{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:51:44Z","timestamp":1789685504169,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Dental Clinics of North America"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.cden.2021.06.003","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T04:35:40Z","timestamp":1628742940000},"page":"75-85","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Evolution of Surgical Techniques and Biomaterials for Periodontal Regeneration"],"prefix":"10.1016","volume":"66","author":[{"given":"Giorgio","family":"Pagni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Tavelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Rasperini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cden.2021.06.003_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1600-051X.1982.tb02095.x","article-title":"New attachment following surgical treatment of human periodontal disease","volume":"9","author":"Nyman","year":"1982","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1902\/jop.1970.41.41.566","article-title":"Iliac transplants in periodontal therapy","volume":"41","author":"Schallhorn","year":"1970","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1034\/j.1600-0757.2000.2220107.x","article-title":"The treatment of intrabony defects with bone grafts","volume":"22","author":"Rosen","year":"2000","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cden.2021.06.003_bib4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1600-051X.1980.tb01965.x","article-title":"Histometric evaluation of periodontal surgery. II. Connective tissue attachment levels after four regenerative procedures","volume":"7","author":"Caton","year":"1980","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/0022034516632497","article-title":"A\u00a0Randomized Clinical Trial Evaluating rh-FGF-2\/beta-TCP in Periodontal Defects","volume":"95","author":"Cochran","year":"2016","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.cden.2021.06.003_bib6","first-page":"247","article-title":"Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review","volume":"2","author":"Esposito","year":"2009","journal-title":"Eur J Oral Implantol"},{"key":"10.1016\/j.cden.2021.06.003_bib7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-0757.2004.37101.x","article-title":"Guided tissue regeneration for periodontal intrabony defects--a Cochrane Systematic Review","volume":"37","author":"Needleman","year":"2005","journal-title":"Periodontol 2000"},{"issue":"Suppl 3","key":"10.1016\/j.cden.2021.06.003_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1600-051X.29.s3.7.x","article-title":"A\u00a0systematic review of graft materials and biological agents for periodontal intraosseous defects","volume":"29","author":"Trombelli","year":"2002","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib9","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1600-051X.2009.01474.x","article-title":"Open flap debridement and guided tissue regeneration after 10 years in infrabony defects","volume":"36","author":"Nickles","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1600-051X.2009.01378.x","article-title":"Guided tissue regeneration with bioabsorbable barriers III 10-year results in infrabony defects","volume":"36","author":"Pretzl","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1600-051X.2008.01295.x","article-title":"Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration","volume":"35","author":"Sculean","year":"2008","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib12","first-page":"668","article-title":"120 infrabony defects treated with regenerative therapy: long-term results","volume":"82","author":"Silvestri","year":"2011","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib13","first-page":"158","article-title":"Significance of early healing events on periodontal repair: a review","volume":"63","author":"Wikesjo","year":"1992","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-0757.1999.tb00145.x","article-title":"Periodontal wound healing and regeneration","volume":"19","author":"Wikesjo","year":"1999","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cden.2021.06.003_bib15","first-page":"11","article-title":"Repair following mucoperiosteal flap surgery with full gingival retention","volume":"39","author":"Hiatt","year":"1968","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib16","first-page":"204","article-title":"Flap technique for periodontal bone implants. Papilla preservation technique","volume":"56","author":"Takei","year":"1985","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib17","first-page":"261","article-title":"The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures","volume":"66","author":"Cortellini","year":"1995","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib18","first-page":"589","article-title":"The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures","volume":"19","author":"Cortellini","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib19","first-page":"578","article-title":"Surgical technique for treatment of infrabony defects with enamel matrix derivative (Emdogain): 3 case reports","volume":"19","author":"Rasperini","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1034\/j.1600-051X.2003.00013.x","article-title":"Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: a controlled clinical study","volume":"30","author":"Wachtel","year":"2003","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-051X.2006.01020.x","article-title":"A\u00a0minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity","volume":"34","author":"Cortellini","year":"2007","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib22","first-page":"353","article-title":"Single-flap approach with buccal access in periodontal reconstructive procedures","volume":"80","author":"Trombelli","year":"2009","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1600-051X.2008.01352.x","article-title":"Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects","volume":"36","author":"Cortellini","year":"2009","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/prd.12048","article-title":"Clinical concepts for regenerative therapy in intrabony defects","volume":"68","author":"Cortellini","year":"2015","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.cden.2021.06.003_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.11607\/prd.2584","article-title":"Entire