{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:37:54Z","timestamp":1789947474589,"version":"4.0.1"},"reference-count":174,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["dental.theclinics.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","theclinics.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Clinics of North America"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.cden.2015.06.007","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T09:46:53Z","timestamp":1443520013000},"page":"885-917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Does Treatment of Periodontal Disease Influence Systemic Disease?"],"prefix":"10.1016","volume":"59","author":[{"given":"Wenche S.","family":"Borgnakke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cden.2015.06.007_bib1","unstructured":"Centers for Disease Control and Prevention. National diabetes statistics report: estimates of diabetes and its burden in the United States, 2014. Atlanta (GA): U.S. Department of Health and Human Services. Available at: http:\/\/www.Cdc.Gov\/diabetes\/pubs\/statsreport14\/national-diabetes-report-web.Pdf. Accessed June 1, 2015."},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.cden.2009.10.002","article-title":"Does periodontal therapy reduce the risk for systemic diseases?","volume":"54","author":"Scannapieco","year":"2010","journal-title":"Dent Clin North Am"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib3","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"Eke","year":"2012","journal-title":"J\u00a0Periodontol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1600-051X.2008.01222.x","article-title":"Periodontal disease definition may determine the association between periodontitis and pregnancy outcomes","volume":"35","author":"Manau","year":"2008","journal-title":"J\u00a0Clin Periodontol"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1902\/annals.2001.6.1.119","article-title":"Insulin resistance and periodontal disease: an epidemiologic overview of research needs and future directions","volume":"6","author":"Donahue","year":"2001","journal-title":"Ann Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib6","series-title":"Periodontal disease and overall health; a clinician's guide","first-page":"83","article-title":"Association between periodontal diseases and diabetes mellitus","author":"Taylor","year":"2010"},{"key":"10.1016\/j.cden.2015.06.007_bib7","series-title":"The oral-systemic health connection: a guide to patient care","first-page":"61","article-title":"The traveling oral microbiome","author":"Borgnakke","year":"2014"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-051X.2011.01784.x","article-title":"Periodontal health status and bacteraemia from daily oral activities: systematic review\/meta-analysis","volume":"39","author":"Tomas","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib9","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0030-4220(54)90071-7","article-title":"Transitory bacteremia","volume":"7","author":"Cobe","year":"1954","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-051X.2006.00924.x","article-title":"Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation","volume":"33","author":"Forner","year":"2006","journal-title":"J\u00a0Clin Periodontol"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib11","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1128\/JCM.02004-07","article-title":"Diverse and novel oral bacterial species in blood following dental procedures","volume":"46","author":"Bahrani-Mougeot","year":"2008","journal-title":"J\u00a0Clin Microbiol"},{"issue":"24","key":"10.1016\/j.cden.2015.06.007_bib12","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1161\/CIRCULATIONAHA.107.758524","article-title":"Bacteremia associated with toothbrushing and dental extraction","volume":"117","author":"Lockhart","year":"2008","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1902\/jop.1980.51.12.691","article-title":"Dental flossing and its relationship to transient bacteremia","volume":"51","author":"Carroll","year":"1980","journal-title":"J\u00a0Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.transci.2008.06.008","article-title":"Update on bacteraemia related to dental procedures","volume":"39","author":"Olsen","year":"2008","journal-title":"Transfus Apher Sci"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib15","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1600-051X.2010.01585.x","article-title":"Systemic inflammation following non-surgical and surgical periodontal therapy","volume":"37","author":"Graziani","year":"2010","journal-title":"J\u00a0Clin Periodontol"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1902\/jop.2014.140197","article-title":"Clinical, microbial, and immune responses observed in patients with diabetes after treatment for gingivitis: a three-month randomized clinical trial","volume":"86","author":"Raslan","year":"2015","journal-title":"J\u00a0Periodontol"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib17","first-page":"383","article-title":"Diabetes mellitus and the dental pulp","volume":"29","author":"Bender","year":"2003","journal-title":"J\u00a0Endod"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1902\/annals.1998.3.1.281","article-title":"Anaerobic bacteremia and fungemia in patients undergoing endodontic therapy: an overview","volume":"3","author":"Debelian","year":"1998","journal-title":"Ann Periodontol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib19","doi-asserted-by":"crossref","first-page":"e98271","DOI":"10.1371\/journal.pone.0098271","article-title":"Dissemination of periodontal pathogens in the bloodstream after periodontal procedures: a systematic review","volume":"9","author":"Horliana","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/jcpe.12029","article-title":"Incidence and magnitude of bacteraemia caused by flossing and by scaling and root planing","volume":"40","author":"Zhang","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1902\/jop.2001.72.2.210","article-title":"Bacteremia due to periodontal probing: a clinical and microbiological investigation","volume":"72","author":"Daly","year":"2001","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev.ph.57.030195.004043","article-title":"Cell biology of atherosclerosis","volume":"57","author":"Ross","year":"1995","journal-title":"Annu Rev Physiol"},{"issue":"14","key":"10.1016\/j.cden.2015.06.007_bib23","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N\u00a0Engl J Med"},{"issue":"8 