{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:44:16Z","timestamp":1791632656902,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["A30065"],"award-info":[{"award-number":["A30065"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.cct.2025.107983","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T19:17:20Z","timestamp":1749237440000},"page":"107983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prostate Assessment using Comparative Interventions \u2013 Fast MRI and Image-fusion for Cancer (IP7-PACIFIC): A prospective, multi-centre, dual sequential randomised controlled trial"],"prefix":"10.1016","volume":"155","author":[{"given":"Nikhil","family":"Mayor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Light","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rawlins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Klimowska-Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiagarajah","family":"Sasikaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Jadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heminder","family":"Sokhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Walls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Oldroyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rockall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Heer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar R.","family":"Padhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimur T.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian","family":"Gabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hashim U.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2025.107983_bb0005","series-title":"Prostate Cancer Statistics","year":"2023"},{"key":"10.1016\/j.cct.2025.107983_bb0010","series-title":"Implementing a Timed Prostate Cancer Diagnostic Pathway Guidance for Local Health and Care Systems","author":"England","year":"2022"},{"issue":"10071","key":"10.1016\/j.cct.2025.107983_bb0015","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cct.2025.107983_bb0020","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-targeted or standard biopsy for prostate-cancer diagnosis","author":"Kasivisvanathan","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.cct.2025.107983_bb0025","article-title":"Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer","volume":"4","author":"Drost","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0030","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.eururo.2017.08.018","article-title":"Optimising the diagnosis of prostate cancer in the era of multiparametric magnetic resonance imaging: a cost-effectiveness analysis based on the prostate MR imaging study (PROMIS)","volume":"73","author":"Faria","year":"2018","journal-title":"Eur. Urol."},{"key":"10.1016\/j.cct.2025.107983_bb0035","series-title":"Prostate Cancer: Diagnosis and Management [D] Evidence Review for Diagnosing and Identifying Clinically Significant Prostate Cancer","year":"2019"},{"issue":"4","key":"10.1016\/j.cct.2025.107983_bb0040","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/JU.0000000000000617","article-title":"Update of the standard operating procedure on the use of multiparametric magnetic resonance imaging for the diagnosis, staging and management of prostate cancer","volume":"203","author":"Bjurlin","year":"2020","journal-title":"J. Urol."},{"issue":"6","key":"10.1016\/j.cct.2025.107983_bb0050","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.eururo.2013.05.049","article-title":"Systematic review of complications of prostate biopsy","volume":"64","author":"Loeb","year":"2013","journal-title":"Eur. Urol."},{"key":"10.1016\/j.cct.2025.107983_bb0055","article-title":"The rapid assessment for prostate imaging and diagnosis (RAPID) prostate cancer diagnostic pathway","author":"Eldred-Evans","year":"2022","journal-title":"BJU Int."},{"key":"10.1016\/j.cct.2025.107983_bb0065","article-title":"Hypersensitivity to gadolinium-based contrast media","volume":"3","author":"Bara","year":"2022","journal-title":"Front. Allergy"},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10534-016-9931-7","article-title":"Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms","volume":"29","author":"Rogosnitzky","year":"2016","journal-title":"Biometals"},{"issue":"6","key":"10.1016\/j.cct.2025.107983_bb0075","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/etc.4116","article-title":"Gadolinium as a new emerging contaminant of aquatic environments","volume":"37","author":"Rogowska","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"issue":"5","key":"10.1016\/j.cct.2025.107983_bb0080","doi-asserted-by":"crossref","first-page":"W226","DOI":"10.2214\/AJR.18.19880","article-title":"Head-to-head comparison between biparametric and multiparametric MRI for the diagnosis of prostate cancer: a systematic review and meta-analysis","volume":"211","author":"Woo","year":"2018","journal-title":"AJR Am. J. Roentgenol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0085","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2214\/AJR.17.18946","article-title":"Diagnostic performance of biparametric MRI for detection of prostate cancer: a systematic review and meta-analysis","volume":"211","author":"Ke","year":"2018","journal-title":"AJR Am. J. Roentgenol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0090","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2214\/AJR.18.20103","article-title":"Abbreviated biparametric versus standard multiparametric MRI for diagnosis of prostate cancer: a systematic review and meta-analysis","volume":"212","author":"Kang","year":"2019","journal-title":"AJR Am. J. Roentgenol."