{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:35:38Z","timestamp":1793147738050,"version":"4.5.0"},"reference-count":164,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dental Clinics of North America"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.cden.2005.03.001","type":"journal-article","created":{"date-parts":[[2005,6,23]],"date-time":"2005-06-23T11:21:43Z","timestamp":1119525703000},"page":"491-516","source":"Crossref","is-referenced-by-count":222,"title":["Etiology and Pathogenesis of Periodontal Diseases"],"prefix":"10.1016","volume":"49","author":[{"given":"Dimitris N.","family":"Tatakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima S.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cden.2005.03.001_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1056\/NEJM199002083220606","article-title":"Periodontal disease","volume":"322","author":"Williams","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cden.2005.03.001_bib3","first-page":"171","article-title":"Absence and presence of fluid from normal and inflamed gingivae","volume":"3","author":"L\u00f6e","year":"1965","journal-title":"Periodontics"},{"key":"10.1016\/j.cden.2005.03.001_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.1966.tb01842.x","article-title":"Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation","volume":"1","author":"Theilade","year":"1966","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.1973.tb00735.x","article-title":"Experimental periodontitis in the beagle dog","volume":"8","author":"Lindhe","year":"1973","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib6","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1128\/IAI.23.2.260-269.1979","article-title":"Longitudinal study of experimentally induced periodontal disease in Macaca arctoides: relationship between microflora and alveolar bone loss","volume":"23","author":"Slots","year":"1979","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.3336774","article-title":"Implantation of Bacteroides gingivalis in nonhuman primates initiates progression of periodontitis","volume":"239","author":"Holt","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.cden.2005.03.001_bib8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-051X.1985.tb00920.x","article-title":"3-year longitudinal study of the periodontal status of an adult population with gingivitis","volume":"12","author":"Listgarten","year":"1985","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-051X.1986.tb01487.x","article-title":"Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age","volume":"13","author":"L\u00f6e","year":"1986","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0765.1999.tb02262.x","article-title":"Milestones in periodontal research and the remaining critical issues","volume":"34","author":"Page","year":"1999","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib11","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1128\/CMR.14.4.727-752.2001","article-title":"Periodontal disease as a specific, albeit chronic, infection: diagnosis and treatment","volume":"14","author":"Loesche","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.cden.2005.03.001_bib12","first-page":"65","article-title":"Chemotherapy of dental plaque infections","volume":"9","author":"Loesche","year":"1976","journal-title":"Oral Sci Rev"},{"key":"10.1016\/j.cden.2005.03.001_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.1966.tb01842.x","article-title":"Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation","volume":"1","author":"Theilade","year":"1966","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1600-0765.1990.tb00924.x","article-title":"Microbial changes associated with the development of puberty gingivitis","volume":"25","author":"Mombelli","year":"1990","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1600-051X.1982.tb02108.x","article-title":"Patterns of progression and regression of advanced destructive periodontal disease","volume":"9","author":"Goodson","year":"1982","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib16","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1073\/pnas.96.25.14547","article-title":"Bacterial diversity within the human subgingival crevice","volume":"96","author":"Kroes","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cden.2005.03.001_bib17","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/JB.183.12.3770-3783.2001","article-title":"Bacterial diversity in human subgingival plaque","volume":"183","author":"Paster","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cden.2005.03.001_bib18","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/IAI.62.5.1889-1895.1994","article-title":"Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive periodontitis","volume":"62","author":"Choi","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF01569816","article-title":"Overview of microbial biofilms","volume":"15","author":"Costerton","year":"1995","journal-title":"J Ind Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib20","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0194-5998(98)70325-0","article-title":"Predictive value of an adherence test for acute otitis media","volume":"118","author":"Danino","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.cden.2005.03.001_bib21","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.1986.57.4.225","article-title":"Bacterial adherence to gingival epithelial cells of rats with naturally occurring gingivitis","volume":"57","author":"Isogai","year":"1986","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0003-9969(89)90070-8","article-title":"Characterization of in vivo salivary-derived enamel