Suppl","key":"10.1016\/j.cden.2015.06.007_bib24","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1902\/jop.2008.080249","article-title":"Inflammation, C-reactive protein, and atherothrombosis","volume":"79","author":"Ridker","year":"2008","journal-title":"J\u00a0Periodontol"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol"},{"key":"10.1016\/j.cden.2015.06.007_bib27","first-page":"636893","article-title":"Periodontitis as a risk factor of atherosclerosis","volume":"2014","author":"Bartova","year":"2014","journal-title":"J\u00a0Immunol Res"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib28","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1034\/j.1600-051X.2001.280812.x","article-title":"Changes in subgingival microflora and humoral immune response following periodontal therapy","volume":"28","author":"Darby","year":"2001","journal-title":"J\u00a0Clin Periodontol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib29","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1631\/jzus.B1200350","article-title":"Short-term microbiological effects of scaling and root planing and essential-oils mouthwash in Chinese adults","volume":"14","author":"He","year":"2013","journal-title":"J\u00a0Zhejiang Univ Sci B"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib30","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1600-0765.2004.00741.x","article-title":"Periodontal therapy: a novel non-drug-induced experimental model to study human inflammation","volume":"39","author":"D'Aiuto","year":"2004","journal-title":"J\u00a0Periodontal Res"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib31","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib32","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/jcpe.12171","article-title":"Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis","volume":"41","author":"Teeuw","year":"2014","journal-title":"J\u00a0Clin Periodontol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib33","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/154405910508400312","article-title":"Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol","volume":"84","author":"D'Aiuto","year":"2005","journal-title":"J\u00a0Dent Res"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib34","first-page":"271","article-title":"Periodontal therapy and biomarkers related to cardiovascular risk","volume":"59","author":"Moura Foz","year":"2010","journal-title":"Minerva Stomatol"},{"issue":"7","key":"10.1016\/j.cden.2015.06.007_bib35","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/jcpe.12110","article-title":"Non-surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study","volume":"40","author":"Vidal","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib36","article-title":"Tracking of plasma antibodies against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis during 15 years","volume":"1","author":"Lakio","year":"2009","journal-title":"J\u00a0Oral Microbiol"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1600-051X.2004.00599.x","article-title":"Longitudinal stability of serum immunoglobulin G responses to periodontal bacteria","volume":"31","author":"Papapanou","year":"2004","journal-title":"J\u00a0Clin Periodontol"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib38","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1902\/jop.2014.130658","article-title":"Serum C-reactive protein and immunoglobulin G antibodies to periodontal pathogens may be effect modifiers of periodontitis and hyperglycemia","volume":"85","author":"Choi","year":"2014","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib39","article-title":"Serum antibody to Porphyromonas gingivalis in metabolic syndrome among an older Japanese population","author":"Iwasaki","year":"2014","journal-title":"Gerodontology"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib40","doi-asserted-by":"crossref","first-page":"e114959","DOI":"10.1371\/journal.pone.0114959","article-title":"Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease","volume":"9","author":"Noble","year":"2014","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib41","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1136\/jnnp.2009.174029","article-title":"Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES-III","volume":"80","author":"Noble","year":"2009","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib42","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2337\/dc08-0545","article-title":"Translating the A1c assay into estimated average glucose values","volume":"31","author":"Nathan","year":"2008","journal-title":"Diabetes Care"},{"issue":"Supplement 1","key":"10.1016\/j.cden.2015.06.007_bib43","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.2337\/dc15-S005","article-title":"Classification and diagnosis of diabetes","volume":"38","author":"American Diabetes Association","year":"2015","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib44","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/jcpe.12391","article-title":"Prediabetes and well-controlled diabetes are not associated with periodontal disease: the SHIP Trend Study","volume":"42","author":"Kowall","year":"2015","journal-title":"J\u00a0Clin Periodontol"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib45","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/jcpe.12307","article-title":"Periodontal findings in individuals with newly identified prediabetes or diabetes mellitus","volume":"41","author":"Lamster","year":"2014","journal-title":"J\u00a0Clin Periodontol"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib46","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s00784-014-1185-6","article-title":"Effect of nonsurgical periodontal therapy (with or without oral doxycycline delivery) on glycemic status and clinical periodontal parameters in patients with prediabetes: a short-term longitudinal randomized case-control study","volume":"18","author":"Javed","year":"2014","journal-title":"Clin Oral Investig"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib47","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1902\/jop.2013.130008","article-title":"Effect of glycemic control on self-perceived oral health, periodontal parameters, and alveolar bone loss among patients with prediabetes","volume":"85","author":"Javed","year":"2014","journal-title":"J\u00a0Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib48","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/MAJ.0b013e31824d5337","article-title":"Periodontal