{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:10:21Z","timestamp":1788261021731,"version":"build-2803163510"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cells &amp; Development"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.cdev.2023.203862","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T13:07:43Z","timestamp":1685711263000},"page":"203862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Intestinal stem cells and their niches in homeostasis and disease"],"prefix":"10.1016","volume":"175","author":[{"given":"Jun","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boutros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cdev.2023.203862_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110958","article-title":"Disruption of the lipolysis pathway results in stem cell death through a sterile immunity-like pathway in adult Drosophila","volume":"39","author":"Aggarwal","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108408","article-title":"Transiently \u201cundead\u201d enterocytes mediate homeostatic tissue turnover in the adult Drosophila midgut","volume":"33","author":"Amcheslavsky","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0015","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/ncb3174","article-title":"Haemocytes control stem cell activity in the Drosophila intestine","volume":"17","author":"Ayyaz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0020","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.3390\/cells10113156","article-title":"Conditional CRISPR-Cas genome editing in Drosophila to generate intestinal tumors","volume":"10","author":"Bahuguna","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cdev.2023.203862_bb0025","doi-asserted-by":"crossref","first-page":"13615","DOI":"10.1038\/ncomms13615","article-title":"Functional exploration of colorectal cancer genomes using Drosophila","volume":"7","author":"Bangi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0030","doi-asserted-by":"crossref","first-page":"eaav6528","DOI":"10.1126\/sciadv.aav6528","article-title":"A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer","volume":"5","author":"Bangi","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cdev.2023.203862_bb0035","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41568-021-00387-5","article-title":"Tumour\u2013host interactions through the lens of Drosophila","volume":"21","author":"Bilder","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cdev.2023.203862_bb0040","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.celrep.2014.05.024","article-title":"Slit\/robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila","volume":"7","author":"Biteau","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0045","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72836","article-title":"Vinculin recruitment to \u03b1-catenin halts the differentiation and maturation of enterocyte progenitors to maintain homeostasis of the Drosophila intestine","volume":"11","author":"Bohere","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cdev.2023.203862_bb0050","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1101\/gad.1827009","article-title":"Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila","volume":"23","author":"Buchon","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.cdev.2023.203862_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006089","article-title":"Remote control of intestinal stem cell activity by haemocytes in Drosophila","volume":"12","author":"Chakrabarti","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cdev.2023.203862_bb0060","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.stemcr.2020.03.021","article-title":"The snakeskin-mesh complex of smooth septate junction restricts Yorkie to regulate intestinal homeostasis in Drosophila","volume":"14","author":"Chen","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0065","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14330","article-title":"A feedback amplification loop between stem cells and their progeny promotes tissue regeneration and tumorigenesis","volume":"5","author":"Chen","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.cdev.2023.203862_bb0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41556-017-0020-0","article-title":"Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells","volume":"20","author":"Chen","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0075","doi-asserted-by":"crossref","first-page":"18702","DOI":"10.1073\/pnas.1109348108","article-title":"Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway","volume":"108","author":"Choi","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0080","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1038\/emboj.2012.248","article-title":"Inducible progenitor-derived wingless regulates adult midgut regeneration in Drosophila: Wg in intestinal regeneration","volume":"31","author":"Cordero","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.cdev.2023.203862_bb0085","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41568-019-0155-3","article-title":"The cancer microbiome","volume":"19","author":"Elinav","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cdev.2023.203862_bb0090","article-title":"Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in the Drosophila intestine","volume":"148","author":"Ferguson","year":"2021","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.cdev.2023.203862_bb0095","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1038\/s41467-022-34270-0","article-title":"A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila","volume":"13","author":"Guo","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0100","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1083\/jcb.201302049","article-title":"Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis","volume":"201","author":"Guo","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0105","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41586-020-2866-8","article-title":"Enteric neurons increase maternal food intake during reproduction","volume":"587","author":"Hadjieconomou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature25744","article-title":"Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel","volume":"555","author":"He","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0115","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1158\/0008-5472.CAN-18-3962","article-title":"The tumor microenvironment innately modulates cancer progression","volume":"79","author":"Hinshaw","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.cdev.2023.203862_bb0120","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1038\/s41467-021-27384-4","article-title":"Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury","volume":"12","author":"Hu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0125","first-page":"4923","article-title":"A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut","volume":"125","author":"Izumi","year":"2012","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0130","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"Jiang","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0135","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.stem.2010.11.026","article-title":"EGFR\/Ras\/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila","volume":"8","author":"Jiang","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005634","article-title":"EGFR\/Ras signaling controls Drosophila intestinal stem cell proliferation via capicua-regulated genes","volume":"11","author":"Jin","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cdev.2023.203862_bb0145","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.devcel.2015.06.010","article-title":"Cell competition modifies adult stem cell and tissue population dynamics in a JAK-STAT-dependent manner","volume":"34","author":"Kolahgar","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0150","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.15252\/embj.201489072","article-title":"Escargot maintains stemness and suppresses differentiation in Drosophila intestinal stem cells","volume":"33","author":"Korzelius","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.cdev.2023.203862_bb0155","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1038\/s41467-019-12003-0","article-title":"The