},{"issue":"44","key":"10.1016\/j.cct.2025.107983_bb0095","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.20316","article-title":"Accuracy of dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate cancer: systematic review and meta-analysis","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0100","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/bju.14759","article-title":"Biparametric vs multiparametric prostate magnetic resonance imaging for the detection of prostate cancer in treatment-na\u00efve patients: a diagnostic test accuracy systematic review and meta-analysis","volume":"124","author":"Alabousi","year":"2019","journal-title":"BJU Int."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/diagnostics12020231","article-title":"Diagnostic accuracy of abbreviated bi-parametric MRI (a-bpMRI) for prostate cancer detection and screening: a multi-reader study","volume":"12","author":"Brembilla","year":"2022","journal-title":"Diagnostics"},{"issue":"4","key":"10.1016\/j.cct.2025.107983_bb0110","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.eururo.2020.03.002","article-title":"Additional value of dynamic contrast-enhanced sequences in multiparametric prostate magnetic resonance imaging: data from the PROMIS study","volume":"78","author":"Bosaily","year":"2020","journal-title":"Eur. Urol."},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2214\/AJR.20.24268","article-title":"PI-RADS committee position on MRI without contrast medium in biopsy-naive men with suspected prostate cancer: narrative review","volume":"216","author":"Schoots","year":"2021","journal-title":"Am. J. Roentgenol."},{"issue":"5","key":"10.1016\/j.cct.2025.107983_bb0120","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.eururo.2018.08.007","article-title":"The SmartTarget biopsy trial: a prospective, within-person randomised, blinded trial comparing the accuracy of visual-registration and magnetic resonance imaging\/ultrasound image-fusion targeted biopsies for prostate cancer risk stratification","volume":"75","author":"Hamid","year":"2019","journal-title":"Eur. Urol."},{"issue":"9","key":"10.1016\/j.cct.2025.107983_bb0125","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/bjc.2017.57","article-title":"The PICTURE study: diagnostic accuracy of multiparametric MRI in men requiring a repeat prostate biopsy","volume":"116","author":"Simmons","year":"2017","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.eururo.2014.10.026","article-title":"Detection of clinically significant prostate cancer using magnetic resonance imaging-ultrasound fusion targeted biopsy: a systematic review","volume":"68","author":"Valerio","year":"2015","journal-title":"Eur. Urol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0135","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41391-021-00449-7","article-title":"Diagnostic accuracy of magnetic resonance imaging targeted biopsy techniques compared to transrectal ultrasound guided biopsy of the prostate: a systematic review and meta-analysis","volume":"25","author":"Bass","year":"2022","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0140","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1148\/radiol.2017161684","article-title":"The current state of MR imaging-targeted biopsy techniques for detection of prostate cancer","volume":"285","author":"Verma","year":"2017","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/bju.13247","article-title":"The value of magnetic resonance imaging and ultrasonography (MRI\/US)-fusion biopsy platforms in prostate cancer detection: a systematic review","volume":"117","author":"Gayet","year":"2016","journal-title":"BJU Int."},{"key":"10.1016\/j.cct.2025.107983_bb0150","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-319-95693-0_7","article-title":"The role of multi-parametric MRI and fusion biopsy for the diagnosis of prostate cancer - a systematic review of current literature","volume":"1095","author":"Sarkar","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000484144","article-title":"Significance of MRI\/transrectal ultrasound fusion three-dimensional model-guided, targeted biopsy based on transrectal ultrasound-guided systematic biopsy in prostate cancer detection: a systematic review and meta-analysis","volume":"100","author":"Tang","year":"2018","journal-title":"Urol. Int."},{"issue":"4","key":"10.1016\/j.cct.2025.107983_bb0160","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.eururo.2016.07.041","article-title":"Comparing three different techniques for magnetic resonance imaging-targeted prostate biopsies: a systematic review of in-bore versus magnetic resonance imaging-transrectal ultrasound fusion versus cognitive registration. Is there a preferred technique?","volume":"71","author":"Wegelin","year":"2017","journal-title":"Eur. Urol."},{"issue":"7840","key":"10.1016\/j.cct.2025.107983_bb0165","article-title":"Short term outcomes of prostate biopsy in men tested for cancer by prostate specific antigen: prospective evaluation within ProtecT study","volume":"344","author":"Rosario","year":"2012","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.eururo.2018.05.035","article-title":"Prostate imaging-reporting and data system steering committee: PI-RADS v2 status update and future directions","volume":"75","author":"Padhani","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.cct.2025.107983_bb0175","unstructured":"American College of Radiology\u00ae Committee on PI-RADS\u00ae, American College of Radiology PI-RADS 2019 v2.1 Available at: https:\/\/www.acr.org\/-\/media\/ACR\/Files\/RADS\/PI-RADS\/PIRADS-V2-1.pdf Accessed on Jan. 1, 2025."