disease in habitual cigarette smokers and nonsmokers with and without prediabetes","volume":"345","author":"Javed","year":"2013","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.cden.2015.06.007_bib49","series-title":"Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose. Evidence Report\/Technology Assessment No. 128","first-page":"312","author":"Santaguida","year":"2005"},{"issue":"Suppl 14","key":"10.1016\/j.cden.2015.06.007_bib50","first-page":"S135","article-title":"Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence","volume":"40","author":"Borgnakke","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib51","first-page":"ZC22","article-title":"The effect of scaling and root planing on glycaemic control, periodontal status and gingival crevicular fluid TNF-\u03b1 levels in an Indian population\u2014to reveal the ambivalent link","volume":"8","author":"Sooray","year":"2014","journal-title":"J\u00a0Clin Diagn Res"},{"issue":"23","key":"10.1016\/j.cden.2015.06.007_bib52","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1001\/jama.2013.282431","article-title":"The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial","volume":"310","author":"Engebretson","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib53","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jebdp.2014.04.017","article-title":"The multi-center randomized controlled trial (RCT) published by the Journal of The American Medical Association (JAMA) on the effect of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental problems","volume":"14","author":"Borgnakke","year":"2014","journal-title":"J\u00a0Evid Based Dent Pract"},{"issue":"18","key":"10.1016\/j.cden.2015.06.007_bib54","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1001\/jama.2014.2228","article-title":"Hemoglobin A1c levels among patients with diabetes receiving nonsurgical periodontal treatment","volume":"311","author":"Chapple","year":"2014","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.14219\/jada.2014.15","article-title":"Selections from the current literature","volume":"145","author":"Pihlstrom","year":"2014","journal-title":"J\u00a0Am Dent Assoc"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib56","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.14219\/jada.2014.112","article-title":"Diabetes and periodontal therapy","volume":"145","author":"Pihlstrom","year":"2014","journal-title":"J\u00a0Am Dent Assoc"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib57","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1177\/154405910508401212","article-title":"Does periodontal treatment improve glycemic control in diabetic patients? a meta-analysis of intervention studies","volume":"84","author":"Janket","year":"2005","journal-title":"J\u00a0Dent Res"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib58","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.diabet.2008.03.006","article-title":"Efficacy of periodontal treatment on glycaemic control in diabetic patients: a meta-analysis of interventional studies","volume":"34","author":"Darr\u00e9","year":"2008","journal-title":"Diabetes Metab"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib59","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2337\/dc09-1378","article-title":"Effect of periodontal treatment on glycemic control of diabetic patients: a systematic review and meta-analysis","volume":"33","author":"Teeuw","year":"2010","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib60","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004714.pub2","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes","author":"Simpson","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"10.1016\/j.cden.2015.06.007_bib61","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1902\/jop.2012.120377","article-title":"Effectiveness of periodontal treatment to improve metabolic control in patients with chronic periodontitis and type 2 diabetes: a meta-analysis of randomized clinical trials","volume":"84","author":"Sgolastra","year":"2013","journal-title":"J\u00a0Periodontol"},{"issue":"Suppl 14","key":"10.1016\/j.cden.2015.06.007_bib62","first-page":"S153","article-title":"Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis","volume":"40","author":"Engebretson","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib63","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/adj.12091","article-title":"Effect of non-surgical periodontal treatment on HbA1c: a meta-analysis of randomized controlled trials","volume":"58","author":"Liew","year":"2013","journal-title":"Aust Dent J"},{"issue":"28","key":"10.1016\/j.cden.2015.06.007_bib64","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1097\/MD.0000000000000292","article-title":"Effects of periodontal therapy on metabolic control in patients with type 2 diabetes mellitus and periodontal disease: a meta-analysis","volume":"93","author":"Wang","year":"2014","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib65","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4077\/CJP.2014.BAC262","article-title":"Effects of periodontal treatment on glycemic control in type 2 diabetic patients: a meta-analysis of randomized controlled trials","volume":"57","author":"Sun","year":"2014","journal-title":"Chin J Physiol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib66","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/jdi.12088","article-title":"Effect of periodontal treatment on glycemic control of patients with diabetes: a systematic review and meta-analysis","volume":"4","author":"Corbella","year":"2013","journal-title":"J\u00a0Diabetes Investig"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib67","doi-asserted-by":"crossref","first-page":"e108412","DOI":"10.1371\/journal.pone.0108412","article-title":"The effect of periodontal treatment on hemoglobin A1c levels of diabetic patients: a systematic review and meta-analysis","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib68","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1056\/NEJM199602293340906","article-title":"Metformin","volume":"334","author":"Bailey","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.cden.2015.06.007_bib69","series-title":"Effective health care program. Comparing medications for adults with type 2 diabetes","first-page":"8","author":"Agency for Healthcare Research and Quality (AHRQ)","year":"2011"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib70","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1902\/jop.2014.130661","article-title":"Comparison