pellicle","volume":"34","author":"Al-Hashimi","year":"1989","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.cden.2005.03.001_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/10454411970080020601","article-title":"Streptococcal adhesion and colonization","volume":"8","author":"Jenkinson","year":"1997","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.cden.2005.03.001_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.micro.54.1.413","article-title":"Oral microbial communities: biofilms, interactions, and genetic systems","volume":"54","author":"Kolenbrander","year":"2000","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/MMBR.66.3.486-505.2002","article-title":"Communication among oral bacteria [table of contents]","volume":"66","author":"Kolenbrander","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.cden.2005.03.001_bib26","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/JB.183.13.3903-3909.2001","article-title":"Signaling system in Porphyromonas gingivalis based on a LuxS protein","volume":"183","author":"Chung","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cden.2005.03.001_bib27","doi-asserted-by":"crossref","first-page":"7625","DOI":"10.1128\/IAI.69.12.7625-7634.2001","article-title":"Intra- and interspecies regulation of gene expression by Actinobacillus actinomycetemcomitans LuxS","volume":"69","author":"Fong","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib28","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1099\/00221287-148-6-1627","article-title":"Role of the Streptococcus gordonii SspB protein in the development of Porphyromonas gingivalis biofilms on streptococcal substrates","volume":"148","author":"Lamont","year":"2002","journal-title":"Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib29","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1128\/JB.185.1.274-284.2003","article-title":"LuxS-based signaling in Streptococcus gordonii: autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis","volume":"185","author":"McNab","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cden.2005.03.001_bib30","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1128\/JB.184.22.6333-6342.2002","article-title":"Novel two-component regulatory system involved in biofilm formation and acid resistance in Streptococcus mutans","volume":"184","author":"Li","year":"2002","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cden.2005.03.001_bib31","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1128\/JB.184.10.2699-2708.2002","article-title":"A quorum-sensing signaling system essential for genetic competence in Streptococcus mutans is involved in biofilm formation","volume":"184","author":"Li","year":"2002","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cden.2005.03.001_bib32","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1128\/JB.185.5.1485-1491.2003","article-title":"Diffusion in biofilms","volume":"185","author":"Stewart","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.cden.2005.03.001_bib33","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1073\/pnas.87.15.5858","article-title":"Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae","volume":"87","author":"Dowson","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.cden.2005.03.001_bib34","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1128\/AAC.45.10.2943-2946.2001","article-title":"Transfer of TN916-like elements in microcosm dental plaques","volume":"45","author":"Roberts","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cden.2005.03.001_bib35","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1128\/AAC.34.11.2043","article-title":"Testing the susceptibility of bacteria in biofilms to antibacterial agents","volume":"34","author":"Anwar","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.cden.2005.03.001_bib36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1128\/IAI.44.2.228-233.1984","article-title":"Effect of saliva on coaggregation of oral Actinomyces and Streptococcus species","volume":"44","author":"Kolenbrander","year":"1984","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib37","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1128\/IAI.68.8.4834-4837.2000","article-title":"Identification of saliva-regulated genes of Streptococcus gordonii DL1 by differential display using random arbitrarily primed PCR","volume":"68","author":"Du","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib38","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1099\/00221287-147-10-2841","article-title":"Regulation of the gtfBC and ftf genes of Streptococcus mutans in biofilms in response to pH and carbohydrate","volume":"147","author":"Li","year":"2001","journal-title":"Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0076-6879(99)10024-7","article-title":"Use of continuous flow techniques in modeling dental plaque biofilms","volume":"310","author":"Bradshaw","year":"1999","journal-title":"Methods Enzymol"},{"issue":"Pt 4","key":"10.1016\/j.cden.2005.03.001_bib40","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1099\/00221287-142-4-963","article-title":"The relationships between leukotoxin production, growth rate and the bicarbonate concentration in a toxin-production-variable strain of Actinobacillus actinomycetemcomitans","volume":"142","author":"Ohta","year":"1996","journal-title":"Microbiol"},{"issue":"Pt 4","key":"10.1016\/j.cden.2005.03.001_bib41","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1099\/00221287-140-4-861","article-title":"The effect of growth rate and haemin on the virulence and proteolytic activity of Porphyromonas gingivalis W50","volume":"140","author":"Marsh","year":"1994","journal-title":"Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/IAI.41.1.19-27.1983","article-title":"Serology of oral Actinobacillus actinomycetemcomitans and serotype