{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:32:54Z","timestamp":1777948374622,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH130728"],"award-info":[{"award-number":["K23MH130728"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002367"],"award-info":[{"award-number":["KL2TR002367"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.cct.2025.107874","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T12:07:44Z","timestamp":1741003664000},"page":"107874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Development of a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders: Study protocol for the naltrexone neuroimaging randomized controlled trial (NN-RCT)"],"prefix":"10.1016","volume":"152","author":[{"given":"Stephani L.","family":"Stancil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariah E.","family":"Brewe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tumberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bartkoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Burns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Wen","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan G.","family":"Brucks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Bartolotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Voss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey R.","family":"Strawn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Abdel-Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2025.107874_bb0005","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1017\/S1092852915000012","article-title":"Advances from neuroimaging studies in eating disorders","volume":"20","author":"Frank","year":"2015","journal-title":"CNS Spectr."},{"issue":"10","key":"10.1016\/j.cct.2025.107874_bb0010","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/jamapsychiatry.2021.1580","article-title":"Association of brain reward response with body mass index and ventral striatal-hypothalamic circuitry among young women with eating disorders","volume":"78","author":"Frank","year":"2021","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.cct.2025.107874_bb0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11920-020-01213-9","article-title":"Reward learning through the Lens of RDoC: a review of theory, assessment, and empirical findings in the eating disorders","volume":"23","author":"Schaefer","year":"2021","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.cct.2025.107874_bb0020","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pnpbp.2017.02.020","article-title":"Neuroendocrinology and brain imaging of reward in eating disorders: a possible key to the treatment of anorexia nervosa and bulimia nervosa","volume":"80","author":"Monteleone","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.cct.2025.107874_bb0025","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1089\/cap.2019.0056","article-title":"Naltrexone reduces binge eating and purging in adolescents in an eating disorder program","volume":"29","author":"Stancil","year":"2019","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.cct.2025.107874_bb0030","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1111\/cts.13399","article-title":"Effects of genotype and food on naltrexone exposure in adolescents","volume":"15","author":"Stancil","year":"2022","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.cct.2025.107874_bb0035","first-page":"675","article-title":"Developmental considerations for the use of naltrexone in children and adolescents","volume":"26","author":"Stancil","year":"2021","journal-title":"J. Pediatr. Pharmacol. Therap."},{"key":"10.1016\/j.cct.2025.107874_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00004850-199510030-00005","article-title":"Naltrexone use in the treatment of anorexia nervosa and bulimia nervosa","volume":"10","author":"Marrazzi","year":"1995","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.cct.2025.107874_bb0045","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/ajcn\/53.4.865","article-title":"Effect of a tricyclic antidepressant and opiate antagonist on binge-eating behavior in normoweight bulimic and obese, binge-eating subjects","volume":"53","author":"Alger","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cct.2025.107874_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/00004714-198904000-00004","article-title":"A placebo-controlled, double-blind crossover study of naltrexone hydrochloride in outpatients with normal weight bulimia","volume":"9","author":"Mitchell","year":"1989","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.cct.2025.107874_bb0055","article-title":"Potential biomarker of brain response to opioid antagonism in adolescents with eating disorders: a pilot study","volume":"14","author":"Stancil","year":"2023","journal-title":"Front. Psychol."},{"key":"10.1016\/j.cct.2025.107874_bb0060","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/cts.13216","article-title":"Target to treatment: a charge to develop biomarkers of response and tolerability in child and adolescent psychiatry","volume":"15","author":"Stancil","year":"2022","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.cct.2025.107874_bb0065","series-title":"CONSORT 2010 Statement: Extension to Randomised Crossover Trials","volume":"vol. 366","author":"Dwan","year":"2019"},{"issue":"Suppl. 20","key":"10.1016\/j.cct.2025.107874_bb0070","first-page":"22","article-title":"The Mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.cct.2025.107874_bb0075","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4088\/JCP.09m05305whi","article-title":"Reliability and validity of the Mini international neuropsychiatric interview for children and adolescents (MINI-KID)","volume":"71","author":"Sheehan","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.cct.2025.107874_bb0080","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1345\/aph.19381","article-title":"The origin of the \u201cideal\u201d body weight equations","volume":"34","author":"Pai","year":"2000","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.cct.2025.107874_bb0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/eat.22180","article-title":"Gender norms, psychometric properties, and validity for the eating pathology symptoms inventory","volume":"47","author":"Forbush","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.cct.2025.107874_bb0090","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1037\/a0032639","article-title":"Development and validation of the eating pathology symptoms inventory (EPSI)","volume":"25","author":"Forbush","year":"2013","journal-title":"Psychol. Assess."},{"key":"10.1016\/j.cct.2025.107874_bb0095","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jadohealth.2020.01.028","article-title":"Correlation of functional magnetic resonance imaging response to visual food stimuli with clinical measures in adolescents with restrictive eating disorders","volume":"67","author":"Ziv","year":"2020","journal-title":"J. Adolesc. Health"},{"key":"10.1016\/j.cct.2025.107874_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2174\/187152710790966704","article-title":"Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics","volume":"9","author":"Ray","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.cct.2025.107874_bb0105","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/scan\/nsz026","article-title":"Naltrexone alters responses to social and physical warmth: implications for social bonding","volume":"14","author":"Inagaki","year":"2019","journal-title":"Soc. Cogn. Affect. Neurosci."