{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:29:23Z","timestamp":1793831363390,"version":"4.6.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.cct.2024.107516","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T14:02:23Z","timestamp":1711461743000},"page":"107516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"special_numbering":"C","title":["Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial"],"prefix":"10.1016","volume":"141","author":[{"given":"Atul","family":"Malhotra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Bednarik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujatro","family":"Chakladar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia P.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Grunstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Fietze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Azarbarzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Sands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathijs C.","family":"Bunck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.cct.2024.107516_bb0005","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.2109080","article-title":"Epidemiology of obstructive sleep apnea: a population health perspective","volume":"165","author":"Young","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.cct.2024.107516_bb0010","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1093\/aje\/kws342","article-title":"Increased prevalence of sleep-disordered breathing in adults","volume":"177","author":"Peppard","year":"2013","journal-title":"Am. J. Epidemiol."},{"issue":"14","key":"10.1016\/j.cct.2024.107516_bb0015","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and management of obstructive sleep apnea: a review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.cct.2024.107516_bb0020","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1164\/rccm.201404-0783OC","article-title":"Enhanced upper-airway muscle responsiveness is a distinct feature of overweight\/obese individuals without sleep apnea","volume":"190","author":"Sands","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"10","key":"10.1016\/j.cct.2024.107516_bb0025","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.5665\/sleep.4072","article-title":"Tongue fat and its relationship to obstructive sleep apnea","volume":"37","author":"Kim","year":"2014","journal-title":"Sleep"},{"issue":"6","key":"10.1016\/j.cct.2024.107516_bb0030","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.2337\/dc08-1776","article-title":"Obstructive sleep apnea among obese patients with type 2 diabetes","volume":"32","author":"Foster","year":"2009","journal-title":"Diabetes Care"},{"issue":"17","key":"10.1016\/j.cct.2024.107516_bb0035","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1001\/archinternmed.2009.266","article-title":"A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the sleep AHEAD study","volume":"169","author":"Foster","year":"2009","journal-title":"Arch. Intern. Med."},{"issue":"2","key":"10.1016\/j.cct.2024.107516_bb0040","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2165\/00003495-200161020-00007","article-title":"Treatment options for sleep apnoea","volume":"61","author":"Grunstein","year":"2001","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.cct.2024.107516_bb0045","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0950-351X(05)80288-5","article-title":"Sleep-disordered breathing and obesity","volume":"8","author":"Grunstein","year":"1994","journal-title":"Bailliere Clin. Endocrinol. Metab."},{"issue":"6 (Pt 1)","key":"10.1016\/j.cct.2024.107516_bb0050","doi-asserted-by":"crossref","first-page":"850","DOI":"10.7326\/0003-4819-103-6-850","article-title":"Weight loss in mildly to moderately obese patients with obstructive sleep apnea","volume":"103","author":"Smith","year":"1985","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.cct.2024.107516_bb0055","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1164\/rccm.201903-0692OC","article-title":"Effect of weight loss on upper airway anatomy and the apnea-hypopnea index. The importance of tongue fat","volume":"201","author":"Wang","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"24","key":"10.1016\/j.cct.2024.107516_bb0060","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1056\/NEJMoa1306187","article-title":"CPAP, weight loss, or both for obstructive sleep apnea","volume":"370","author":"Chirinos","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.cct.2024.107516_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1056\/NEJMoa2206038","article-title":"SURMOUNT-1 investigators, Tirzepatide once weekly for the treatment of obesity","volume":"387","author":"Jastreboff","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.cct.2024.107516_bb0070","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1164\/rccm.201807-1326ST","article-title":"The role of weight management in the treatment of adult obstructive sleep apnea","volume":"198","author":"Hudgel","year":"2018","journal-title":"Off. Am. Thorac. Soc. Clin. Pract. Guidel. Am. J. Respir. Critic. Care Med."},{"key":"10.1016\/j.cct.2024.107516_bb0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.molmet.2018.09.009","article-title":"LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept","volume":"18","author":"Coskun","year":"2018","journal-title":"Mol. Metab."},{"issue":"6","key":"10.1016\/j.cct.2024.107516_bb0080","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa2107519","article-title":"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes","volume":"385","author":"Fr\u00edas","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"10300","key":"10.1016\/j.cct.2024.107516_bb0085","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(21)01443-4","article-title":"Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial","volume":"398","author":"Ludvik","year":"2021","journal-title":"Lancet"},{"issue":"10313","key":"10.1016\/j.cct.2024.107516_bb0090","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/S0140-6736(21)02188-7","article-title":"Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial","volume":"398","author":"Del Prato","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.cct.2024.107516_bb0095","author":"Human Energy Requirements"},{"issue":"11","key":"10.1016\/j.cct.2024.107516_bb0100","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1164\/rccm.201408-1498LE","article-title":"Effect of parapharyngeal fat on dynamic obstruction of the upper airway in patients with obstructive sleep apnea","volume":"190","author":"Jang","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.cct.2024.107516_bb0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00043.2008","article-title":"Pathophysiology of sleep apnea","volume":"90","author":"Dempsey","year":"2010","journal-title":"Physiol. Rev."