of glycated hemoglobin levels in individuals without diabetes and with and without periodontitis before and after non-surgical periodontal therapy","volume":"85","author":"Perayil","year":"2014","journal-title":"J\u00a0Periodontol"},{"issue":"Suppl 1","key":"10.1016\/j.cden.2015.06.007_bib71","first-page":"23","article-title":"Short-term effects of non-surgical periodontal therapy on clinical measures of impaired glucose tolerance in people with prediabetes and chronic periodontitis","volume":"88","author":"Giblin","year":"2014","journal-title":"J\u00a0Dent Hyg"},{"issue":"7","key":"10.1016\/j.cden.2015.06.007_bib72","doi-asserted-by":"crossref","first-page":"e232","DOI":"10.1902\/jop.2013.130400","article-title":"Routine prophylaxes every 3 months improves chronic periodontitis status in type 2 diabetes","volume":"85","author":"Lopez","year":"2014","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib73","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-230X-12-16","article-title":"Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease","volume":"12","author":"Yoneda","year":"2012","journal-title":"BMC Gastroenterol"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib74","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.archoralbio.2014.05.003","article-title":"Periodontal disease and metabolic syndrome: a qualitative critical review of their association","volume":"59","author":"Watanabe","year":"2014","journal-title":"Arch Oral Biol"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib75","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1093\/ndt\/gfr209","article-title":"Periodontal disease is associated with metabolic syndrome in hemodialysis patients","volume":"26","author":"Chen","year":"2011","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib76","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1902\/jop.2013.130319","article-title":"Relation of periodontitis and metabolic syndrome with gestational glucose metabolism disorder","volume":"85","author":"Bullon","year":"2014","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib77","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00592-014-0586-y","article-title":"Systemic exposure to a common periodontal pathogen and missing teeth are associated with metabolic syndrome","volume":"52","author":"Hyv\u00e4rinen","year":"2014","journal-title":"Acta Diabetol"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib78","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1902\/jop.2010.090594","article-title":"A\u00a0cohort study on the association between periodontal disease and the development of metabolic syndrome","volume":"81","author":"Morita","year":"2010","journal-title":"J\u00a0Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib79","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jcpe.12361","article-title":"Associations between the number of natural teeth and metabolic syndrome in adults","volume":"42","author":"Zhu","year":"2015","journal-title":"J\u00a0Clin Periodontol"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib80","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1089\/met.2010.0002","article-title":"Cardioprotective effect of periodontal therapy in metabolic syndrome: a pilot study in Indian subjects","volume":"8","author":"Acharya","year":"2010","journal-title":"Metab Syndr Relat Disord"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib81","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1177\/0022034512440707","article-title":"Oral health behavior and metabolic syndrome and its components in adults","volume":"91","author":"Kobayashi","year":"2012","journal-title":"J\u00a0Dent Res"},{"issue":"10","key":"10.1016\/j.cden.2015.06.007_bib82","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1902\/jop.2011.100719","article-title":"Detection of periodontal bacteria in atheromatous plaque by nested polymerase chain reaction","volume":"82","author":"Figuero","year":"2011","journal-title":"J\u00a0Periodontol"},{"issue":"10","key":"10.1016\/j.cden.2015.06.007_bib83","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1902\/jop.2000.71.10.1554","article-title":"Identification of periodontal pathogens in atheromatous plaques","volume":"71","author":"Haraszthy","year":"2000","journal-title":"J\u00a0Periodontol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib84","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.ATV.0000155018.67835.1a","article-title":"Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis","volume":"25","author":"Kozarov","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib85","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.atherosclerosis.2014.07.034","article-title":"Periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation","volume":"236","author":"Range","year":"2014","journal-title":"Atherosclerosis"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib86","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1902\/jop.2014.130604","article-title":"Quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms","volume":"85","author":"Figuero","year":"2014","journal-title":"J\u00a0Periodontol"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib87","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1128\/IAI.67.11.5792-5798.1999","article-title":"Invasion of human coronary artery cells by periodontal pathogens","volume":"67","author":"Dorn","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib88","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1600-0528.2010.00582.x","article-title":"Association between periodontal pathogens and risk of nonfatal myocardial infarction","volume":"39","author":"Andriankaja","year":"2011","journal-title":"Community Dent Oral Epidemiol"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib89","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2217\/fca.11.75","article-title":"Bacterial invasion of vascular cell types: vascular infectology and atherogenesis","volume":"8","author":"Kozarov","year":"2012","journal-title":"Future Cardiol"},{"issue":"Suppl 14","key":"10.1016\/j.cden.2015.06.007_bib90","first-page":"S30","article-title":"Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology","volume":"40","author":"Reyes","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib91","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1254\/jphs.09R22FM","article-title":"Roles of oral bacteria in cardiovascular diseases \u2013 from molecular mechanisms to clinical cases: