{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:55:14Z","timestamp":1790344514985,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013200","name":"Government of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Contemporary Clinical Trials"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.cct.2026.108410","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:42:06Z","timestamp":1784590926000},"page":"108410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Optimizing prostate biopsy decision making \u2013 (MUSIC-screen): A 1:1 randomized controlled trial comparing micro-ultrasound versus multiparametric magnetic resonance imaging for prostate cancer diagnosis"],"prefix":"10.1016","volume":"168","author":[{"given":"Melis","family":"Guer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alp Tuna","family":"Beksac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Brisbane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Cash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeet","family":"Ghai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Heinrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Lavigueur-Blouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"L\u00f6ffeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lughezzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles","family":"Mannas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara N.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Nahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian P.","family":"Struck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Toledano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Urdaneta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kinnaird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cct.2026.108410_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.cct.2026.108410_bb0010","series-title":"Presented at the EAU Annual Congress Madrid 2025","author":"EAU Guidelines","year":"2026"},{"key":"10.1016\/j.cct.2026.108410_bb0015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5489\/cuaj.4888","article-title":"Canadian Urological Association recommendations on prostate cancer screening and early diagnosis","volume":"11","author":"Rendon","year":"2017","journal-title":"Can. Urol. Assoc. J."},{"key":"10.1016\/j.cct.2026.108410_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/S0197-2456(00)00098-2","article-title":"Design of the Prostate, lung, colorectal and ovarian (PLCO) Cancer screening trial","volume":"21","author":"Prorok","year":"2000","journal-title":"Control. Clin. Trials"},{"key":"10.1016\/j.cct.2026.108410_bb0025","article-title":"Microultrasonography-guided vs MRI-guided biopsy for prostate cancer diagnosis: the OPTIMUM randomized clinical trial","author":"Kinnaird","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.cct.2026.108410_bb0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/bju.15277","article-title":"Risk-adapted biopsy decision based on prostate magnetic resonance imaging and prostate-specific antigen density for enhanced biopsy avoidance in first prostate cancer diagnostic evaluation","volume":"127","author":"Schoots","year":"2021","journal-title":"BJU Int."},{"key":"10.1016\/j.cct.2026.108410_bb0035","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41391-024-00852-w","article-title":"Risk calculators for the detection of prostate cancer: a systematic review","volume":"27","author":"Denijs","year":"2024","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"10.1016\/j.cct.2026.108410_bb0040","first-page":"15","article-title":"A contemporary review: mpMRI in prostate cancer screening and diagnosis","volume":"43","author":"Launer","year":"2025","journal-title":"Urol. Oncol. Semin. Orig. Investig."},{"key":"10.1016\/j.cct.2026.108410_bb0045","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.eururo.2019.10.024","article-title":"Multiparametric magnetic resonance imaging for the detection of clinically significant prostate Cancer: what urologists need to know. Part 2: interpretation","volume":"77","author":"Isra\u00ebl","year":"2020","journal-title":"Eur. Urol."},{"key":"10.1016\/j.cct.2026.108410_bb0050","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.euf.2018.10.008","article-title":"Accuracy and variability of prostate multiparametric magnetic resonance imaging interpretation using the prostate imaging reporting and data system: a blinded comparison of radiologists","volume":"6","author":"Pickersgill","year":"2020","journal-title":"Eur. Urol. Focus"},{"key":"10.1016\/j.cct.2026.108410_bb0055","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.2106\/JBJS.N.01141","article-title":"Prevalence of total hip and knee replacement in the United States","volume":"97","author":"Kremers","year":"2015","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.cct.2026.108410_bb0060","series-title":"Chronic Kidney Disease in the United States, 2023","author":"Centers for Disease Control and Prevention","year":"2023"},{"key":"10.1016\/j.cct.2026.108410_bb0065","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2147\/NDT.S2699","article-title":"Prevalence of claustrophobia and magnetic resonance imaging after coronary artery bypass graft surgery","volume":"4","author":"Katznelson","year":"2008","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.cct.2026.108410_bb0070","article-title":"Micro-ultrasound for prostate cancer","author":"Guer","year":"2025","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.cct.2026.108410_bb0075","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.juro.2015.12.093","article-title":"Assessing cancer risk on novel 29 MHz Micro-ultrasound images of the prostate: creation of the micro-ultrasound protocol for prostate risk identification","volume":"196","author":"Ghai","year":"2016","journal-title":"J. Urol."