{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T19:33:51Z","timestamp":1785180831106,"version":"3.55.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020692","name":"Memphis Research Consortium","doi-asserted-by":"publisher","award":["MR\/W025051\/1"],"award-info":[{"award-number":["MR\/W025051\/1"]}],"id":[{"id":"10.13039\/100020692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009855","name":"Roy Castle Lung Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["BCCG1C8R"],"award-info":[{"award-number":["BCCG1C8R"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["EDDCPGM\\\\100002"],"award-info":[{"award-number":["EDDCPGM\\\\100002"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014780","name":"Longfonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cells &amp; Development"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.cdev.2024.203905","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T12:05:20Z","timestamp":1707739520000},"page":"203905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Epithelial stem and progenitor cells of the upper airway"],"prefix":"10.1016","volume":"177","author":[{"given":"Maral J.","family":"Rouhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam M.","family":"Janes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla F.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.cdev.2024.203905_bb0005","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrc3217","article-title":"Epithelial stem cells, wound healing and cancer","volume":"12","author":"Arwert","year":"2012","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.cdev.2024.203905_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1258\/002367788780746539","article-title":"Morphology of the terminal bronchiolar region of common laboratory mammals","volume":"22","author":"Bal","year":"1988","journal-title":"Lab. Anim"},{"issue":"7904","key":"10.1016\/j.cdev.2024.203905_bb0015","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-022-04552-0","article-title":"Human distal airways contain a multipotent secretory cell that can regenerate alveoli","volume":"604","author":"Basil","year":"2022","journal-title":"Nature"},{"issue":"6 Pt 1","key":"10.1016\/j.cdev.2024.203905_bb0020","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1164\/ajrccm.157.6.9707011","article-title":"Number and proliferation of basal and parabasal cells in normal human airway epithelium","volume":"157","author":"Boers","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0025","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1164\/rccm.201507-1414OC","article-title":"Rapid expansion of human epithelial stem cells suitable for airway tissue engineering","volume":"194","author":"Butler","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"11","key":"10.1016\/j.cdev.2024.203905_bb0030","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1164\/rccm.201904-0792OC","article-title":"Single-cell reconstruction of human basal cell diversity in Normal and idiopathic pulmonary fibrosis lungs","volume":"202","author":"Carraro","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.cdev.2024.203905_bb0035","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1164\/rccm.201911-2199OC","article-title":"A single-cell atlas of the human healthy airways","volume":"202","author":"Deprez","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.cdev.2024.203905_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.744969","article-title":"Preclinical application of conditional reprogramming culture system for laryngeal and Hypopharyngeal carcinoma","volume":"9","author":"Dong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.cdev.2024.203905_bb0045","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1158\/2159-8290.CD-18-1522","article-title":"Oral mucosal organoids as a potential platform for personalized cancer therapy","volume":"9","author":"Driehuis","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.cdev.2024.203905_bb0050","doi-asserted-by":"crossref","unstructured":"Ghosh M, Brechbuhl HM, Smith RW, et al. Context-dependent differentiation of multipotential keratin 14-expressing tracheal basal cells. Am. J. Respir. Cell Mol. Biol. Aug 2011;45(2):403\u201310. doi:https:\/\/doi.org\/10.1165\/rcmb.2010-0283OC.","DOI":"10.1165\/rcmb.2010-0283OC"},{"issue":"4","key":"10.1016\/j.cdev.2024.203905_bb0055","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00437-2018","article-title":"The \u201cone airway, one disease\u201d concept in light of Th2 inflammation","volume":"52","author":"Giovannini-Chami","year":"2018","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.cdev.2024.203905_bb0060","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1038\/s41467-020-16239-z","article-title":"Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium","volume":"11","author":"Goldfarbmuren","year":"2020","journal-title":"Nat. Commun."},{"issue":"2 Suppl","key":"10.1016\/j.cdev.2024.203905_bb0065","doi-asserted-by":"crossref","first-page":"11S","DOI":"10.1378\/chest.111.2_Supplement.11S","article-title":"One airway, one disease","volume":"111","author":"Grossman","year":"1997","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.cdev.2024.203905_bb0070","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","article-title":"Regulation of immune responses by the airway epithelial cell landscape","volume":"21","author":"Hewitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.cdev.2024.203905_bb0075","doi-asserted-by":"crossref","first-page":"L643","DOI":"10.1152\/ajplung.00155.2003","article-title":"In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations","volume":"286","author":"Hong","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0080","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cell.2020.05.042","article-title":"SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract","volume":"182","author":"Hou","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.cdev.2024.203905_bb0095","first-page":"891","article-title":"A correlative light microscopy, transmission and scanning electron microscopy study of the ferret lung","volume":"3","author":"Hyde","year":"1979","journal-title":"Scan. Electron Microsc."