involvement of Porphyromonas gingivalis in the development of human aortic aneurysm","volume":"113","author":"Wada","year":"2010","journal-title":"J\u00a0Pharmacol Sci"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib92","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/CIRCIMAGING.113.000382","article-title":"Focal arterial inflammation precedes subsequent calcification in the same location: a longitudinal FDG-PET\/CT study","volume":"6","author":"Abdelbaky","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib93","doi-asserted-by":"crossref","first-page":"e54860","DOI":"10.1371\/journal.pone.0054860","article-title":"Mobilization of endothelial progenitors by recurrent bacteremias with a periodontal pathogen","volume":"8","author":"Kebschull","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib94","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/HCO.0000000000000068","article-title":"Should we expand the concept of coronary heart disease equivalents?","volume":"29","author":"Katsiki","year":"2014","journal-title":"Curr Opin Cardiol"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib95","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1902\/jop.2009.090499","article-title":"Periodontal disease and recurrent cardiovascular events in survivors of myocardial infarction (MI): the Western New York Acute MI study","volume":"81","author":"Dorn","year":"2010","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib96","doi-asserted-by":"crossref","first-page":"854340","DOI":"10.1155\/2013\/854340","article-title":"Periodontal disease is an independent predictor of intracardiac calcification","volume":"2013","author":"Pressman","year":"2013","journal-title":"Biomed Res Int"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD009197.pub2","article-title":"Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis","author":"Li","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib98","first-page":"145","article-title":"Effect of non-surgical periodontal therapy on serum levels of TNF-a, Il-6 and C-reactive protein in periodontitis subjects with stable coronary heart disease","volume":"16","author":"Zhou","year":"2013","journal-title":"Chin J Dent Res"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib99","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1902\/jop.2009.080007","article-title":"Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease","volume":"80","author":"Offenbacher","year":"2009","journal-title":"J\u00a0Periodontol"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib100","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1600-051X.2012.01942.x","article-title":"Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial","volume":"39","author":"Bokhari","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib101","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.atherosclerosis.2009.03.035","article-title":"Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis","volume":"206","author":"Buhlin","year":"2009","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib102","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00011-013-0669-1","article-title":"Interleukin-18 promoter polymorphisms and plasma levels are associated with increased risk of periodontitis: a meta-analysis","volume":"63","author":"Li","year":"2014","journal-title":"Inflamm Res"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib103","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/MCA.0b013e32832e5c73","article-title":"Interleukin-18: an independent predictor of cardiovascular events in patients with acute coronary syndrome after 6 months of follow-up","volume":"20","author":"Furtado","year":"2009","journal-title":"Coron Artery Dis"},{"issue":"10","key":"10.1016\/j.cden.2015.06.007_bib104","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1161\/ATVBAHA.109.202697","article-title":"Interleukin-18 as a predictor of future events in patients with acute coronary syndromes","volume":"30","author":"Hartford","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2013.01.025","article-title":"Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis","volume":"228","author":"van den Oord","year":"2013","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib106","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2014.06.002","article-title":"Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis","volume":"236","author":"Orlandi","year":"2014","journal-title":"Atherosclerosis"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib107","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/HYPERTENSIONAHA.114.03359","article-title":"Effect of periodontal therapy on arterial structure and function among Aboriginal Australians: a randomized, controlled trial","volume":"64","author":"Kapellas","year":"2014","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib108","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1186\/ar4289","article-title":"Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis","volume":"15","author":"Arvikar","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib109","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/18715303113139990040","article-title":"Associations between periodontitis and systemic inflammatory diseases: response to treatment","volume":"7","author":"El-Shinnawi","year":"2013","journal-title":"Recent Pat Endocr Metab Immune Drug Discov"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib110","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.semarthrit.2014.04.009","article-title":"Does periodontal treatment influence clinical and biochemical measures for rheumatoid arthritis? A systematic review and meta-analysis","volume":"44","author":"Kaur","year":"2014","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib111","first-page":"180","article-title":"Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis","volume":"18","author":"Savioli","year":"2012","journal-title":"J\u00a0Clin Rheumatol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib112","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/RHU.0b013e3180690616","article-title":"Control of periodontal infection reduces the severity of active rheumatoid arthritis","volume":"13","author":"Al-Katma","year":"2007","journal-title":"J\u00a0Clin Rheumatol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib113","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1590\/S0103-64402009000500001","article-title":"Relationship between periodontitis and rheumatoid arthritis