},{"issue":"10","key":"10.1016\/j.cct.2024.107516_bb0110","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.5665\/sleep.4072","article-title":"Tongue fat and its relationship to obstructive sleep apnea","volume":"37","author":"Kim","year":"2014","journal-title":"Sleep"},{"issue":"14","key":"10.1016\/j.cct.2024.107516_bb0115","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/eurheartj\/ehy624","article-title":"The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the osteoporotic fractures in men study and the sleep heart health study","volume":"40","author":"Azarbarzin","year":"2019","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.cct.2024.107516_bb0120","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.chest.2020.03.053","article-title":"The sleep apnea-specific hypoxic burden predicts incident heart failure","volume":"158","author":"Azarbarzin","year":"2020","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.cct.2024.107516_bb0125","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1164\/rccm.202209-1808OC","article-title":"Sleep apnea physiological burdens and cardiovascular morbidity and mortality","volume":"208","author":"Labarca","year":"2023","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cct.2024.107516_bb0130","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00828-2023","article-title":"Hypoxic burden to guide CPAP treatment allocation in patients with obstructive sleep apnoea: a post-hoc study of the ISAACC trial","author":"Pinilla","year":"2023","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.cct.2024.107516_bb0135","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1183\/09031936.00062914","article-title":"Quantifying the ventilatory control contribution to sleep apnoea using polysomnography","volume":"45","author":"Terrill","year":"2015","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.cct.2024.107516_bb0140","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsx183","article-title":"Quantifying the arousal threshold using polysomnography in obstructive sleep apnea","volume":"41","author":"Sands","year":"2018","journal-title":"Sleep"},{"issue":"9","key":"10.1016\/j.cct.2024.107516_bb0145","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1164\/rccm.201707-1435OC","article-title":"Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea","volume":"197","author":"Sands","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.cct.2024.107516_bb0150","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1513\/AnnalsATS.202203-271OC","article-title":"Pathophysiology underlying demographic and obesity determinants of sleep apnea severity","volume":"20","author":"Sands","year":"2023","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"12","key":"10.1016\/j.cct.2024.107516_bb0155","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/jamaoto.2013.5338","article-title":"Diagnosis of obstructive sleep apnea by peripheral arterial tonometry: meta-analysis","volume":"139","author":"Yalamanchali","year":"2013","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"issue":"24","key":"10.1016\/j.cct.2024.107516_bb0160","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1056\/NEJMoa1306766","article-title":"CPAP versus oxygen in obstructive sleep apnea","volume":"370","author":"Gottlieb","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.cct.2024.107516_bb0165","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.chest.2017.11.005","article-title":"Patient engagement using new technology to improve adherence to positive airway pressure therapy: a retrospective analysis","volume":"153","author":"Malhotra","year":"2018","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.cct.2024.107516_bb0170","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.otohns.2006.08.007","article-title":"Treatment compliance in patients lost to follow-up after polysomnography","volume":"136","author":"Lin","year":"2007","journal-title":"Otolaryngol. Head Neck Surg."},{"issue":"10","key":"10.1016\/j.cct.2024.107516_bb0175","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1056\/NEJMoa1606599","article-title":"SAVE investigators and coordinators, CPAP for prevention of cardiovascular events in obstructive sleep apnea","volume":"375","author":"McEvoy","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.cct.2024.107516_bb0180","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archinte.163.5.565","article-title":"Continuous positive airway pressure for treating sleepiness in a diverse popultaion with obstructive sleep apnea: results of a meta-analysis","volume":"163","author":"Patel","year":"2003","journal-title":"Arch Intern Med."},{"issue":"7","key":"10.1016\/j.cct.2024.107516_bb0185","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.cjca.2015.02.007","article-title":"Future of sleep-disordered breathing therapy using a mechanistic approach","volume":"31","author":"Jen","year":"2015","journal-title":"Can. J. Cardiol."},{"issue":"10","key":"10.1016\/j.cct.2024.107516_bb0190","first-page":"835","article-title":"An instrument to measure functional status outcomes for disorders of excessive sleepiness","volume":"20","author":"Weaver","year":"1997","journal-title":"Sleep"},{"issue":"3","key":"10.1016\/j.cct.2024.107516_bb0195","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s11325-022-02703-1","article-title":"The language of sleepiness in obstructive sleep apnea beyond the Epworth","volume":"27","author":"Sunwoo","year":"2022","journal-title":"Sleep Breath."},{"issue":"10","key":"10.1016\/j.cct.2024.107516_bb0200","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1513\/AnnalsATS.202101-060OC","article-title":"Effect of continuous positive airway pressure on weight and local adiposity in adults with obstructive sleep apnea: a meta-analysis","volume":"18","author":"Chen","year":"2021","journal-title":"Ann. Am. Thorac. Soc."},{"issue":"7","key":"10.1016\/j.cct.2024.107516_bb0205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jacc.2013.05.045","article-title":"Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome","volume":"62","author":"Drager","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.cct.2024.107516_bb0210","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012065","article-title":"The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome","volume":"5","author":"Drager","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.cct.2024.107516_bb0215","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1136\/thoraxjnl-2014-205361","article-title":"Effects of CPAP on body weight in patients with obstructive sleep apnoea: a meta-analysis of randomised trials","volume":"70","author":"Drager","year":"2015","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.cct.2024.107516_bb0220","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","article-title":"A new method for measuring daytime sleepiness: the Epworth sleepiness scale","volume":"14","author":"Johns","year":"1991","journal-title":"Sleep"},{"issue":"7","key":"10.1016\/j.cct.2024.107516_bb0225","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1164\/rccm.201704-0672LE","article-title":"The Epworth sleepiness scale: minimum clinically important difference in obstructive sleep apnea","volume":"197","author":"Patel","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714424000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714424000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T03:49:19Z","timestamp":1715658559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714424000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":45,"alternative-id":["S1551714424000995"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2024.107516","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2024.107516","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Eli Lilly and Company. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107516"}}