distribution in human periodontal disease","volume":"41","author":"Zambon","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1471-4906(01)02169-X","article-title":"Does the shape of lipid A determine the interaction of LPS with Toll-like receptors?","volume":"23","author":"Netea","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib44","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/154411130301400603","article-title":"Oral microbial heat-shock proteins and their potential contributions to infections","volume":"14","author":"Goulhen","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.cden.2005.03.001_bib45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1574-6968.2000.tb08900.x","article-title":"Localization of heat shock proteins in clinical Actinobacillus actinomycetemcomitans strains and their effects on epithelial cell proliferation","volume":"182","author":"Paju","year":"2000","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.cden.2005.03.001_bib46","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1128\/IAI.70.5.2492-2501.2002","article-title":"Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients","volume":"70","author":"Yamazaki","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1046\/j.1365-2249.2002.01723.x","article-title":"Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease","volume":"127","author":"Ueki","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib48","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/IAI.65.5.1980-1984.1997","article-title":"A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells","volume":"65","author":"Njoroge","year":"1997","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib49","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1600-0765.1999.tb02282.x","article-title":"Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis","volume":"34","author":"Curtis","year":"1999","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib50","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1128\/IAI.60.4.1455-1464.1992","article-title":"Porphyromonas gingivalis virulence in mice: induction of immunity to bacterial components","volume":"60","author":"Kesavalu","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mpat.1997.0161","article-title":"Porphyromonas gingivalis virulence in a murine lesion model: effects of immune alterations","volume":"23","author":"Kesavalu","year":"1997","journal-title":"Microb Pathog"},{"key":"10.1016\/j.cden.2005.03.001_bib52","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1902\/jop.2001.72.5.641","article-title":"Protease-active extracellular protein preparations from Porphyromonas gingivalis W83 induce N-cadherin proteolysis, loss of cell adhesion, and apoptosis in human epithelial cells","volume":"72","author":"Chen","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib53","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/MMBR.60.2.316-341.1996","article-title":"Bacterial modulins: a novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis","volume":"60","author":"Henderson","year":"1996","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.cden.2005.03.001_bib54","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/154405910308200503","article-title":"New bacterial species associated with chronic periodontitis","volume":"82","author":"Kumar","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.cden.2005.03.001_bib55","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1902\/jop.1992.63.4s.322","article-title":"The bacterial etiology of destructive periodontal disease: current concepts","volume":"63","author":"Socransky","year":"1992","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib56","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1128\/JCM.40.6.2187-2191.2002","article-title":"Prevalent bacterial species and novel phylotypes in advanced noma lesions","volume":"40","author":"Paster","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib57","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1128\/JCM.40.3.821-825.2002","article-title":"Association of Bacteroides forsythus and a novel Bacteroides phylotype with periodontitis","volume":"40","author":"Leys","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib58","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1177\/00220345000790021301","article-title":"Campylobacter species in health, gingivitis, and periodontitis","volume":"79","author":"Macuch","year":"2000","journal-title":"J Dent Res"},{"key":"10.1016\/j.cden.2005.03.001_bib59","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1902\/jop.2000.71.2.209","article-title":"Peptostreptococcus micros smooth and rough genotypes in periodontitis and gingivitis","volume":"71","author":"Kremer","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-0765.1980.tb00265.x","article-title":"The subgingival microbial flora during pregnancy","volume":"15","author":"Kornman","year":"1980","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib61","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1600-051X.1988.tb01590.x","article-title":"The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases","volume":"15","author":"Dzink","year":"1988","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib62","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1600-051X.1988.tb01577.x","article-title":"Clinical, microbiological and immunological features of subjects with destructive periodontal diseases","volume":"15","author":"Haffajee","year":"1988","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib63","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1600-051X.1985.tb00936.x","article-title":"Gram negative species associated with active destructive periodontal