{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:09:42Z","timestamp":1787666982371,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.cct.2023.107415","type":"journal-article","created":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T17:45:37Z","timestamp":1702835137000},"page":"107415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The Exercise aNd hEArt transplant (ENEA) trial \u2013 a registry-based randomized controlled trial evaluating the safety and efficacy of cardiac telerehabilitation after heart transplant"],"prefix":"10.1016","volume":"136","author":[{"given":"Paolo","family":"Pedersini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Picciolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Salvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Toccafondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Novembre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Gualerzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Cusmano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Garascia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tavanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Masciocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mannini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Bedoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuccia","family":"Morici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2023.107415_bb0005","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1177\/2047487320913379","article-title":"Secondary prevention through comprehensive cardiovascular rehabilitation: from knowledge to implementation. 2020 update. A position paper from the secondary prevention and rehabilitation section of the European Association of Preventive Cardiology","volume":"28","author":"Ambrosetti","year":"2021","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.cct.2023.107415_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028313","article-title":"Neuropsychological profile in a large group of heart transplant candidates","volume":"6","author":"Mapelli","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.cct.2023.107415_bb0015","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1751-7133.2011.00242.x","article-title":"Cognitive impairment in patients with advanced heart failure and its implications on decision-making capacity","volume":"17","author":"Gaviria","year":"2011","journal-title":"Congest. Heart Fail."},{"key":"10.1016\/j.cct.2023.107415_bb0020","first-page":"CD012264","article-title":"Exercise-based cardiac rehabilitation in heart transplant recipients","volume":"4","author":"Anderson","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.cct.2023.107415_bb0025","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1034\/j.1399-0012.2002.1o100.x","article-title":"Regular physical exercise improves endothelial function in heart transplant recipients","volume":"16","author":"Schmidt","year":"2002","journal-title":"Clin. Transpl."},{"key":"10.1016\/j.cct.2023.107415_bb0030","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1056\/NEJM199901283400404","article-title":"A controlled trial of exercise rehabilitation after heart transplantation","volume":"340","author":"Kobashigawa","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cct.2023.107415_bb0035","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.healun.2017.05.017","article-title":"Cardiac rehabilitation and readmissions after heart transplantation","volume":"37","author":"Bachmann","year":"2018","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.cct.2023.107415_bb0040","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cardfail.2020.01.011","article-title":"The role of cardiac rehabilitation in reducing major adverse cardiac events in heart transplant patients","volume":"26","author":"Uithoven","year":"2020","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.cct.2023.107415_bb0045","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00421-003-0952-x","article-title":"Exercise after heart transplantation","volume":"90","author":"Marconi","year":"2003","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.cct.2023.107415_bb0050","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s11136-021-02763-y","article-title":"Life experiences of adult heart transplant recipients: a new life, challenges, and coping","volume":"30","author":"Fatma","year":"2021","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.cct.2023.107415_bb0055","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/1474515120937838","article-title":"Fear of graft rejection after heart transplantation - a nationwide cross-sectional cohort study","volume":"20","author":"Forsberg","year":"2021","journal-title":"Eur. J. Cardiovasc. Nurs."},{"key":"10.1016\/j.cct.2023.107415_bb0060","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1097\/HCR.0000000000000121","article-title":"A systematic review of the effects of Telerehabilitation in patients with cardiopulmonary diseases","volume":"35","author":"Hwang","year":"2015","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"10.1016\/j.cct.2023.107415_bb0065","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/medicina58101321","article-title":"The potential of cardiac Telerehabilitation as delivery rehabilitation care model in heart failure during COVID-19 and transmissible disease outbreak: a systematic scoping review of the latest RCTs","volume":"58","author":"Maulana","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.cct.2023.107415_bb0070","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuropharm.2018.09.011","article-title":"TBI Rehabilomics research: conceptualizing a humoral triad for designing effective rehabilitation interventions","volume":"145","author":"Wagner","year":"2019","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.cct.2023.107415_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnbot.2021.742163","article-title":"Neuromechanical biomarkers for robotic neurorehabilitation","volume":"15","author":"Garro","year":"2021","journal-title":"Front. Neurorobot."