},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/bju.14361","article-title":"National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection - recommendations from a UK consensus meeting","volume":"122","author":"Brizmohun Appayya","year":"2018","journal-title":"BJU Int."},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0185","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bju.15285","article-title":"Certification in reporting multiparametric magnetic resonance imaging of the prostate: recommendations of a UK consensus meeting","volume":"127","author":"Barrett","year":"2021","journal-title":"BJU Int."},{"key":"10.1016\/j.cct.2025.107983_bb0190","series-title":"Courses and Workshops","year":"2024"},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/bju.14916","article-title":"Likert vs PI-RADS v2: a comparison of two radiological scoring systems for detection of clinically significant prostate cancer","volume":"125","author":"Khoo","year":"2020","journal-title":"BJU Int."},{"issue":"5","key":"10.1016\/j.cct.2025.107983_bb0200","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.euo.2020.06.007","article-title":"Prostate imaging quality (PI-QUAL): a new quality control scoring system for multiparametric magnetic resonance imaging of the prostate from the PRECISION trial","volume":"3","author":"Giganti","year":"2020","journal-title":"Eur. Urol. Oncol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0205","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/bju.14865","article-title":"Optimising the number of cores for magnetic resonance imaging-guided targeted and systematic transperineal prostate biopsy","volume":"125","author":"Hansen","year":"2020","journal-title":"BJU Int."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/JU.0000000000000527","article-title":"Minimum magnetic resonance imaging-ultrasound fusion targeted biopsy cores needed for prostate cancer detection: multivariable retrospective, lesion based analyses of patients treated with radical prostatectomy","volume":"203","author":"Leyh-Bannurah","year":"2020","journal-title":"J. Urol."},{"issue":"5","key":"10.1016\/j.cct.2025.107983_bb0215","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.euo.2018.09.006","article-title":"Optimizing the number of cores targeted during prostate magnetic resonance imaging fusion target biopsy","volume":"1","author":"Kenigsberg","year":"2018","journal-title":"Eur. Urol. Oncol."},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0220","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/his.13712","article-title":"Defining clinically significant prostate cancer on the basis of pathological findings","volume":"74","author":"Matoso","year":"2019","journal-title":"Histopathology"},{"key":"10.1016\/j.cct.2025.107983_bb0225","series-title":"4 Economic Evaluation | NICE Health Technology Evaluations: The Manual | Guidance","year":"2024"},{"issue":"7","key":"10.1016\/j.cct.2025.107983_bb0230","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1007\/s00330-020-06782-0","article-title":"Diagnostic accuracy of biparametric versus multiparametric prostate MRI: assessment of contrast benefit in clinical practice","volume":"30","author":"Zawaideh","year":"2020","journal-title":"Eur. Radiol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0235","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.0219","article-title":"Assessment of the diagnostic accuracy of biparametric magnetic resonance imaging for prostate cancer in biopsy-naive men: the biparametric MRI for detection of prostate cancer (BIDOC) study","volume":"1","author":"Boesen","year":"2018","journal-title":"JAMA Netw. Open"},{"issue":"4","key":"10.1016\/j.cct.2025.107983_bb0240","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-070280","article-title":"Comparing biparametric to multiparametric MRI in the diagnosis of clinically significant prostate cancer in biopsy-naive men (PRIME): a prospective, international, multicentre, non-inferiority within-patient, diagnostic yield trial protocol","volume":"13","author":"Asif","year":"2023","journal-title":"BMJ Open"},{"key":"10.1016\/j.cct.2025.107983_bb0245","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.clinimag.2022.11.013","article-title":"Index lesion detection in multifocal prostate cancer: simplified PI-RADS biparametric MRI vs PI-RADS v2.1 multiparametric MRI","volume":"94","author":"Scialpi","year":"2023","journal-title":"Clin. Imaging"},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0250","article-title":"Prevalence of MRI lesions in men responding to a GP-led invitation for a prostate health check: a prospective cohort study","volume":"2","author":"Moore","year":"2023","journal-title":"BMJ Oncol."