lesions","volume":"12","author":"Dzink","year":"1985","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-302X.1989.tb00398.x","article-title":"The predominant cultivable microbiota of crevicular epithelial cells","volume":"4","author":"Dzink","year":"1989","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib65","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1902\/jop.1994.65.9.892","article-title":"Actinobacillus actinomycetemcomitans in adult periodontitis","volume":"65","author":"Zambon","year":"1994","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-051X.1985.tb01348.x","article-title":"Actinobacillus actinomycetemcomitans in human periodontal disease","volume":"12","author":"Zambon","year":"1985","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib67","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1902\/jop.2000.71.6.912","article-title":"Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis","volume":"71","author":"Haraszthy","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib68","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1128\/JCM.42.9.4141-4146.2004","article-title":"Prevalence of periodontal pathogens in dental plaque of children","volume":"42","author":"Gafan","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib69","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1902\/jop.1985.56.8.443","article-title":"Clinical and microbiological evaluation of therapy for juvenile periodontitis","volume":"56","author":"Kornman","year":"1985","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib70","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1902\/jop.2000.71.6.981","article-title":"Human herpesviruses and Porphyromonas gingivalis are associated with juvenile periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib71","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1399-302x.2004.00161.x","article-title":"Microbiological profile of early onset\/aggressive periodontitis patients","volume":"19","author":"Kamma","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib72","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1902\/jop.2003.74.10.1460","article-title":"Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population","volume":"74","author":"Takeuchi","year":"2003","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib73","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1902\/jop.2003.74.9.1329","article-title":"Distribution of periodontal pathogens in Korean aggressive periodontitis","volume":"74","author":"Lee","year":"2003","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib74","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1099\/ijs.0.02806-0","article-title":"Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated from lesions of human periodontitis and acute necrotizing ulcerative gingivitis","volume":"54","author":"Wyss","year":"2004","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.cden.2005.03.001_bib75","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1902\/jop.1979.50.7.350","article-title":"The predominant cultivable microbiota of the periodontal abscess","volume":"50","author":"Newman","year":"1979","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib76","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1034\/j.1600-051x.2000.027006387.x","article-title":"The periodontal abscess (I). Clinical and microbiological findings","volume":"27","author":"Herrera","year":"2000","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib77","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1600-051x.2004.00477.x","article-title":"Modulation of clinical expression of plaque-induced gingivitis. I. Background review and rationale","volume":"31","author":"Tatakis","year":"2004","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1600-051x.2004.00478.x","article-title":"Modulation of clinical expression of plaque-induced gingivitis. II. Identification of \u201chigh-responder\u201d and \u201clow-responder\u201d subjects","volume":"31","author":"Trombelli","year":"2004","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib79","first-page":"6","article-title":"\u00dcber den Einfluss der Parodontalen Resistenze auf die Experimentelle Gingivitis","volume":"34","author":"Wiedemann","year":"1979","journal-title":"Dtsch Zahnarztl Z"},{"key":"10.1016\/j.cden.2005.03.001_bib80","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0765.1994.tb01209.x","article-title":"Effect of pre-experimental maintenance care duration on the development of gingivitis in a partial mouth experimental gingivitis model","volume":"29","author":"van der Weijden","year":"1994","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib81","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1902\/jop.2005.76.1.49","article-title":"Modulation of clinical expression of plaque-induced gingivitis: interleukin-1 gene cluster polymorphisms","volume":"76","author":"Scapoli","year":"2005","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib82","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1600-0757.1997.tb00198.x","article-title":"Genetic factors in the pathogenesis of periodontitis","volume":"14","author":"Hart","year":"1997","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cden.2005.03.001_bib83","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","article-title":"Evidence of a substantial genetic basis for risk of adult periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib84","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1902\/jop.1999.70.1.49","article-title":"Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognoses and tooth