{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:42:47Z","timestamp":1786502567631,"version":"build-2736575974"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Clinics of North America"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.cden.2019.12.010","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T07:58:03Z","timestamp":1580457483000},"page":"411-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of the Dental Patient with Bleeding Dyscrasias"],"prefix":"10.1016","volume":"64","author":[{"given":"Leslie R.","family":"Halpern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl","family":"Clarkson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cden.2019.12.010_bib1","series-title":"Anesthesia complications in the dental office","first-page":"103","article-title":"Anesthetic considerations for patients with bleeding disorders","author":"Beirne","year":"2014"},{"key":"10.1016\/j.cden.2019.12.010_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1521-6934(03)00014-2","article-title":"Blood coagulation","volume":"17","author":"Norris","year":"2003","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.cden.2019.12.010_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.coms.2016.06.004","article-title":"Systemic disease and bleeding disorders for the oral and maxillofacial surgeon","volume":"28","author":"Haghighi","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.cden.2019.12.010_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/archinte.1994.00420030084008","article-title":"The international normalized ratio: a guide to understanding and correcting its problems","volume":"154","author":"Hirsh","year":"1994","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.cden.2019.12.010_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.coms.2011.04.006","article-title":"Complications in oral and maxillofacial surgery: management of hemostasis and bleeding disorders in surgical procedures","volume":"23","author":"Maimquist","year":"2011","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.cden.2019.12.010_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.coms.2016.06.006","article-title":"Hemophilia: what the oral and maxillofacial surgeon needs to know","volume":"28","author":"Smith","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.cden.2019.12.010_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.thromres.2013.10.020","article-title":"The history of Hemophilia: a short review","volume":"134","author":"Schramm","year":"2014","journal-title":"Thromb Res"},{"key":"10.1016\/j.cden.2019.12.010_bib8","first-page":"178","article-title":"The modern treatment of hemophilia: a narrative review","volume":"11","author":"Franchini","year":"2013","journal-title":"Blood Transfus"},{"issue":"8","key":"10.1016\/j.cden.2019.12.010_bib9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/1076029616675969","article-title":"von Willebrand disease: a concise review and update for the practicing physician","volume":"23","author":"Swami","year":"2017","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.cden.2019.12.010_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.coms.2016.06.001","article-title":"Platelet abnormalities in the oral and maxillofacial surgery patient","volume":"28","author":"Bruno","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.cden.2019.12.010_bib11","first-page":"443","article-title":"Adminstration of coagulation-altering therapy in the patient presenting for oral health and maxillofacial surgery","volume":"28","author":"Halaszynski","year":"2016","journal-title":"Oral Maxillofac Surg"},{"issue":"1","key":"10.1016\/j.cden.2019.12.010_bib12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bjoms.2014.09.009","article-title":"Dental extractions and risk of bleeding in patients taking single and dual antiplatelet treatment","volume":"53","author":"Bajkin","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.cden.2019.12.010_bib13","doi-asserted-by":"crossref","first-page":"h2391","DOI":"10.1136\/bmj.h2391","article-title":"Peri-procedural management of patients taking oral anticoagulants","volume":"351","author":"Daniels","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.cden.2019.12.010_bib14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jacc.2013.08.1623","article-title":"The HAS-BLED score has better prediction accuracy for major bleeding than CHADS2 VASc scores in anticoagulated patients with atrial fibrillation","volume":"62","author":"Roldan","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.cden.2019.12.010_bib15","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1160\/TH13-07-0552","article-title":"Comparison of the CHADS2, CHAD2DS2-VASc and HAS-BLED