},{"key":"10.1016\/j.cct.2026.108410_bb0080","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1007\/s00345-023-04591-w","article-title":"Assessing cancer risk in the anterior part of the prostate using micro-ultrasound: validation of a novel distinct protocol","volume":"41","author":"Schaer","year":"2023","journal-title":"World. J. Urol."},{"key":"10.1016\/j.cct.2026.108410_bb0085","article-title":"External validation of the PRI-MUS scoring system: a secondary analysis of the OPTIMUM randomized controlled trial","author":"Lazarovich","year":"2026","journal-title":"J. Urol."},{"key":"10.1016\/j.cct.2026.108410_bb0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.48083\/KKVJ7280","article-title":"Prostate cancer detection by novice micro-ultrasound users enrolled in a training program","volume":"3","author":"Cash","year":"2022","journal-title":"Soc. Int. Urol. J."},{"key":"10.1016\/j.cct.2026.108410_bb0095","series-title":"Magnetic Resonance Imaging Contraindications","author":"Ghadimi","year":"2025"},{"key":"10.1016\/j.cct.2026.108410_bb0100","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5489\/cuaj.10021","article-title":"CUA guidelines on prostate biopsy methodology","volume":"4","author":"El-Hakim","year":"2010","journal-title":"Can. Urol. Assoc. J."},{"key":"10.1016\/j.cct.2026.108410_bb0105","author":"ISO 14155:2026(en)"},{"key":"10.1016\/j.cct.2026.108410_bb0110","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.eururo.2019.02.033","article-title":"Prostate imaging reporting and data system version 2.1: 2019 update of prostate imaging reporting and data system version 2","volume":"76","author":"Turkbey","year":"2019","journal-title":"Eur. Urol."},{"key":"10.1016\/j.cct.2026.108410_bb0115","unstructured":"Canadian Agency for Drugs and Technologies in Health Agence Canadienne des M\u00e9dicaments et des Technologies de la Sant\u00e9 2006."},{"key":"10.1016\/j.cct.2026.108410_bb0120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jval.2015.02.001","article-title":"Cost-effectiveness analysis alongside clinical trials II - an ISPOR good research practices task force report","volume":"18","author":"Ramsey","year":"2015","journal-title":"Value Health"},{"key":"10.1016\/j.cct.2026.108410_bb0125","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/jnci\/90.12.925","article-title":"Short-term effects of population-based screening for prostate cancer on health-related quality of life","volume":"90","author":"Essink-Bot","year":"1998","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.cct.2026.108410_bb0130","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.urology.2014.08.044","article-title":"Minimally important difference for the expanded prostate cancer index composite short form","volume":"85","author":"Skolarus","year":"2015","journal-title":"Urology"},{"key":"10.1016\/j.cct.2026.108410_bb0135","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.euo.2023.09.013","article-title":"Magnetic resonance imaging-targeted versus systematic prostate biopsies: 2-year follow-up of a prospective randomized trial (PRECISE)","volume":"7","author":"Klotz","year":"2024","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.cct.2026.108410_bb0140","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/jamasurg.2019.1734","article-title":"Comparison of targeted vs systematic prostate biopsy in men who are biopsy naive: the prospective assessment of image registration in the diagnosis of prostate cancer (PAIREDCAP) study","volume":"154","author":"Elkhoury","year":"2019","journal-title":"JAMA Surg."},{"key":"10.1016\/j.cct.2026.108410_bb0145","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1056\/NEJMoa1801993","article-title":"MRI-targeted or standard biopsy for prostate-cancer diagnosis","volume":"378","author":"Kasivisvanathan","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cct.2026.108410_bb0150","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0140-6736(16)32401-1","article-title":"Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study","volume":"389","author":"Ahmed","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.cct.2026.108410_bb0155","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1470-2045(25)00100-7","article-title":"Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial","volume":"26","author":"Bryant","year":"2025","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.cct.2026.108410_bb0160","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.clgc.2016.07.007","article-title":"Transperineal versus transrectal MRI\/TRUS fusion targeted biopsy: detection rate of clinically significant prostate Cancer","volume":"15","author":"Pepe","year":"2017","journal-title":"Clin. Genitourin. Cancer"}],"container-title":["Contemporary Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714426001965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1551714426001965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:34:53Z","timestamp":1786520093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1551714426001965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":32,"alternative-id":["S1551714426001965"],"URL":"https:\/\/doi.org\/10.1016\/j.cct.2026.108410","relation":{},"ISSN":["1551-7144"],"issn-type":[{"value":"1551-7144","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimizing prostate biopsy decision making \u2013 (MUSIC-screen): A 1:1 randomized controlled trial comparing micro-ultrasound versus multiparametric magnetic resonance imaging for prostate cancer diagnosis","name":"articletitle","label":"Article Title"},{"value":"Contemporary Clinical Trials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cct.2026.108410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"108410"}}