},{"issue":"1","key":"10.1016\/j.cdev.2024.203905_bb0100","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ijc.31383","article-title":"Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors","volume":"143","author":"Hynds","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cdev.2024.203905_bb0105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/7651_2016_5","article-title":"Expansion of human airway basal stem cells and their differentiation as 3D Tracheospheres","volume":"1576","author":"Hynds","year":"2019","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.cdev.2024.203905_bb0110","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1165\/rcmb.2013-0453TR","article-title":"Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine","volume":"51","author":"Judge","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.cdev.2024.203905_bb0115","unstructured":"K S. Functional histoanatomy of the Human Larynx."},{"issue":"7904","key":"10.1016\/j.cdev.2024.203905_bb0120","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-022-04541-3","article-title":"Human distal lung maps and lineage hierarchies reveal a bipotent progenitor","volume":"604","author":"Kadur Lakshminarasimha Murthy","year":"2022","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.cdev.2024.203905_bb0125","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm.3642","article-title":"Lung regeneration: mechanisms, applications and emerging stem cell populations","volume":"20","author":"Kotton","year":"2014","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.cdev.2024.203905_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053817","article-title":"Alveolar type II cells possess the capability of initiating lung tumor development","volume":"7","author":"Lin","year":"2012","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ydbio.2014.12.037","article-title":"Ontogeny of the mouse vocal fold epithelium","volume":"399","author":"Lungova","year":"2015","journal-title":"Dev Biol."},{"issue":"9","key":"10.1016\/j.cdev.2024.203905_bb0140","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.stem.2023.07.014","article-title":"Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells","volume":"30","author":"Ma","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0145","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/ilar\/ilx030","article-title":"Nonhuman primate models of respiratory disease: past, present, and future","volume":"58","author":"Miller","year":"2017","journal-title":"ILAR J."},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0150","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1242\/dev.116855","article-title":"Notch3-jagged signaling controls the pool of undifferentiated airway progenitors","volume":"142","author":"Mori","year":"2015","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0155","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.stem.2016.05.012","article-title":"Dual SMAD signaling inhibition enables long-term expansion of diverse epithelial basal cells","volume":"19","author":"Mou","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.cdev.2024.203905_bb0160","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41591-020-01227-z","article-title":"Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics","volume":"27","author":"Muus","year":"2021","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.cdev.2024.203905_bb0165","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1440-1827.1998.tb03865.x","article-title":"Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways","volume":"48","author":"Nakajima","year":"1998","journal-title":"Pathol. Int."},{"issue":"6","key":"10.1016\/j.cdev.2024.203905_bb0170","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1164\/rccm.201804-0734OC","article-title":"Localization of secretory mucins MUC5AC and MUC5B in normal\/healthy human airways","volume":"199","author":"Okuda","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"7720","key":"10.1016\/j.cdev.2024.203905_bb0175","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.cdev.2024.203905_bb0180","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1165\/rcmb.2020-0440TR","article-title":"Stem cell-derived respiratory epithelial cell cultures as human disease models","volume":"64","author":"Orr","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.cdev.2024.203905_bb0185","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.stem.2015.01.002","article-title":"Injury induces direct lineage segregation of functionally distinct airway basal stem\/progenitor cell subpopulations","volume":"16","author":"Pardo-Saganta","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.cdev.2024.203905_bb0190","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2009.04.002","article-title":"The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium","volume":"4","author":"Rawlins","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"31","key":"10.1016\/j.cdev.2024.203905_bb0195","doi-asserted-by":"crossref","first-page":"12771","DOI":"10.1073\/pnas.0906850106","article-title":"Basal cells as stem cells of the mouse trachea and human airway epithelium","volume":"106","author":"Rock","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9\u201310","key":"10.1016\/j.cdev.2024.203905_bb0200","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1242\/dmm.006031","article-title":"Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling","volume":"3","author":"Rock","year":"2010","journal-title":"Dis Model Mech. Sep-Oct"},{"issue":"6","key":"10.1016\/j.cdev.2024.203905_bb0205","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.stem.2011.04.003","article-title":"Notch-dependent differentiation of adult airway basal stem cells","volume":"8","author":"Rock","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.cdev.2024.203905_bb0210","doi-asserted-by":"crossref","unstructured":"Rogers CS, Abraham WM, Brogden KA, et al. The porcine lung as a potential model for cystic fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. Aug 2008;295(2):L240\u2013L263. doi:https:\/\/doi.org\/10.1152\/ajplung.90203.2008.","DOI":"10.1152\/ajplung.90203.2008"},{"issue":"20","key":"10.1016\/j.cdev.2024.203905_bb0215","doi-asserted-by":"crossref","DOI":"10.1242\/dev.177428","article-title":"Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures","volume":"146","author":"Ruiz Garcia","year":"2019","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.cdev.2024.203905_bb0220","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2018100300","article-title":"Long-term expanding human airway organoids for disease modeling","volume":"38","author":"Sachs","year":"2019","journal-title":"EMBO J."