Philadelphia prostate cancer consensus conference 2019","volume":"38","author":"Giri","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cct.2022.106821_bb0015","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.18.02181","article-title":"Germline testing for men with prostate cancer: navigating an expanding new world of germline evaluation for precision therapy and precision management","author":"Giri","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cct.2022.106821_bb0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.6004\/jnccn.2019.7307","article-title":"Germline and somatic pathogenic variants in prostate cancer for the clinician","volume":"17","author":"Cheng","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"10.1016\/j.cct.2022.106821_bb0025","series-title":"Germlines of Prostate Cancer (PDQ\u00ae)","year":"2022"},{"key":"10.1016\/j.cct.2022.106821_bb0035","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1200\/JCO.20.01035","article-title":"Rucaparib in men with metastatic castration-resistant prostate cancer harboring a BRCA1 or BRCA2 gene alteration","volume":"38","author":"Abida","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.cct.2022.106821_bb0040","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1911440","article-title":"Olaparib for metastatic castrationresistant prostate cancer","volume":"382","author":"de Bono","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cct.2022.106821_bb0045","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA-repair gene pathogenic variants in men with metastatic prostate cancer","volume":"375","author":"Pritchard","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cct.2022.106821_bb0050","article-title":"Inherited pathogenic variants in males undergoing multigene panel testing for prostate cancer \u2013 emerging implications for personalized prostate cancer germline evaluation","author":"Giri","year":"2022","journal-title":"J. Clin. Oncol. Precis. Oncol."},{"key":"10.1016\/j.cct.2022.106821_bb0055","doi-asserted-by":"crossref","DOI":"10.1001\/jamaoncol.2018.6760","article-title":"Prevalence of germline variants in prostate cancer and implications for current germline testing guidelines","author":"Nicolosi","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.cct.2022.106821_bb0065","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41431-018-0252-x","article-title":"The global state of the germline counseling profession","volume":"27","author":"Abacan","year":"2019","journal-title":"Eur. J. Hum. Germlines"},{"key":"10.1016\/j.cct.2022.106821_bb0070","series-title":"Cancer Germlines Overview (PDQ\u00ae)\u2013Health Professional Version","year":"2022"},{"issue":"2","key":"10.1016\/j.cct.2022.106821_bb0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10897-011-9462-x","article-title":"Essential elements of germline cancer risk assessment, counseling, and testing: updated recommendations of the National Society of germline counselors","volume":"21","author":"Riley","year":"2012","journal-title":"J. Genet. Couns."},{"issue":"1","key":"10.1016\/j.cct.2022.106821_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.euo.2020.11.011","article-title":"Clinical implications of germline testing in newly diagnosed prostate cancer","volume":"4","author":"Loeb","year":"2021","journal-title":"Eur. Urol. Oncol."},{"issue":"2","key":"10.1016\/j.cct.2022.106821_bb0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.cct.2022.106821_bb0090","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.ejca.2005.06.020","article-title":"An assessment of the efficacy of cancer genetic counselling using real-time videoconferencing technology (telemedicine) compared to face-to-face consultations","volume":"41","author":"Coelho","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.cct.2022.106821_bb0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/A:1022663324006","article-title":"Assessment of the effectiveness of genetic counseling by telephone compared to a clinic visit","volume":"12","author":"Sangha","year":"2003","journal-title":"J. Genet. Couns."},{"key":"10.1016\/j.cct.2022.106821_bb0105","article-title":"Pretest genetic education video versus genetic counseling for men considering prostate cancer germline testing: a patient-choice study to address urgent practice needs","volume":"5","author":"Russo","year":"2021","journal-title":"JCO Precis. Oncol."},{"issue":"1","key":"10.1016\/j.cct.2022.106821_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmoldx.2016.10.002","article-title":"Standards and guidelines for the interpretation and reporting of sequence variants in cancer \u2013 A joint consensus recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists","volume":"19","author":"Li","year":"2017","journal-title":"J. Mol. Diag"},{"issue":"5","key":"10.1016\/j.cct.2022.106821_bb0115","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Germlines and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"issue":"8","key":"10.1016\/j.cct.2022.106821_bb0120","first-page":"588","article-title":"Brief questions to identify patients with inadequate health literacy","volume":"36","author":"Chew","year":"2004","journal-title":"Fam. Med."},{"issue":"11","key":"10.1016\/j.cct.2022.106821_bb0125","doi-asserted-by":"crossref","first-page":"966","DOI":"10.7326\/0003-4819-127-11-199712010-00003","article-title":"The role of numeracy in understanding the benefit of screening mammography","volume":"127","author":"Schwartz","year":"1997","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.cct.2022.106821_bb0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/0272989X9501500105","article-title":"Validation of a decisional conflict scale","volume":"15","author":"O'Connor","year":"1995","journal-title":"Med. Dec Making"},{"issue":"2","key":"10.1016\/j.cct.2022.106821_bb0135","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pec.2004.02.007","article-title":"Development and validation of a breast Cancer germline counseling knowledge questionnaire","volume":"56","author":"Erblich","year":"2005","journal-title":"Patient Educ. Couns."},{"key":"10.1016\/j.cct.2022.106821_bb0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1023\/B:JOGC.0000035523.96133.bc","article-title":"Patient satisfaction with cancer germline counseling: a psychometric analysis of the germline counseling satisfaction scale","volume":"13","author":"DeMarco","year":"2004","journal-title":"J. Genet. Couns."},{"issue":"10","key":"10.1016\/j.cct.2022.106821_bb0145","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.cct.2022.106821_bb0150","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1245\/s10434-019-07549-8","article-title":"Consensus guidelines on genetic` testing for hereditary breast Cancer from the American Society of Breast Surgeons","volume":"26","author":"Manahan","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.cct.2022.106821_bb0155","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1200\/JCO.21.01761","article-title":"Germline genetic testing for women with breast Cancer: shifting the paradigm from whom to test to whom NOT to test","volume":"39","author":"Tung","year":"2021","journal-title":"J. Clin. Oncol."}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714422001471?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714422001471?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:00:08Z","timestamp":1761555608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714422001471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":28,"alternative-id":["S1551714422001471"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2022.106821","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Technology-enhanced AcceleRation of Germline Evaluation for Therapy (TARGET): A randomized controlled trial of a pretest patient-driven webtool vs. genetic counseling for prostate cancer germline testing","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2022.106821","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106821"}}