{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:34:26Z","timestamp":1776746066267,"version":"3.51.2"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006108","name":"NCATS","doi-asserted-by":"publisher","award":["UL1 TR001085"],"award-info":[{"award-number":["UL1 TR001085"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012256","name":"Cerebral Palsy Alliance Research Foundation","doi-asserted-by":"publisher","award":["PRG01719"],"award-info":[{"award-number":["PRG01719"]}],"id":[{"id":"10.13039\/100012256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.cct.2022.106886","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T11:51:30Z","timestamp":1660909890000},"page":"106886","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A phase-II clinical trial of targeted cerebral near infrared spectroscopy using standardized treatment guidelines to improve brain oxygenation in preterm infants (BOx-II): A study protocol"],"prefix":"10.1016","volume":"120","author":[{"given":"Zachary","family":"Vesoulis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Fairchild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santina","family":"Zanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Chalak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Noroozi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Chock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0005","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1542\/peds.2004-1309","article-title":"On behalf of the Australian and New Zealand neonatal network. Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand neonatal network","volume":"115","author":"Darlow","year":"2005","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.cct.2022.106886_bb0010","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ophtha.2008.09.051","article-title":"A change in oxygen supplementation can decrease the incidence of retinopathy of prematurity","volume":"116","author":"Sears","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.cct.2022.106886_bb0015","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpeds.2017.02.071","article-title":"Oxygen targeting in infants born extremely preterm who are small for gestational age: a need for heightened vigilance","volume":"186","author":"Schmidt","year":"2017","journal-title":"J. Pediatr."},{"issue":"11","key":"10.1016\/j.cct.2022.106886_bb0020","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1136\/bjo.2006.098582","article-title":"Early treatment for retinopathy of prematurity cooperative group. The early treatment for retinopathy of prematurity study: structural findings at age 2 years","volume":"90","author":"Good","year":"2006","journal-title":"Br. J. Ophthalmol."},{"issue":"2","key":"10.1016\/j.cct.2022.106886_bb0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1542\/peds.105.2.295","article-title":"Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: primary outcomes","volume":"105","year":"2000","journal-title":"Pediatrics."},{"issue":"22","key":"10.1016\/j.cct.2022.106886_bb0030","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1056\/NEJMoa1302298","article-title":"Oxygen saturation and outcomes in preterm infants","volume":"368","author":"Stenson","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.cct.2022.106886_bb0035","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa0911781","article-title":"Target ranges of oxygen saturation in extremely preterm infants","volume":"362","author":"SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0040","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1001\/jamapediatrics.2014.3307","article-title":"Oxygen saturation target range for extremely preterm infants: a systematic review and meta-analysis","volume":"169","author":"Manja","year":"2015","journal-title":"JAMA Pediatr."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0045","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000501859","article-title":"Postnatal cerebral hyperoxia is associated with an increased risk of severe retinopathy of prematurity","volume":"116","author":"Richter","year":"2019","journal-title":"Neonatology"},{"issue":"6","key":"10.1016\/j.cct.2022.106886_bb0050","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1179\/174313209X383286","article-title":"Near infrared technology in neuroscience: past, present and future","volume":"31","author":"Calderon-Arnulphi","year":"2009","journal-title":"Neurol. Res."},{"issue":"1","key":"10.1016\/j.cct.2022.106886_bb0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4103\/2152-7806.81722","article-title":"Near-infrared spectroscopy monitoring of cerebral oxygen during assisted ventilation","volume":"2","author":"Booth","year":"2011","journal-title":"Surg. Neurol. Int."},{"issue":"6","key":"10.1016\/j.cct.2022.106886_bb0060","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/ANC.0b013e3182337ebb","article-title":"Understanding near-infrared spectroscopy","volume":"11","author":"Marin","year":"2011","journal-title":"Adv. Neonatal. Care"},{"key":"10.1016\/j.cct.2022.106886_bb0065","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7635","article-title":"Cerebral near infrared spectroscopy oximetry in extremely preterm infants: phase II randomised clinical trial","volume":"350","author":"Hyttel-Sorensen","year":"2015","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.cct.2022.106886_bb0070","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1186\/s13063-019-3955-6","article-title":"Cerebral near-infrared spectroscopy monitoring versus treatment as usual for extremely preterm infants: a protocol for the SafeBoosC randomised clinical phase III trial","volume":"20","author":"Hansen","year":"2019","journal-title":"Trials"},{"key":"10.1016\/j.cct.2022.106886_bb0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1745-6215-14-120","article-title":"A phase II randomized clinical trial on cerebral near-infrared spectroscopy plus a treatment guideline versus treatment as usual for extremely preterm infants during the first three days of life (SafeBoosC): study protocol for a randomized controlled trial","volume":"14","author":"Hyttel-Sorensen","year":"2013","journal-title":"Trials"},{"issue":"3","key":"10.1016\/j.cct.2022.106886_bb0080","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000351346","article-title":"The SafeBoosC phase II randomised clinical trial: a treatment guideline