Papilla Preservation Technique: A Novel Surgical Approach for Regenerative Treatment of Deep and Wide Intrabony Defects","volume":"37","author":"Aslan","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib26","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1600-051X.2011.01768.x","article-title":"Periodontal regeneration versus extraction and prosthetic replacement of teeth severely compromised by attachment loss to the apex: 5-year results of an ongoing randomized clinical trial","volume":"38","author":"Cortellini","year":"2011","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib27","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.11607\/prd.1628","article-title":"The soft tissue wall technique for the regenerative treatment of non-contained infrabony defects: a case series","volume":"33","author":"Rasperini","year":"2013","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib28","article-title":"Interproximal attachment gain: The challenge of periodontal regeneration","author":"Rasperini","year":"2020","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib29","first-page":"567","article-title":"A\u00a0novel approach to minimizing gingival recession in the treatment of vertical bony defects","volume":"79","author":"Zucchelli","year":"2008","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib30","first-page":"1075","article-title":"Efficacy of tunnel technique in the treatment of localized and multiple gingival recessions: A systematic review and meta-analysis","volume":"89","author":"Tavelli","year":"2018","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib31","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jcpe.12178","article-title":"Tunnel technique with connective tissue graft versus coronally advanced flap with enamel matrix derivative for root coverage: a RCT using 3D digital measuring methods. Part I. Clinical and patient-centred outcomes","volume":"41","author":"Zuhr","year":"2014","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib32","first-page":"454","article-title":"Periodontal reconstructive surgery of deep intraosseous defects using an apical approach. Non-incised papillae surgical approach (NIPSA): A retrospective cohort study","volume":"90","author":"Moreno Rodriguez","year":"2019","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib33","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/jcpe.13158","article-title":"Supra-alveolar attachment gain in the treatment of combined intra-suprabony periodontal defects by non-incised papillae surgical approach","volume":"46","author":"Moreno Rodriguez","year":"2019","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib34","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.11607\/prd.3138","article-title":"Periodontal Regenerative Treatment of Intrabony Defects in the Esthetic Zone Using Modified Vestibular Incision Subperiosteal Tunnel Access (M-VISTA)","volume":"38","author":"Najafi","year":"2018","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib35","doi-asserted-by":"crossref","first-page":"781","DOI":"10.11607\/prd.4282","article-title":"Connective Tissue Grafts with Nonincised Papillae Surgical Approach for Periodontal Reconstruction in Noncontained Defects","volume":"39","author":"Moreno Rodriguez","year":"2019","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib36","first-page":"348","article-title":"Effect of a Connective Tissue Graft in Combination With a Single Flap Approach in the Regenerative Treatment of Intraosseous Defects","volume":"88","author":"Trombelli","year":"2017","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib37","doi-asserted-by":"crossref","first-page":"601","DOI":"10.11607\/prd.1978","article-title":"The connective tissue graft wall technique and enamel matrix derivative to improve root coverage and clinical attachment levels in Miller Class IV gingival recession","volume":"34","author":"Zucchelli","year":"2014","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib38","doi-asserted-by":"crossref","first-page":"673","DOI":"10.11607\/prd.3083","article-title":"Connective Tissue Graft Wall Technique and Enamel Matrix Derivative for the Treatment of Infrabony Defects: Case Reports","volume":"37","author":"Zucchelli","year":"2017","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1600-051X.2004.00542.x","article-title":"Prognostic factors for alveolar regeneration: effect of a space-providing biomaterial on guided tissue regeneration","volume":"31","author":"Polimeni","year":"2004","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib40","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.dental.2012.04.022","article-title":"Recent advances in the development of GTR\/GBR membranes for periodontal regeneration--a materials perspective","volume":"28","author":"Bottino","year":"2012","journal-title":"Dent Mater"},{"key":"10.1016\/j.cden.2021.06.003_bib41","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/biot.201100294","article-title":"Polymeric membranes for guided bone regeneration","volume":"6","author":"Gentile","year":"2011","journal-title":"Biotechnol J"},{"key":"10.1016\/j.cden.2021.06.003_bib42","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jbm.1038","article-title":"Physicochemical, mechanical, and biological properties of commercial membranes for GTR","volume":"58","author":"Milella","year":"2001","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.cden.2021.06.003_bib43","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/j.1600-0501.2008.01546.x","article-title":"Cross-linked and non-cross-linked collagen barrier membranes disintegrate following surgical exposure to the oral environment: a histological study in the cat","volume":"19","author":"Tal","year":"2008","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.cden.2021.06.003_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ma12132197","article-title":"New Perspectives in the Use of Biomaterials for Periodontal Regeneration","volume":"12","author":"Ausenda","year":"2019","journal-title":"Materials (Basel)"},{"key":"10.1016\/j.cden.2021.06.003_bib45","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1600-0501.2009.01881.x","article-title":"The effect of deproteinized bovine bone on osteoblast growth factors and proinflammatory cytokine