},{"key":"10.1016\/j.cct.2025.107874_bb0110","first-page":"1207","article-title":"Duration of occupancy of opiate receptors by naltrexone","volume":"29","author":"Lee","year":"1988","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.cct.2025.107874_bb0115","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/oby.20741","article-title":"Tonic hyper-connectivity of reward neurocircuitry in obese children","volume":"22","author":"Black","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.cct.2025.107874_bb0120","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/ijo.2010.84","article-title":"Obese children show hyperactivation to food pictures in brain networks linked to motivation, reward and cognitive control","volume":"34","author":"Bruce","year":"2010","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.cct.2025.107874_bb0125","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jpeds.2012.10.003","article-title":"Brain responses to food logos in obese and healthy weight children","volume":"162","author":"Bruce","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.cct.2025.107874_bb0130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/oby.2009.220","article-title":"Neural mechanisms associated with food motivation in obese and healthy weight adults","volume":"18","author":"Martin","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.cct.2025.107874_bb0135","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cct.2014.12.008","article-title":"Brain function predictors and outcome of weight loss and weight loss maintenance","volume":"40","author":"Szabo-Reed","year":"2015","journal-title":"Contemp. Clin. Trials"},{"key":"10.1016\/j.cct.2025.107874_bb0140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.dcn.2018.04.004","article-title":"Recruiting the ABCD sample: design considerations and procedures","volume":"32","author":"Garavan","year":"2018","journal-title":"Dev. Cogn. Neurosci."},{"key":"10.1016\/j.cct.2025.107874_bb0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.dcn.2018.03.001","article-title":"The adolescent brain cognitive development (ABCD) study: imaging acquisition across 21 sites","volume":"32","author":"Casey","year":"2018","journal-title":"Dev. Cogn. Neurosci."},{"key":"10.1016\/j.cct.2025.107874_bb0150","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1037\/a0030550","article-title":"New tricks for an old measure: the development of the Barratt impulsiveness scale-brief (BIS-brief)","volume":"25","author":"Steinberg","year":"2013","journal-title":"Psychol. Assess."},{"key":"10.1016\/j.cct.2025.107874_bb0155","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/1534582303257007","article-title":"Drug abuse as a problem of impaired control: current approaches and findings","volume":"2","author":"Fillmore","year":"2003","journal-title":"Behav. Cogn. Neurosci. Rev."},{"key":"10.1016\/j.cct.2025.107874_bb0160","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1037\/abn0000204","article-title":"Eating disorder-specific risk factors moderate the relationship between negative urgency and binge eating: a behavioral genetic investigation","volume":"126","author":"Racine","year":"2017","journal-title":"J. Abnorm. Psychol."},{"key":"10.1016\/j.cct.2025.107874_bb0165","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.comppsych.2016.01.010","article-title":"Associations between negative affect and binge\/purge behaviors in women with anorexia nervosa: considering the role of negative urgency","volume":"66","author":"Culbert","year":"2016","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.cct.2025.107874_bb0170","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0191-8869(00)00064-7","article-title":"The five factor model and impulsivity: using a structural model of personality to understand impulsivity","volume":"30","author":"Whiteside","year":"2001","journal-title":"Personal. Individ. Differ."},{"key":"10.1016\/j.cct.2025.107874_bb0175","series-title":"The UPPS-P: Assessing Five Personality Pathways to Impulsive Behavior","first-page":"10","author":"Lynam","year":"2006"},{"key":"10.1016\/j.cct.2025.107874_bb0180","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1016\/j.paid.2007.06.016","article-title":"Adolescents\u2019 performance on delay and probability discounting tasks: contributions of age, intelligence, executive functioning, and self-reported externalizing behavior","volume":"43","author":"Olson","year":"2007","journal-title":"Personal. Individ. Differ."},{"key":"10.1016\/j.cct.2025.107874_bb0185","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/erv.2543","article-title":"Delay discounting of reward and impulsivity in eating disorders: from anorexia nervosa to binge eating disorder","volume":"25","author":"Steward","year":"2017","journal-title":"Eur. Eat. Disord. Rev."},{"key":"10.1016\/j.cct.2025.107874_bb0190","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput. Biomed. Res."},{"key":"10.1016\/j.cct.2025.107874_bb0195","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nmeth.1635","article-title":"Large-scale automated synthesis of human functional neuroimaging data","volume":"8","author":"Yarkoni","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.cct.2025.107874_bb0200","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/oby.21119","article-title":"Resting-state brain connectivity after surgical and behavioral weight loss","volume":"23","author":"Lepping","year":"2015","journal-title":"Obesity"},{"key":"10.1016\/j.cct.2025.107874_bb0205","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/cpt.2312","article-title":"Analysis approaches to identify Pharmacogenetic associations with pharmacodynamics","volume":"110","author":"Hertz","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.cct.2025.107874_bb0210","first-page":"233","article-title":"The NIMH \u2018Fast-fail Trials\u2019 (FAST) initiative: rationale, promise, and progress","volume":"34","author":"Grabb","year":"2020","journal-title":"Pharmaceut. Med."},{"key":"10.1016\/j.cct.2025.107874_bb0215","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamapsychiatry.2017.3572","article-title":"Utility of imaging-based biomarkers for glutamate-targeted drug development in psychotic disorders: a randomized clinical trial","volume":"75","author":"Javitt","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.cct.2025.107874_bb0220","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuroimage.2011.02.004","article-title":"Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach","volume":"56","author":"Schacht","year":"2011","journal-title":"NeuroImage"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714425000680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714425000680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T07:28:48Z","timestamp":1777793328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714425000680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":44,"alternative-id":["S1551714425000680"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2025.107874","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders: Study protocol for the naltrexone neuroimaging randomized controlled trial (NN-RCT)","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2025.107874","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107874"}}