for targeted near-infrared-derived cerebral tissue oxygenation versus standard treatment in extremely preterm infants","volume":"104","author":"Pellicer","year":"2013","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.cct.2022.106886_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262640","article-title":"Early cerebral hypoxia in extremely preterm infants and neurodevelopmental impairment at 2 year of age: A post hoc analysis of the SafeBoosC II trial. Schm\u00f6lzer GM, editor","volume":"17","author":"Plomgaard","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0090","doi-asserted-by":"crossref","first-page":"275F","DOI":"10.1136\/fn.88.4.F275","article-title":"Limitations of ultrasonography for diagnosing white matter damage in preterm infants","volume":"88","author":"Debillon","year":"2003","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"issue":"2","key":"10.1016\/j.cct.2022.106886_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neurad.2012.03.006","article-title":"Accuracy of head ultrasound for the detection of intracranial hemorrhage in preterm neonates: comparison with brain MRI and susceptibility-weighted imaging","volume":"40","author":"Intrapiromkul","year":"2013","journal-title":"J. Neuroradiol."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.earlhumdev.2011.08.011","article-title":"Ultrasound detection of posterior fossa abnormalities in full-term neonates","volume":"88","author":"Steggerda","year":"2012","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.cct.2022.106886_bb0105","article-title":"Reference values of regional cerebral oxygen saturation during the first 3 days of life in preterm neonates","author":"Alderliesten","year":"2015","journal-title":"Pediatr. Res. [Internet]"},{"issue":"8","key":"10.1016\/j.cct.2022.106886_bb0110","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1364\/BOE.7.002973","article-title":"Comparison of tissue oximeters on a liquid phantom with adjustable optical properties","volume":"7","author":"Kleiser","year":"2016","journal-title":"Biomed. Opt. Express"},{"issue":"1","key":"10.1016\/j.cct.2022.106886_bb0115","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1364\/BOE.9.000086","article-title":"Comparison of tissue oximeters on a liquid phantom with adjustable optical properties: an extension","volume":"9","author":"Kleiser","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.cct.2022.106886_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-022-02082-z","article-title":"Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Early brain and abdominal oxygenation in extremely low birth weight infants","author":"Chock","year":"2022","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.cct.2022.106886_bb0125","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jpeds.2020.08.036","article-title":"Cerebral oxygenation and autoregulation in preterm infants (early NIRS study)","volume":"227","author":"Chock","year":"2020","journal-title":"J. Pediatr."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0130","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41390-020-01189-5","article-title":"The hidden consequence of intraventricular hemorrhage: persistent cerebral desaturation after IVH in preterm infants","volume":"89","author":"Vesoulis","year":"2021","journal-title":"Pediatr. Res."},{"issue":"6","key":"10.1016\/j.cct.2022.106886_bb0135","first-page":"470","article-title":"Determinants of blood pressure in infants admitted to neonatal intensive care units: a prospective multicenter study. Philadelphia neonatal blood pressure study group","volume":"15","author":"Zubrow","year":"1995","journal-title":"J. Perinatol."},{"issue":"11","key":"10.1016\/j.cct.2022.106886_bb0140","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.3174\/ajnr.A3521","article-title":"New MR imaging assessment tool to define brain abnormalities in very preterm infants at term","volume":"34","author":"Kidokoro","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"2","key":"10.1016\/j.cct.2022.106886_bb0145","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.cct.2022.106886_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J. Biomed. Inform."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0155","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41372-021-00946-6","article-title":"Neonatal NIRS monitoring: recommendations for data capture and review of analytics","volume":"41","author":"Vesoulis","year":"2021","journal-title":"J. Perinatol."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0160","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/ppe.12471","article-title":"Accounting for twin births in sample size calculations for randomised trials","volume":"32","author":"Yelland","year":"2018","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"1","key":"10.1016\/j.cct.2022.106886_bb0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1255\/jnirs.972","article-title":"A review of near infrared spectroscopy for term and preterm newborns","volume":"20","author":"Wolf","year":"2012","journal-title":"J. Near Infrared Spectrosc."},{"key":"10.1016\/j.cct.2022.106886_bb0170","first-page":"46","article-title":"Monitoring cerebral oxygenation in neonates: an update","volume":"5","author":"Dix","year":"2017","journal-title":"Front. Pediatr."},{"issue":"4","key":"10.1016\/j.cct.2022.106886_bb0175","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000151642","article-title":"Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls","volume":"94","author":"van Bel","year":"2008","journal-title":"Neonatology"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714422002129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714422002129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T08:56:33Z","timestamp":1761555393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714422002129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":35,"alternative-id":["S1551714422002129"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2022.106886","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A phase-II clinical trial of targeted cerebral near infrared spectroscopy using standardized treatment guidelines to improve brain oxygenation in preterm infants (BOx-II): A study protocol","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2022.106886","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106886"}}