survival","volume":"70","author":"McGuire","year":"1999","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib85","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1902\/jop.2002.73.2.231","article-title":"A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis","volume":"73","author":"Greenstein","year":"2002","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib86","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00439-003-1065-7","article-title":"Localized aggressive periodontitis is linked to human chromosome 1q25","volume":"114","author":"Li","year":"2004","journal-title":"Hum Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib87","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1902\/jop.2001.72.3.368","article-title":"Relationship of periodontopathic bacteria with early-onset periodontitis in Down's syndrome","volume":"72","author":"Amano","year":"2001","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib88","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/jmg.36.12.881","article-title":"Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome","volume":"36","author":"Hart","year":"1999","journal-title":"J Med Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib89","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-051X.1981.tb02347.x","article-title":"Manifestations and treatment of periodontal disease in a patient suffering from cyclic neutropenia","volume":"8","author":"Rylander","year":"1981","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib90","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/70544","article-title":"Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis","volume":"23","author":"Horwitz","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib91","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1902\/jop.1995.66.9.808","article-title":"Infantile genetic agranulocytosis (Kostmann type). A case report","volume":"66","author":"Saglam","year":"1995","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib92","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1182\/blood.V96.7.2317","article-title":"Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia","volume":"96","author":"Dale","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.cden.2005.03.001_bib93","first-page":"527","article-title":"The Chediak-Higashi syndrome: case report","volume":"37","author":"Gillig","year":"1970","journal-title":"ASDC J Dent Child"},{"key":"10.1016\/j.cden.2005.03.001_bib94","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005792-197207000-00001","article-title":"The Ch\u00e9diak-Higashi syndrome: studies in four patients and a review of the literature","volume":"51","author":"Blume","year":"1972","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.cden.2005.03.001_bib95","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ng1196-307","article-title":"Identification and mutation analysis of the complete gene for Ch\u00e9diak-Higashi syndrome","volume":"14","author":"Nagle","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00278288","article-title":"The Papillon-Lef\u00e8vre syndrome: keratosis palmoplantaris with periodontopathy. Report of a case and review of the cases in the literature","volume":"51","author":"Haneke","year":"1979","journal-title":"Hum Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib97","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/70525","article-title":"Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis","volume":"23","author":"Toomes","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib98","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1902\/jop.1987.58.6.400","article-title":"Periodontal manifestations of the heritable Mac-1, LFA-1, deficiency syndrome. Clinical, histopathologic and molecular characteristics","volume":"58","author":"Waldrop","year":"1987","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib99","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.164.3.855","article-title":"LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in hybrid cells","volume":"164","author":"Marlin","year":"1986","journal-title":"J Exp Med"},{"key":"10.1016\/j.cden.2005.03.001_bib100","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1902\/jop.1997.68.5.473","article-title":"Periodontal findings in Cohen syndrome with chronic neutropenia","volume":"68","author":"Alaluusua","year":"1997","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib101","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1086\/375454","article-title":"Cohen syndrome is caused by mutations in a novel gene, COH1, encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport","volume":"72","author":"Kolehmainen","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.cden.2005.03.001_bib102","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1177\/00220345960750021001","article-title":"Serum cotinine levels, smoking, and periodontal attachment loss","volume":"75","author":"Gonzalez","year":"1996","journal-title":"J Dent Res"},{"key":"10.1016\/j.cden.2005.03.001_bib103","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.14219\/jada.archive.1995.0327","article-title":"Smoking and its effects on early-onset periodontitis","volume":"126","author":"Schenkein","year":"1995","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.cden.2005.03.001_bib104","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1902\/jop.1994.65.3.260","article-title":"Assessment of risk for periodontal disease. I. Risk indicators for attachment loss","volume":"65","author":"Grossi","year":"1994","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib105","doi-asserted-by":"crossref","first-page":"599","DOI":"10.14219\/jada.archive.1997.0259","article-title":"Effects of smoking and smoking cessation on healing after mechanical periodontal