},{"key":"10.1016\/j.cct.2023.107415_bb0080","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.ajt.2023.02.025","article-title":"The evolving use of biomarkers in heart transplantation: consensus of an expert panel","volume":"23","author":"Kobashigawa","year":"2023","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.cct.2023.107415_bb0085","doi-asserted-by":"crossref","first-page":"10816","DOI":"10.1038\/s41598-018-29193-0","article-title":"Differences in biochemical markers between heart-transplanted and left ventricular assist device implanted patients, during cardiac rehabilitation","volume":"8","author":"Racca","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cct.2023.107415_bb0090","doi-asserted-by":"crossref","first-page":"27066","DOI":"10.3402\/jev.v4.27066","article-title":"Biological properties of extracellular vesicles and their physiological functions","volume":"4","author":"Y\u00e1\u00f1ez-M\u00f3","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.cct.2023.107415_bb0095","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.healun.2020.06.011","article-title":"Circulating extracellular vesicles as non-invasive biomarker of rejection in heart transplant","volume":"39","author":"Castellani","year":"2020","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.cct.2023.107415_bb0100","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated Neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.cct.2023.107415_bb0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fcvm.2020.00047","article-title":"Extracellular endothelial cell-derived vesicles: emerging role in cardiac and vascular remodeling in heart failure","volume":"7","author":"Berezin","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.cct.2023.107415_bb0110","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1021\/acs.analchem.8b00941","article-title":"Detection and characterization of different brain-derived subpopulations of plasma exosomes by surface Plasmon resonance imaging","volume":"90","author":"Picciolini","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.cct.2023.107415_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113649","article-title":"An SPRi-based biosensor pilot study: analysis of multiple circulating extracellular vesicles and hippocampal volume in Alzheimer\u2019s disease","volume":"192","author":"Picciolini","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.cct.2023.107415_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114796","article-title":"Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury","volume":"194","author":"Tallon","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.cct.2023.107415_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102737","article-title":"Plasma-derived extracellular vesicles released after endurance exercise exert cardioprotective activity through the activation of antioxidant pathways","volume":"63","author":"Lisi","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.cct.2023.107415_bb0130","article-title":"Effectiveness of exercise-based cardiac rehabilitation for heart transplant recipients: a systematic review and Meta-analysis","volume":"16","author":"Costa","year":"2023","journal-title":"Health Serv. Insights"},{"key":"10.1016\/j.cct.2023.107415_bb0135","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/jnu.12318","article-title":"Cross-validation of the Minnesota living with heart failure questionnaire","volume":"49","author":"Mogle","year":"2017","journal-title":"J. Nurs. Scholarsh."},{"key":"10.1016\/j.cct.2023.107415_bb0140","first-page":"983","article-title":"Health status of heart transplant recipients versus patients awaiting heart transplantation: a preliminary evaluation of the SF-36 questionnaire","volume":"12","author":"Rector","year":"1993","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.cct.2023.107415_bb0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1477-7525-12-84","article-title":"A confirmatory bifactor analysis of the hospital anxiety and depression scale in an Italian community sample","volume":"12","author":"Iani","year":"2014","journal-title":"Health Qual. Life Outcomes"},{"key":"10.1016\/j.cct.2023.107415_bb0150","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.cct.2023.107415_bb0155","doi-asserted-by":"crossref","first-page":"7937","DOI":"10.3390\/ijms24097937","article-title":"Multiplexing biosensor for the detection of extracellular vesicles as biomarkers of tissue damage and recovery after ischemic stroke","volume":"24","author":"Picciolini","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.cct.2023.107415_bb0160","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/biostatistics\/kxv047","article-title":"On the repeated measures designs and sample sizes for randomized controlled trials","volume":"17","author":"Tango","year":"2016","journal-title":"Biostatistics."}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714423003385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714423003385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:02:04Z","timestamp":1761555724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714423003385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":32,"alternative-id":["S1551714423003385"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2023.107415","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Exercise aNd hEArt transplant (ENEA) trial \u2013 a registry-based randomized controlled trial evaluating the safety and efficacy of cardiac telerehabilitation after heart transplant","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2023.107415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107415"}}