},{"issue":"12","key":"10.1016\/j.cct.2025.107983_bb0255","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1056\/NEJMoa2406050","article-title":"Results after four years of screening for prostate cancer with PSA and MRI","volume":"391","author":"Hugosson","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0260","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.54577","article-title":"Repeated prostate cancer screening using prostate-specific antigen testing and magnetic resonance imaging: a secondary analysis of the STHLM3-MRI randomized clinical trial","volume":"7","author":"Nordstr\u00f6m","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"6","key":"10.1016\/j.cct.2025.107983_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002813","article-title":"Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: a prospective multi-institutional trial","volume":"16","author":"Jambor","year":"2019","journal-title":"PLoS Med."},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0270","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/bju.15876","article-title":"Incidence of significant prostate cancer after negative MRI and systematic biopsy in the FUTURE trial","volume":"131","author":"Exterkate","year":"2023","journal-title":"BJU Int."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0275","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.euo.2023.08.002","article-title":"Diagnostic performance of prostate-specific antigen density for detecting clinically significant prostate cancer in the era of magnetic resonance imaging: a systematic review and meta-analysis","volume":"7","author":"Wang","year":"2024","journal-title":"Eur. Urol. Oncol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0280","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/bju.15277","article-title":"Risk-adapted biopsy decision based on prostate magnetic resonance imaging and prostate-specific antigen density for enhanced biopsy avoidance in first prostate cancer diagnostic evaluation","volume":"127","author":"Schoots","year":"2021","journal-title":"BJU Int."},{"issue":"1153","key":"10.1016\/j.cct.2025.107983_bb0285","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/bjr\/tqad027","article-title":"Risk stratification of prostate cancer with MRI and prostate-specific antigen density-based tool for personalized decision making","volume":"97","author":"Rajendran","year":"2024","journal-title":"Br. J. Radiol."},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0290","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.4258","article-title":"Magnetic resonance imaging, clinical, and biopsy findings in suspected prostate cancer: a systematic review and meta-analysis","volume":"7","author":"Haj-Mirzaian","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0295","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.juro.2011.03.147","article-title":"Characterizing clinically significant prostate cancer using template prostate mapping biopsy","volume":"186","author":"Ahmed","year":"2011","journal-title":"J. Urol."},{"issue":"11","key":"10.1016\/j.cct.2025.107983_bb0300","doi-asserted-by":"crossref","first-page":"e509","DOI":"10.1016\/S1470-2045(12)70388-1","article-title":"Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy?","volume":"13","author":"Ahmed","year":"2012","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.cct.2025.107983_bb0305","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.juro.2015.01.126","article-title":"Gleason 6 prostate cancer: translating biology into population health","volume":"194","author":"Eggener","year":"2015","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.cct.2025.107983_bb0310","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.eururo.2011.05.006","article-title":"The contemporary concept of significant versus insignificant prostate cancer","volume":"60","author":"Ploussard","year":"2011","journal-title":"Eur. Urol."},{"issue":"11","key":"10.1016\/j.cct.2025.107983_bb0315","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jama.280.11.969","article-title":"Biochemical outcome after radical prostatectomy, external beam radiation therapy, or interstitial radiation therapy for clinically localized prostate cancer","volume":"280","author":"D\u2019Amico","year":"1998","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.cct.2025.107983_bb0320","doi-asserted-by":"crossref","first-page":"479","DOI":"10.6004\/jnccn.2019.0023","article-title":"Prostate cancer, version 2.2019, NCCN clinical practice guidelines in oncology","volume":"17","author":"Mohler","year":"2019","journal-title":"J. Natl. Compr. Cancer Netw."},{"issue":"1","key":"10.1016\/j.cct.2025.107983_bb0325","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-018-1019-5","article-title":"The Cambridge prognostic groups for improved prediction of disease mortality at diagnosis in primary non-metastatic prostate cancer: a validation study","volume":"16","author":"Gnanapragasam","year":"2018","journal-title":"BMC Med."}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714425001776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714425001776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:05:00Z","timestamp":1778868300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714425001776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":63,"alternative-id":["S1551714425001776"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2025.107983","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prostate Assessment using Comparative Interventions \u2013 Fast MRI and Image-fusion for Cancer (IP7-PACIFIC): A prospective, multi-centre, dual sequential randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2025.107983","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107983"}}