therapy","volume":"128","author":"Grossi","year":"1997","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.cden.2005.03.001_bib106","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1902\/jop.2004.75.2.196","article-title":"Cigarette smoking and the periodontal patient","volume":"75","author":"Johnson","year":"2004","journal-title":"J Periodontol"},{"issue":"Suppl","key":"10.1016\/j.cden.2005.03.001_bib107","doi-asserted-by":"crossref","first-page":"30S","DOI":"10.14219\/jada.archive.2001.0386","article-title":"Dentistry's role in tobacco control","volume":"132","author":"Tomar","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.cden.2005.03.001_bib108","doi-asserted-by":"crossref","first-page":"945","DOI":"10.7326\/0003-4819-140-11-200406010-00035","article-title":"The evolving diabetes burden in the United States","volume":"140","author":"Engelgau","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.cden.2005.03.001_bib109","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2337\/diacare.27.7.1798","article-title":"Type 2 diabetes in the young: the evolving epidemic: the international diabetes federation consensus workshop","volume":"27","author":"Alberti","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.cden.2005.03.001_bib110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1902\/annals.2001.6.1.91","article-title":"The relationship between periodontal diseases and diabetes: an overview","volume":"6","author":"Soskolne","year":"2001","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib111","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1172\/JCI8942","article-title":"Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice","volume":"105","author":"Lalla","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cden.2005.03.001_bib112","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1902\/annals.2001.6.1.113","article-title":"Receptor for advanced glycation end products, inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalities","volume":"6","author":"Lalla","year":"2001","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib113","first-page":"235","article-title":"Pathogenesis of inflammatory periodontal disease. A summary of current work","volume":"34","author":"Page","year":"1976","journal-title":"Lab Invest"},{"key":"10.1016\/j.cden.2005.03.001_bib114","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-0714.1985.tb00474.x","article-title":"Neutrophil function and oral disease","volume":"14","author":"Van Dyke","year":"1985","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.cden.2005.03.001_bib115","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils","volume":"320","author":"Weiss","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.cden.2005.03.001_bib116","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0765.1992.tb02088.x","article-title":"Neutrophil-mediated damage to human gingival epithelial cells","volume":"27","author":"Altman","year":"1992","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib117","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1600-0765.1990.tb00918.x","article-title":"Neutrophil-mediated damage to human periodontal ligament-derived fibroblasts: role of lipopolysaccharide","volume":"25","author":"Deguchi","year":"1990","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib118","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0003-9969(75)90052-7","article-title":"Conversion of stable established gingivitis in the dog into destructive periodontitis","volume":"20","author":"Schroeder","year":"1975","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.cden.2005.03.001_bib119","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-0765.1990.tb00914.x","article-title":"Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis","volume":"25","author":"Gangbar","year":"1990","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib120","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1600-0765.1991.tb01622.x","article-title":"Gingival crevicular fluid elastase-inhibitor complex: correlation with clinical indices and subgingival flora","volume":"26","author":"Zafiropoulos","year":"1991","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib121","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1902\/jop.2000.71.4.521","article-title":"Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis","volume":"71","author":"Caton","year":"2000","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib122","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1902\/annals.2003.8.1.12","article-title":"Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. A systematic review","volume":"8","author":"Reddy","year":"2003","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib123","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1902\/jop.2004.75.3.441","article-title":"Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial","volume":"75","author":"Gapski","year":"2004","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib124","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1601-0825.2000.tb00325.x","article-title":"Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases","volume":"6","author":"Waddington","year":"2000","journal-title":"Oral Dis"},{"key":"10.1016\/j.cden.2005.03.001_bib125","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1600-0765.1984.tb01012.x","article-title":"The effect of oxygen-derived free radicals on gingival proteoglycans and hyaluronic acid","volume":"19","author":"Bartold","year":"1984","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib126","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/0006-291X(90)90780-Q","article-title":"Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases","volume":"171","author":"Saari","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.cden.2005.03.001_bib127","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4049\/jimmunol.136.2.636","article-title":"Neutrophil-mediated