production","volume":"21","author":"Amerio","year":"2010","journal-title":"Clin Oral Implants Res"},{"key":"10.1016\/j.cden.2021.06.003_bib46","first-page":"265","article-title":"Socket grafting in the posterior maxilla reduces the need for sinus augmentation","volume":"30","author":"Rasperini","year":"2010","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib47","first-page":"157","article-title":"Long-term stable periodontal regeneration by means of autologous bone grafting in patients with severe periodontitis","volume":"32","author":"Verdugo","year":"2012","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib48","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-051X.2011.01844.x","article-title":"A\u00a0Bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies","volume":"39","author":"Tu","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib49","first-page":"1223","article-title":"Cell- and gene-based therapeutic strategies for periodontal regenerative medicine","volume":"82","author":"Rios","year":"2011","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib50","doi-asserted-by":"crossref","first-page":"153S","DOI":"10.1177\/0022034515588303","article-title":"3D-printed Bioresorbable Scaffold for Periodontal Repair","volume":"94","author":"Rasperini","year":"2015","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.cden.2021.06.003_bib51","first-page":"171","article-title":"Formation of intermediate cementum. III: 3H-tryptophan and 3H-proline uptake into the epithelial root sheath of Hertwig in\u00a0vitro","volume":"2","author":"Lindskog","year":"1982","journal-title":"J\u00a0Craniofac Genet Dev Biol"},{"key":"10.1016\/j.cden.2021.06.003_bib52","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0304-4165(89)90021-4","article-title":"Human and mouse cementum proteins immunologically related to enamel proteins","volume":"991","author":"Slavkin","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.cden.2021.06.003_bib53","first-page":"1270","article-title":"In\u00a0vitro wound healing responses to enamel matrix derivative","volume":"71","author":"Hoang","year":"2000","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib54","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jcpe.12546","article-title":"Twenty years of enamel matrix derivative: the past, the present and the future","volume":"43","author":"Miron","year":"2016","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib55","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0765.2003.00667.x","article-title":"The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect","volume":"38","author":"Yoneda","year":"2003","journal-title":"J\u00a0Periodontal Res"},{"key":"10.1016\/j.cden.2021.06.003_bib56","first-page":"213","article-title":"Periodontal regeneration in human Class II furcations using purified recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with bone allograft","volume":"23","author":"Camelo","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"10.1016\/j.cden.2021.06.003_bib57","first-page":"522","article-title":"Platelet-derived growth factor-modulated guided tissue regenerative therapy","volume":"66","author":"Cho","year":"1995","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib58","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1600-051X.1989.tb02334.x","article-title":"A\u00a0combination of platelet-derived and insulin-like growth factors enhances periodontal regeneration","volume":"16","author":"Lynch","year":"1989","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib59","first-page":"2205","article-title":"Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial","volume":"76","author":"Nevins","year":"2005","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib60","first-page":"641","article-title":"Differential effect of TGF-beta 1 and PDGF on proliferation of periodontal ligament cells and gingival fibroblasts","volume":"65","author":"Dennison","year":"1994","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib61","first-page":"515","article-title":"Mitogenic, chemotactic, and synthetic responses of rat periodontal ligament fibroblastic cells to polypeptide growth factors in\u00a0vitro","volume":"63","author":"Matsuda","year":"1992","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib62","first-page":"462","article-title":"Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet-derived growth factor","volume":"66","author":"Park","year":"1995","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib63","first-page":"147","article-title":"Biologics-based regenerative technologies for periodontal soft tissue engineering","volume":"91","author":"Tavelli","year":"2020","journal-title":"J\u00a0Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/jcpe.12643","article-title":"Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis","volume":"44","author":"Castro","year":"2017","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.cden.2021.06.003_bib65","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s00784-017-2133-z","article-title":"Use of platelet-rich fibrin in regenerative dentistry: a systematic review","volume":"21","author":"Miron","year":"2017","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.cden.2021.06.003_bib66","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/jcpe.13086","article-title":"Treatment of intrabony periodontal defects using rhFGF-2 in combination with deproteinized bovine bone mineral or rhFGF-2 alone: A 6-month randomized controlled trial","volume":"46","author":"Saito","year":"2019","journal-title":"J\u00a0Clin Periodontol"}],"container-title":["Dental Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853221000422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011853221000422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T01:08:31Z","timestamp":1757898511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011853221000422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0011853221000422"],"URL":"https:\/\/doi.org\/10.1016\/j.cden.2021.06.003","relation":{},"ISSN":["0011-8532"],"issn-type":[{"value":"0011-8532","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Evolution of Surgical Techniques and Biomaterials for Periodontal Regeneration","name":"articletitle","label":"Article Title"},{"value":"Dental Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cden.2021.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}