scores for the prediction of clinically relevant bleeding in anticoagulated patients with atrial fibrillation: the AMADEUS trial","volume":"110","author":"Apostolakis","year":"2013","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1016\/j.cden.2019.12.010_bib16","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.oooo.2013.07.026","article-title":"Management recommendations for invasive dental treatment in patients using oral antithrombotic medication, including novel oral anticoagulants","volume":"116","author":"Van Diermen","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"issue":"6","key":"10.1016\/j.cden.2019.12.010_bib17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.adaj.2015.01.017","article-title":"Risk factors for bleeding after oral surgery in patients who continued using oral anticoagulant therapy","volume":"146","author":"Bajkin","year":"2015","journal-title":"J\u00a0Am Dent Assoc"},{"issue":"1","key":"10.1016\/j.cden.2019.12.010_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1067\/moe.2002.123828","article-title":"Oral surgery in patients on anticoagulant therapy","volume":"94","author":"Scully","year":"2002","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"7","key":"10.1016\/j.cden.2019.12.010_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.12968\/denu.2004.31.7.379","article-title":"Management of dental patients on warfarin therapy in a primary care setting","volume":"31","author":"Chugani","year":"2004","journal-title":"Dent Update"},{"key":"10.1016\/j.cden.2019.12.010_bib20","first-page":"1","article-title":"Should oral anticoagulant therapy be continued during dental extraction? A meta-analysis","volume":"16","author":"Yan","year":"2016","journal-title":"BMC Oral Health"},{"issue":"8","key":"10.1016\/j.cden.2019.12.010_bib21","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.joms.2007.03.003","article-title":"Dentoalveolar procedures for the anticoagulated patients: literature recommendations versus current practice","volume":"65","author":"Ward","year":"2007","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.cden.2019.12.010_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.coms.2016.06.011","article-title":"Warfarin and newer agents: what the oral surgeon needs to know","volume":"28","author":"Steed","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.cden.2019.12.010_bib23","author":"Lip"},{"key":"10.1016\/j.cden.2019.12.010_bib24","first-page":"1","article-title":"Clinical practice guide on anticoagulant dosing and management of anticoagulant associated bleeding","volume":"8","author":"Cushman","year":"2011","journal-title":"American Society of Hematology"},{"issue":"1","key":"10.1016\/j.cden.2019.12.010_bib25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.annemergmed.2015.04.036","article-title":"Thromboembolic events after vitamin K antagonist reversal with 4-factor prothrombin complex concentrate: analyses of two randomized, plasma controlled studies","volume":"67","author":"Milling","year":"2016","journal-title":"Ann Emerg Med"},{"issue":"2 Suppl","key":"10.1016\/j.cden.2019.12.010_bib26","doi-asserted-by":"crossref","first-page":"e326S","DOI":"10.1378\/chest.11-2298","article-title":"Perioperative management of antithrombotic therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Douketis","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.cden.2019.12.010_bib27","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.coms.2016.06.008","article-title":"Heparin and Lovenox: what the oral and maxillofacial needs to know","volume":"28","author":"Di Pasquale","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"3","key":"10.1016\/j.cden.2019.12.010_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0266-4356(94)90101-5","article-title":"The use of thromboembolic prophylaxis in oral and maxillofacial surgery","volume":"32","author":"Farr","year":"1994","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"983","key":"10.1016\/j.cden.2019.12.010_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/pgmj.2007.059188","article-title":"Heparin induced thrombocytopenia: diagnosis and management update","volume":"83","author":"Ahmed","year":"2007","journal-title":"Postgrad Med J"},{"issue":"1","key":"10.1016\/j.cden.2019.12.010_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/0003088-200948010-00001","article-title":"Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development","volume":"48","author":"Eriksson","year":"2009","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.cden.2019.12.010_bib31","author":"Leung"},{"issue":"10","key":"10.1016\/j.cden.2019.12.010_bib32","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1161\/01.CIR.103.10.1479","article-title":"Recombinant