},{"issue":"7839","key":"10.1016\/j.cdev.2024.203905_bb0225","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/s41586-020-3014-1","article-title":"Progenitor identification and SARS-CoV-2 infection in human distal lung organoids","volume":"588","author":"Salahudeen","year":"2020","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.cdev.2024.203905_bb0230","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"issue":"7475","key":"10.1016\/j.cdev.2024.203905_bb0235","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature12777","article-title":"Dedifferentiation of committed epithelial cells into stem cells in vivo","volume":"503","author":"Tata","year":"2013","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cdev.2024.203905_bb0240","article-title":"Shared gene expression alterations in nasal and bronchial epithelium for lung cancer detection","volume":"109","author":"Team AS","year":"2017","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.cdev.2024.203905_bb0245","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00966","article-title":"Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors","volume":"2","author":"Teixeira","year":"2013","journal-title":"Elife"},{"issue":"7536","key":"10.1016\/j.cdev.2024.203905_bb0250","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature14112","article-title":"Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury","volume":"517","author":"Vaughan","year":"2015","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.cdev.2024.203905_bb0255","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/s41591-019-0468-5","article-title":"A cellular census of human lungs identifies novel cell states in health and in asthma","volume":"25","author":"Vieira Braga","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.cdev.2024.203905_bb0260","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.celrep.2015.06.011","article-title":"Clonal dynamics reveal two distinct populations of basal cells in slow-turnover airway epithelium","volume":"12","author":"Watson","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.cdev.2024.203905_bb0265","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1152\/jappl.1962.17.2.343","article-title":"A principle for counting tissue structures on random sections","volume":"17","author":"Weibel","year":"1962","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.cdev.2024.203905_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.942622","article-title":"Transcriptome dynamics in the developing larynx, Trachea, and esophagus","volume":"10","author":"Wendt","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.cdev.2024.203905_bb0275","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ncb3580","article-title":"Local lung hypoxia determines epithelial fate decisions during alveolar regeneration","volume":"19","author":"Xi","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"13","key":"10.1016\/j.cdev.2024.203905_bb0280","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1073\/pnas.1112499109","article-title":"Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma","volume":"109","author":"Xu","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7794","key":"10.1016\/j.cdev.2024.203905_bb0285","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41586-020-1961-1","article-title":"Tobacco smoking and somatic mutations in human bronchial epithelium","volume":"578","author":"Yoshida","year":"2020","journal-title":"Nature"},{"issue":"7896","key":"10.1016\/j.cdev.2024.203905_bb0290","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41586-021-04345-x","article-title":"Local and systemic responses to SARS-CoV-2 infection in children and adults","volume":"602","author":"Yoshida","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2024.203905_bb0295","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1038\/srep04619","article-title":"Reduced growth and proliferation dynamics of nasal epithelial stem\/progenitor cells in nasal polyps in vitro","volume":"4","author":"Yu","year":"2014","journal-title":"Sci Rep"},{"issue":"7798","key":"10.1016\/j.cdev.2024.203905_bb0300","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.cdev.2024.203905_bb0305","first-page":"11","article-title":"Airway basal cells show regionally distinct potential to undergo metaplastic differentiation","author":"Zhou","year":"2022","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.cdev.2024.203905_bb0310","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"issue":"7536","key":"10.1016\/j.cdev.2024.203905_bb0315","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nature13903","article-title":"p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration","volume":"517","author":"Zuo","year":"2015","journal-title":"Nature"}],"container-title":["Cells &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290124000068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667290124000068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:27:37Z","timestamp":1778930857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667290124000068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":61,"alternative-id":["S2667290124000068"],"URL":"https:\/\/doi.org\/10.1016\/j.cdev.2024.203905","relation":{},"ISSN":["2667-2901"],"issn-type":[{"value":"2667-2901","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epithelial stem and progenitor cells of the upper airway","name":"articletitle","label":"Article Title"},{"value":"Cells & Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cdev.2024.203905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"203905"}}