WT1-like transcription factor Klumpfuss maintains lineage commitment of enterocyte progenitors in the Drosophila intestine","volume":"10","author":"Korzelius","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0160","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/MOG.0000000000000887","article-title":"Implications of Paneth cell dysfunction on gastrointestinal health and disease","volume":"38","author":"Lee","year":"2022","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.cdev.2023.203862_bb0165","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.cub.2015.12.072","article-title":"Tissue crowding induces caspase-dependent competition for space","volume":"26","author":"Levayer","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.devcel.2012.12.010","article-title":"Trachea-derived dpp controls adult midgut homeostasis in Drosophila","volume":"24","author":"Li","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0175","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.celrep.2020.01.041","article-title":"A switch in tissue stem cell identity causes neuroendocrine tumors in Drosophila gut","volume":"30","author":"Li","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0180","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nature23678","article-title":"Feedback regulation of steady-state epithelial turnover and organ size","volume":"548","author":"Liang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0185","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nature07329","article-title":"Paracrine wingless signalling controls self-renewal of Drosophila intestinal stem cells","volume":"455","author":"Lin","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0190","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jmcb\/mjp028","article-title":"Paracrine unpaired signaling through the JAK\/STAT pathway controls self-renewal and lineage differentiation of Drosophila intestinal stem cells","volume":"2","author":"Lin","year":"2010","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110572","article-title":"Microbes affect gut epithelial cell composition through immune-dependent regulation of intestinal stem cell differentiation","volume":"38","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0200","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.stem.2017.02.012","article-title":"Amitosis of polyploid cells regenerates functional stem cells in the Drosophila intestine","volume":"20","author":"Lucchetta","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0205","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1073\/pnas.1715165115","article-title":"POSH regulates Hippo signaling through ubiquitin-mediated expanded degradation","volume":"115","author":"Ma","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0210","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76010","article-title":"An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine","volume":"11","author":"Marchetti","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.cdev.2023.203862_bb0215","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1073\/pnas.1401160111","article-title":"Systematic screen of chemotherapeutics in Drosophila stem cell tumors","volume":"111","author":"Markstein","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0220","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature04371","article-title":"Evidence that stem cells reside in the adult Drosophila midgut epithelium","volume":"439","author":"Micchelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0225","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022583118","article-title":"A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis","volume":"118","author":"Mukherjee","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111495","article-title":"MicroRNA mediated regulation of the onset of enteroblast differentiation in the Drosophila adult intestine","volume":"41","author":"Mukherjee","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0235","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.devcel.2020.12.007","article-title":"Homeostatic regulation of ROS-triggered hippo-Yki pathway via autophagic clearance of ref(2)P\/p62 in the Drosophila intestine","volume":"56","author":"Nagai","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0240","doi-asserted-by":"crossref","first-page":"ar32","DOI":"10.1091\/mbc.E21-03-0139","article-title":"Rab21 in enterocytes participates in intestinal epithelium maintenance","volume":"33","author":"Nassari","year":"2022","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0245","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.63807","article-title":"RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis","volume":"10","author":"N\u00e1szai","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.cdev.2023.203862_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110505","article-title":"Biotin controls intestinal stem cell mitosis and host-microbiome interactions","volume":"38","author":"Neophytou","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0255","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.cub.2020.01.082","article-title":"Disruption of EGF feedback by intestinal tumors and neighboring cells in Drosophila","volume":"30","author":"Ngo","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0260","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2011.08.048","article-title":"Altered modes of stem cell division drive adaptive intestinal growth","volume":"147","author":"O\u2019Brien","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.cdev.2023.203862_bb0265","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature04333","article-title":"The adult Drosophila posterior midgut is maintained by pluripotent stem cells","volume":"439","author":"Ohlstein","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0270","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.semcdb.2014.03.012","article-title":"Tissue design: how Drosophila tumors remodel their neighborhood","volume":"28","author":"Patel","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0275","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ncb3214","article-title":"Niche appropriation by Drosophila intestinal stem cell tumours","volume":"17","author":"Patel","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0280","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1038\/s41467-019-12336-w","article-title":"Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut","volume":"10","author":"Patel","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0285","doi-asserted-by":"crossref","first-page":"eabm1847","DOI":"10.1126\/sciadv.abm1847","article-title":"Cellular shape reinforces niche to stem cell signaling in the small intestine","volume":"8","author":"Pentinmikko","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.cdev.2023.203862_bb0290","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41556-021-00676-z","article-title":"Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila","volume":"23","author":"Perochon","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0295","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.celrep.2017.07.078","article-title":"Constitutive immune activity promotes tumorigenesis in Drosophila intestinal progenitor cells","volume":"20","author":"Petkau","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0300","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1136\/gutjnl-2018-317571","article-title":"Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis","volume":"68","author":"van der Post","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.cdev.2023.203862_bb0305","doi-asserted-by":"crossref","first-page":"11677","DOI":"10.1038\/s41598-017-11199-9","article-title":"Local juvenile hormone activity regulates gut homeostasis and tumor growth in adult