and the effect of non-surgical periodontal treatment","volume":"20","author":"Pinho Mde","year":"2009","journal-title":"Braz Dent J"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib114","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-051X.2005.00689.x","article-title":"Periodontal infection as a possible severity factor for rheumatoid arthritis","volume":"32","author":"Ribeiro","year":"2005","journal-title":"J\u00a0Clin Periodontol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1177\/0022034513483142","article-title":"Periodontal disease and rheumatoid arthritis:\u00a0a systematic review","volume":"92","author":"Kaur","year":"2013","journal-title":"J\u00a0Dent Res"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib116","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1902\/jop.2013.130079","article-title":"Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis","volume":"84","author":"Okada","year":"2013","journal-title":"J\u00a0Periodontol"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib117","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1902\/jop.2009.080447","article-title":"Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factor inhibitors","volume":"80","author":"Ortiz","year":"2009","journal-title":"J\u00a0Periodontol"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib118","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/art.1780380107","article-title":"Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis","volume":"38","author":"Prevoo","year":"1995","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.cden.2015.06.007_bib119","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s00296-013-2781-5","article-title":"Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1 beta and DAS28 in rheumatoid arthritis patients","volume":"33","author":"Biyikoglu","year":"2013","journal-title":"Rheumatol Int"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib120","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/odi.12017","article-title":"Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients","volume":"19","author":"Erciyas","year":"2013","journal-title":"Oral Dis"},{"key":"10.1016\/j.cden.2015.06.007_bib121","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1745-6215-14-253","article-title":"Effect of periodontal treatment on the clinical parameters of patients with rheumatoid arthritis: study protocol of the randomized, controlled ESPERA trial","volume":"14","author":"Monsarrat","year":"2013","journal-title":"Trials"},{"issue":"27","key":"10.1016\/j.cden.2015.06.007_bib122","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1097\/MD.0000000000000195","article-title":"Could early rheumatoid arthritis resolve after periodontitis treatment only?: Case report and review of the literature","volume":"93","author":"Salemi","year":"2014","journal-title":"Medicine (Baltimore)"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib123","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1086\/593193","article-title":"Genetic relationships between respiratory pathogens isolated from dental plaque and bronchoalveolar lavage fluid from patients in the intensive care unit undergoing mechanical ventilation","volume":"47","author":"Heo","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib124","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1600-051X.2009.01387.x","article-title":"Periodontitis and nosocomial lower respiratory tract infection: preliminary findings","volume":"36","author":"Gomes-Filho","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib125","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/j.1532-5415.2008.01825.x","article-title":"Modification of the risk of mortality from pneumonia with oral hygiene care","volume":"56","author":"Bassim","year":"2008","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib126","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1902\/annals.2003.8.1.54","article-title":"Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease; a systematic review","volume":"8","author":"Scannapieco","year":"2003","journal-title":"Ann Periodontol"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib127","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1902\/jop.2006.060010","article-title":"Systematic review of the association between respiratory diseases and oral health","volume":"77","author":"Azarpazhooh","year":"2006","journal-title":"J\u00a0Periodontol"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib128","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1111\/j.1532-5415.2008.01926.x","article-title":"A\u00a0systematic review of the preventive effect of oral hygiene on pneumonia and respiratory tract infection in elderly people in hospitals and nursing homes: effect estimates and methodological quality of randomized controlled trials","volume":"56","author":"Sjogren","year":"2008","journal-title":"J\u00a0Am Geriatr Soc"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1741-2358.2012.00637.x","article-title":"Oral health care and aspiration pneumonia in frail older people: a systematic literature review","volume":"30","author":"van der Maarel-Wierink","year":"2013","journal-title":"Gerodontology"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib130","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008367.pub2","article-title":"Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia","author":"Shi","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib131","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-051X.2011.01808.x","article-title":"Oral hygiene, periodontal health and chronic obstructive pulmonary disease exacerbations","volume":"39","author":"Liu","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib132","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1600-051X.2009.01448.x","article-title":"Periodontal health, oral health behaviours, and chronic obstructive pulmonary disease","volume":"36","author":"Wang","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib133","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/jcpe.12247","article-title":"Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: a 2-year pilot randomized controlled trial","volume":"41","author":"Zhou","year":"2014","journal-title":"J\u00a0Clin Periodontol"},{"issue":"7","key":"10.1016\/j.cden.2015.06.007_bib134","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1902\/jop.2012.120399","article-title":"Initial periodontal treatment for prevention of chronic obstructive