hirudin in clinical practice : focus on lepirudin","volume":"103","author":"Greinacher","year":"2001","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.cden.2019.12.010_bib33","first-page":"1536","article-title":"Dabigatran and dental extractions: case report","volume":"23","author":"Dinkova","year":"2017","journal-title":"J\u00a0IMAB"},{"key":"10.1016\/j.cden.2019.12.010_bib34","first-page":"d74","article-title":"Implications of dabigatran, a direct thrombin inhibitor, for oral surgery practice","volume":"79","author":"Davis","year":"2013","journal-title":"J\u00a0Can Dent Assoc"},{"issue":"Suppl 1","key":"10.1016\/j.cden.2019.12.010_bib35","first-page":"25","article-title":"Perioperative management of direct oral anticoagulants (DOACs): a systemic review","volume":"9","author":"Sunkara","year":"2016","journal-title":"Health Serv Insights"},{"key":"10.1016\/j.cden.2019.12.010_bib36","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/jth.12969","article-title":"Recommendation on the nomenclature for oral anticoagulants: communication from the SSC of the ISTH","volume":"13","author":"Barnes","year":"2015","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.cden.2019.12.010_bib37","author":"Garcia"},{"key":"10.1016\/j.cden.2019.12.010_bib38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.coms.2016.06.003","article-title":"Aspirin, Plavix, and other antiplatelet medications: what the oral and maxillofacial surgeon needs to know","volume":"28","author":"Ghantous","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"key":"10.1016\/j.cden.2019.12.010_bib39","first-page":"235","article-title":"Collaborative overview of randomized trials of antiplatelet treatment, 1: prevention of vascular death, MI, stroke by prolonged antiplatelet therapy in different categories of patients. Antiplatelet Trialists Collaboration","volume":"308","year":"1994","journal-title":"Br Med J"},{"issue":"6","key":"10.1016\/j.cden.2019.12.010_bib40","doi-asserted-by":"crossref","first-page":"e863","DOI":"10.4317\/medoral.15.e863","article-title":"Evaluation of bleeding risk and measurement methods in dental patients","volume":"15","author":"Canigral","year":"2010","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"3","key":"10.1016\/j.cden.2019.12.010_bib41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.tripleo.2007.03.003","article-title":"Aspirin and bleeding in dentistry: an update and recommendations","volume":"104","author":"Brennan","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"6","key":"10.1016\/j.cden.2019.12.010_bib42","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/CIRCULATIONAHA.106.180944","volume":"1159","author":"Grines","year":"2007","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.cden.2019.12.010_bib43","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2710.2007.00844.x","article-title":"Possible case of potentiation of the antiplatelet effect of cilostazol by grapefruit juice","volume":"32","author":"Aniguchi","year":"2007","journal-title":"J\u00a0Clin Pharm Ther"},{"issue":"12","key":"10.1016\/j.cden.2019.12.010_bib44","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.ijom.2012.09.024","article-title":"Orbitalk hemorrhage associated with orbital fractures in geriatric patients on antiplatelet or anticoagulant therapy","volume":"42","author":"Mauer","year":"2013","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"7","key":"10.1016\/j.cden.2019.12.010_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1542\/pir.34.7.289","article-title":"Hemophilia: in review","volume":"34","author":"Zimmerman","year":"2013","journal-title":"Pediatr Rev"},{"key":"10.1016\/j.cden.2019.12.010_bib46","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1055\/s-0033-1354426","article-title":"Defining severity of hemophilia: more than factor levels","volume":"39","author":"Pavlova","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.cden.2019.12.010_bib47","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1055\/s-0032-1326779","article-title":"Acquired hemophilia A","volume":"38","author":"Webert","year":"2012","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.cden.2019.12.010_bib48","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.thromres.2013.10.016","article-title":"Inhibitors in patients with haemophilia A","volume":"134","author":"Kreuz","year":"2014","journal-title":"Thromb Res"},{"issue":"2","key":"10.1016\/j.cden.2019.12.010_bib49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/phar.1173","article-title":"The reversal of inhibitors in congenital hemophilia","volume":"33","author":"DeFrates","year":"2013","journal-title":"Pharmacotherapy"},{"issue":"Suppl1","key":"10.1016\/j.cden.2019.12.010_bib50","first-page":"s319","article-title":"Key