solubilization of the subendothelial matrix: oxidative and nonoxidative mechanisms of proteolysis used by normal and chronic granulomatous disease phagocytes","volume":"136","author":"Weiss","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib128","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1902\/jop.2003.74.1.66","article-title":"Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis","volume":"74","author":"Kantarci","year":"2003","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib129","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1128\/IAI.60.6.2481-2487.1992","article-title":"Altered diacylglycerol level and metabolism in neutrophils from patients with localized juvenile periodontitis","volume":"60","author":"Tyagi","year":"1992","journal-title":"Infect Immun"},{"key":"10.1016\/j.cden.2005.03.001_bib130","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-051X.1991.tb01118.x","article-title":"Superoxide formation and chemiluminescence of peripheral polymorphonuclear leukocytes in rapidly progressive periodontitis patients","volume":"18","author":"Shapira","year":"1991","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib131","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1600-051X.1995.tb00159.x","article-title":"Variational expression of functionally different macrophage markers (27E10, 25F9, RM3\/1) in normal gingiva and inflammatory periodontal disease","volume":"22","author":"Schlegel Gomez","year":"1995","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib132","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1034\/j.1600-051X.1999.260309.x","article-title":"Relative proportions of mononuclear cell types in periodontal lesions analyzed by immunohistochemistry","volume":"26","author":"Lappin","year":"1999","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib133","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1096-9896(1998110)186:3<281::AID-PATH200>3.0.CO;2-7","article-title":"Failure of macrophage activation in destructive periodontal disease","volume":"186","author":"Chapple","year":"1998","journal-title":"J Pathol"},{"key":"10.1016\/j.cden.2005.03.001_bib134","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1902\/jop.1986.57.11.699","article-title":"In situ demonstration of natural killer (NK) cells in human gingival tissue","volume":"57","author":"Wynne","year":"1986","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.1989.tb00851.x","article-title":"Comparison of NK-cell (Leu-7+ and Leu-11b+) populations in clinically healthy gingiva, chronic gingivitis and chronic adult periodontitis","volume":"24","author":"Cobb","year":"1989","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib136","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/154405910508400503","article-title":"Impaired cytotoxicity in Papillon-Lef\u00e8vre syndrome","volume":"84","author":"Lundgren","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.cden.2005.03.001_bib137","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S1286-4579(02)00038-2","article-title":"Human natural killer cell deficiencies and susceptibility to infection","volume":"4","author":"Orange","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.cden.2005.03.001_bib138","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1034\/j.1399-6576.2002.460806.x","article-title":"Immune response in asymptomatic smokers","volume":"46","author":"Zeidel","year":"2002","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.cden.2005.03.001_bib139","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00915729","article-title":"Phenotypic analyses of mononuclear cells recovered from healthy and diseased human periodontal tissues","volume":"7","author":"Stoufi","year":"1987","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib140","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1902\/jop.1987.58.8.569","article-title":"Phenotypic and functional analysis of T cells extracted from chronically inflamed human periodontal tissues","volume":"58","author":"Cole","year":"1987","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib141","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"Teng","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.cden.2005.03.001_bib142","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411010120020301","article-title":"Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption","volume":"12","author":"Taubman","year":"2001","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.cden.2005.03.001_bib143","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2174\/1381612013397807","article-title":"Osteoprotegerin: a physiological and pharmacological inhibitor of bone resorption","volume":"7","author":"Kostenuik","year":"2001","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.cden.2005.03.001_bib144","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/154405910408300216","article-title":"Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis","volume":"83","author":"Mogi","year":"2004","journal-title":"J Dent Res"},{"key":"10.1016\/j.cden.2005.03.001_bib145","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1359\/jbmr.2002.17.2.210","article-title":"Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis","volume":"17","author":"Kanzaki","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.cden.2005.03.001_bib146","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1034\/j.1600-0765.2001.00604.x","article-title":"Periodontal ligament cells secrete the factor that inhibits osteoclastic differentiation and function: the factor is osteoprotegerin\/osteoclastogenesis inhibitory