pulmonary disease exacerbations","volume":"84","author":"Kucukcoskun","year":"2013","journal-title":"J\u00a0Periodontol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib135","first-page":"204","article-title":"Effects of periodontal instrumentation on quality of life and illness in patients with chronic obstructive pulmonary disease: a pilot study","volume":"86","author":"Agado","year":"2012","journal-title":"J\u00a0Dent Hyg"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib136","first-page":"51","article-title":"Dental problems in a potential kidney transplant recipient: case report and literature review","volume":"56","author":"Wilczynska-Borawska","year":"2010","journal-title":"Ann Acad Med Stetin"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib137","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1053\/j.ajkd.2010.09.016","article-title":"Relationship between periodontal disease and mortality in patients treated with maintenance hemodialysis","volume":"57","author":"Chen","year":"2011","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib138","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/jcpe.12067","article-title":"Periodontitis and chronic kidney disease: a systematic review of the association of diseases and the effect of periodontal treatment on estimated glomerular filtration rate","volume":"40","author":"Chambrone","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib139","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1471-2369-14-90","volume":"14","author":"Strippoli","year":"2013","journal-title":"BMC Nephrol"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib140","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1902\/jop.2013.130427","article-title":"Association among oral health parameters, periodontitis, and its treatment and mortality in patients undergoing hemodialysis","volume":"85","author":"De Souza","year":"2014","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib141","doi-asserted-by":"crossref","DOI":"10.1053\/j.ajkd.2015.04.051","article-title":"Dental health and mortality in people with end-stage kidney disease treated with hemodialysis: A multinational cohort study","author":"Palmer","year":"2015","journal-title":"Am J Kidney Dis"},{"issue":"7","key":"10.1016\/j.cden.2015.06.007_bib142","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/jcpe.12263","article-title":"The periodontal health component of The Renal Impairment In Secondary Care (RIISC) cohort study: a description of the rationale, methodology and initial baseline results","volume":"41","author":"Sharma","year":"2014","journal-title":"J\u00a0Clin Periodontol"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib143","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/ndt\/gft401","article-title":"Prevalence and severity of oral disease in adults with chronic kidney disease: a systematic review of observational studies","volume":"29","author":"Ruospo","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.cden.2015.06.007_bib144","article-title":"Cystatin C-based estimated glomerular filtration rate and periodontitis","author":"Iwasaki","year":"2014","journal-title":"Gerodontology"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib145","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/1744-9987.12105","article-title":"Periodontal treatment reduces chronic systemic inflammation in peritoneal dialysis patients","volume":"18","author":"Siribamrungwong","year":"2013","journal-title":"Ther Apher Dial"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib146","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.2337\/diacare.28.12.2890","article-title":"Serum interleukin-18 levels are associated with nephropathy and atherosclerosis in Japanese patients with type 2 diabetes","volume":"28","author":"Nakamura","year":"2005","journal-title":"Diabetes Care"},{"issue":"1\u20132","key":"10.1016\/j.cden.2015.06.007_bib147","first-page":"23","article-title":"Imbalance of interleukin-18 and interleukin-18 binding protein in patients with IgA nephropathy implicating renal vasculopathy","volume":"61","author":"Shimizu","year":"2015","journal-title":"Clin Lab"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib148","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jebdp.2013.07.002","article-title":"Periodontitis may be associated with chronic kidney disease, but current evidence is insufficient","volume":"13","author":"Borgnakke","year":"2013","journal-title":"J\u00a0Evid Based Dent Pract"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib149","first-page":"79","article-title":"History of dental infections associates with cancer in periodontally healthy subjects: a 24-year follow-up study from Sweden","volume":"5","author":"Virtanen","year":"2014","journal-title":"J\u00a0Cancer"},{"issue":"9","key":"10.1016\/j.cden.2015.06.007_bib150","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1902\/jop.2014.140039","article-title":"Oral bacteria as drivers for colorectal cancer","volume":"85","author":"Han","year":"2014","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2015.06.007_bib151","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mib.2014.11.013","article-title":"Fusobacterium nucleatum: a commensal-turned pathogen","volume":"23","author":"Han","year":"2015","journal-title":"Curr Opin Microbiol"},{"issue":"7","key":"10.1016\/j.cden.2015.06.007_bib152","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/archoto.2012.873","article-title":"Local inflammation and human papillomavirus status of head and neck cancers","volume":"138","author":"Tezal","year":"2012","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.cden.2015.06.007_bib153","doi-asserted-by":"crossref","first-page":"575242","DOI":"10.1155\/2012\/575242","article-title":"Interaction between chronic inflammation and oral HPV infection in the etiology of head and neck cancers","volume":"2012","author":"Tezal","year":"2012","journal-title":"Int J Otolaryngol"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib154","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1177\/0022034513487559","article-title":"Mobile microbiome: oral bacteria in extra-oral infections and inflammation","volume":"92","author":"Han","year":"2013","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.cden.2015.06.007_bib155","first-page":"1","article-title":"Is periodontitis a risk factor for cognitive impairment and dementia? a case-control