issues in inhibitor management in patients with haemophilia","volume":"12","author":"Gomez","year":"2014","journal-title":"Blood Transfus"},{"key":"10.1016\/j.cden.2019.12.010_bib51","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1055\/s-0033-1354425","article-title":"FEIBA versus novoseven in hemophilia patients with inhibitors","volume":"39","author":"Francini","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.cden.2019.12.010_bib52","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/bjh.13365","article-title":"the current status of prophylactic replacement therapy in children and adults with haemophilia","volume":"169","author":"Ljung","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.cden.2019.12.010_bib53","first-page":"e1","article-title":"Guidelines for the management of hemophilia","volume":"19","author":"Srivastava","year":"2012","journal-title":"Haemophilia"},{"issue":"5","key":"10.1016\/j.cden.2019.12.010_bib54","first-page":"395","article-title":"Outpatient minor oral surgery in patients with hemophilia: a case series of 23 patients","volume":"11","author":"Ramos","year":"2019","journal-title":"J\u00a0Clin Exp Dent"},{"key":"10.1016\/j.cden.2019.12.010_bib55","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/hae.13122","article-title":"Risk-based management of dental procedures in patients with inherited bleeding disorders: development of a dental bleeding risk assessment and treatment tool (DeBRATT)","volume":"23","author":"Rasaratnam","year":"2017","journal-title":"Haemophilia"},{"key":"10.1016\/j.cden.2019.12.010_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.e2707","article-title":"Diagnosis and maangement of hemophilia","volume":"344","author":"Fijnvandraat","year":"2012","journal-title":"BMJ"},{"issue":"Suppl 1","key":"10.1016\/j.cden.2019.12.010_bib57","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/anae.12899","article-title":"Surgery in patients with inherited bleeding disorders","volume":"70","author":"Mensah","year":"2015","journal-title":"Anaesthesia"},{"key":"10.1016\/j.cden.2019.12.010_bib58","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMra1601561","article-title":"Von Willebrand\u2019s Disease","volume":"375","author":"Leebeek","year":"2016","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.cden.2019.12.010_bib59","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1055\/s-0037-1613992","article-title":"Impact, diagnosis and treatment of von Willebrand disease","volume":"84","author":"Sadler","year":"2000","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1016\/j.cden.2019.12.010_bib60","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1182\/blood-2003-06-2072","article-title":"Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study","volume":"103","author":"Federici","year":"2004","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.cden.2019.12.010_bib61","first-page":"246","article-title":"A\u00a0review of haemostasis following minor oral surgery procedures","volume":"7","author":"Ria","year":"2017","journal-title":"J\u00a0Dent Health Oral Disord Ther"},{"issue":"3","key":"10.1016\/j.cden.2019.12.010_bib62","article-title":"Interventions for treating post-extraction bleeding","author":"Kumbargere Nagraj","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.cden.2019.12.010_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.coms.2016.06.007","article-title":"Topical hemostatic agents: what the oral and maxillofacial surgeon needs to know","volume":"28","author":"Vezeau","year":"2016","journal-title":"Oral Maxillofac Surg Clin North Am"},{"issue":"3","key":"10.1016\/j.cden.2019.12.010_bib64","first-page":"35","article-title":"Local hemostatic agents in the management of bleeding in oral surgery","volume":"9","author":"Kumar","year":"2016","journal-title":"Asian J Pharm Clin Res"}],"container-title":["Dental Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853219301107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853219301107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T01:08:03Z","timestamp":1757898483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011853219301107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0011853219301107"],"URL":"https:\/\/doi.org\/10.1016\/j.cden.2019.12.010","relation":{},"ISSN":["0011-8532"],"issn-type":[{"value":"0011-8532","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment of the Dental Patient with Bleeding Dyscrasias","name":"articletitle","label":"Article Title"},{"value":"Dental Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cden.2019.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}