factor","volume":"36","author":"Wada","year":"2001","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib147","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-051X.1979.tb01930.x","article-title":"Conversion of a stable T-cell lesion to a progressive B-cell lesion in the pathogenesis of chronic inflammatory periodontal disease: an hypothesis","volume":"6","author":"Seymour","year":"1979","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib148","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1902\/jop.1988.59.10.656","article-title":"In situ lymphocyte subpopulations from active versus stable periodontal sites","volume":"59","author":"Reinhardt","year":"1988","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib149","first-page":"416","article-title":"Interleukin-1 and bone metabolism: a review","volume":"64","author":"Tatakis","year":"1993","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib150","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1034\/j.1600-051X.2003.00416.x","article-title":"Effect of smoking on gingival crevicular fluid cytokine profile during experimental gingivitis","volume":"30","author":"Giannopoulou","year":"2003","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib151","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1600-051X.2004.00504.x","article-title":"Bone resorbing activity and cytokine levels in gingival crevicular fluid before and after treatment of periodontal disease","volume":"31","author":"Holmlund","year":"2004","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib152","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1086\/341778","article-title":"Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists","volume":"186","author":"Delima","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.cden.2005.03.001_bib153","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4049\/jimmunol.160.1.403","article-title":"IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis","volume":"160","author":"Assuma","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib154","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1902\/jop.1998.69.12.1419","article-title":"Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis","volume":"69","author":"Graves","year":"1998","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib155","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-051X.1997.tb01178.x","article-title":"Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases","volume":"24","author":"Salvi","year":"1997","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib156","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1902\/jop.2003.74.1.97","article-title":"Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship","volume":"74","author":"Nishimura","year":"2003","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib157","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1600-051X.1993.tb00699.x","article-title":"Flurbiprofen in the prevention and treatment of experimental gingivitis","volume":"20","author":"Heasman","year":"1993","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib158","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1902\/jop.1989.60.9.485","article-title":"Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen","volume":"60","author":"Williams","year":"1989","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib159","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/154405910308200812","article-title":"Accelerated alveolar bone loss in mice lacking interleukin-10","volume":"82","author":"Al-Rasheed","year":"2003","journal-title":"J Dent Res"},{"key":"10.1016\/j.cden.2005.03.001_bib160","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1600-0765.2004.00760.x","article-title":"The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss","volume":"39","author":"Sasaki","year":"2004","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.cden.2005.03.001_bib161","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1902\/jop.2004.75.9.1209","article-title":"Relative proportions of T-cell subpopulations and cytokines that mediate and regulate the adaptive immune response in patients with aggressive periodontitis","volume":"75","author":"Suarez","year":"2004","journal-title":"J Periodontol"},{"key":"10.1016\/j.cden.2005.03.001_bib162","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jdent.2004.04.003","article-title":"Effect of periodontal therapy on crevicular fluid interleukin-1beta and interleukin-10 levels in chronic periodontitis","volume":"32","author":"Goutoudi","year":"2004","journal-title":"J Dent"},{"key":"10.1016\/j.cden.2005.03.001_bib163","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.4049\/jimmunol.171.12.6856","article-title":"Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators","volume":"171","author":"Serhan","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.cden.2005.03.001_bib164","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/154405910308200202","article-title":"Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases","volume":"82","author":"Van Dyke","year":"2003","journal-title":"J Dent Res"}],"container-title":["Dental Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853205000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853205000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:32:16Z","timestamp":1683120736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011853205000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":164,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0011853205000170"],"URL":"https:\/\/doi.org\/10.1016\/j.cden.2005.03.001","relation":{},"ISSN":["0011-8532"],"issn-type":[{"value":"0011-8532","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}