study","volume":"86","author":"Gil-Montoya","year":"2014","journal-title":"J\u00a0Periodontol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib156","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/jcpe.12086","article-title":"Discovering medical conditions associated with periodontitis using linked electronic health records","volume":"40","author":"Boland","year":"2013","journal-title":"J\u00a0Clin Periodontol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib157","first-page":"838","article-title":"Is there a relationship between chronic periodontitis and erectile dysfunction?","volume":"10","author":"Oguz","year":"2013","journal-title":"J\u00a0Sex Med"},{"issue":"12","key":"10.1016\/j.cden.2015.06.007_bib158","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1902\/jop.2011.110049","article-title":"Association between chronic periodontitis and vasculogenic erectile dysfunction","volume":"82","author":"Sharma","year":"2011","journal-title":"J\u00a0Periodontol"},{"issue":"4","key":"10.1016\/j.cden.2015.06.007_bib159","first-page":"1111","article-title":"Erectile dysfunction might be associated with chronic periodontal disease: two ends of the cardiovascular spectrum","volume":"6","author":"Zadik","year":"2009","journal-title":"J\u00a0Sex Med"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib160","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/and.12294","article-title":"Exploration of the association between chronic periodontal disease and erectile dysfunction from a population-based view point","volume":"47","author":"Tsao","year":"2015","journal-title":"Andrologia"},{"issue":"6","key":"10.1016\/j.cden.2015.06.007_bib161","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1600-051X.2012.01879.x","article-title":"A\u00a0nationwide population-based study on the association between chronic periodontitis and erectile dysfunction","volume":"39","author":"Keller","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib162","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/aid.2006.0140","article-title":"Clinical manifestations associated with HTLV type I infection: a cross-sectional study","volume":"23","author":"Caskey","year":"2007","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib163","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MEG.0b013e32835a2b70","article-title":"Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis","volume":"25","author":"Brito","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib164","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s11926-012-0314-y","article-title":"The role of the microbiome in rheumatic diseases","volume":"15","author":"Yeoh","year":"2013","journal-title":"Curr Rheumatol Rep"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib165","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/lary.20542","article-title":"Lemierre's syndrome: a systematic review","volume":"119","author":"Karkos","year":"2009","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.cden.2015.06.007_bib166","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jmii.2012.03.003","article-title":"Lemierre's syndrome in a patient with habitual toothpick usage","volume":"46","author":"Wu","year":"2013","journal-title":"J\u00a0Microbiol Immunol Infect"},{"issue":"11","key":"10.1016\/j.cden.2015.06.007_bib167","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/jnnp-2012-304635","article-title":"The connection between ruptured cerebral aneurysms and odontogenic bacteria","volume":"84","author":"Pyysalo","year":"2013","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.cden.2015.06.007_bib168","doi-asserted-by":"crossref","DOI":"10.1177\/0022034515580795","article-title":"Oral infections, metabolic inflammation, genetics, and cardiometabolic diseases","author":"Janket","year":"2015","journal-title":"J\u00a0Dent Res"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib169","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0022034513511084","article-title":"Body mass index as a predictive factor of periodontal therapy outcomes","volume":"93","author":"Suvan","year":"2014","journal-title":"J\u00a0Dent Res"},{"issue":"2","key":"10.1016\/j.cden.2015.06.007_bib170","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jebdp.2014.04.024","article-title":"BMI is a predictor of periodontal therapy outcomes","volume":"14","author":"Palomo","year":"2014","journal-title":"J\u00a0Evid Based Dent Pract"},{"issue":"1","key":"10.1016\/j.cden.2015.06.007_bib171","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1902\/jop.2014.140266","article-title":"Effects of scaling and root planing on clinical response and serum levels of adipocytokines in obese patients with chronic periodontitis","volume":"86","author":"Goncalves","year":"2015","journal-title":"J\u00a0Periodontol"},{"issue":"5","key":"10.1016\/j.cden.2015.06.007_bib172","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s11596-014-1343-8","article-title":"Maternal periodontal disease and risk of preeclampsia: a meta-analysis","volume":"34","author":"Huang","year":"2014","journal-title":"J\u00a0Huazhong Univ Sci Technolog Med Sci"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib173","doi-asserted-by":"crossref","first-page":"e71387","DOI":"10.1371\/journal.pone.0071387","article-title":"Relationship between periodontitis and pre-eclampsia: a meta-analysis","volume":"8","author":"Sgolastra","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.cden.2015.06.007_bib174","doi-asserted-by":"crossref","first-page":"e70901","DOI":"10.1371\/journal.pone.0070901","article-title":"Periodontal disease and risk of preeclampsia: a meta-analysis of observational studies","volume":"8","author":"Wei","year":"2013","journal-title":"PLoS One"}],"container-title":["Dental Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853215000622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853215000622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:47:52Z","timestamp":1718110072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011853215000622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":174,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0011853215000622"],"URL":"https:\/\/doi.org\/10.1016\/j.cden.2015.06.007","relation":{},"ISSN":["0011-8532"],"issn-type":[{"value":"0011-8532","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Does Treatment of Periodontal Disease Influence Systemic Disease?","name":"articletitle","label":"Article Title"},{"value":"Dental Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cden.2015.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}