Drosophila","volume":"7","author":"Rahman","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0310","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235294","article-title":"Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury","volume":"15","author":"Ramond","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.cdev.2023.203862_bb0315","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018101346","article-title":"Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila","volume":"38","author":"Reiff","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.cdev.2023.203862_bb0320","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/ncb3454","article-title":"Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis","volume":"19","author":"Resnik-Docampo","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0325","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/19336934.2018.1441651","article-title":"Keeping it tight: the relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila","volume":"12","author":"Resnik-Docampo","year":"2018","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.cdev.2023.203862_bb0330","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.cub.2014.04.007","article-title":"Local control of intestinal stem cell homeostasis by Enteroendocrine cells in the adult Drosophila midgut","volume":"24","author":"Scopelliti","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0335","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1242\/dev.052506","article-title":"The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration","volume":"137","author":"Shaw","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.cdev.2023.203862_bb0340","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature19788","article-title":"The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila","volume":"538","author":"Singh","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2023.203862_bb0345","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/s42255-022-00679-6","article-title":"Intestinal plasticity and metabolism as regulators of organismal energy homeostasis","volume":"4","author":"Stojanovi\u0107","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.cdev.2023.203862_bb0350","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cub.2015.12.043","article-title":"Cell competition drives the growth of intestinal adenomas in Drosophila","volume":"26","author":"Suijkerbuijk","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0355","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41556-021-00674-1","article-title":"Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila","volume":"23","author":"Tamamouna","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0360","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.201409025","article-title":"Injury-stimulated hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells","volume":"208","author":"Tian","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0365","doi-asserted-by":"crossref","first-page":"E2699","DOI":"10.1073\/pnas.1617790114","article-title":"Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration","volume":"114","author":"Tian","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cdev.2023.203862_bb0370","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022110834","article-title":"Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut","volume":"41","author":"Tian","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.cdev.2023.203862_bb0375","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41568-019-0231-8","article-title":"Outcompeting cancer","volume":"20","author":"Vishwakarma","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.cdev.2023.203862_bb0380","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ydbio.2013.03.020","article-title":"APC loss-induced intestinal tumorigenesis in Drosophila: roles of Ras in Wnt signaling activation and tumor progression","volume":"378","author":"Wang","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0385","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/cbin.11289","article-title":"Heparan sulfate maintains adult midgut homeostasis in Drosophila","volume":"44","author":"Wei","year":"2020","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.cdev.2023.203862_bb0390","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","article-title":"Tumor microenvironment and therapeutic response","volume":"387","author":"Wu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cdev.2023.203862_bb0395","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.celrep.2018.12.079","article-title":"The septate junction protein Tsp2A restricts intestinal stem cell activity via endocytic regulation of aPKC and hippo signaling","volume":"26","author":"Xu","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2023.203862_bb0400","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1073\/pnas.1900103117","article-title":"An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity","volume":"117","author":"Xu","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0405","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ydbio.2011.03.018","article-title":"EGFR, wingless and JAK\/STAT signaling cooperatively maintain Drosophila intestinal stem cells","volume":"354","author":"Xu","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0410","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2202133119","article-title":"Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1\/Xbp1s activation","volume":"119","author":"Yang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.cdev.2023.203862_bb0415","first-page":"644","article-title":"Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut","volume":"142","author":"Zeng","year":"2015","journal-title":"Dev. Camb. Engl."},{"key":"10.1016\/j.cdev.2023.203862_bb0420","doi-asserted-by":"crossref","first-page":"10219","DOI":"10.1038\/ncomms10219","article-title":"Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis","volume":"6","author":"Zhai","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0425","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006854","article-title":"A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila","volume":"13","author":"Zhai","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.cdev.2023.203862_bb0430","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1016\/j.cub.2022.07.003","article-title":"EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and \u03b2-oxidation","volume":"32","author":"Zhang","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0435","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ydbio.2012.10.023","article-title":"The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK\/STAT signaling in the stem cell microenvironment","volume":"373","author":"Zhou","year":"2013","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0440","article-title":"JNK-dependent intestinal barrier failure disrupts host\u2013microbe homeostasis during tumorigenesis","author":"Zhou","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.cdev.2023.203862_bb0445","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ydbio.2014.12.017","article-title":"Dpp\/Gbb signaling is required for normal intestinal regeneration during infection","volume":"399","author":"Zhou","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.cdev.2023.203862_bb0450","doi-asserted-by":"crossref","first-page":"14289","DOI":"10.1038\/ncomms14289","article-title":"ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration","volume":"8","author":"Zhou","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cdev.2023.203862_bb0455","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1016\/j.devcel.2021.06.007","article-title":"Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth","volume":"56","author":"Zhou","year":"2021","journal-title":"Dev. Cell"}],"container-title":["Cells &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290123000384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290123000384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T02:23:55Z","timestamp":1725157435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667290123000384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":91,"alternative-id":["S2667290123000384"],"URL":"https:\/\/doi.org\/10.1016\/j.cdev.2023.203862","relation":{},"ISSN":["2667-2901"],"issn-type":[{"value":"2667-2901","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal stem cells and their niches in homeostasis and disease","name":"articletitle","label":"Article Title"},{"value":"Cells & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cdev.2023.203862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"203862"}}