{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T18:18:38Z","timestamp":1781115518827,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cells &amp; Development"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.cdev.2021.203711","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T04:16:12Z","timestamp":1625112972000},"page":"203711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["MicroRNA-361 suppresses the biological processes of hepatic stellate cells in HBV-relative hepatic fibrosis by NF-kappaB p65"],"prefix":"10.1016","volume":"167","author":[{"given":"Ge","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huikai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cdev.2021.203711_bb0005","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.canlet.2010.10.015","article-title":"Targeting apoptosis pathways in pancreatic cancer","volume":"332","author":"Arlt","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cdev.2021.203711_bb0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0016-5085(03)00695-4","article-title":"Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II","volume":"125","author":"Bataller","year":"2003","journal-title":"Gastroenterology."},{"key":"10.1016\/j.cdev.2021.203711_bb0015","first-page":"205","article-title":"Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives","volume":"6","author":"D\u00edaz-L\u00f3pez","year":"2014","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.cdev.2021.203711_bb0020","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/hep.21802","article-title":"Nuclear factor-?B and the hepatic inflammation-fibrosis-cancer axis","volume":"46","author":"Elsharkawy","year":"2007","journal-title":"Hepatology."},{"key":"10.1016\/j.cdev.2021.203711_bb0025","doi-asserted-by":"crossref","first-page":"G15","DOI":"10.1152\/ajpgi.00451.2010","article-title":"Therapeutic targets in liver fibrosis","volume":"300","author":"Fallowfield","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.cdev.2021.203711_bb0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","article-title":"Evolving challenges in hepatic fibrosis","volume":"7","author":"Friedman","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.cdev.2021.203711_bb0035","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00018-013-1545-4","article-title":"NF-kappaB pathways in hematological malignancies","volume":"71","author":"Gasparini","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.cdev.2021.203711_bb0040","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1111\/j.1582-4934.2008.00533.x","article-title":"MicroRNA involvement in hepatocellular carcinoma","volume":"12","author":"Gramantieri","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.cdev.2021.203711_bb0045","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/hep.24515","article-title":"Biomarkers of liver fibrosis: what lies beneath the receiver operating characteristic curve?","volume":"54","author":"Guha","year":"2011","journal-title":"Hepatology."},{"key":"10.1016\/j.cdev.2021.203711_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1755-1536-5-12","article-title":"Induction of microRNA-214-5p in human and rodent liver fibrosis","volume":"5","author":"Iizuka","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.cdev.2021.203711_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049568","article-title":"The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma","volume":"7","author":"Kanitz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.cdev.2021.203711_bb0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.canlet.2014.05.022","article-title":"Epithelial\u2013mesenchymal transition-associated miRNAs in ovarian carcinoma, with highlight on the miR-200 family: prognostic value and prospective role in ovarian cancer therapeutics","volume":"351","author":"Koutsaki","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cdev.2021.203711_bb0065","series-title":"Isolation and Culture of Primary Hepatocytes From Resected Human Liver Tissue","first-page":"57","author":"LeCluyse","year":"2010"},{"key":"10.1016\/j.cdev.2021.203711_bb0070","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbrc.2014.01.140","article-title":"MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6 (STAT6)","volume":"445","author":"Liu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.cdev.2021.203711_bb0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.arcmed.2006.09.006","article-title":"Reversal effect of thalidomide on established hepatic cirrhosis in rats via inhibition of nuclear factor-?B\/inhibitor of nuclear factor-?B pathway","volume":"38","author":"Lv","year":"2007","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.cdev.2021.203711_bb0080","doi-asserted-by":"crossref","first-page":"17404","DOI":"10.18632\/oncotarget.3744","article-title":"MiR-361-5p inhibits colorectal and gastric cancer growth and metastasis by targeting staphylococcal nuclease domain containing-1","volume":"6","author":"Ma","year":"2015","journal-title":"Oncotarget."},{"key":"10.1016\/j.cdev.2021.203711_bb0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/bju.12488","article-title":"Recent insights into NF-kappaB signalling pathways and the link between inflammation and prostate cancer","volume":"114","author":"Nguyen","year":"2014","journal-title":"BJU Int."},{"key":"10.1016\/j.cdev.2021.203711_bb0090","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1053\/j.gastro.2004.10.003","article-title":"Inhibition of inhibitor of ?B kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis","volume":"128","author":"Oakley","year":"2005","journal-title":"Gastroenterology."},{"key":"10.1016\/j.cdev.2021.203711_bb0095","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s11596-015-1457-7","article-title":"Resveratrol-downregulated phosphorylated liver kinase B1 is involved in senescence of acute myeloid leukemia stem cells","volume":"35","author":"Peng","year":"2015","journal-title":"J. Huazhong Univ. Sci. Technol. Med Sci."},{"key":"10.1016\/j.cdev.2021.203711_bb0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12935-015-0185-1","article-title":"MicroRNA (miRNA) in cancer","volume":"15","author":"Reddy","year":"2015","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.cdev.2021.203711_bb0105","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1007\/s13277-014-1887-z","article-title":"Restoring TGF\u00df1 pathway-related microRNAs: possible impact in metastatic prostate cancer development","volume":"35","author":"Santos","year":"2014","journal-title":"Tumor Biol."},{"key":"10.1016\/j.cdev.2021.203711_bb0110","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/cdd.2014.200","article-title":"miR-361-regulated prohibitin inhibits mitochondrial fission and apoptosis and protects heart from ischemia injury","volume":"22","author":"Wang","year":"2015","journal-title":"Cell death and differentiation."},{"key":"10.1016\/j.cdev.2021.203711_bb0115","series-title":"Isolation and culture of Hepatic Stellate Cells. Fibrosis Research","first-page":"99","author":"Weiskirchen","year":"2005"},{"key":"10.1016\/j.cdev.2021.203711_bb0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1053\/gast.2001.27188","article-title":"Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats","volume":"121","author":"Wright","year":"2001","journal-title":"Gastroenterology."},{"key":"10.1016\/j.cdev.2021.203711_bb0125","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/hep.23384","article-title":"Contemporary clinical research of traditional Chinese medicines for chronic hepatitis B in China: an analytical review","volume":"51","author":"Zhang","year":"2010","journal-title":"Hepatology."}],"container-title":["Cells &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290121000450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290121000450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:37:19Z","timestamp":1757407039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667290121000450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":25,"alternative-id":["S2667290121000450"],"URL":"https:\/\/doi.org\/10.1016\/j.cdev.2021.203711","relation":{},"ISSN":["2667-2901"],"issn-type":[{"value":"2667-2901","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNA-361 suppresses the biological processes of hepatic stellate cells in HBV-relative hepatic fibrosis by NF-kappaB p65","name":"articletitle","label":"Article Title"},{"value":"Cells & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cdev.2021.203711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"203711"}}